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The map label for this gene is upp [H]

Identifier: 93007087

GI number: 93007087

Start: 2781027

End: 2781674

Strand: Direct

Name: upp [H]

Synonym: Pcryo_2263

Alternate gene names: 93007087

Gene position: 2781027-2781674 (Clockwise)

Preceding gene: 93007079

Following gene: 93007088

Centisome position: 90.89

GC content: 44.29

Gene sequence:

>648_bases
ATGAGCGACTTAAAAATCACTGTTATCGATCACCCGTTAGTCCGTCATAAACTCAGCCTTATGCGCGAAAAAGACTGTAG
TACTTATAAGTTTCGTACATTAACCAAAGAGCTTGCGCGCTTGATGGCGTATGAAGCTAGCCGCGATTTTGAAATTGAAA
CCTTTCCGATGGAAGGCTGGTGTGGTGAAATCATTGGTGAGCAAATCATCGGTAAGACGGCAACTATCGTACCGATTTTA
CGCGCGGGTATTGGTATGCTTGATGGGGTGCTCGATTTGATTCCTACGGCAAAAATCTCTGTCGTTGGTTTACAGCGCGA
TGAAGAAACCTTACAACCGGTGCCGTTCTTTGAAAAGTTTGTTAGCCACATGGACAAACGCCCAGCCCTTATCATTGACC
CAATGTTAGCCACTGGCGGCTCGATGGTTGCAACTATCGAAATGCTTAAGAAAAACGGCTGTACCAATATCAAAGCCTTG
GTATTGGTTGCCGCACCTGAAGGCGTCCGTGTAGTCAATGAAGCACATCCTGACGTGACTATTTATACTGCTGCATTAGA
TAGTCATTTGGATGAGCACGGTTATATCATTCCAGGTCTGGGCGATGCTGGTGATAAAATCTTTGGTAAGCAATTATTTA
ATAAGTAA

Upstream 100 bases:

>100_bases
TAAGCTTACTATTGATGGGCTAAATATAGGGTTGAAGTGCAGTAAGTGTTGTATCTTTTATACTAATCAAGCATCAGACC
AAAAAACCAAGAGAATACTT

Downstream 100 bases:

>100_bases
GCCAAAGCAGATAAACTAAGACAAGCTGTCGTCTCAAACAACATGACATATGTACAAAACATCAATGATAAGGATATAAG
ATGAACGTATTGATTACAGG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSDLKITVIDHPLVRHKLSLMREKDCSTYKFRTLTKELARLMAYEASRDFEIETFPMEGWCGEIIGEQIIGKTATIVPIL
RAGIGMLDGVLDLIPTAKISVVGLQRDEETLQPVPFFEKFVSHMDKRPALIIDPMLATGGSMVATIEMLKKNGCTNIKAL
VLVAAPEGVRVVNEAHPDVTIYTAALDSHLDEHGYIIPGLGDAGDKIFGKQLFNK

Sequences:

>Translated_215_residues
MSDLKITVIDHPLVRHKLSLMREKDCSTYKFRTLTKELARLMAYEASRDFEIETFPMEGWCGEIIGEQIIGKTATIVPIL
RAGIGMLDGVLDLIPTAKISVVGLQRDEETLQPVPFFEKFVSHMDKRPALIIDPMLATGGSMVATIEMLKKNGCTNIKAL
VLVAAPEGVRVVNEAHPDVTIYTAALDSHLDEHGYIIPGLGDAGDKIFGKQLFNK
>Mature_214_residues
SDLKITVIDHPLVRHKLSLMREKDCSTYKFRTLTKELARLMAYEASRDFEIETFPMEGWCGEIIGEQIIGKTATIVPILR
AGIGMLDGVLDLIPTAKISVVGLQRDEETLQPVPFFEKFVSHMDKRPALIIDPMLATGGSMVATIEMLKKNGCTNIKALV
LVAAPEGVRVVNEAHPDVTIYTAALDSHLDEHGYIIPGLGDAGDKIFGKQLFNK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=205, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI57863312, Length=205, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=62.0192307692308, Blast_Score=281, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17539892, Length=208, Percent_Identity=25, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=208, Percent_Identity=25, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=35.2331606217617, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.0935960591133, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.0935960591133, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.0935960591133, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.0935960591133, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23720; Mature: 23589

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKITVIDHPLVRHKLSLMREKDCSTYKFRTLTKELARLMAYEASRDFEIETFPMEGW
CCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
CGEIIGEQIIGKTATIVPILRAGIGMLDGVLDLIPTAKISVVGLQRDEETLQPVPFFEKF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCHHHHH
VSHMDKRPALIIDPMLATGGSMVATIEMLKKNGCTNIKALVLVAAPEGVRVVNEAHPDVT
HHHHCCCCCEEECCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHCCCCCEE
IYTAALDSHLDEHGYIIPGLGDAGDKIFGKQLFNK
EEEEHHHHCCCCCCEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SDLKITVIDHPLVRHKLSLMREKDCSTYKFRTLTKELARLMAYEASRDFEIETFPMEGW
CCCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
CGEIIGEQIIGKTATIVPILRAGIGMLDGVLDLIPTAKISVVGLQRDEETLQPVPFFEKF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCHHHHH
VSHMDKRPALIIDPMLATGGSMVATIEMLKKNGCTNIKALVLVAAPEGVRVVNEAHPDVT
HHHHCCCCCEEECCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHCCCCCEE
IYTAALDSHLDEHGYIIPGLGDAGDKIFGKQLFNK
EEEEHHHHCCCCCCEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA