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The map label for this gene is tpm

Identifier: 93007068

GI number: 93007068

Start: 2753462

End: 2754121

Strand: Direct

Name: tpm

Synonym: Pcryo_2244

Alternate gene names: 93007068

Gene position: 2753462-2754121 (Clockwise)

Preceding gene: 93007067

Following gene: 93007069

Centisome position: 89.99

GC content: 41.21

Gene sequence:

>660_bases
ATGAATCCAGAATTTTGGCAGGCTCGCTGGAAGGAAAAACGCATCGGCTTTAATCAGCCTAAAGTGAATCCTTTGTTGAT
TAAATACTTTTCAGATTTAAAGATGGCCACCGGAAGCCGTATATTCATCCCTTTATGCGGCAAATCTATTGATATGATTT
GGCTAGCCAATCAAGGTTTTGATATGGTCGGCGTTGAATTGGTTGAGTCAGCGGTACAGGAATTTTTTGCTGAAAATAAT
ATCTCTTATACGATAAAAGCGCATGATAAAAATTCAAATATTAAATGCTATCAAGGGCAGTTATCAGGACAAACAATAGC
GTTATGGGTTGCAGATATATTTATGCTACGTACTAATGATGTTGGTCGCGTTGATGCGGTCTACGATCGAGCAGCATTAA
TTGCGATGCCAGCAGAGTTGCGCCCGCAATATAGTCAGCAAGTTATCGACCTCAGTCAAAACGCTCATCAGTTATTACTG
ACACTCAATTACGACCAAAATGAGCGAGCAGGACCGCCCTTTTCAATCAGTCATGAGCAAATCCAGCAGTACTATAGCGC
TCACTATCAAATTCAAGAGCTTGAGGGCAAACCATCGACTTTAAACGCCGCACCTGAGATGACGGTGACAGAGAATGTTT
GGTTGTTGAATAAACCATAA

Upstream 100 bases:

>100_bases
GAGTTAATGACTTTAACAATATCAAGCGACAAGTTATGATAATGCATCGACTGTAAAAAATAACTGATAATAGAAATTCT
TATAACTGAAGGCTAAAGCA

Downstream 100 bases:

>100_bases
GCGAGAAATCTAATGAAAATTTTAGTGAGTTTCGTAAGTCTCATTGCTTTCTTATTAGTCGTATTGACAGGCCCTCTTTA
TAAGTATGACATCATTGAAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MNPEFWQARWKEKRIGFNQPKVNPLLIKYFSDLKMATGSRIFIPLCGKSIDMIWLANQGFDMVGVELVESAVQEFFAENN
ISYTIKAHDKNSNIKCYQGQLSGQTIALWVADIFMLRTNDVGRVDAVYDRAALIAMPAELRPQYSQQVIDLSQNAHQLLL
TLNYDQNERAGPPFSISHEQIQQYYSAHYQIQELEGKPSTLNAAPEMTVTENVWLLNKP

Sequences:

>Translated_219_residues
MNPEFWQARWKEKRIGFNQPKVNPLLIKYFSDLKMATGSRIFIPLCGKSIDMIWLANQGFDMVGVELVESAVQEFFAENN
ISYTIKAHDKNSNIKCYQGQLSGQTIALWVADIFMLRTNDVGRVDAVYDRAALIAMPAELRPQYSQQVIDLSQNAHQLLL
TLNYDQNERAGPPFSISHEQIQQYYSAHYQIQELEGKPSTLNAAPEMTVTENVWLLNKP
>Mature_219_residues
MNPEFWQARWKEKRIGFNQPKVNPLLIKYFSDLKMATGSRIFIPLCGKSIDMIWLANQGFDMVGVELVESAVQEFFAENN
ISYTIKAHDKNSNIKCYQGQLSGQTIALWVADIFMLRTNDVGRVDAVYDRAALIAMPAELRPQYSQQVIDLSQNAHQLLL
TLNYDQNERAGPPFSISHEQIQQYYSAHYQIQELEGKPSTLNAAPEMTVTENVWLLNKP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=194, Percent_Identity=35.0515463917526, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_PSYCK (Q1Q8I2)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_581505.1
- ProteinModelPortal:   Q1Q8I2
- SMR:   Q1Q8I2
- STRING:   Q1Q8I2
- GeneID:   4035542
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_2244
- NMPDR:   fig|335284.3.peg.2245
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   VDAIYDR
- BioCyc:   PCRY335284:PCRYO_2244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 25045; Mature: 25045

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPEFWQARWKEKRIGFNQPKVNPLLIKYFSDLKMATGSRIFIPLCGKSIDMIWLANQGF
CCCHHHHHHHHHHCCCCCCCCCCHHHEEEHHHHHHCCCCEEEEEECCCCEEEEEEECCCC
DMVGVELVESAVQEFFAENNISYTIKAHDKNSNIKCYQGQLSGQTIALWVADIFMLRTND
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEEEHEEECCC
VGRVDAVYDRAALIAMPAELRPQYSQQVIDLSQNAHQLLLTLNYDQNERAGPPFSISHEQ
CCCHHHHHCCEEEEECCHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHH
IQQYYSAHYQIQELEGKPSTLNAAPEMTVTENVWLLNKP
HHHHHHHCEEEEECCCCCCCCCCCCCCEEECCEEEEECC
>Mature Secondary Structure
MNPEFWQARWKEKRIGFNQPKVNPLLIKYFSDLKMATGSRIFIPLCGKSIDMIWLANQGF
CCCHHHHHHHHHHCCCCCCCCCCHHHEEEHHHHHHCCCCEEEEEECCCCEEEEEEECCCC
DMVGVELVESAVQEFFAENNISYTIKAHDKNSNIKCYQGQLSGQTIALWVADIFMLRTND
CHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEEEHEEECCC
VGRVDAVYDRAALIAMPAELRPQYSQQVIDLSQNAHQLLLTLNYDQNERAGPPFSISHEQ
CCCHHHHHCCEEEEECCHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHH
IQQYYSAHYQIQELEGKPSTLNAAPEMTVTENVWLLNKP
HHHHHHHCEEEEECCCCCCCCCCCCCCEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA