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The map label for this gene is cobD [H]

Identifier: 94971817

GI number: 94971817

Start: 145416

End: 146333

Strand: Direct

Name: cobD [H]

Synonym: Dgeo_2348

Alternate gene names: 94971817

Gene position: 145416-146333 (Clockwise)

Preceding gene: 94971818

Following gene: 94972338

Centisome position: 25.33

GC content: 73.97

Gene sequence:

>918_bases
GTGAGGCGGCCTGCACTGCTCTTGGCGCTTGTGCTGGACGCGCTGGGCGAACCTCCCGCGCGGCTGCATCCCGTGGTGGG
GATGGGGACCTTTCTGAAGGCGGCGCGGGGGCGCTGGCGGGGCCGTACCCCGGCGGCACAGGGGCGAGAGGGGGCCGTGG
GCTGGGCGCTGGGGGCGGGCGGCGTGGTCGGCGCGGCGGGGCTGGGCACGCGACTGCCGGGAGGGTGGATCACGCAGGGC
ATGCTGCTCAAGCCGCTGCTGGCCCGGCGGGCGCTGTTTGCTGCGGTGGCGGAGGTTCAGGCGGCCCTTGCGGCAGACGA
CCTGCCGGAGGCGCGGCGCCTGCTTGCCTGGCACCTGGTCAGCCGCGAAACTGGTGATCTGAGTGCCGCGGAGGTCGCCG
GGGCCGCTGTGGAGAGCCTGGCCGAGAACCTCAGTGACAGCGTGGTGGCCCCGCTGCTGTGGTTTCGCGTCGGTGGCCTG
CCGCTCGCCGCCCTGTACCGCTACGCCAATACGGCGGACGCCCTGTGGGGCTACCGCACCCCCGAGCTGGAATATGCGGG
CAAGTTGGCTGCCCGCGCCGACGACCTGCTCAACCTTGCCCCGGCCCGGCTGACGGCCCTTTGTGCGCTCCTGGCAGCCC
TGCCGGCAGGCCTGGACGCCCCCGGAGCCTGGCGGGTCTGGCGGCAGGATGCTCGGAAAACGGCCAGTCCCAACGCCGGC
CATCCCATGAGCGCCTTTGCCGGGGCGCTGGGCGTGCGGTTGGACAAACGGGGCGTGTATGTCCTGCACGGACAGGGACG
CCCGCCCGCTCCCGCCGACCTGCCCCGCGCCTTGCGCCTCGCGCGCTGGACGCTCGCCCTCGCGACGCTGACCCTGCTGC
TGCCCGGGAGACTGCTGCCGGGAGGCCGTCATGCCTGA

Upstream 100 bases:

>100_bases
TAGAGGAGGGCTACGCGCGCGGCCACGTGCTTGCGAGTTACCTACACCTGCATTGGGGGGCTTCGGCCCAACTCGCCGAG
CGGCTGGTGGAGGCGTGCTC

Downstream 100 bases:

>100_bases
CCTGCCCCCCCTGCTTCCCCGTGCGCCACACGGCGGACCGAGCAGCCGGCCCTTCACGGGGCTGGACTTCAGCGTGAACG
CCAACCCCTACGGCCCGAAT

Product: cobalamin biosynthesis protein CobD

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRRPALLLALVLDALGEPPARLHPVVGMGTFLKAARGRWRGRTPAAQGREGAVGWALGAGGVVGAAGLGTRLPGGWITQG
MLLKPLLARRALFAAVAEVQAALAADDLPEARRLLAWHLVSRETGDLSAAEVAGAAVESLAENLSDSVVAPLLWFRVGGL
PLAALYRYANTADALWGYRTPELEYAGKLAARADDLLNLAPARLTALCALLAALPAGLDAPGAWRVWRQDARKTASPNAG
HPMSAFAGALGVRLDKRGVYVLHGQGRPPAPADLPRALRLARWTLALATLTLLLPGRLLPGGRHA

Sequences:

>Translated_305_residues
MRRPALLLALVLDALGEPPARLHPVVGMGTFLKAARGRWRGRTPAAQGREGAVGWALGAGGVVGAAGLGTRLPGGWITQG
MLLKPLLARRALFAAVAEVQAALAADDLPEARRLLAWHLVSRETGDLSAAEVAGAAVESLAENLSDSVVAPLLWFRVGGL
PLAALYRYANTADALWGYRTPELEYAGKLAARADDLLNLAPARLTALCALLAALPAGLDAPGAWRVWRQDARKTASPNAG
HPMSAFAGALGVRLDKRGVYVLHGQGRPPAPADLPRALRLARWTLALATLTLLLPGRLLPGGRHA
>Mature_305_residues
MRRPALLLALVLDALGEPPARLHPVVGMGTFLKAARGRWRGRTPAAQGREGAVGWALGAGGVVGAAGLGTRLPGGWITQG
MLLKPLLARRALFAAVAEVQAALAADDLPEARRLLAWHLVSRETGDLSAAEVAGAAVESLAENLSDSVVAPLLWFRVGGL
PLAALYRYANTADALWGYRTPELEYAGKLAARADDLLNLAPARLTALCALLAALPAGLDAPGAWRVWRQDARKTASPNAG
HPMSAFAGALGVRLDKRGVYVLHGQGRPPAPADLPRALRLARWTLALATLTLLLPGRLLPGGRHA

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 31936; Mature: 31936

Theoretical pI: Translated: 11.41; Mature: 11.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPALLLALVLDALGEPPARLHPVVGMGTFLKAARGRWRGRTPAAQGREGAVGWALGAG
CCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
GVVGAAGLGTRLPGGWITQGMLLKPLLARRALFAAVAEVQAALAADDLPEARRLLAWHLV
CHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SRETGDLSAAEVAGAAVESLAENLSDSVVAPLLWFRVGGLPLAALYRYANTADALWGYRT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PELEYAGKLAARADDLLNLAPARLTALCALLAALPAGLDAPGAWRVWRQDARKTASPNAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
HPMSAFAGALGVRLDKRGVYVLHGQGRPPAPADLPRALRLARWTLALATLTLLLPGRLLP
CCHHHHHHHHHCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGRHA
CCCCC
>Mature Secondary Structure
MRRPALLLALVLDALGEPPARLHPVVGMGTFLKAARGRWRGRTPAAQGREGAVGWALGAG
CCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
GVVGAAGLGTRLPGGWITQGMLLKPLLARRALFAAVAEVQAALAADDLPEARRLLAWHLV
CHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SRETGDLSAAEVAGAAVESLAENLSDSVVAPLLWFRVGGLPLAALYRYANTADALWGYRT
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PELEYAGKLAARADDLLNLAPARLTALCALLAALPAGLDAPGAWRVWRQDARKTASPNAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
HPMSAFAGALGVRLDKRGVYVLHGQGRPPAPADLPRALRLARWTLALATLTLLLPGRLLP
CCHHHHHHHHHCEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGRHA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA