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The map label for this gene is yfnC [H]

Identifier: 94985710

GI number: 94985710

Start: 1712606

End: 1713772

Strand: Reverse

Name: yfnC [H]

Synonym: Dgeo_1610

Alternate gene names: 94985710

Gene position: 1713772-1712606 (Counterclockwise)

Preceding gene: 94985712

Following gene: 94985705

Centisome position: 69.46

GC content: 68.12

Gene sequence:

>1167_bases
ATGCAAGCGACCGCTGCCCACACCGCCGCCCGCCACGCTGCCGCCATCGCGGTCGCGGTCACGGCGGGCCACTTTATCAA
TGATGCCTACGGGGCGATGCTCACGCCCCTGACCCCGGCCCTGCAGGGCAAGTTTGGCGTCAGCATCGCGGCCGTGACCC
TGCTCTCCAGCGTCTACAGCCTCACCAGCAGCGTGCTGCAACCGCTGCTCGGCATCCTGGGTGAACGAGTGGATCGCCGT
TACGCCGCCGCGCTTGGCCCGCTGATGACTGGCCTGGGTCTCACGCTGCTGGGCTTTGTGCCCTGGTTTGGGGCGCTCGT
GCTGCTGGTGGCGGTGGCGGGATTCGGCAGCGGGTTCTTTCACCCGGCGGGCGCAGCCTACGTCGCCCTGAATAGCCCGC
CCCAGAAGCGGGGACTGTGGGCCAGCTTATTTAGCGCGGGCGGCACGGCGGGGATGGCGCTGGGGCCGGTGTTCGCGGGT
GTGGGCCTCACGCACTTGCCCTGGTTTGCCCTGATCGGGGCCGTGATTGCTGCTTTGACCTTTGCCCTGACGCCGTCCAG
CCTGGCGACGGGGCGCCGGATCAGCCTGGCCGAGTATGCCCGCATCTTCCGGGGGCCGCTGGTGTGGCTGTGGGGGATGG
CGGTGCTGCGCTCGCTTGCCAGCATGGGCTACAACGCGATGCTCCCCTTTATCCTCAAAAACCGCGGCTTCGGAATGCGC
GAGGTGGGCATCACATTGGCCGTGTATGCCGTCGCGAGTGCCGTTGGCGGCATCGTCGGTGGGCGGGCCAGCGACCGTTA
CGGGCGGGTGCCGGTGCTGCGTTCGGCCATTCTCAGCACCATTCCGCCCTTCGCGCTGCTGATCCTGTCCAGTCCGGCAA
ACTGGTGGTTTTATCCGCTCACGTTTCTGGTGGGGGCGGCGGTCAACGCCAGCATCCCGGTCGGGGTGGTCGCGGCGCAG
GAGTACGCGCCGGGGCACGTCGCCGTCGCCAGCTCCATCATGATGGGGTTCTCGTGGGGATTTGCGGGGTTGCTGGTCTT
TCTGGTGGGGGCGCTGGCGGATGCCAGCACGCCGACCATCGCCGCGCTCGCCAGCCTGACCCTCTTGATTCCGAGTGCTT
TGATCGCCTACCGGTTGCCGGAGCCGCGGGGAGCGGCGTTCGAGTAG

Upstream 100 bases:

>100_bases
TGTTAAAAATTTCACGCCTTGTGAATTTGCTTGTGTCTCCGGGGGTGGGGGTGGCCCGTCACGCCGGACGGCCAGGCGGC
GGCTGACGTAGGGTAAGTCG

Downstream 100 bases:

>100_bases
GCGGCGAAAAGGGGAGGCGGTCCGGGCCGCTGTGACCCGGGACAGGGGGCTGTTCGCCTTCAGCCCCGCGTCCGCGCTTC
CCGCTGCCGCCGCACAAAGG

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MQATAAHTAARHAAAIAVAVTAGHFINDAYGAMLTPLTPALQGKFGVSIAAVTLLSSVYSLTSSVLQPLLGILGERVDRR
YAAALGPLMTGLGLTLLGFVPWFGALVLLVAVAGFGSGFFHPAGAAYVALNSPPQKRGLWASLFSAGGTAGMALGPVFAG
VGLTHLPWFALIGAVIAALTFALTPSSLATGRRISLAEYARIFRGPLVWLWGMAVLRSLASMGYNAMLPFILKNRGFGMR
EVGITLAVYAVASAVGGIVGGRASDRYGRVPVLRSAILSTIPPFALLILSSPANWWFYPLTFLVGAAVNASIPVGVVAAQ
EYAPGHVAVASSIMMGFSWGFAGLLVFLVGALADASTPTIAALASLTLLIPSALIAYRLPEPRGAAFE

Sequences:

>Translated_388_residues
MQATAAHTAARHAAAIAVAVTAGHFINDAYGAMLTPLTPALQGKFGVSIAAVTLLSSVYSLTSSVLQPLLGILGERVDRR
YAAALGPLMTGLGLTLLGFVPWFGALVLLVAVAGFGSGFFHPAGAAYVALNSPPQKRGLWASLFSAGGTAGMALGPVFAG
VGLTHLPWFALIGAVIAALTFALTPSSLATGRRISLAEYARIFRGPLVWLWGMAVLRSLASMGYNAMLPFILKNRGFGMR
EVGITLAVYAVASAVGGIVGGRASDRYGRVPVLRSAILSTIPPFALLILSSPANWWFYPLTFLVGAAVNASIPVGVVAAQ
EYAPGHVAVASSIMMGFSWGFAGLLVFLVGALADASTPTIAALASLTLLIPSALIAYRLPEPRGAAFE
>Mature_388_residues
MQATAAHTAARHAAAIAVAVTAGHFINDAYGAMLTPLTPALQGKFGVSIAAVTLLSSVYSLTSSVLQPLLGILGERVDRR
YAAALGPLMTGLGLTLLGFVPWFGALVLLVAVAGFGSGFFHPAGAAYVALNSPPQKRGLWASLFSAGGTAGMALGPVFAG
VGLTHLPWFALIGAVIAALTFALTPSSLATGRRISLAEYARIFRGPLVWLWGMAVLRSLASMGYNAMLPFILKNRGFGMR
EVGITLAVYAVASAVGGIVGGRASDRYGRVPVLRSAILSTIPPFALLILSSPANWWFYPLTFLVGAAVNASIPVGVVAAQ
EYAPGHVAVASSIMMGFSWGFAGLLVFLVGALADASTPTIAALASLTLLIPSALIAYRLPEPRGAAFE

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=344, Percent_Identity=27.6162790697674, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 39966; Mature: 39966

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATAAHTAARHAAAIAVAVTAGHFINDAYGAMLTPLTPALQGKFGVSIAAVTLLSSVYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHH
LTSSVLQPLLGILGERVDRRYAAALGPLMTGLGLTLLGFVPWFGALVLLVAVAGFGSGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HPAGAAYVALNSPPQKRGLWASLFSAGGTAGMALGPVFAGVGLTHLPWFALIGAVIAALT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FALTPSSLATGRRISLAEYARIFRGPLVWLWGMAVLRSLASMGYNAMLPFILKNRGFGMR
HHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
EVGITLAVYAVASAVGGIVGGRASDRYGRVPVLRSAILSTIPPFALLILSSPANWWFYPL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHH
TFLVGAAVNASIPVGVVAAQEYAPGHVAVASSIMMGFSWGFAGLLVFLVGALADASTPTI
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AALASLTLLIPSALIAYRLPEPRGAAFE
HHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQATAAHTAARHAAAIAVAVTAGHFINDAYGAMLTPLTPALQGKFGVSIAAVTLLSSVYS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHH
LTSSVLQPLLGILGERVDRRYAAALGPLMTGLGLTLLGFVPWFGALVLLVAVAGFGSGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HPAGAAYVALNSPPQKRGLWASLFSAGGTAGMALGPVFAGVGLTHLPWFALIGAVIAALT
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FALTPSSLATGRRISLAEYARIFRGPLVWLWGMAVLRSLASMGYNAMLPFILKNRGFGMR
HHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHH
EVGITLAVYAVASAVGGIVGGRASDRYGRVPVLRSAILSTIPPFALLILSSPANWWFYPL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHHH
TFLVGAAVNASIPVGVVAAQEYAPGHVAVASSIMMGFSWGFAGLLVFLVGALADASTPTI
HHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AALASLTLLIPSALIAYRLPEPRGAAFE
HHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]