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The map label for this gene is copS [H]

Identifier: 93005533

GI number: 93005533

Start: 832470

End: 833957

Strand: Direct

Name: copS [H]

Synonym: Pcryo_0703

Alternate gene names: 93005533

Gene position: 832470-833957 (Clockwise)

Preceding gene: 93005532

Following gene: 93005534

Centisome position: 27.21

GC content: 41.33

Gene sequence:

>1488_bases
ATGAGATATAAATTTAAGAATCGACGTTGGCCGCTGTTATGGCGCACTGTTTTTTTACTGACCATATTTGTTGTCATCTC
TCAAGTCACTATTTATATATGGGTCCAGCGCTCTGTTAACGAGCACTTTGAGCAAATGGACTCAGAGATCATTACTCATG
CCGCGTTTAATTTGCGCAAACGTATGGTTGCCTTGGGCGAAGACGTAAAGCCATTAACAGCTTCAAAGTCCCAATCACTC
ATTGATGACAATCACCTGCATTCTTCTTGGCTAGATTATGATTTAAAAACGCTAATATCAGATAAAAACGGCAAATTATT
ATCCAGCGATCCCAGTAATTTCATCCATGATTTACCGACCGACTTTAGCTTGTTACAACTACGGCAGGACTATCGCGATC
AGCAGTTTATGATCAGGATTAATAGTAGACATTATCGAGCGATGGTCATTGCAAACCACGAGGCTTTGGCACTTATTGCG
CTGCCTATCGATGTTCATCATCAGTATCTAATACATTTTAATCGCCAGCTGAGCTTGATACTGATCGCGATCACACTATT
ACTGGTGTCAATTGCCGCATTAAGTGTCTATTGGGGATTTGCACCACTCGCTACTATCGTCCAAAAGATGAAGAGCATTA
ATCCTGAACAGTTACATGAAAGAGTGGTGGTCAGTAATATGCCCTTAGAGCTACGACCATTGGCTGAGTCTTATAACTTA
ATGATGGAAAAGCTGGAAAGTAATTTTGAATCGTTATCACGCTTCTCAGATAATATTGCCCATGAGCTACGTACTCCGCT
GGCGACGCTTGGCACTCAAACCCAAGTGATGTTAAGTAAGCCTAGAGCGAGCCATGAATATGTTGAGCAGCTGCACCATC
AGCATGACACCCTTGAGCAGTTATCTACGCTGATTAATAATATGCTGCTGCTAGCAAAGACACAAAAAGGGCTGTCTGAC
TCACAGCTCAATCAGATTGATACCGAGTCAATGTTCACTAAGCTTATTGATTACTATGAGCTAATCGCAGAAGATCGGAA
TATCTCTTTTGAAAAGACGGGCAACTTCCAAGCTGTGCTAGGAGATGAAAGCTTATTACAAAGACTGTTCGCCAATCTCA
TGTCAAATGCCATTTATTATGCTGCTAGTGACAGTGTGATTATTATTGAAGCCTCTAGTATTGAGATCCCCACTGTGCCT
CATACTGTCACGAGTGATAAGCAAGATATGAGGTCGTCTATATTAAATCCTGCATCTTTCAAGGTAGTGATCACCAATCG
ATTGGATCAACCATTGACTCAAGTAGAGGCTGATAAACTGTTTGAGCGCTTTTACCGTCATGATAAAACGAATACGATGC
ATTCGGGAACAGGCTTAGGCTTATCTATCGTGCAAGCTATCGCCAATGCCCATAATGGCAAGGTCAGTATTACTATAAAA
GATGAGTCTTACTTTCAAGTCAATGTTGAGTTGATGATGGCTAGATAA

Upstream 100 bases:

>100_bases
TTTGACACCAAGCTGATTCACACAGTACGCGGTATGGGCTACAGGTTAGAGCCGCTGGCTGTAGGCGTGGGCGACGATGA
CAAAGATGATCCAAAATAAA

Downstream 100 bases:

>100_bases
ATAAGTATCAAATAAGAAAATTCGAGCTTCTCGTCCCACTTAGCCAAATAATTAAGACTGTATTTAGATGTTATTGTTTA
AGCAAATGTCGCCTCGATTA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MRYKFKNRRWPLLWRTVFLLTIFVVISQVTIYIWVQRSVNEHFEQMDSEIITHAAFNLRKRMVALGEDVKPLTASKSQSL
IDDNHLHSSWLDYDLKTLISDKNGKLLSSDPSNFIHDLPTDFSLLQLRQDYRDQQFMIRINSRHYRAMVIANHEALALIA
LPIDVHHQYLIHFNRQLSLILIAITLLLVSIAALSVYWGFAPLATIVQKMKSINPEQLHERVVVSNMPLELRPLAESYNL
MMEKLESNFESLSRFSDNIAHELRTPLATLGTQTQVMLSKPRASHEYVEQLHHQHDTLEQLSTLINNMLLLAKTQKGLSD
SQLNQIDTESMFTKLIDYYELIAEDRNISFEKTGNFQAVLGDESLLQRLFANLMSNAIYYAASDSVIIIEASSIEIPTVP
HTVTSDKQDMRSSILNPASFKVVITNRLDQPLTQVEADKLFERFYRHDKTNTMHSGTGLGLSIVQAIANAHNGKVSITIK
DESYFQVNVELMMAR

Sequences:

>Translated_495_residues
MRYKFKNRRWPLLWRTVFLLTIFVVISQVTIYIWVQRSVNEHFEQMDSEIITHAAFNLRKRMVALGEDVKPLTASKSQSL
IDDNHLHSSWLDYDLKTLISDKNGKLLSSDPSNFIHDLPTDFSLLQLRQDYRDQQFMIRINSRHYRAMVIANHEALALIA
LPIDVHHQYLIHFNRQLSLILIAITLLLVSIAALSVYWGFAPLATIVQKMKSINPEQLHERVVVSNMPLELRPLAESYNL
MMEKLESNFESLSRFSDNIAHELRTPLATLGTQTQVMLSKPRASHEYVEQLHHQHDTLEQLSTLINNMLLLAKTQKGLSD
SQLNQIDTESMFTKLIDYYELIAEDRNISFEKTGNFQAVLGDESLLQRLFANLMSNAIYYAASDSVIIIEASSIEIPTVP
HTVTSDKQDMRSSILNPASFKVVITNRLDQPLTQVEADKLFERFYRHDKTNTMHSGTGLGLSIVQAIANAHNGKVSITIK
DESYFQVNVELMMAR
>Mature_495_residues
MRYKFKNRRWPLLWRTVFLLTIFVVISQVTIYIWVQRSVNEHFEQMDSEIITHAAFNLRKRMVALGEDVKPLTASKSQSL
IDDNHLHSSWLDYDLKTLISDKNGKLLSSDPSNFIHDLPTDFSLLQLRQDYRDQQFMIRINSRHYRAMVIANHEALALIA
LPIDVHHQYLIHFNRQLSLILIAITLLLVSIAALSVYWGFAPLATIVQKMKSINPEQLHERVVVSNMPLELRPLAESYNL
MMEKLESNFESLSRFSDNIAHELRTPLATLGTQTQVMLSKPRASHEYVEQLHHQHDTLEQLSTLINNMLLLAKTQKGLSD
SQLNQIDTESMFTKLIDYYELIAEDRNISFEKTGNFQAVLGDESLLQRLFANLMSNAIYYAASDSVIIIEASSIEIPTVP
HTVTSDKQDMRSSILNPASFKVVITNRLDQPLTQVEADKLFERFYRHDKTNTMHSGTGLGLSIVQAIANAHNGKVSITIK
DESYFQVNVELMMAR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=321, Percent_Identity=31.1526479750779, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=33.7748344370861, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788393, Length=365, Percent_Identity=26.5753424657534, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=486, Percent_Identity=23.8683127572016, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=23.6607142857143, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56811; Mature: 56811

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYKFKNRRWPLLWRTVFLLTIFVVISQVTIYIWVQRSVNEHFEQMDSEIITHAAFNLRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
RMVALGEDVKPLTASKSQSLIDDNHLHSSWLDYDLKTLISDKNGKLLSSDPSNFIHDLPT
HHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCC
DFSLLQLRQDYRDQQFMIRINSRHYRAMVIANHEALALIALPIDVHHQYLIHFNRQLSLI
CHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEEEEEHHHHHHHHHHCCCHHHHH
LIAITLLLVSIAALSVYWGFAPLATIVQKMKSINPEQLHERVVVSNMPLELRPLAESYNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHH
MMEKLESNFESLSRFSDNIAHELRTPLATLGTQTQVMLSKPRASHEYVEQLHHQHDTLEQ
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
LSTLINNMLLLAKTQKGLSDSQLNQIDTESMFTKLIDYYELIAEDRNISFEKTGNFQAVL
HHHHHHHHEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEE
GDESLLQRLFANLMSNAIYYAASDSVIIIEASSIEIPTVPHTVTSDKQDMRSSILNPASF
CCHHHHHHHHHHHHCCCEEEEECCCEEEEEECCEECCCCCCCCCCCHHHHHHHHCCCCCE
KVVITNRLDQPLTQVEADKLFERFYRHDKTNTMHSGTGLGLSIVQAIANAHNGKVSITIK
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
DESYFQVNVELMMAR
CCCEEEEEEEEEEEC
>Mature Secondary Structure
MRYKFKNRRWPLLWRTVFLLTIFVVISQVTIYIWVQRSVNEHFEQMDSEIITHAAFNLRK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
RMVALGEDVKPLTASKSQSLIDDNHLHSSWLDYDLKTLISDKNGKLLSSDPSNFIHDLPT
HHHHHCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCHHHHHCCCC
DFSLLQLRQDYRDQQFMIRINSRHYRAMVIANHEALALIALPIDVHHQYLIHFNRQLSLI
CHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCEEEEEEEEHHHHHHHHHHCCCHHHHH
LIAITLLLVSIAALSVYWGFAPLATIVQKMKSINPEQLHERVVVSNMPLELRPLAESYNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHHH
MMEKLESNFESLSRFSDNIAHELRTPLATLGTQTQVMLSKPRASHEYVEQLHHQHDTLEQ
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
LSTLINNMLLLAKTQKGLSDSQLNQIDTESMFTKLIDYYELIAEDRNISFEKTGNFQAVL
HHHHHHHHEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEE
GDESLLQRLFANLMSNAIYYAASDSVIIIEASSIEIPTVPHTVTSDKQDMRSSILNPASF
CCHHHHHHHHHHHHCCCEEEEECCCEEEEEECCEECCCCCCCCCCCHHHHHHHHCCCCCE
KVVITNRLDQPLTQVEADKLFERFYRHDKTNTMHSGTGLGLSIVQAIANAHNGKVSITIK
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEE
DESYFQVNVELMMAR
CCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]