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The map label for this gene is serS

Identifier: 99080835

GI number: 99080835

Start: 1066244

End: 1067536

Strand: Reverse

Name: serS

Synonym: TM1040_0994

Alternate gene names: 99080835

Gene position: 1067536-1066244 (Counterclockwise)

Preceding gene: 99080845

Following gene: 99080829

Centisome position: 33.35

GC content: 63.5

Gene sequence:

>1293_bases
ATGCATGATATCCGTGCAATCCGCGAGAATCCGGCCGCTTTCGACGCCGCCCTGGCCCGTCGTGGAGACTCTGCCCTGTC
GTCTCAGGTGCTGGAACTCGACGAGGCCCGCCGCGCCAAGATCCTCGCGGCCGAAACCGCTCAGGCCGACCAGAACAAGG
CCGCCAAAGCCATCGGCGCCGCCAAGGCGAAGGGCGATGAGGCCGAGTTTGAGCGCCTGCGCGCCGAAGTGGCCGACAAG
AAGGCCGAAGTGGCCGCCATGCAGGCCGAAGCCAAGGAGCTGGATGCCAAGCTCACCGACATGCTCGCGCGCATCCCCAA
TAGCCCGGCCGAAGATGTGCCGGACGGCGCAGACGAGGACGACAACGTCGAGGTAAAGCGCTGGGGCGATGTGCCCGCGT
TCGATTTTGACCCCAAGGAGCATTTCGAGATCGCCGGTGTCGCCAAGGCGATGGACTTTGAAACCGCCGCCAAGATTTCT
GGCTCGCGCTTTGTGGTGCTGAAAGGCGCTGTCGCACGGATCCACCGCGCACTGGCGCAGTTCATGGTCGACACCCATGT
CGACGAAAACGGCCTCACCGAGGTGAACTCGCCCGTGCTGGTGCGGGATGAGGCCATGTATGGCACCGACAAGCTGCCGA
AATTCGGCGAGGACAGCTATCAGACCACCAATGGCTGGTGGCTGGTGCCCACCTCCGAGGTGCCGCTGACCTATTCGGTG
GCCGGAGACGTCATCGACGAGGCAGCGCTGCCGATCCGCTACACCGCGCATACGCTGTGTTTCCGCTCGGAGGCAGGCTC
GGCAGGCAAGGACACCTCGGGCATGCTGCGCCAGCATCAGTTCGAGAAGGTCGAAATGGTGTCGATCGTGCATCCCGAGA
CCTCCGACGAGGAGCAAAAGCGCATGTTGGGATGCGCCGAGGGCATTCTGGAAAAGCTCGGCATTCCCTATCGCACCGTC
GTGCTCTGCACCGGCGACATGGGCTTTGGCGCGCGTCGCACCTATGACATCGAGGCCTGGGTGCCGGGGCAAAACACCTA
TCGTGAGATTTCTTCGGTTTCGACCACAGGCGACTTTCAGGCCCGCCGCATGAACGCGCGCTTCAAGCCCGCAGATGGGG
GCAAGCCGGAGTTCCTGCACACGCTCAATGGCTCCGGTCTTGCGGTGGGGCGCTGTCTCATTGCGGTGCTCGAAAACGGC
CAGCAGGCGGATGGGTCGGTAAAACTGCCCGACGCGCTTGCGCCTTATCTTGGCGGCAAGTTGACCTTGACCGCAGAGGG
CCAACTGGCCTGA

Upstream 100 bases:

>100_bases
GCCACAGGGCCTGGAACACAGCCCCTGCCCCCTTCCCCTTCGCGCCCCTCTCGGGCATAGCTAGCGTCACTGATTCAAAC
TGCATCACAGGAGCAGACCC

Downstream 100 bases:

>100_bases
TCTAAACCGCCTGCCGGGCCGAGGGGTGTCCCCCAGCCCATCGCAACAGAGCGTTAAAACAGAAAAACCGGTGCCACATC
GCACCGGTTTTTTCACTCAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDIRAIRENPAAFDAALARRGDSALSSQVLELDEARRAKILAAETAQADQNKAAKAIGAAKAKGDEAEFERLRAEVADK
KAEVAAMQAEAKELDAKLTDMLARIPNSPAEDVPDGADEDDNVEVKRWGDVPAFDFDPKEHFEIAGVAKAMDFETAAKIS
GSRFVVLKGAVARIHRALAQFMVDTHVDENGLTEVNSPVLVRDEAMYGTDKLPKFGEDSYQTTNGWWLVPTSEVPLTYSV
AGDVIDEAALPIRYTAHTLCFRSEAGSAGKDTSGMLRQHQFEKVEMVSIVHPETSDEEQKRMLGCAEGILEKLGIPYRTV
VLCTGDMGFGARRTYDIEAWVPGQNTYREISSVSTTGDFQARRMNARFKPADGGKPEFLHTLNGSGLAVGRCLIAVLENG
QQADGSVKLPDALAPYLGGKLTLTAEGQLA

Sequences:

>Translated_430_residues
MHDIRAIRENPAAFDAALARRGDSALSSQVLELDEARRAKILAAETAQADQNKAAKAIGAAKAKGDEAEFERLRAEVADK
KAEVAAMQAEAKELDAKLTDMLARIPNSPAEDVPDGADEDDNVEVKRWGDVPAFDFDPKEHFEIAGVAKAMDFETAAKIS
GSRFVVLKGAVARIHRALAQFMVDTHVDENGLTEVNSPVLVRDEAMYGTDKLPKFGEDSYQTTNGWWLVPTSEVPLTYSV
AGDVIDEAALPIRYTAHTLCFRSEAGSAGKDTSGMLRQHQFEKVEMVSIVHPETSDEEQKRMLGCAEGILEKLGIPYRTV
VLCTGDMGFGARRTYDIEAWVPGQNTYREISSVSTTGDFQARRMNARFKPADGGKPEFLHTLNGSGLAVGRCLIAVLENG
QQADGSVKLPDALAPYLGGKLTLTAEGQLA
>Mature_430_residues
MHDIRAIRENPAAFDAALARRGDSALSSQVLELDEARRAKILAAETAQADQNKAAKAIGAAKAKGDEAEFERLRAEVADK
KAEVAAMQAEAKELDAKLTDMLARIPNSPAEDVPDGADEDDNVEVKRWGDVPAFDFDPKEHFEIAGVAKAMDFETAAKIS
GSRFVVLKGAVARIHRALAQFMVDTHVDENGLTEVNSPVLVRDEAMYGTDKLPKFGEDSYQTTNGWWLVPTSEVPLTYSV
AGDVIDEAALPIRYTAHTLCFRSEAGSAGKDTSGMLRQHQFEKVEMVSIVHPETSDEEQKRMLGCAEGILEKLGIPYRTV
VLCTGDMGFGARRTYDIEAWVPGQNTYREISSVSTTGDFQARRMNARFKPADGGKPEFLHTLNGSGLAVGRCLIAVLENG
QQADGSVKLPDALAPYLGGKLTLTAEGQLA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=389, Percent_Identity=30.5912596401028, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI16306548, Length=439, Percent_Identity=30.0683371298405, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=32.4324324324324, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=50.3512880562061, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17539260, Length=445, Percent_Identity=28.9887640449438, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17542084, Length=345, Percent_Identity=30.4347826086957, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321799, Length=433, Percent_Identity=28.4064665127021, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320226, Length=391, Percent_Identity=31.4578005115089, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24581334, Length=336, Percent_Identity=32.1428571428571, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17737985, Length=366, Percent_Identity=29.2349726775956, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SILST (Q1GHY9)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612989.1
- ProteinModelPortal:   Q1GHY9
- SMR:   Q1GHY9
- STRING:   Q1GHY9
- GeneID:   4078156
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0994
- NMPDR:   fig|292414.1.peg.3069
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q1GHY9
- ProtClustDB:   PRK05431
- BioCyc:   SSP292414:TM1040_0994-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46584; Mature: 46584

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRAIRENPAAFDAALARRGDSALSSQVLELDEARRAKILAAETAQADQNKAAKAIGA
CCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHH
AKAKGDEAEFERLRAEVADKKAEVAAMQAEAKELDAKLTDMLARIPNSPAEDVPDGADED
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCC
DNVEVKRWGDVPAFDFDPKEHFEIAGVAKAMDFETAAKISGSRFVVLKGAVARIHRALAQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCHHHHHHHHHHH
FMVDTHVDENGLTEVNSPVLVRDEAMYGTDKLPKFGEDSYQTTNGWWLVPTSEVPLTYSV
HHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEH
AGDVIDEAALPIRYTAHTLCFRSEAGSAGKDTSGMLRQHQFEKVEMVSIVHPETSDEEQK
HHHHHHHCCCCEEEHHHHEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCHHHH
RMLGCAEGILEKLGIPYRTVVLCTGDMGFGARRTYDIEAWVPGQNTYREISSVSTTGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCH
ARRMNARFKPADGGKPEFLHTLNGSGLAVGRCLIAVLENGQQADGSVKLPDALAPYLGGK
HHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCE
LTLTAEGQLA
EEEEECCCCC
>Mature Secondary Structure
MHDIRAIRENPAAFDAALARRGDSALSSQVLELDEARRAKILAAETAQADQNKAAKAIGA
CCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHH
AKAKGDEAEFERLRAEVADKKAEVAAMQAEAKELDAKLTDMLARIPNSPAEDVPDGADED
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCC
DNVEVKRWGDVPAFDFDPKEHFEIAGVAKAMDFETAAKISGSRFVVLKGAVARIHRALAQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCEEEEECCHHHHHHHHHHH
FMVDTHVDENGLTEVNSPVLVRDEAMYGTDKLPKFGEDSYQTTNGWWLVPTSEVPLTYSV
HHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEH
AGDVIDEAALPIRYTAHTLCFRSEAGSAGKDTSGMLRQHQFEKVEMVSIVHPETSDEEQK
HHHHHHHCCCCEEEHHHHEEEECCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCHHHH
RMLGCAEGILEKLGIPYRTVVLCTGDMGFGARRTYDIEAWVPGQNTYREISSVSTTGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCH
ARRMNARFKPADGGKPEFLHTLNGSGLAVGRCLIAVLENGQQADGSVKLPDALAPYLGGK
HHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCEECCHHHHHHCCCE
LTLTAEGQLA
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA