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The map label for this gene is norM [H]

Identifier: 94985515

GI number: 94985515

Start: 1500631

End: 1502031

Strand: Reverse

Name: norM [H]

Synonym: Dgeo_1415

Alternate gene names: 94985515

Gene position: 1502031-1500631 (Counterclockwise)

Preceding gene: 94985516

Following gene: 94985514

Centisome position: 60.88

GC content: 68.59

Gene sequence:

>1401_bases
ATGTCTGTTGTCCCCGCCTCGGCATCTGAATCGATTCAATCTCGCTCGCCTGCGCGCGAGATTGCAGCCATCGCCGTTCC
CGTCAGTTTGGAGATGGTGTTGCAGTTGGTGCTGACCTTCGTGAATCAGGTGGTCGTGGGCACGCTGGGCGCGGTGGCGG
TCGCGGCGGTGGGCCTCGCCGGCAGCGTGAGCTTCCTGTTCTTCGTGACGCTGGGGGCGTTGGGTTCGGGGACCAGCATC
CTGGTTGCGCGGCGGGCTGGGGCGGGCGATCAGGTAGGCGTGAACGGGACGCTGACGGTGGCGCTCGTGGTGAGCGTGCT
GCTCGCGGCGGTGGCGACGGTGCCGACGATCCTGGGATCTGGGAGCCTGCTGCAACTGGCTGGCGGGGCGCCGGACGTGA
TGCGGGTGGCCCGGCCGTACCTCCAGGTCAGCATGCTGTCTCTGGTGCCCGGAGTGGTGGGCTGGATCCTCAGCGGGGCG
CTGCGGTCGCTGGGCCATGCCCGCACGCCGATGGTCGCCACCATGATTACGGTTGTCGTGGAGAGCCTCGCGGCCCTAGG
CCTGGTCTTTGGCGTAGGTCCGCTCCCGGAGCTGGGGGTGGTGGGGGCAGCCTGGGCGCTGGTCATCGCGCAGACCTTGA
AGGCACTGCTGCTGGCAGTGCTGGTGTACGGTCCGCGCCAGCTGGCGGCCTTCACCCTGCCTCCGGCAGGCATGCGCCGG
GTGGTGGCCCTGCCCCTCCTCACCCTGTCGGCACCCATTGCCCTGACCGAGTTTGTGTGGAGCCTGGGGGGCTTCATCTA
CGCCGCCGTGTTCGCGCGCGTGGGCACGCAGGCGCTGGCGGCCAGCCAGATTGTCGGGACACTGGAAGGCATCTTTATCG
TGGGCAGCTTTGGCCTGATGAGCGCGACCACCGTGCTGGTGGGGCGTGCGTTGGGAGCAGGTGACGGTTTCGGTGCGCGG
GCATGGCTGGGCCGGGTGAGCCGTGCCGGGCTGCTGACCGGTTTGGGCTTTGGCCTGCTGTTCGCTCTGAGCACCCTGCT
GTTGCCGCTGCTGTTTCCTGCAGTTGGCGCGGACGTGCGCGCGATTGCGGTCGGCGGCATCCTGATGAACGCCGCCACCC
AGGTCATCAAGGTCCGCAACATGATCCTGGGGGGCGGCGCACTGCCCAGCGCGGGAGACGGCAAGGGCGTGATCATTGGC
GACGTGGTCGGCGCGTTCGTGGTGGGGTTGCCCCTCGCTATCGTGCTGGGCCTGTCTACCCCGCTGGGCGTCTGGGGTGT
GTTTCTGGCCCGGATCCTAGACGAGCTTGCCAAGGTCAGTGTGTTTGAGTGGCGCCGCCGCCGGGTGAACTGGGAGGCGC
TGGCGTCGGCACCGCAGGGACCGGAGGTGGCGGCGCACTGA

Upstream 100 bases:

>100_bases
AGGACGCACCCTTCCCGCGTCCACCGTGTCGAGTCCTGTGTCTAGCTCTCCGCCATTCGGCTGACCGCTTCCCGCCCGCT
CGGGTGTACCTTGGCGCGGT

Downstream 100 bases:

>100_bases
AGAGACGGGGCGGAGCGGTCAACAGCCAATAGGGTAACGGTGACTACTCAGCAGGGGGAGTTGATGTCTGCGGCAAGGTA
GAGTAGGGCATCACACAGGA

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSVVPASASESIQSRSPAREIAAIAVPVSLEMVLQLVLTFVNQVVVGTLGAVAVAAVGLAGSVSFLFFVTLGALGSGTSI
LVARRAGAGDQVGVNGTLTVALVVSVLLAAVATVPTILGSGSLLQLAGGAPDVMRVARPYLQVSMLSLVPGVVGWILSGA
LRSLGHARTPMVATMITVVVESLAALGLVFGVGPLPELGVVGAAWALVIAQTLKALLLAVLVYGPRQLAAFTLPPAGMRR
VVALPLLTLSAPIALTEFVWSLGGFIYAAVFARVGTQALAASQIVGTLEGIFIVGSFGLMSATTVLVGRALGAGDGFGAR
AWLGRVSRAGLLTGLGFGLLFALSTLLLPLLFPAVGADVRAIAVGGILMNAATQVIKVRNMILGGGALPSAGDGKGVIIG
DVVGAFVVGLPLAIVLGLSTPLGVWGVFLARILDELAKVSVFEWRRRRVNWEALASAPQGPEVAAH

Sequences:

>Translated_466_residues
MSVVPASASESIQSRSPAREIAAIAVPVSLEMVLQLVLTFVNQVVVGTLGAVAVAAVGLAGSVSFLFFVTLGALGSGTSI
LVARRAGAGDQVGVNGTLTVALVVSVLLAAVATVPTILGSGSLLQLAGGAPDVMRVARPYLQVSMLSLVPGVVGWILSGA
LRSLGHARTPMVATMITVVVESLAALGLVFGVGPLPELGVVGAAWALVIAQTLKALLLAVLVYGPRQLAAFTLPPAGMRR
VVALPLLTLSAPIALTEFVWSLGGFIYAAVFARVGTQALAASQIVGTLEGIFIVGSFGLMSATTVLVGRALGAGDGFGAR
AWLGRVSRAGLLTGLGFGLLFALSTLLLPLLFPAVGADVRAIAVGGILMNAATQVIKVRNMILGGGALPSAGDGKGVIIG
DVVGAFVVGLPLAIVLGLSTPLGVWGVFLARILDELAKVSVFEWRRRRVNWEALASAPQGPEVAAH
>Mature_465_residues
SVVPASASESIQSRSPAREIAAIAVPVSLEMVLQLVLTFVNQVVVGTLGAVAVAAVGLAGSVSFLFFVTLGALGSGTSIL
VARRAGAGDQVGVNGTLTVALVVSVLLAAVATVPTILGSGSLLQLAGGAPDVMRVARPYLQVSMLSLVPGVVGWILSGAL
RSLGHARTPMVATMITVVVESLAALGLVFGVGPLPELGVVGAAWALVIAQTLKALLLAVLVYGPRQLAAFTLPPAGMRRV
VALPLLTLSAPIALTEFVWSLGGFIYAAVFARVGTQALAASQIVGTLEGIFIVGSFGLMSATTVLVGRALGAGDGFGARA
WLGRVSRAGLLTGLGFGLLFALSTLLLPLLFPAVGADVRAIAVGGILMNAATQVIKVRNMILGGGALPSAGDGKGVIIGD
VVGAFVVGLPLAIVLGLSTPLGVWGVFLARILDELAKVSVFEWRRRRVNWEALASAPQGPEVAAH

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=459, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47096; Mature: 46965

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVPASASESIQSRSPAREIAAIAVPVSLEMVLQLVLTFVNQVVVGTLGAVAVAAVGLA
CCCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSVSFLFFVTLGALGSGTSILVARRAGAGDQVGVNGTLTVALVVSVLLAAVATVPTILGS
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GSLLQLAGGAPDVMRVARPYLQVSMLSLVPGVVGWILSGALRSLGHARTPMVATMITVVV
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ESLAALGLVFGVGPLPELGVVGAAWALVIAQTLKALLLAVLVYGPRQLAAFTLPPAGMRR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHH
VVALPLLTLSAPIALTEFVWSLGGFIYAAVFARVGTQALAASQIVGTLEGIFIVGSFGLM
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHH
SATTVLVGRALGAGDGFGARAWLGRVSRAGLLTGLGFGLLFALSTLLLPLLFPAVGADVR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIAVGGILMNAATQVIKVRNMILGGGALPSAGDGKGVIIGDVVGAFVVGLPLAIVLGLST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
PLGVWGVFLARILDELAKVSVFEWRRRRVNWEALASAPQGPEVAAH
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SVVPASASESIQSRSPAREIAAIAVPVSLEMVLQLVLTFVNQVVVGTLGAVAVAAVGLA
CCCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSVSFLFFVTLGALGSGTSILVARRAGAGDQVGVNGTLTVALVVSVLLAAVATVPTILGS
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GSLLQLAGGAPDVMRVARPYLQVSMLSLVPGVVGWILSGALRSLGHARTPMVATMITVVV
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ESLAALGLVFGVGPLPELGVVGAAWALVIAQTLKALLLAVLVYGPRQLAAFTLPPAGMRR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHH
VVALPLLTLSAPIALTEFVWSLGGFIYAAVFARVGTQALAASQIVGTLEGIFIVGSFGLM
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHH
SATTVLVGRALGAGDGFGARAWLGRVSRAGLLTGLGFGLLFALSTLLLPLLFPAVGADVR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AIAVGGILMNAATQVIKVRNMILGGGALPSAGDGKGVIIGDVVGAFVVGLPLAIVLGLST
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCC
PLGVWGVFLARILDELAKVSVFEWRRRRVNWEALASAPQGPEVAAH
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]