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The map label for this gene is nhaA [H]

Identifier: 93006947

GI number: 93006947

Start: 2600035

End: 2601237

Strand: Direct

Name: nhaA [H]

Synonym: Pcryo_2123

Alternate gene names: 93006947

Gene position: 2600035-2601237 (Clockwise)

Preceding gene: 93006945

Following gene: 93006948

Centisome position: 84.97

GC content: 43.31

Gene sequence:

>1203_bases
ATGGCAATACATAAAATCAGAGCGTTTTTTAATCTCGAGGCTTCGGGCGGTATCGTCCTAGCGCTGGCAGCTATCGCAGC
AATGATTATTGCTAATACTTCTCTAAATACGTGGTACGAATCCTTTATTCACGCACCTGTCGCTATTCAAATTGGCAGCT
TCTCAATCGCTAAAGATGCGCATCATTGGATTAATGATGGCTTGATGGCAGTGTTCTTCTTTTTAGTGGGACTTGAGCTT
AAGCGTGAAGTGTTAATCGGCGAGCTGTCCAATGTAAAGCAAATTATCTTGCCAGCAGGAGCGGCTCTTGGCGGCATGAT
CATGCCAGCCATCGTCTATCTGTTTTTTAACTATAATGAACCTGAGTTTTGGCGAGGTTGGGCGATTCCTGCCGCAACCG
ATATCGCCTTTGCTCTTGGTATTTTGAGTTTACTTGGTAATCGCGTACCCAATTCATTAAAAGTATTCTTAGTCTCGATT
GCTATCTTTGATGATATCGGCGCGATTATTATCATCGCTTTATTTTATACCAATGATTTATCACTTGGTTCACTGGCTAT
CGCGGGCTTATGTCTGCCGTTTTTATATCTGCTTAATCGCCGTAACGTTACTAGCATAACTCCTTATTTGCTAATTGGCG
TTATCATGTGGGTTGCCGTACTCAAATCCGGTATCCATGCAACGTTAGCTGGGGTTGTATTGGCGCTATTTATTCCTTTA
TTTGATCGCACTGACCCTGAGCATTCCCCGCTTGAAGAGCTTGAACACGACCTACAAAACACAGTTTCTTACGGTATCCT
GCCATTATTTGCTTTTGCCAATGCGGGCATTTCGCTTAAGGGCGCAGGGTTTGGTGAGCTGTTTCATTCTGTACCGCTTG
GTATTGCCGCTGGACTGTTCATCGGTAAACAAGTAGGCGTCATGCTGATGTGCTGGTTAATTTTTAAATTGGGCATTTCT
ACTATGCCAAAAGGCATGAACTTTAAGCAAATCTACGGCGCAGCATTGTTATGTGGTGTAGGCTTTACCATGAGTTTGTT
TATCGGTGGGCTTGCATTTGCCGGTGAGACACCATTATTTGATGAGCGTTTGGGTATCATTATGGGTTCAATCGTCTCTG
GTATCGCAGGTTATATGATGCTCAAAGCCACTTTAAAAGATGAGGTTAATGTAACCTCTGTAGACTTAACGCGTCATTCT
TAA

Upstream 100 bases:

>100_bases
CATATGTGGTCGCGTACTTAAGGCGGAGCCATTACAGACATACAAGAATACTTGAGCTTTTGAATACTTTCGCACGTTTT
ATTTAGTTAATGAGGACAAT

Downstream 100 bases:

>100_bases
TGTACGATTGAGCTACTTTATCCCAAAGTAGCTCAATCAACTTCATAAAAAGCAGTTGCTACAGAGTTGCTCATAAATAT
GGATTCCATCGACATCTCTA

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MAIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDAHHWINDGLMAVFFFLVGLEL
KREVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNEPEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSI
AIFDDIGAIIIIALFYTNDLSLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPL
FDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLFIGKQVGVMLMCWLIFKLGIS
TMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLFDERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS

Sequences:

>Translated_400_residues
MAIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDAHHWINDGLMAVFFFLVGLEL
KREVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNEPEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSI
AIFDDIGAIIIIALFYTNDLSLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPL
FDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLFIGKQVGVMLMCWLIFKLGIS
TMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLFDERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS
>Mature_399_residues
AIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDAHHWINDGLMAVFFFLVGLELK
REVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNEPEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSIA
IFDDIGAIIIIALFYTNDLSLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPLF
DRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLFIGKQVGVMLMCWLIFKLGIST
MPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLFDERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=390, Percent_Identity=52.0512820512821, Blast_Score=361, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 43085; Mature: 42954

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDA
CCHHHEEHHEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHH
HHWINDGLMAVFFFLVGLELKREVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSIAIFDDIGAIIIIALFYTNDL
CCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPL
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLF
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHH
IGKQVGVMLMCWLIFKLGISTMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure 
AIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDA
CHHHEEHHEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCHHHHHH
HHWINDGLMAVFFFLVGLELKREVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
PEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSIAIFDDIGAIIIIALFYTNDL
CCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPL
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLF
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHH
IGKQVGVMLMCWLIFKLGISTMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA