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The map label for this gene is uvrB [H]

Identifier: 93005567

GI number: 93005567

Start: 866100

End: 868088

Strand: Direct

Name: uvrB [H]

Synonym: Pcryo_0737

Alternate gene names: 93005567

Gene position: 866100-868088 (Clockwise)

Preceding gene: 93005564

Following gene: 93005568

Centisome position: 28.31

GC content: 45.6

Gene sequence:

>1989_bases
ATGGTCACCGAGTTTGAGCCAGCAGGCGATCAGCCGCAAGCGATAAAGAAACTGGTTAATGGTATTAATGCTGGCATGGA
TGAGCAGCTATTACTGGGTGTGACGGGTTCTGGTAAGACCTATACCATGGCAAAGGTCATCTCTGAGACGCAACGTCCAA
CTATTATCATGGCACATAATAAAACGCTTGCCGCTCAGTTATATGGTGAGTTTAAGTCGTTTTTCCCCAATAATGCAGTT
GAGTATTTCGTCAGTTATTATGACTATTATCAGCCAGAAGCCTATGTCGCAGCGAGCGATACTTTTATCGAAAAAGACAG
CGCCATTAATGATCATATTGACCAGATGCGTCTGTCAGCGACGCGTGCACTACTTGAGCGTCGTGATGCAATTATCGTCG
CCTCGGTATCCTGTATCTATGGTCTAGGTGATCCAGAAAGTTATCTAAAAATGCTGCTGCACGTCGTCGTTGGTGACAAA
ATCGATCGCACTGCTACCATTAAACGTCTTGTTGAAATGCAATATACGCGCAATGAGCTAGACTTTGGACGAGGTACGTA
TCGGCTGCGTGGTGAGCTGTTAGATATTTATCCTGCTGAGTCTGAGCAGCTAGCGGTGCGTGTGCACTTGTTTGATAATG
AAGTGGAAAAAATCACGTGGTTTGATCCTTTAACGGGTAAGACCGTGCGTACCGTGCCACGTATTACTATTTATCCAAAA
TCACATTACGTGACGCCGCGCAATAAATTGGAGGCTGCGAGCCATACAATTCGTGCTGAGCTTGAGCCACGCTTGGAGTA
TTTCCGCGAAAACAATAAACTAATTGAAGCACAGCGTCTTAAAGAGCGTACTCAGTATGATCTTGAGATGATTCAACAGC
TCGGCTACTGTAACGGTATCGAAAACTACTCACAGCATCTGTCTGGTCGTCCATCAGGGGAAGCACCACCGACTTTGTTT
GATTACATTCCAGAGGATGCGTTATTATTTCTTGATGAGTCGCACGTGACTGTGTCGCAGATTGGTGCAATGTATAAGGG
CGATAGATCGCGTAAAGAGAATCTTGTCAATTATGGCTTTCGTCTACCAAGTGCTATGAATAACCGCCCGATGAAGTTTG
AAGAGTGGGAGCGTATCAAGCCTAAGACTATTTATGTGAGTGCCACGCCTGCATTGTATGAGCTTGAGCACAGCGAGCAA
GTGGTCGAGCAAGTCGTACGTCCGACCGGTTTGATTGACCCTGAAATTGAGATACGTCCTGTATTGACGCAAGTCGATGA
TGTGCTGTCTGAGATTACCAAGCGCCGAGAAAAAGACGAACGCGTGTTAATCACTACCTTGACCAAGCGTATGTCAGAGG
ATTTGACCAGCTATCTCAAAGAATATGATGTCAAAGTTGCTTACCTACACTCGGATATCGATACCCTTGAGCGTATGCAG
ATTATCCATGAGCTGCGTACGGGCGTACATGATGTGTTGGTCGGCATTAATCTATTGCGTGAAGGGTTAGATATGCCAGA
GGTGTCATTGGTCGCGATATTTGATGCCGATAAAGAGGGTTTTTTGCGCTCTGAACGTGCTCTGATTCAGACCATTGGTC
GGGCGGCGCGTCATATTAATGGTAAAGCCATTCTCTATGCTGATCGTATTACCAACAGTATGCAAAAAGCGATCGATGAG
ACCGATCGTCGCCGCGAAAAACAAGTCGCCTTCAACCTTGAACATAACATTACGCCAACAGGTGCGCGCCGTAGTATCAC
GGATAAAATTGACACAGGTGATGACCATGATGCCAACGATAATCAGATGATTCCAATTAAGAGCAATCTGCCTGATGTCG
ATATCAGTATCTTACGCAGTCCTGATTTATTGGCTAAAGAGATCAATCGTCTTGAGAAGCTCATGAAGCAGATGTCGCGT
GACTTAAAGTTTGAGGATGCCGCGAAAACGCGTGACAAAGTGCTAGAGCTAAAAGCGCATTTACTGTAA

Upstream 100 bases:

>100_bases
GTCGCGTCAGTTAAATCAATTGGCCACTCAGCTGCAAGGCGAAGCTGAAATTAGTGGTGTCAACGCGTCTGGGACACAAA
TATCAAGTCGTGCTTTTGAG

Downstream 100 bases:

>100_bases
AGAGTAAAACTATAATTTCAAAATAGTAATAAAAAGGTGAGTTGCCAACGGTGCAGCTCACCTTTTTTATGGTCTTTTTA
TAACCAAAATAACCTCGCTT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MVTEFEPAGDQPQAIKKLVNGINAGMDEQLLLGVTGSGKTYTMAKVISETQRPTIIMAHNKTLAAQLYGEFKSFFPNNAV
EYFVSYYDYYQPEAYVAASDTFIEKDSAINDHIDQMRLSATRALLERRDAIIVASVSCIYGLGDPESYLKMLLHVVVGDK
IDRTATIKRLVEMQYTRNELDFGRGTYRLRGELLDIYPAESEQLAVRVHLFDNEVEKITWFDPLTGKTVRTVPRITIYPK
SHYVTPRNKLEAASHTIRAELEPRLEYFRENNKLIEAQRLKERTQYDLEMIQQLGYCNGIENYSQHLSGRPSGEAPPTLF
DYIPEDALLFLDESHVTVSQIGAMYKGDRSRKENLVNYGFRLPSAMNNRPMKFEEWERIKPKTIYVSATPALYELEHSEQ
VVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEITKRREKDERVLITTLTKRMSEDLTSYLKEYDVKVAYLHSDIDTLERMQ
IIHELRTGVHDVLVGINLLREGLDMPEVSLVAIFDADKEGFLRSERALIQTIGRAARHINGKAILYADRITNSMQKAIDE
TDRRREKQVAFNLEHNITPTGARRSITDKIDTGDDHDANDNQMIPIKSNLPDVDISILRSPDLLAKEINRLEKLMKQMSR
DLKFEDAAKTRDKVLELKAHLL

Sequences:

>Translated_662_residues
MVTEFEPAGDQPQAIKKLVNGINAGMDEQLLLGVTGSGKTYTMAKVISETQRPTIIMAHNKTLAAQLYGEFKSFFPNNAV
EYFVSYYDYYQPEAYVAASDTFIEKDSAINDHIDQMRLSATRALLERRDAIIVASVSCIYGLGDPESYLKMLLHVVVGDK
IDRTATIKRLVEMQYTRNELDFGRGTYRLRGELLDIYPAESEQLAVRVHLFDNEVEKITWFDPLTGKTVRTVPRITIYPK
SHYVTPRNKLEAASHTIRAELEPRLEYFRENNKLIEAQRLKERTQYDLEMIQQLGYCNGIENYSQHLSGRPSGEAPPTLF
DYIPEDALLFLDESHVTVSQIGAMYKGDRSRKENLVNYGFRLPSAMNNRPMKFEEWERIKPKTIYVSATPALYELEHSEQ
VVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEITKRREKDERVLITTLTKRMSEDLTSYLKEYDVKVAYLHSDIDTLERMQ
IIHELRTGVHDVLVGINLLREGLDMPEVSLVAIFDADKEGFLRSERALIQTIGRAARHINGKAILYADRITNSMQKAIDE
TDRRREKQVAFNLEHNITPTGARRSITDKIDTGDDHDANDNQMIPIKSNLPDVDISILRSPDLLAKEINRLEKLMKQMSR
DLKFEDAAKTRDKVLELKAHLL
>Mature_662_residues
MVTEFEPAGDQPQAIKKLVNGINAGMDEQLLLGVTGSGKTYTMAKVISETQRPTIIMAHNKTLAAQLYGEFKSFFPNNAV
EYFVSYYDYYQPEAYVAASDTFIEKDSAINDHIDQMRLSATRALLERRDAIIVASVSCIYGLGDPESYLKMLLHVVVGDK
IDRTATIKRLVEMQYTRNELDFGRGTYRLRGELLDIYPAESEQLAVRVHLFDNEVEKITWFDPLTGKTVRTVPRITIYPK
SHYVTPRNKLEAASHTIRAELEPRLEYFRENNKLIEAQRLKERTQYDLEMIQQLGYCNGIENYSQHLSGRPSGEAPPTLF
DYIPEDALLFLDESHVTVSQIGAMYKGDRSRKENLVNYGFRLPSAMNNRPMKFEEWERIKPKTIYVSATPALYELEHSEQ
VVEQVVRPTGLIDPEIEIRPVLTQVDDVLSEITKRREKDERVLITTLTKRMSEDLTSYLKEYDVKVAYLHSDIDTLERMQ
IIHELRTGVHDVLVGINLLREGLDMPEVSLVAIFDADKEGFLRSERALIQTIGRAARHINGKAILYADRITNSMQKAIDE
TDRRREKQVAFNLEHNITPTGARRSITDKIDTGDDHDANDNQMIPIKSNLPDVDISILRSPDLLAKEINRLEKLMKQMSR
DLKFEDAAKTRDKVLELKAHLL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=661, Percent_Identity=63.5400907715582, Blast_Score=853, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=315, Percent_Identity=23.1746031746032, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75862; Mature: 75862

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTEFEPAGDQPQAIKKLVNGINAGMDEQLLLGVTGSGKTYTMAKVISETQRPTIIMAHN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHCCCCEEEEECC
KTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVAASDTFIEKDSAINDHIDQMRLSA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
TRALLERRDAIIVASVSCIYGLGDPESYLKMLLHVVVGDKIDRTATIKRLVEMQYTRNEL
HHHHHHHCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
DFGRGTYRLRGELLDIYPAESEQLAVRVHLFDNEVEKITWFDPLTGKTVRTVPRITIYPK
CCCCCEEEEECCEEEECCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEECCCEEEEECC
SHYVTPRNKLEAASHTIRAELEPRLEYFRENNKLIEAQRLKERTQYDLEMIQQLGYCNGI
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCH
ENYSQHLSGRPSGEAPPTLFDYIPEDALLFLDESHVTVSQIGAMYKGDRSRKENLVNYGF
HHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCC
RLPSAMNNRPMKFEEWERIKPKTIYVSATPALYELEHSEQVVEQVVRPTGLIDPEIEIRP
CCCHHCCCCCCCCHHHHCCCCCEEEEECCCHHEEHHHHHHHHHHHHCCCCCCCCCCEEHH
VLTQVDDVLSEITKRREKDERVLITTLTKRMSEDLTSYLKEYDVKVAYLHSDIDTLERMQ
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
IIHELRTGVHDVLVGINLLREGLDMPEVSLVAIFDADKEGFLRSERALIQTIGRAARHIN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GKAILYADRITNSMQKAIDETDRRREKQVAFNLEHNITPTGARRSITDKIDTGDDHDAND
CCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NQMIPIKSNLPDVDISILRSPDLLAKEINRLEKLMKQMSRDLKFEDAAKTRDKVLELKAH
CEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LL
CC
>Mature Secondary Structure
MVTEFEPAGDQPQAIKKLVNGINAGMDEQLLLGVTGSGKTYTMAKVISETQRPTIIMAHN
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEHHHHHHHHCCCCEEEEECC
KTLAAQLYGEFKSFFPNNAVEYFVSYYDYYQPEAYVAASDTFIEKDSAINDHIDQMRLSA
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
TRALLERRDAIIVASVSCIYGLGDPESYLKMLLHVVVGDKIDRTATIKRLVEMQYTRNEL
HHHHHHHCCEEEEEEEHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
DFGRGTYRLRGELLDIYPAESEQLAVRVHLFDNEVEKITWFDPLTGKTVRTVPRITIYPK
CCCCCEEEEECCEEEECCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEECCCEEEEECC
SHYVTPRNKLEAASHTIRAELEPRLEYFRENNKLIEAQRLKERTQYDLEMIQQLGYCNGI
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCH
ENYSQHLSGRPSGEAPPTLFDYIPEDALLFLDESHVTVSQIGAMYKGDRSRKENLVNYGF
HHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHCC
RLPSAMNNRPMKFEEWERIKPKTIYVSATPALYELEHSEQVVEQVVRPTGLIDPEIEIRP
CCCHHCCCCCCCCHHHHCCCCCEEEEECCCHHEEHHHHHHHHHHHHCCCCCCCCCCEEHH
VLTQVDDVLSEITKRREKDERVLITTLTKRMSEDLTSYLKEYDVKVAYLHSDIDTLERMQ
HHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHH
IIHELRTGVHDVLVGINLLREGLDMPEVSLVAIFDADKEGFLRSERALIQTIGRAARHIN
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCC
GKAILYADRITNSMQKAIDETDRRREKQVAFNLEHNITPTGARRSITDKIDTGDDHDAND
CCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NQMIPIKSNLPDVDISILRSPDLLAKEINRLEKLMKQMSRDLKFEDAAKTRDKVLELKAH
CEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA