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The map label for this gene is argF [H]

Identifier: 94985705

GI number: 94985705

Start: 1706986

End: 1707909

Strand: Reverse

Name: argF [H]

Synonym: Dgeo_1605

Alternate gene names: 94985705

Gene position: 1707909-1706986 (Counterclockwise)

Preceding gene: 94985710

Following gene: 94985704

Centisome position: 69.22

GC content: 66.45

Gene sequence:

>924_bases
ATGGCCGGGCGCGACTTCCTGAGCAACCTAGACATGACGCCGGGGGAGCTGCGGGCGGTGCTGGACACGGCCCACGCCAT
GAAGCGCGGGGAGTGGCGCGGCGTGAAGCCGCTCTCCGGCCTCAGCCTCGCGCTGATTTTTGAAAAGGCTTCTTTGCGGA
CCCGCACCACTTTCGACGTGGGCATGTACCAGCTCGGCGGGCACGCGATTACCCTCAGCAACCAGGAGATCGGCCTGGGC
ACCCGCGAGCGCGTCAGCGACGTGGCCCGCAACCTCGAACGCTGGGTGGACGGGGTGATGGGCCGGGTGTACCTCCAGCA
GACGCTGCAAGAACTCGCCGACCACGCGGCCATTCCGGTCATCAATGGCCTTTCGGATATGCTGCACCCCGCCCAGCTGC
TGGCTGACTACCAGACCATCGAGGAGGAATTTGGCCCCGACCTGCGCGGGCGCCGGGTGGTGTACATCGGGGACGGCAAC
AACCTCGCCAACAGCCACATCCACCTGGGCATCCTCACTGGGACGGACGTCACCATCGTGACCCCAGTCGGGTACGAGCC
GAACGGCTCCGTGCTGATGGACGCTGTGAAGCGCGGGGCGCAGGTCACCCTGACGAACGACCTCTCCGCCGTCGAGGGGG
CCGACGTGCTGTACACCGATGTCTGGATCTCGATGGGCCAGGAGGCCGAAGCCGACATCCGCCGCCGCGCCTTCCGGGGC
TATCAGGTCACGCCCGCCATGCTGGACACCATCGCCCCACACGGCATTTTCTTGCATTGCCTCCCCGCCCACTACGGCGA
GGAGACGGTGCCCGAGGCGACCGAGCACCCCAAGAGCCGCGTCTTTGACCAGGCCGAAAACCGCCTCCACGCGCAAAAGG
CGCTGCTGTATCACGTGATGGGCGAGATGAAGCCCCGTTGGTAG

Upstream 100 bases:

>100_bases
GGTCGCCCGCTCCTCCGCAAAGTCCAGGACAGCAAAGAAGTCGCAGCCGGTAACGAATAATCCTGCACTCCTCACGCCGG
AAACGCTGCCTGCTCCGGTG

Downstream 100 bases:

>100_bases
GGTAGACCTGAGATGACTCCCCCCCGCATCTTTATCGACGGCGAGGCCGGAACGACTGGTCTGCAGATCCGCGCCCGGTT
AGAGGGCCGCGAAGACCTGG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MAGRDFLSNLDMTPGELRAVLDTAHAMKRGEWRGVKPLSGLSLALIFEKASLRTRTTFDVGMYQLGGHAITLSNQEIGLG
TRERVSDVARNLERWVDGVMGRVYLQQTLQELADHAAIPVINGLSDMLHPAQLLADYQTIEEEFGPDLRGRRVVYIGDGN
NLANSHIHLGILTGTDVTIVTPVGYEPNGSVLMDAVKRGAQVTLTNDLSAVEGADVLYTDVWISMGQEAEADIRRRAFRG
YQVTPAMLDTIAPHGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKALLYHVMGEMKPRW

Sequences:

>Translated_307_residues
MAGRDFLSNLDMTPGELRAVLDTAHAMKRGEWRGVKPLSGLSLALIFEKASLRTRTTFDVGMYQLGGHAITLSNQEIGLG
TRERVSDVARNLERWVDGVMGRVYLQQTLQELADHAAIPVINGLSDMLHPAQLLADYQTIEEEFGPDLRGRRVVYIGDGN
NLANSHIHLGILTGTDVTIVTPVGYEPNGSVLMDAVKRGAQVTLTNDLSAVEGADVLYTDVWISMGQEAEADIRRRAFRG
YQVTPAMLDTIAPHGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKALLYHVMGEMKPRW
>Mature_306_residues
AGRDFLSNLDMTPGELRAVLDTAHAMKRGEWRGVKPLSGLSLALIFEKASLRTRTTFDVGMYQLGGHAITLSNQEIGLGT
RERVSDVARNLERWVDGVMGRVYLQQTLQELADHAAIPVINGLSDMLHPAQLLADYQTIEEEFGPDLRGRRVVYIGDGNN
LANSHIHLGILTGTDVTIVTPVGYEPNGSVLMDAVKRGAQVTLTNDLSAVEGADVLYTDVWISMGQEAEADIRRRAFRGY
QVTPAMLDTIAPHGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKALLYHVMGEMKPRW

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=316, Percent_Identity=41.4556962025316, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI18105007, Length=315, Percent_Identity=26.3492063492064, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786469, Length=328, Percent_Identity=39.0243902439024, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1790703, Length=322, Percent_Identity=39.4409937888199, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI48994908, Length=314, Percent_Identity=24.5222929936306, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=30.42071197411, Blast_Score=145, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24642586, Length=270, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 33963; Mature: 33832

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRDFLSNLDMTPGELRAVLDTAHAMKRGEWRGVKPLSGLSLALIFEKASLRTRTTFDV
CCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCHHH
GMYQLGGHAITLSNQEIGLGTRERVSDVARNLERWVDGVMGRVYLQQTLQELADHAAIPV
HHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
INGLSDMLHPAQLLADYQTIEEEFGPDLRGRRVVYIGDGNNLANSHIHLGILTGTDVTIV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEEE
TPVGYEPNGSVLMDAVKRGAQVTLTNDLSAVEGADVLYTDVWISMGQEAEADIRRRAFRG
EECCCCCCCHHHHHHHHCCCEEEEECCCCHHCCCCCEEHHHHHHCCCCHHHHHHHHHHCC
YQVTPAMLDTIAPHGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKALLYHVM
CCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GEMKPRW
HHCCCCC
>Mature Secondary Structure 
AGRDFLSNLDMTPGELRAVLDTAHAMKRGEWRGVKPLSGLSLALIFEKASLRTRTTFDV
CCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHCCCCCCHHH
GMYQLGGHAITLSNQEIGLGTRERVSDVARNLERWVDGVMGRVYLQQTLQELADHAAIPV
HHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
INGLSDMLHPAQLLADYQTIEEEFGPDLRGRRVVYIGDGNNLANSHIHLGILTGTDVTIV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEEE
TPVGYEPNGSVLMDAVKRGAQVTLTNDLSAVEGADVLYTDVWISMGQEAEADIRRRAFRG
EECCCCCCCHHHHHHHHCCCEEEEECCCCHHCCCCCEEHHHHHHCCCCHHHHHHHHHHCC
YQVTPAMLDTIAPHGIFLHCLPAHYGEETVPEATEHPKSRVFDQAENRLHAQKALLYHVM
CCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GEMKPRW
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]