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The map label for this gene is purM [H]

Identifier: 93006680

GI number: 93006680

Start: 2291000

End: 2292049

Strand: Direct

Name: purM [H]

Synonym: Pcryo_1856

Alternate gene names: 93006680

Gene position: 2291000-2292049 (Clockwise)

Preceding gene: 93006676

Following gene: 93006681

Centisome position: 74.87

GC content: 47.9

Gene sequence:

>1050_bases
ATGAGTAACAAGCCTTCTTTAAGCTACAAAGATGCTGGCGTTGATATTGATGCTGGCGATGCGTTGGTGCAACGTATTAA
ATCCGTGGCAAAAGCCACCTCACGTCCTGAAGTGGTGGGCGGACTTGGCGGCTTTGGGGCGCTTTGTCGCATTCCGACTG
GTTACACCTCACCGTTATTAGTTTCGGGTACTGACGGTGTCGGCACTAAGCTTAAACTGGCATTACAATTGAATCGACAT
GACACCATTGGTATCGACTTGGTCGCTATGTGTGTCAACGACTTATTGGTTTGCGGTGCTGAGCCTTTGTTTTTCTTAGA
CTACTATGCAACTGGTAAGCTTGACGTCGATGTTGCAGCTACTGTTGTTACGGGTATAGGTGAAGGCTGTAAATTATCAA
ATTGCGCGCTTATCGGCGGCGAAACGGCTGAGATGCCAGGCATGTATCAGGACGACGATTATGACCTAGCGGGATTCTGC
GTCGGTGTGGTTGAAGAAGCAGAAGTCATCACTGGCGAAAACGTGGCTGAAGGCGATGTATTAATTGCTCTTGCCTCAAG
TGGCGCGCATTCCAATGGCTACTCATTGGTACGTAAAGTCATTGAAGTCAGCGGTGTGGATGTGACTAGTAGCAATGAGC
AGCTAGATGGTCAGTCTATCCAAGATGCCTTGATGGCACCGACCCGTATTTATGTTAAAGCGATTAAAGCGCTACAAGAT
ACCCTTGGTAGCTCAGCCCTACATGCGATGTCACATATTACTGGCGGCGGCTTAACCGATAACCTGCCACGTGTATTACC
TGAAACGCTAGCCGCTAGCATCGATACGAATAGCTGGCAGTTCTCAGAGCTATTCACTTGGTTACAAAACCAAGGTAATA
TCGAGCAAAGCGAGATGTATCGTACCTTTAACTGCGGCGTTGGGTTTGTTATCGTCGTACCCAAAGATAAAGCCGAAGCT
GCTATCCAAACCTTGAATGATGCTGGCGAAAAAGCATGGAAATTAGGTGAAATGGTCAAGCGCGAAGCGGATGCTGTGGT
GTACCGTTAA

Upstream 100 bases:

>100_bases
GATTTTTGGGTATAATGCGCGCACAATCTGCAAAATTCATATGACCGACACGCGTTTTTACTGACTGACCTTCATTCCCT
ATAAAATTTGTGAGATGACC

Downstream 100 bases:

>100_bases
TGCTAGCCAATAACACCAGTCATGCCAACAAACCATTACGCATTGCCGTTTTGGTATCTGGTAGCGGTAGCAACTTACAA
GTATTGATTGATGCTATGCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSNKPSLSYKDAGVDIDAGDALVQRIKSVAKATSRPEVVGGLGGFGALCRIPTGYTSPLLVSGTDGVGTKLKLALQLNRH
DTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDVAATVVTGIGEGCKLSNCALIGGETAEMPGMYQDDDYDLAGFC
VGVVEEAEVITGENVAEGDVLIALASSGAHSNGYSLVRKVIEVSGVDVTSSNEQLDGQSIQDALMAPTRIYVKAIKALQD
TLGSSALHAMSHITGGGLTDNLPRVLPETLAASIDTNSWQFSELFTWLQNQGNIEQSEMYRTFNCGVGFVIVVPKDKAEA
AIQTLNDAGEKAWKLGEMVKREADAVVYR

Sequences:

>Translated_349_residues
MSNKPSLSYKDAGVDIDAGDALVQRIKSVAKATSRPEVVGGLGGFGALCRIPTGYTSPLLVSGTDGVGTKLKLALQLNRH
DTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDVAATVVTGIGEGCKLSNCALIGGETAEMPGMYQDDDYDLAGFC
VGVVEEAEVITGENVAEGDVLIALASSGAHSNGYSLVRKVIEVSGVDVTSSNEQLDGQSIQDALMAPTRIYVKAIKALQD
TLGSSALHAMSHITGGGLTDNLPRVLPETLAASIDTNSWQFSELFTWLQNQGNIEQSEMYRTFNCGVGFVIVVPKDKAEA
AIQTLNDAGEKAWKLGEMVKREADAVVYR
>Mature_348_residues
SNKPSLSYKDAGVDIDAGDALVQRIKSVAKATSRPEVVGGLGGFGALCRIPTGYTSPLLVSGTDGVGTKLKLALQLNRHD
TIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDVAATVVTGIGEGCKLSNCALIGGETAEMPGMYQDDDYDLAGFCV
GVVEEAEVITGENVAEGDVLIALASSGAHSNGYSLVRKVIEVSGVDVTSSNEQLDGQSIQDALMAPTRIYVKAIKALQDT
LGSSALHAMSHITGGGLTDNLPRVLPETLAASIDTNSWQFSELFTWLQNQGNIEQSEMYRTFNCGVGFVIVVPKDKAEAA
IQTLNDAGEKAWKLGEMVKREADAVVYR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=51.3274336283186, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=51.3274336283186, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=51.3274336283186, Blast_Score=345, Evalue=3e-95,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=65.1785714285714, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17567511, Length=340, Percent_Identity=40.5882352941176, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=349, Percent_Identity=44.6991404011461, Blast_Score=306, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24582400, Length=296, Percent_Identity=44.2567567567568, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36863; Mature: 36732

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKPSLSYKDAGVDIDAGDALVQRIKSVAKATSRPEVVGGLGGFGALCRIPTGYTSPLL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHCCCCCCCCCEE
VSGTDGVGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDVAA
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHH
TVVTGIGEGCKLSNCALIGGETAEMPGMYQDDDYDLAGFCVGVVEEAEVITGENVAEGDV
HHHHHCCCCCEECCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCE
LIALASSGAHSNGYSLVRKVIEVSGVDVTSSNEQLDGQSIQDALMAPTRIYVKAIKALQD
EEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
TLGSSALHAMSHITGGGLTDNLPRVLPETLAASIDTNSWQFSELFTWLQNQGNIEQSEMY
HHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCHHHHH
RTFNCGVGFVIVVPKDKAEAAIQTLNDAGEKAWKLGEMVKREADAVVYR
EEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECC
>Mature Secondary Structure 
SNKPSLSYKDAGVDIDAGDALVQRIKSVAKATSRPEVVGGLGGFGALCRIPTGYTSPLL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHCCCCCCCCCEE
VSGTDGVGTKLKLALQLNRHDTIGIDLVAMCVNDLLVCGAEPLFFLDYYATGKLDVDVAA
EECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHH
TVVTGIGEGCKLSNCALIGGETAEMPGMYQDDDYDLAGFCVGVVEEAEVITGENVAEGDV
HHHHHCCCCCEECCEEEECCCHHCCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCE
LIALASSGAHSNGYSLVRKVIEVSGVDVTSSNEQLDGQSIQDALMAPTRIYVKAIKALQD
EEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
TLGSSALHAMSHITGGGLTDNLPRVLPETLAASIDTNSWQFSELFTWLQNQGNIEQSEMY
HHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCHHHHH
RTFNCGVGFVIVVPKDKAEAAIQTLNDAGEKAWKLGEMVKREADAVVYR
EEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA