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The map label for this gene is lysR [H]

Identifier: 99080689

GI number: 99080689

Start: 900379

End: 901287

Strand: Reverse

Name: lysR [H]

Synonym: TM1040_0848

Alternate gene names: 99080689

Gene position: 901287-900379 (Counterclockwise)

Preceding gene: 99080698

Following gene: 99080685

Centisome position: 28.16

GC content: 60.4

Gene sequence:

>909_bases
GTGCAGTTTAAACTCCGCCAGCTTCAGGCTTTCAGGGCCGTTGCGGAAACCGGCAGCATCACCAAGGCGGCAGAGGCGCT
TGGCGTCTCGCAGCCTGCAGTGAGTCGCCTGATTTCGGATTTTTCCGCGTCCATGGACCTGGAATTGTTCCAGCGCCGCC
GCGGCATCCTCGAACCGACAAGCGATTCTCGCCATCTTCTGACCGAGGTGCGCCGGATTCTCGCAGGGCTTGATCACCTA
GAAGATCTGCGCCGCGATCTGAAGGAACGCACGGGCGGGCACATGCGGATTGCCTGCCTGCCGGGATTTGCCACCTCTCA
TCTGCCTCAGGTTCTTGCCCAGTTTATGAAGGAACGCCCCGGCGTCACCGTGGCGCTGGAACCCGACCGCCCCGAGCGCA
TCCTGGAGTGGATCATAGGAGAGCAATATGACTGTGGTATAACGGATGACTTTGCCGGCCACCCCGCCACCGAGAGCATT
GATCTCTTTGTGCGTTCGGCCTGCATCCTGCCTCCAAGGCATCCGCTCGAGCACAAGACCATCATCACCCCGCGCGATCT
GGCCGGTGAAAAACTCATTCATACCCGGCGCGACAGCGGCTTTTATCGTCGTCTGTCCCGGGCCTTTGCGGAATATGAAA
CGGAGATGAACAGCCTCATTGAGGTGCGCCAGTTTACCACTGCCTGCCTCATGGTGCGCGAGGGCGTGGGGGCCTCGGTG
GTGAGTGCGCTGGACGCTGAGGGGTTTCGCGACAGAGGGATTGTGATCAAACCTTTCGAGCCAAAGATCCACCACCGGTT
GTCGATCCTCTTCCCCAGCGCCGTCAGCGTGCCGCGCGTGGTGCGTGATTTTATGGATGTCTTTGTCGAAAGCCTCTCCC
CGGTGCTGGCCTCGCCCGCACCGAAATAG

Upstream 100 bases:

>100_bases
TGCGTCATAATTCAAGTGAAAGTTTCACAACAGTGACATAACAGTATATTATAAATACTGTCATCAGGCTCGGAAAATTC
ACCGCAGGAAGGACGCAACA

Downstream 100 bases:

>100_bases
GCGCGGGAGGCATGCGACTAGAGACTGTCTAAGTGGTCGCGATTGTGGTGTGAGAAACCGGGGGAGGCCTGTCATCTCGG
GCCTCGGCGCCGGACATGCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MQFKLRQLQAFRAVAETGSITKAAEALGVSQPAVSRLISDFSASMDLELFQRRRGILEPTSDSRHLLTEVRRILAGLDHL
EDLRRDLKERTGGHMRIACLPGFATSHLPQVLAQFMKERPGVTVALEPDRPERILEWIIGEQYDCGITDDFAGHPATESI
DLFVRSACILPPRHPLEHKTIITPRDLAGEKLIHTRRDSGFYRRLSRAFAEYETEMNSLIEVRQFTTACLMVREGVGASV
VSALDAEGFRDRGIVIKPFEPKIHHRLSILFPSAVSVPRVVRDFMDVFVESLSPVLASPAPK

Sequences:

>Translated_302_residues
MQFKLRQLQAFRAVAETGSITKAAEALGVSQPAVSRLISDFSASMDLELFQRRRGILEPTSDSRHLLTEVRRILAGLDHL
EDLRRDLKERTGGHMRIACLPGFATSHLPQVLAQFMKERPGVTVALEPDRPERILEWIIGEQYDCGITDDFAGHPATESI
DLFVRSACILPPRHPLEHKTIITPRDLAGEKLIHTRRDSGFYRRLSRAFAEYETEMNSLIEVRQFTTACLMVREGVGASV
VSALDAEGFRDRGIVIKPFEPKIHHRLSILFPSAVSVPRVVRDFMDVFVESLSPVLASPAPK
>Mature_302_residues
MQFKLRQLQAFRAVAETGSITKAAEALGVSQPAVSRLISDFSASMDLELFQRRRGILEPTSDSRHLLTEVRRILAGLDHL
EDLRRDLKERTGGHMRIACLPGFATSHLPQVLAQFMKERPGVTVALEPDRPERILEWIIGEQYDCGITDDFAGHPATESI
DLFVRSACILPPRHPLEHKTIITPRDLAGEKLIHTRRDSGFYRRLSRAFAEYETEMNSLIEVRQFTTACLMVREGVGASV
VSALDAEGFRDRGIVIKPFEPKIHHRLSILFPSAVSVPRVVRDFMDVFVESLSPVLASPAPK

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=300, Percent_Identity=35, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI145693105, Length=275, Percent_Identity=26.5454545454545, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI157672245, Length=189, Percent_Identity=31.2169312169312, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789173, Length=269, Percent_Identity=28.2527881040892, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87081904, Length=191, Percent_Identity=28.7958115183246, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788887, Length=300, Percent_Identity=24.3333333333333, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=146, Percent_Identity=26.027397260274, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33889; Mature: 33889

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFKLRQLQAFRAVAETGSITKAAEALGVSQPAVSRLISDFSASMDLELFQRRRGILEPT
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
SDSRHLLTEVRRILAGLDHLEDLRRDLKERTGGHMRIACLPGFATSHLPQVLAQFMKERP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
GVTVALEPDRPERILEWIIGEQYDCGITDDFAGHPATESIDLFVRSACILPPRHPLEHKT
CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCE
IITPRDLAGEKLIHTRRDSGFYRRLSRAFAEYETEMNSLIEVRQFTTACLMVREGVGASV
ECCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VSALDAEGFRDRGIVIKPFEPKIHHRLSILFPSAVSVPRVVRDFMDVFVESLSPVLASPA
HHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PK
CC
>Mature Secondary Structure
MQFKLRQLQAFRAVAETGSITKAAEALGVSQPAVSRLISDFSASMDLELFQRRRGILEPT
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
SDSRHLLTEVRRILAGLDHLEDLRRDLKERTGGHMRIACLPGFATSHLPQVLAQFMKERP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
GVTVALEPDRPERILEWIIGEQYDCGITDDFAGHPATESIDLFVRSACILPPRHPLEHKT
CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCE
IITPRDLAGEKLIHTRRDSGFYRRLSRAFAEYETEMNSLIEVRQFTTACLMVREGVGASV
ECCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VSALDAEGFRDRGIVIKPFEPKIHHRLSILFPSAVSVPRVVRDFMDVFVESLSPVLASPA
HHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]