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The map label for this gene is atoB [H]

Identifier: 94310791

GI number: 94310791

Start: 2007441

End: 2008619

Strand: Reverse

Name: atoB [H]

Synonym: Rmet_1853

Alternate gene names: 94310791

Gene position: 2008619-2007441 (Counterclockwise)

Preceding gene: 94310792

Following gene: 335055551

Centisome position: 51.13

GC content: 64.72

Gene sequence:

>1179_bases
ATGAACGAGGCAGTCATCGTATCCACCGCCCGCACCGGGCTGGCCAAGAGCTGGAAGGGCGCTTTCAACATGACCCACGG
CGCGACCCTGGGCGGTCATGCCGTACAGCACGCCATCGCCCGCGCGAAGATCGAAGCCGGTGAAGTGGAAGACGTGCTGA
TGGGTTGTGCCAACCCCGAGGGCGCCACCGGCGCCAACATCGCGCGCCAGATCGCCCTGCGAGCTGGTTGCCCGGTGACC
GTGCCAGGCGCCACCGTGAACCGTTTCTGCTCGTCCGGCCTGCAGACCATTGCCATGGCCGCGCAGCGCGTGATCGCAGA
TGAGGGCGACATCTTCGTCGCTGGCGGCGTGGAGTCGATCTCGTGCGTTCAGCAGGACATGAACCGCCACATGATTCAGG
AAAGCTGGCTGAACAAGAACAAGCCGGAAATCTACTGGAGCATGCTGCAGACCGCCGAGAACGTGGCCAAGCGCTACAAC
ATCGGTAAGGATCGCCAGGACGAGTACGGCGTGCAGAGCCAACTGCGTGCCGCCGCTGCCCTGGAAGCCGGCAAGTTCAA
GGACGAAATCGTGCCGATGACGGTGCTGGCAGGCGTGGCCGACAAGGCCACCGGCCAGCTGATGACGAAGGAAGTCACGA
TCGACGCCGACGAAGGTATCCGTGCCGACACCACGCTGGAAGCCGTGTCGAAGATCCGCACGGCCATGCCGGGTGGCGTG
ATCACCGCCGGCAATGCCTCGCAGTTCTCGGATGGCGCCTCGGCAGCCGTCGTGATGAACGCACGCGTGGCCGCCGCCAA
GGGCCTGCAGCCGTTGGGCGTCTTCCGTGGTTTTGCCGTGGCGGGTTGCGAGCCTGACGAAATGGGTATCGGCCCGGTGT
TTGCGGTGCCGAAGCTGCTGAAGAAGGCTGGCCTGAAGGTTGACGACATCGGTCTGTGGGAACTGAACGAAGCGTTCGCC
GTGCAGGTGCTGTACTGCGCCGACAAGCTGGGCATCCCGATGGATCGCCTGAACGTCAACGGCGGCGCGATCGCCGTGGG
TCACCCGTACGGTGTGTCGGGCGCGCGTCTGGTCGGCCATGCGCTGATCGAAGGCAAGCGCCGTGGCGTCAAGTACGTCG
TGGTGACGATGTGCATCGGCGGTGGTCAGGGTGCCGCCGGCCTGTTCGAAGTGCTGTAA

Upstream 100 bases:

>100_bases
CCTGGCTCCCTGAGTCCTGAAGCGTCACGCAACGAAAGCCGAACACACCGAATATTTCTCGCAAGTTTGCAAGAGACACC
AAGATACCGAGGAGCAACAC

Downstream 100 bases:

>100_bases
GGCATCTCGGGCACACACTGTGTTCCCCCTCTCTCATGCAATGGGAGAGGGGCGGGGGAGCGAGCTTTCCGGTTCAGGCG
GCGATCTGTCGCAAGCCGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIARAKIEAGEVEDVLMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQDMNRHMIQESWLNKNKPEIYWSMLQTAENVAKRYN
IGKDRQDEYGVQSQLRAAAALEAGKFKDEIVPMTVLAGVADKATGQLMTKEVTIDADEGIRADTTLEAVSKIRTAMPGGV
ITAGNASQFSDGASAAVVMNARVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVDDIGLWELNEAFA
VQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Sequences:

>Translated_392_residues
MNEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIARAKIEAGEVEDVLMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQDMNRHMIQESWLNKNKPEIYWSMLQTAENVAKRYN
IGKDRQDEYGVQSQLRAAAALEAGKFKDEIVPMTVLAGVADKATGQLMTKEVTIDADEGIRADTTLEAVSKIRTAMPGGV
ITAGNASQFSDGASAAVVMNARVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVDDIGLWELNEAFA
VQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
>Mature_392_residues
MNEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIARAKIEAGEVEDVLMGCANPEGATGANIARQIALRAGCPVT
VPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESISCVQQDMNRHMIQESWLNKNKPEIYWSMLQTAENVAKRYN
IGKDRQDEYGVQSQLRAAAALEAGKFKDEIVPMTVLAGVADKATGQLMTKEVTIDADEGIRADTTLEAVSKIRTAMPGGV
ITAGNASQFSDGASAAVVMNARVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLLKKAGLKVDDIGLWELNEAFA
VQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGHALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=41.4322250639386, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=37.7171215880893, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=35.5163727959698, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=33.4170854271357, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4504327, Length=399, Percent_Identity=30.0751879699248, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=30.2030456852792, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=39.119804400978, Blast_Score=250, Evalue=9e-68,
Organism=Escherichia coli, GI48994986, Length=396, Percent_Identity=39.1414141414141, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788554, Length=407, Percent_Identity=40.2948402948403, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI87082165, Length=409, Percent_Identity=36.1858190709046, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=30.7142857142857, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=38.5390428211587, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=35.6608478802993, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=30.5936073059361, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=399, Percent_Identity=32.0802005012531, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=26.8542199488491, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.6262626262626, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=31.0945273631841, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=39.4088669950739, Blast_Score=248, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=36.7977528089888, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=34.9127182044888, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137578, Length=409, Percent_Identity=31.7848410757946, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40949; Mature: 40949

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIARAKIEAGEVEDVLMGCANPE
CCCEEEEEECHHCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQDMNRHMIQESWLNKNKPEIYWSMLQTAENVAKRYNIGKDRQDEYGVQSQLRAAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LEAGKFKDEIVPMTVLAGVADKATGQLMTKEVTIDADEGIRADTTLEAVSKIRTAMPGGV
HHHCCCHHHHHHHHHHHHCCCHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCE
ITAGNASQFSDGASAAVVMNARVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KKAGLKVDDIGLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEECCCCEECCHHHHEEHEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MNEAVIVSTARTGLAKSWKGAFNMTHGATLGGHAVQHAIARAKIEAGEVEDVLMGCANPE
CCCEEEEEECHHCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCC
GATGANIARQIALRAGCPVTVPGATVNRFCSSGLQTIAMAAQRVIADEGDIFVAGGVESI
CCCHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQDMNRHMIQESWLNKNKPEIYWSMLQTAENVAKRYNIGKDRQDEYGVQSQLRAAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
LEAGKFKDEIVPMTVLAGVADKATGQLMTKEVTIDADEGIRADTTLEAVSKIRTAMPGGV
HHHCCCHHHHHHHHHHHHCCCHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCE
ITAGNASQFSDGASAAVVMNARVAAAKGLQPLGVFRGFAVAGCEPDEMGIGPVFAVPKLL
EECCCCCCCCCCCCEEEEEECHHHHHCCCCHHHHHHCCEEECCCCCCCCCCHHHHHHHHH
KKAGLKVDDIGLWELNEAFAVQVLYCADKLGIPMDRLNVNGGAIAVGHPYGVSGARLVGH
HHCCCCEECCCCEECCHHHHEEHEEEHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHH
ALIEGKRRGVKYVVVTMCIGGGQGAAGLFEVL
HHHHHCCCCCEEEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]