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The map label for this gene is cobW [H]

Identifier: 94971823

GI number: 94971823

Start: 135152

End: 136255

Strand: Direct

Name: cobW [H]

Synonym: Dgeo_2354

Alternate gene names: 94971823

Gene position: 135152-136255 (Clockwise)

Preceding gene: 94971824

Following gene: 94971822

Centisome position: 23.54

GC content: 67.84

Gene sequence:

>1104_bases
ATGACCCCCCCCACTTTCAAGACCCCTGTCACCATCGTCACCGGATTTCTCGGCAGCGGCAAGACCACCCTGCTGGGCAA
TCTGCTCAACCAAACCCATGACCGCACCCTGGCCCTGATTGTGAATGAGTTCGGAGAGGTCAGCATCGACGGCCCGCTGC
TGGAGGTGCGGGAAGACGGCGTGGAACTGCACGATGTTCACGGCGGCCTGCTCGCCTACGGCGGCGAGGGGGACGCTTTC
CGCCGCACCCTGCGGGCCCTGCGCGAGCGCCGCCACACCTTCGACCACGTTCTGATCGAGACGAGCGGCCTGGCGGTGCC
CACTGCCGTCATGGTTACCCTGGAGGAGCCGGAGTTCGCGGCGGATTTCCTGCTCGACGCCACCTTAGTGGTGGTGGATA
CGCCGCTGTTGCTGGCGGGCGCCTTCAGCCCCGAGGCGGGTGACGAGGCGCAGCAGAGCGCCGCCCGCGTGTTTGACGCG
CAACTGGAGTATGCGGACGTGGCGGTGCTGAACAAGATCGACGCCCTGAGTGATGCCGACCTGCTGCAGGCCGAGGCAGA
TGTGCGGCACCGCGCGCCCCGCGTGCGTTTCCTGGAGCTGGCCTACGGCGCAAAGCTCGACACCCAGCTCACCCTCGGGC
TGAACCTGCACGGCAGCCGCCGCGGCGCCGCGCACCAGGCCCCGGTCAGCGGCGCCCCCGACGAACTGATGCAGCCCCTC
CACGACCACAGCGCCCTCGACGGGCACTCGCACGGCGACCTGGACGCCCACGTGCACAGCCTGAGTACCCACCAGCACTT
CCACGAGCACGACCCCGGCTGGCAGTCTTTCCGCCTGACGAGCGACGAGGCGCAGAACCTGCCCGAACTTGTCCGCACCG
TGCAGAACGTGGCCCGCGTCTTCCCGGTGCTGCGCGTCAAGGGTTTCGTGCAGGGAGAGGACGGTGGGCGCTACGCCGTG
CAGGCGGTGCGGTCGCGGGTAGAGACCCATGCGGCCCCCCCCAAGGTGGACGCTCCCAACGAACTGATCTTTATCGGCTA
TCACGTCAGCCGCAAAAAGGTCACCGAAGCGCTCCAAAAGGCGCTGCCGCAGCGGTGGGGTTGA

Upstream 100 bases:

>100_bases
TCCCGCTGATGGTGGTGCGTCGCCCACCGCCCGTGCCCGGCGCCTTTTTTACGGCGGACGCCCTGCTTGAAGCCCTCTTT
TTCCAGCTCAAGGAGCTTGC

Downstream 100 bases:

>100_bases
GATGACGCGCTCTTCACCTGACGCCGCCCCCCGGGCCGACCTCGCCGCGCCGCTCACCCTGCGCCAAAGCGTGCTGCAGG
GCCTTCCCTACCTGCTGGTG

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTPPTFKTPVTIVTGFLGSGKTTLLGNLLNQTHDRTLALIVNEFGEVSIDGPLLEVREDGVELHDVHGGLLAYGGEGDAF
RRTLRALRERRHTFDHVLIETSGLAVPTAVMVTLEEPEFAADFLLDATLVVVDTPLLLAGAFSPEAGDEAQQSAARVFDA
QLEYADVAVLNKIDALSDADLLQAEADVRHRAPRVRFLELAYGAKLDTQLTLGLNLHGSRRGAAHQAPVSGAPDELMQPL
HDHSALDGHSHGDLDAHVHSLSTHQHFHEHDPGWQSFRLTSDEAQNLPELVRTVQNVARVFPVLRVKGFVQGEDGGRYAV
QAVRSRVETHAAPPKVDAPNELIFIGYHVSRKKVTEALQKALPQRWG

Sequences:

>Translated_367_residues
MTPPTFKTPVTIVTGFLGSGKTTLLGNLLNQTHDRTLALIVNEFGEVSIDGPLLEVREDGVELHDVHGGLLAYGGEGDAF
RRTLRALRERRHTFDHVLIETSGLAVPTAVMVTLEEPEFAADFLLDATLVVVDTPLLLAGAFSPEAGDEAQQSAARVFDA
QLEYADVAVLNKIDALSDADLLQAEADVRHRAPRVRFLELAYGAKLDTQLTLGLNLHGSRRGAAHQAPVSGAPDELMQPL
HDHSALDGHSHGDLDAHVHSLSTHQHFHEHDPGWQSFRLTSDEAQNLPELVRTVQNVARVFPVLRVKGFVQGEDGGRYAV
QAVRSRVETHAAPPKVDAPNELIFIGYHVSRKKVTEALQKALPQRWG
>Mature_366_residues
TPPTFKTPVTIVTGFLGSGKTTLLGNLLNQTHDRTLALIVNEFGEVSIDGPLLEVREDGVELHDVHGGLLAYGGEGDAFR
RTLRALRERRHTFDHVLIETSGLAVPTAVMVTLEEPEFAADFLLDATLVVVDTPLLLAGAFSPEAGDEAQQSAARVFDAQ
LEYADVAVLNKIDALSDADLLQAEADVRHRAPRVRFLELAYGAKLDTQLTLGLNLHGSRRGAAHQAPVSGAPDELMQPLH
DHSALDGHSHGDLDAHVHSLSTHQHFHEHDPGWQSFRLTSDEAQNLPELVRTVQNVARVFPVLRVKGFVQGEDGGRYAVQ
AVRSRVETHAAPPKVDAPNELIFIGYHVSRKKVTEALQKALPQRWG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=243, Percent_Identity=32.0987654320988, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI126722884, Length=243, Percent_Identity=32.0987654320988, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI146231952, Length=355, Percent_Identity=27.0422535211268, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI223941779, Length=187, Percent_Identity=34.2245989304813, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI148727351, Length=357, Percent_Identity=27.4509803921569, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI119120938, Length=132, Percent_Identity=37.1212121212121, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI223941776, Length=232, Percent_Identity=30.1724137931034, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788499, Length=168, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082430, Length=189, Percent_Identity=32.2751322751323, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 40050; Mature: 39918

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPTFKTPVTIVTGFLGSGKTTLLGNLLNQTHDRTLALIVNEFGEVSIDGPLLEVREDG
CCCCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCEEEEEEHHCCCEECCCCCHHHHHCC
VELHDVHGGLLAYGGEGDAFRRTLRALRERRHTFDHVLIETSGLAVPTAVMVTLEEPEFA
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEECCCCHH
ADFLLDATLVVVDTPLLLAGAFSPEAGDEAQQSAARVFDAQLEYADVAVLNKIDALSDAD
HHHHHHCCCEEECCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LLQAEADVRHRAPRVRFLELAYGAKLDTQLTLGLNLHGSRRGAAHQAPVSGAPDELMQPL
HHHHHHHHHHCCCCEEEEEEHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
HDHSALDGHSHGDLDAHVHSLSTHQHFHEHDPGWQSFRLTSDEAQNLPELVRTVQNVARV
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHCHHHHHHHHHHHHHH
FPVLRVKGFVQGEDGGRYAVQAVRSRVETHAAPPKVDAPNELIFIGYHVSRKKVTEALQK
HHHHHHHCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
ALPQRWG
HHHCCCC
>Mature Secondary Structure 
TPPTFKTPVTIVTGFLGSGKTTLLGNLLNQTHDRTLALIVNEFGEVSIDGPLLEVREDG
CCCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCEEEEEEHHCCCEECCCCCHHHHHCC
VELHDVHGGLLAYGGEGDAFRRTLRALRERRHTFDHVLIETSGLAVPTAVMVTLEEPEFA
CEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEECCCCHH
ADFLLDATLVVVDTPLLLAGAFSPEAGDEAQQSAARVFDAQLEYADVAVLNKIDALSDAD
HHHHHHCCCEEECCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LLQAEADVRHRAPRVRFLELAYGAKLDTQLTLGLNLHGSRRGAAHQAPVSGAPDELMQPL
HHHHHHHHHHCCCCEEEEEEHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
HDHSALDGHSHGDLDAHVHSLSTHQHFHEHDPGWQSFRLTSDEAQNLPELVRTVQNVARV
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHCHHHHHHHHHHHHHH
FPVLRVKGFVQGEDGGRYAVQAVRSRVETHAAPPKVDAPNELIFIGYHVSRKKVTEALQK
HHHHHHHCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHH
ALPQRWG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]