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The map label for this gene is hisC1 [H]

Identifier: 93005568

GI number: 93005568

Start: 868317

End: 869369

Strand: Direct

Name: hisC1 [H]

Synonym: Pcryo_0738

Alternate gene names: 93005568

Gene position: 868317-869369 (Clockwise)

Preceding gene: 93005567

Following gene: 93005569

Centisome position: 28.38

GC content: 41.41

Gene sequence:

>1053_bases
ATGCAAAATAATAAATGCTTAGAATTAAATGCGAATGAAAACTCACTAGGCATGTCAGCTTCTGCCAAACAAGCCATTAC
AGACTCTTTAGGTGCAGGCTTCCGTTATCCAGATAACCCACGTGCGGCACTCATTAGCAAAATTGCCACCATCCATGGCG
TGGCAGAAAACCAAATCTCATTAGGCAATGGCTCGACTGAAAATATTCGAGCTACCTTACAAATGCTGCAATATAAAGCT
CTAAAAGAGGGCAGGCAGTTTCAAATGGTGATCCCTGTTCCCACTTTTGATTGCGCAGAGATGTATGCAAATGCAATTGG
CGTGCCCGTCGTCAAGATACCGTTAACCACTGAAAACTATGATTATGATTTTGACGAACTACAAAAAGCAGCTGACGATT
TTGATGGCATAAGCCTACTTTACATTTGTAATCCAAACAACCCAACTGGAATCATTACTTCAACTTCAAGGCTTAAAGCT
TGGGTAAGTAATGCACCAGACAACCATTACTTTTTATTAGATCAAGCGTACTTGGAGTACGTGTCAGACGCAAGCTTTGA
GAGTGGGATTGAATGGGTAAAACAAGGGTTATCAGACAAGCTTATTGTCATTCATACTTTTTCAAAGTTATGTGCCTTAG
CTGGTATGCGAGTGGGCTATGCGATTTCTAACCCGCAAGCTATTGAGACTGTCGAAGCATTTATGTCTATGGATAACACC
AACTTGTCAGGTGCGGTTGCTGCTATTGCGACGTTAAATGATGCAGAGTTTTTAGCGCTAAGTTTGCGCAATACCAATCA
GTCGCGTCAGATGATTGAAACAGTCTTAGACGATCTGGGACTGCGTTATTTACCCTCACAGACCAACTTTATTTTTCATG
AAATAAAAGGTGATTTAAAAACATATATCGACAGAATGCGAGACCATGGCATCAAGGTTGGTCGCGAGTTCCCACCTGTT
ACAGGCTTCAACCGCTTAACACTTGGTACGCCTGATGAAATGGCAGCATTTATCAAAGTACTAAAGTTATTTCGTGAAAA
GGACTGGGTATAA

Upstream 100 bases:

>100_bases
TGGTAATGACAAAACTTGTGTTTATACTAAATGCCAATTAATATGATATCAATGAGCAATATGAACTTATAACAACGGAC
GTTGAGGCACATAATCCATC

Downstream 100 bases:

>100_bases
GTGAGATAAATCATATGTCTTAACCAACCTCAAACGCAGTTTTACATATCCCACCTTAAAAAACACCACTTTATCTTATA
AGATTGGTCAGTTAAGCACA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MQNNKCLELNANENSLGMSASAKQAITDSLGAGFRYPDNPRAALISKIATIHGVAENQISLGNGSTENIRATLQMLQYKA
LKEGRQFQMVIPVPTFDCAEMYANAIGVPVVKIPLTTENYDYDFDELQKAADDFDGISLLYICNPNNPTGIITSTSRLKA
WVSNAPDNHYFLLDQAYLEYVSDASFESGIEWVKQGLSDKLIVIHTFSKLCALAGMRVGYAISNPQAIETVEAFMSMDNT
NLSGAVAAIATLNDAEFLALSLRNTNQSRQMIETVLDDLGLRYLPSQTNFIFHEIKGDLKTYIDRMRDHGIKVGREFPPV
TGFNRLTLGTPDEMAAFIKVLKLFREKDWV

Sequences:

>Translated_350_residues
MQNNKCLELNANENSLGMSASAKQAITDSLGAGFRYPDNPRAALISKIATIHGVAENQISLGNGSTENIRATLQMLQYKA
LKEGRQFQMVIPVPTFDCAEMYANAIGVPVVKIPLTTENYDYDFDELQKAADDFDGISLLYICNPNNPTGIITSTSRLKA
WVSNAPDNHYFLLDQAYLEYVSDASFESGIEWVKQGLSDKLIVIHTFSKLCALAGMRVGYAISNPQAIETVEAFMSMDNT
NLSGAVAAIATLNDAEFLALSLRNTNQSRQMIETVLDDLGLRYLPSQTNFIFHEIKGDLKTYIDRMRDHGIKVGREFPPV
TGFNRLTLGTPDEMAAFIKVLKLFREKDWV
>Mature_350_residues
MQNNKCLELNANENSLGMSASAKQAITDSLGAGFRYPDNPRAALISKIATIHGVAENQISLGNGSTENIRATLQMLQYKA
LKEGRQFQMVIPVPTFDCAEMYANAIGVPVVKIPLTTENYDYDFDELQKAADDFDGISLLYICNPNNPTGIITSTSRLKA
WVSNAPDNHYFLLDQAYLEYVSDASFESGIEWVKQGLSDKLIVIHTFSKLCALAGMRVGYAISNPQAIETVEAFMSMDNT
NLSGAVAAIATLNDAEFLALSLRNTNQSRQMIETVLDDLGLRYLPSQTNFIFHEIKGDLKTYIDRMRDHGIKVGREFPPV
TGFNRLTLGTPDEMAAFIKVLKLFREKDWV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=348, Percent_Identity=26.4367816091954, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=308, Percent_Identity=24.025974025974, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38831; Mature: 38831

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNKCLELNANENSLGMSASAKQAITDSLGAGFRYPDNPRAALISKIATIHGVAENQIS
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LGNGSTENIRATLQMLQYKALKEGRQFQMVIPVPTFDCAEMYANAIGVPVVKIPLTTENY
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCC
DYDFDELQKAADDFDGISLLYICNPNNPTGIITSTSRLKAWVSNAPDNHYFLLDQAYLEY
CCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEECHHHHHHHHHCCCCCEEEEEHHHHHHH
VSDASFESGIEWVKQGLSDKLIVIHTFSKLCALAGMRVGYAISNPQAIETVEAFMSMDNT
HHCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCHHCEEECCCHHHHHHHHHHHCCCC
NLSGAVAAIATLNDAEFLALSLRNTNQSRQMIETVLDDLGLRYLPSQTNFIFHEIKGDLK
CCCHHHHHEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHH
TYIDRMRDHGIKVGREFPPVTGFNRLTLGTPDEMAAFIKVLKLFREKDWV
HHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQNNKCLELNANENSLGMSASAKQAITDSLGAGFRYPDNPRAALISKIATIHGVAENQIS
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
LGNGSTENIRATLQMLQYKALKEGRQFQMVIPVPTFDCAEMYANAIGVPVVKIPLTTENY
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCC
DYDFDELQKAADDFDGISLLYICNPNNPTGIITSTSRLKAWVSNAPDNHYFLLDQAYLEY
CCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEECHHHHHHHHHCCCCCEEEEEHHHHHHH
VSDASFESGIEWVKQGLSDKLIVIHTFSKLCALAGMRVGYAISNPQAIETVEAFMSMDNT
HHCCCHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCHHCEEECCCHHHHHHHHHHHCCCC
NLSGAVAAIATLNDAEFLALSLRNTNQSRQMIETVLDDLGLRYLPSQTNFIFHEIKGDLK
CCCHHHHHEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHH
TYIDRMRDHGIKVGREFPPVTGFNRLTLGTPDEMAAFIKVLKLFREKDWV
HHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA