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The map label for this gene is msrA [H]

Identifier: 93007067

GI number: 93007067

Start: 2752724

End: 2753245

Strand: Direct

Name: msrA [H]

Synonym: Pcryo_2243

Alternate gene names: 93007067

Gene position: 2752724-2753245 (Clockwise)

Preceding gene: 93007064

Following gene: 93007068

Centisome position: 89.96

GC content: 41.76

Gene sequence:

>522_bases
ATGCAAACCATTATATTAGGCGGTGGCTGTTTTTGGTGCACCGAATCAGTATTTTTATCCGTAAAAGGCGTACAGTCTGT
AATATCAGGTTATATGGGCGGCGATGCGGTATCAGCCAATTATGAAGCAGTCTGCGGTGGGAATACTGGTCACGTTGAAG
TGATTAAAGTCGAATTTGACGAATCGATTGTCCCATTAGAAGTGATACTTGATGTCTTCTTTGCCACTCATGATCCCACT
ACAATGGATCGTCAGGGTAATGATGTAGGTAGCCAATATCGTAGCGTCGTGTTCTACACTGATGAAACGCAAAAACCGAC
CATCGATCGTACCATTAATAAACTGCGTGACATGGGTATAAATGTGGTGACCGAAGTACATCCTGCGGTTGAATTTTATC
AAGCAGAAGACACACATCAAGACTTTTTTAATCGCAACCCAGGACAAGCTTATTGCAACTTTGCCATACCACCAAAACTT
GCTAAACTACGTAAAGAATTCAGTCAATATATGGTGAGCTAA

Upstream 100 bases:

>100_bases
CAGGCAACTGCACTGTTAAGCTAAATGTATATCGCCAAGCAAAATAGATTTGTAAAACATGCTTGGCTCATATTTTATAA
TGATAAGAATAGGAAAAATT

Downstream 100 bases:

>100_bases
GCATCACATTGCCTAACAATTTATTCGTTTCAGACATGTCTTAATTTATTATTTAATAAAAGCCAAATGCTTATAATATA
AGTATTTGGCTTTTTTAATT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MQTIILGGGCFWCTESVFLSVKGVQSVISGYMGGDAVSANYEAVCGGNTGHVEVIKVEFDESIVPLEVILDVFFATHDPT
TMDRQGNDVGSQYRSVVFYTDETQKPTIDRTINKLRDMGINVVTEVHPAVEFYQAEDTHQDFFNRNPGQAYCNFAIPPKL
AKLRKEFSQYMVS

Sequences:

>Translated_173_residues
MQTIILGGGCFWCTESVFLSVKGVQSVISGYMGGDAVSANYEAVCGGNTGHVEVIKVEFDESIVPLEVILDVFFATHDPT
TMDRQGNDVGSQYRSVVFYTDETQKPTIDRTINKLRDMGINVVTEVHPAVEFYQAEDTHQDFFNRNPGQAYCNFAIPPKL
AKLRKEFSQYMVS
>Mature_173_residues
MQTIILGGGCFWCTESVFLSVKGVQSVISGYMGGDAVSANYEAVCGGNTGHVEVIKVEFDESIVPLEVILDVFFATHDPT
TMDRQGNDVGSQYRSVVFYTDETQKPTIDRTINKLRDMGINVVTEVHPAVEFYQAEDTHQDFFNRNPGQAYCNFAIPPKL
AKLRKEFSQYMVS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=36.4779874213836, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=36.4779874213836, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=36.6013071895425, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=32.9192546583851, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=26.875, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553131, Length=154, Percent_Identity=26.6233766233766, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664631, Length=160, Percent_Identity=26.875, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19278; Mature: 19278

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIILGGGCFWCTESVFLSVKGVQSVISGYMGGDAVSANYEAVCGGNTGHVEVIKVEFD
CCEEEECCCHHHHHHHHHEEHHHHHHHHHHHCCCCEECCCCEEEECCCCCCEEEEEEECC
ESIVPLEVILDVFFATHDPTTMDRQGNDVGSQYRSVVFYTDETQKPTIDRTINKLRDMGI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCEEEEEECCCCCCCHHHHHHHHHHCCC
NVVTEVHPAVEFYQAEDTHQDFFNRNPGQAYCNFAIPPKLAKLRKEFSQYMVS
CEEEHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTIILGGGCFWCTESVFLSVKGVQSVISGYMGGDAVSANYEAVCGGNTGHVEVIKVEFD
CCEEEECCCHHHHHHHHHEEHHHHHHHHHHHCCCCEECCCCEEEECCCCCCEEEEEEECC
ESIVPLEVILDVFFATHDPTTMDRQGNDVGSQYRSVVFYTDETQKPTIDRTINKLRDMGI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCEEEEEECCCCCCCHHHHHHHHHHCCC
NVVTEVHPAVEFYQAEDTHQDFFNRNPGQAYCNFAIPPKLAKLRKEFSQYMVS
CEEEHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA