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The map label for this gene is purM [H]

Identifier: 94985716

GI number: 94985716

Start: 1718605

End: 1719672

Strand: Reverse

Name: purM [H]

Synonym: Dgeo_1616

Alternate gene names: 94985716

Gene position: 1719672-1718605 (Counterclockwise)

Preceding gene: 94985717

Following gene: 94985715

Centisome position: 69.7

GC content: 68.82

Gene sequence:

>1068_bases
ATGACGCAAGGCAAGATGGACTCGGCCCAGGCGGGAGCATCGGCATACGAGCGAGCAGGTGTGAGCATCGACGCGGGGCA
CCGGGCCGTCGCCCTGATGAAAGACGCGGTTGCCCGCACCCACACCCCCGCCGTTTTGGGCGGCATCGGTGGCTTCGGCG
GGCTGTTTCGCGCGGCTTTTGGGCACCTGAATGACCCCGTGCTGGTCGCCTCGACCGACGGTGTGGGCACCAAAACGAAG
GTGGCGGTGCGGACTGGGCGCTTTGCGGGACTGGGCGCAGACATCGTGAACCACTGTGTCAACGACATCCTGGTGCAGGG
TGCGCGGCCCCTTTTCTTCCTCGACTACGTCGCGATGGGGCGGCTCCTGCCCGAGCGGGTGGCGGAGGTGGTGACCGGCG
CGGCGCGGGCCTGTGAGGCGCTGGGCGTGGCGCTGCTGGGCGGGGAGACCGCTGAGATGCCCGGTGTATATGTAGAGGGC
GAACTGGATATCGTGGGCACGATTGTGGGTGTGGTGGACCGGCACAAGCTCATCGACGGCGCGCGCCTGCAGCCCGGTGA
CGTGGTGATCGCCCTGCCCAGCACGGGACTCCACACCAACGGATATAGCCTGGCGCGGATGGCCCTGGCCGACTTGGACT
GGGAGGAGGCCCGTGCGGACCTGGGCGGTGAGCGGCTGGCTGATCTGCTCACCGTGCCGCACCGGGCCTACCTGGGGGCC
TTTGACGCGCTGCAGGCGGCGGGCGTGGACGTGCGCGGCATGGCCCATATCACCGGGGGCGGACTGGTGGACAACCCGCC
GCGCATCTTTCCAGCCGGGGTGGGAATGCGGGTAAACACCGCGTCTTGGACGGTGCCGCCCCTCTTCGAGCTGATCGTGC
GCCAGGCGGGAGTGGCGCGGGAGGAAGCCTTCCGTGCGCTGAACATGGGGGTCGGTTTCCTGTTCATCGTGCCCGCCGCG
CAGGGAGAAGCGGCGCTGGCCTCCTTGCGCGGTGCGGGCGAGTCGCCGTGGGTGATCGGGGAGATGGTGCCCGGTTCCGG
CGTGACCTTTGACGGAGTACCTGCTTGA

Upstream 100 bases:

>100_bases
TGCCCTGCGCTGGTGGCTGGCCCGCCGCGCCGTCAAGGAGGCCAAAGTCGGGTAAACTGCGCGGCGGACCGCCCCAACTG
GGGGCGCTTCCGGGAGGAGC

Downstream 100 bases:

>100_bases
CCAGGCACCGGCCCCCGACGGGCTTCACCCCACCCGATCGCCGGACGGCAACCGAGTTTTGGGTCGTGCGGCACGGCGAG
AGCATCTGGAACGCCGACGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTQGKMDSAQAGASAYERAGVSIDAGHRAVALMKDAVARTHTPAVLGGIGGFGGLFRAAFGHLNDPVLVASTDGVGTKTK
VAVRTGRFAGLGADIVNHCVNDILVQGARPLFFLDYVAMGRLLPERVAEVVTGAARACEALGVALLGGETAEMPGVYVEG
ELDIVGTIVGVVDRHKLIDGARLQPGDVVIALPSTGLHTNGYSLARMALADLDWEEARADLGGERLADLLTVPHRAYLGA
FDALQAAGVDVRGMAHITGGGLVDNPPRIFPAGVGMRVNTASWTVPPLFELIVRQAGVAREEAFRALNMGVGFLFIVPAA
QGEAALASLRGAGESPWVIGEMVPGSGVTFDGVPA

Sequences:

>Translated_355_residues
MTQGKMDSAQAGASAYERAGVSIDAGHRAVALMKDAVARTHTPAVLGGIGGFGGLFRAAFGHLNDPVLVASTDGVGTKTK
VAVRTGRFAGLGADIVNHCVNDILVQGARPLFFLDYVAMGRLLPERVAEVVTGAARACEALGVALLGGETAEMPGVYVEG
ELDIVGTIVGVVDRHKLIDGARLQPGDVVIALPSTGLHTNGYSLARMALADLDWEEARADLGGERLADLLTVPHRAYLGA
FDALQAAGVDVRGMAHITGGGLVDNPPRIFPAGVGMRVNTASWTVPPLFELIVRQAGVAREEAFRALNMGVGFLFIVPAA
QGEAALASLRGAGESPWVIGEMVPGSGVTFDGVPA
>Mature_354_residues
TQGKMDSAQAGASAYERAGVSIDAGHRAVALMKDAVARTHTPAVLGGIGGFGGLFRAAFGHLNDPVLVASTDGVGTKTKV
AVRTGRFAGLGADIVNHCVNDILVQGARPLFFLDYVAMGRLLPERVAEVVTGAARACEALGVALLGGETAEMPGVYVEGE
LDIVGTIVGVVDRHKLIDGARLQPGDVVIALPSTGLHTNGYSLARMALADLDWEEARADLGGERLADLLTVPHRAYLGAF
DALQAAGVDVRGMAHITGGGLVDNPPRIFPAGVGMRVNTASWTVPPLFELIVRQAGVAREEAFRALNMGVGFLFIVPAAQ
GEAALASLRGAGESPWVIGEMVPGSGVTFDGVPA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=338, Percent_Identity=40.2366863905325, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI209869995, Length=338, Percent_Identity=40.2366863905325, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI209869993, Length=338, Percent_Identity=40.2366863905325, Blast_Score=241, Evalue=9e-64,
Organism=Escherichia coli, GI1788845, Length=326, Percent_Identity=43.558282208589, Blast_Score=263, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=35.0877192982456, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6321203, Length=345, Percent_Identity=38.8405797101449, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=33.4494773519164, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36604; Mature: 36473

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQGKMDSAQAGASAYERAGVSIDAGHRAVALMKDAVARTHTPAVLGGIGGFGGLFRAAF
CCCCCCCHHHHCHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHH
GHLNDPVLVASTDGVGTKTKVAVRTGRFAGLGADIVNHCVNDILVQGARPLFFLDYVAMG
HCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLLPERVAEVVTGAARACEALGVALLGGETAEMPGVYVEGELDIVGTIVGVVDRHKLIDG
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCC
ARLQPGDVVIALPSTGLHTNGYSLARMALADLDWEEARADLGGERLADLLTVPHRAYLGA
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHH
FDALQAAGVDVRGMAHITGGGLVDNPPRIFPAGVGMRVNTASWTVPPLFELIVRQAGVAR
HHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHCCHH
EEAFRALNMGVGFLFIVPAAQGEAALASLRGAGESPWVIGEMVPGSGVTFDGVPA
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TQGKMDSAQAGASAYERAGVSIDAGHRAVALMKDAVARTHTPAVLGGIGGFGGLFRAAF
CCCCCCHHHHCHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHH
GHLNDPVLVASTDGVGTKTKVAVRTGRFAGLGADIVNHCVNDILVQGARPLFFLDYVAMG
HCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RLLPERVAEVVTGAARACEALGVALLGGETAEMPGVYVEGELDIVGTIVGVVDRHKLIDG
HHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCC
ARLQPGDVVIALPSTGLHTNGYSLARMALADLDWEEARADLGGERLADLLTVPHRAYLGA
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCHHHHHHH
FDALQAAGVDVRGMAHITGGGLVDNPPRIFPAGVGMRVNTASWTVPPLFELIVRQAGVAR
HHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHCCHH
EEAFRALNMGVGFLFIVPAAQGEAALASLRGAGESPWVIGEMVPGSGVTFDGVPA
HHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA