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The map label for this gene is pyrC [H]

Identifier: 93006689

GI number: 93006689

Start: 2303762

End: 2304832

Strand: Direct

Name: pyrC [H]

Synonym: Pcryo_1865

Alternate gene names: 93006689

Gene position: 2303762-2304832 (Clockwise)

Preceding gene: 93006687

Following gene: 93006690

Centisome position: 75.29

GC content: 45.94

Gene sequence:

>1071_bases
ATGACTGATTCAATTAGAGAATTGACCATCCTACAACCCGATGATTGGCACATTCATTTGCGTGACGATAAGGCGCTAGC
AACCACAGTTCCTCATGCGGCAGAGAGCTTTAATCGCGTCATCTGTATGCCAAACCTTGTACCACCAGTCAAAAACGTTG
ACGACGCGCAAGCATATCGCGCGCGTATCATGCAACATCTAGAAATCAGCAATCTGAGCGCTGAGCGTAAAGCATCATTT
GACCCGCGCATGACCTTGTATCTCACCGATCATACCACCGCACAAGATATTGAGCTGGCGGCAAAGTCTGGCATCGTACA
AGCGGTCAAGCTCTATCCTGCTGGTGCTACCACCAACTCTGCTGATGGCGTCACCGACATCAATGCCTGTGTCAATGTCT
TTGAAGCGCTTGAAAAATACAATCTACCTTTGCTGCTACATGGAGAAGTCACTCACGACCATGTTGATATTTTTGATCGT
GAAAAGCGCTTTTTGGATGAAGTGATGGTACAAATCATCGCAAAGTTCCCAACCATGAAAATTGTGATGGAGCATATCAC
CACCAGTGATGCGGCTGATTTTGTCTTGTCACAAGGCAATCAAATTGCTGCCACTATTACGCCGCAGCATTTGATGTTTA
ACCGCAATCACCTATTGCTTGGTGGTATTAAACCGCACTTCTATTGCTTGCCTATCTTAAAGCGGGAAAGCCATCAGAAA
GTATTGCTTGATGTCGCTACCAGCGGCAACCCAAAATTCTTTTTAGGTACTGATTCTGCACCCCATGCGACCGATAAGAA
AGAAGCGGCTTGTGGCTGTGCTGGCTGCTATAGCGCAGCGACTGCACTACCTTTATATGCCACAGCGTTTGATAGTGTTG
GTAAAATTGACAGATTAGAAGGGTTCACCAGTCGTTTTGGTGCACAATTTTACGGTTTGCCCGTTAACGAGAGCACGGTC
ACCCTTGTTAACGCACCTATGCAAATACCAACAAATTATCCTTATTTTGATGGTAGCTCATTAACTCCACTGATGGCAGG
CGAGACATTACCTTGGTCGATCAAAGGATAA

Upstream 100 bases:

>100_bases
TCAGCCACATATTTAGTCAGGTAAGCAAATCTGTTATGATAGCCGCACAGCAAGACTCCCTTTTACTCCCAGATATGACG
ATATAGAGCGCGACGATACT

Downstream 100 bases:

>100_bases
TTTTTAATTAAAACTCTTTTTTATAAAGTAAAATTATCTGTATTTTATCCTATGATAGTAATGCTATCTGTCCATTGAAA
AATAGTATGAGTGTCATAGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTDSIRELTILQPDDWHIHLRDDKALATTVPHAAESFNRVICMPNLVPPVKNVDDAQAYRARIMQHLEISNLSAERKASF
DPRMTLYLTDHTTAQDIELAAKSGIVQAVKLYPAGATTNSADGVTDINACVNVFEALEKYNLPLLLHGEVTHDHVDIFDR
EKRFLDEVMVQIIAKFPTMKIVMEHITTSDAADFVLSQGNQIAATITPQHLMFNRNHLLLGGIKPHFYCLPILKRESHQK
VLLDVATSGNPKFFLGTDSAPHATDKKEAACGCAGCYSAATALPLYATAFDSVGKIDRLEGFTSRFGAQFYGLPVNESTV
TLVNAPMQIPTNYPYFDGSSLTPLMAGETLPWSIKG

Sequences:

>Translated_356_residues
MTDSIRELTILQPDDWHIHLRDDKALATTVPHAAESFNRVICMPNLVPPVKNVDDAQAYRARIMQHLEISNLSAERKASF
DPRMTLYLTDHTTAQDIELAAKSGIVQAVKLYPAGATTNSADGVTDINACVNVFEALEKYNLPLLLHGEVTHDHVDIFDR
EKRFLDEVMVQIIAKFPTMKIVMEHITTSDAADFVLSQGNQIAATITPQHLMFNRNHLLLGGIKPHFYCLPILKRESHQK
VLLDVATSGNPKFFLGTDSAPHATDKKEAACGCAGCYSAATALPLYATAFDSVGKIDRLEGFTSRFGAQFYGLPVNESTV
TLVNAPMQIPTNYPYFDGSSLTPLMAGETLPWSIKG
>Mature_355_residues
TDSIRELTILQPDDWHIHLRDDKALATTVPHAAESFNRVICMPNLVPPVKNVDDAQAYRARIMQHLEISNLSAERKASFD
PRMTLYLTDHTTAQDIELAAKSGIVQAVKLYPAGATTNSADGVTDINACVNVFEALEKYNLPLLLHGEVTHDHVDIFDRE
KRFLDEVMVQIIAKFPTMKIVMEHITTSDAADFVLSQGNQIAATITPQHLMFNRNHLLLGGIKPHFYCLPILKRESHQKV
LLDVATSGNPKFFLGTDSAPHATDKKEAACGCAGCYSAATALPLYATAFDSVGKIDRLEGFTSRFGAQFYGLPVNESTVT
LVNAPMQIPTNYPYFDGSSLTPLMAGETLPWSIKG

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=355, Percent_Identity=50.4225352112676, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323452, Length=373, Percent_Identity=30.8310991957105, Blast_Score=159, Evalue=7e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39214; Mature: 39083

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSIRELTILQPDDWHIHLRDDKALATTVPHAAESFNRVICMPNLVPPVKNVDDAQAYR
CCCCCCEEEEECCCCCEEEEECCCEEECCCCHHHHHCCEEEECCCCCCCCCCCCHHHHHH
ARIMQHLEISNLSAERKASFDPRMTLYLTDHTTAQDIELAAKSGIVQAVKLYPAGATTNS
HHHHHHHHHCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCC
ADGVTDINACVNVFEALEKYNLPLLLHGEVTHDHVDIFDREKRFLDEVMVQIIAKFPTMK
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
IVMEHITTSDAADFVLSQGNQIAATITPQHLMFNRNHLLLGGIKPHFYCLPILKRESHQK
HHHHHHCCCHHHHHHHHCCCEEEEEECHHHHEECCCEEEEECCCCCEEEEEECCCCCCCE
VLLDVATSGNPKFFLGTDSAPHATDKKEAACGCAGCYSAATALPLYATAFDSVGKIDRLE
EEEEEECCCCCEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GFTSRFGAQFYGLPVNESTVTLVNAPMQIPTNYPYFDGSSLTPLMAGETLPWSIKG
HHHHHHCCEEEECCCCCCEEEEEECCEECCCCCCCCCCCCCCHHHCCCCCCEECCC
>Mature Secondary Structure 
TDSIRELTILQPDDWHIHLRDDKALATTVPHAAESFNRVICMPNLVPPVKNVDDAQAYR
CCCCCEEEEECCCCCEEEEECCCEEECCCCHHHHHCCEEEECCCCCCCCCCCCHHHHHH
ARIMQHLEISNLSAERKASFDPRMTLYLTDHTTAQDIELAAKSGIVQAVKLYPAGATTNS
HHHHHHHHHCCCCCHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCC
ADGVTDINACVNVFEALEKYNLPLLLHGEVTHDHVDIFDREKRFLDEVMVQIIAKFPTMK
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
IVMEHITTSDAADFVLSQGNQIAATITPQHLMFNRNHLLLGGIKPHFYCLPILKRESHQK
HHHHHHCCCHHHHHHHHCCCEEEEEECHHHHEECCCEEEEECCCCCEEEEEECCCCCCCE
VLLDVATSGNPKFFLGTDSAPHATDKKEAACGCAGCYSAATALPLYATAFDSVGKIDRLE
EEEEEECCCCCEEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GFTSRFGAQFYGLPVNESTVTLVNAPMQIPTNYPYFDGSSLTPLMAGETLPWSIKG
HHHHHHCCEEEECCCCCCEEEEEECCEECCCCCCCCCCCCCCHHHCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA