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The map label for this gene is cusR [H]

Identifier: 93005532

GI number: 93005532

Start: 831752

End: 832468

Strand: Direct

Name: cusR [H]

Synonym: Pcryo_0702

Alternate gene names: 93005532

Gene position: 831752-832468 (Clockwise)

Preceding gene: 93005524

Following gene: 93005533

Centisome position: 27.18

GC content: 42.96

Gene sequence:

>717_bases
ATGAAAGTACTGTTAGTAGAAGATGAGCAAAAACTTGGAGAATATATTAAAAAAGGCTTAACTGAGGCCGGCTTCATCGT
GGATCATTATATGACTGGTCTAGATGGCTATCATGCGCTAATGACTGAAGAATTTAGTGTGGTGCTGATGGATGTGATGC
TACCTGACGTCAGTGGCTTTGAGCTGATACAGCGCTACCGTGCTGCTGAAAAGCATACGCCTGTTTTATTTTTAACCGCT
AAAGATGATTTAAGCGATCGAATCAAAGGTATTGAAATTGGTGGCGATGATTATCTGACCAAGCCTTTTGCTTTTGCTGA
GCTGATTGTTAGAATAAAAAGCCTGTTACGCCGTGCCAACCAATCGGACTATAAAAGCACGGTCATACATACCGCTGATC
TGAAAATGGATATTGCCAAACGCACTGTATATAGAGGCGACACCCTTATCAAACTGACTGCCAAAGAGTTTGCTTTATTA
CAGTTTTTCCTAGAACGTCAAGGTGAAGTACTGCCACGTACTGTGATTGCCTCGCAAGTATGGGATATAAATTTTGACAG
CGATACCAATGTCATTGACGTAGCTATCAGACGTCTGCGAATCAAAATCGACGATGGTTTTGACACCAAGCTGATTCACA
CAGTACGCGGTATGGGCTACAGGTTAGAGCCGCTGGCTGTAGGCGTGGGCGACGATGACAAAGATGATCCAAAATAA

Upstream 100 bases:

>100_bases
GCGCCGTTATAACAAGAACTTTTGATAAATATATAGATGATAATCTAACAACGTTAGTGATACGCTGTTGACAAATATAA
TGATATGAAGGTGGGCGACG

Downstream 100 bases:

>100_bases
AATGAGATATAAATTTAAGAATCGACGTTGGCCGCTGTTATGGCGCACTGTTTTTTTACTGACCATATTTGTTGTCATCT
CTCAAGTCACTATTTATATA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKVLLVEDEQKLGEYIKKGLTEAGFIVDHYMTGLDGYHALMTEEFSVVLMDVMLPDVSGFELIQRYRAAEKHTPVLFLTA
KDDLSDRIKGIEIGGDDYLTKPFAFAELIVRIKSLLRRANQSDYKSTVIHTADLKMDIAKRTVYRGDTLIKLTAKEFALL
QFFLERQGEVLPRTVIASQVWDINFDSDTNVIDVAIRRLRIKIDDGFDTKLIHTVRGMGYRLEPLAVGVGDDDKDDPK

Sequences:

>Translated_238_residues
MKVLLVEDEQKLGEYIKKGLTEAGFIVDHYMTGLDGYHALMTEEFSVVLMDVMLPDVSGFELIQRYRAAEKHTPVLFLTA
KDDLSDRIKGIEIGGDDYLTKPFAFAELIVRIKSLLRRANQSDYKSTVIHTADLKMDIAKRTVYRGDTLIKLTAKEFALL
QFFLERQGEVLPRTVIASQVWDINFDSDTNVIDVAIRRLRIKIDDGFDTKLIHTVRGMGYRLEPLAVGVGDDDKDDPK
>Mature_238_residues
MKVLLVEDEQKLGEYIKKGLTEAGFIVDHYMTGLDGYHALMTEEFSVVLMDVMLPDVSGFELIQRYRAAEKHTPVLFLTA
KDDLSDRIKGIEIGGDDYLTKPFAFAELIVRIKSLLRRANQSDYKSTVIHTADLKMDIAKRTVYRGDTLIKLTAKEFALL
QFFLERQGEVLPRTVIASQVWDINFDSDTNVIDVAIRRLRIKIDDGFDTKLIHTVRGMGYRLEPLAVGVGDDDKDDPK

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=57.3991031390135, Blast_Score=266, Evalue=8e-73,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=46.8181818181818, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=35.1351351351351, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=34.6846846846847, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=37.10407239819, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.7354260089686, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=33.1838565022422, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.6244541484716, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.981981981982, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=30.4347826086957, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=27.0042194092827, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27045; Mature: 27045

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLVEDEQKLGEYIKKGLTEAGFIVDHYMTGLDGYHALMTEEFSVVLMDVMLPDVSGF
CEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELIQRYRAAEKHTPVLFLTAKDDLSDRIKGIEIGGDDYLTKPFAFAELIVRIKSLLRRAN
HHHHHHHHHHCCCCEEEEEECCCHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCC
QSDYKSTVIHTADLKMDIAKRTVYRGDTLIKLTAKEFALLQFFLERQGEVLPRTVIASQV
CCCHHHHEEEECCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHH
WDINFDSDTNVIDVAIRRLRIKIDDGFDTKLIHTVRGMGYRLEPLAVGVGDDDKDDPK
EEECCCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHCCCEEECEEEEECCCCCCCCCC
>Mature Secondary Structure
MKVLLVEDEQKLGEYIKKGLTEAGFIVDHYMTGLDGYHALMTEEFSVVLMDVMLPDVSGF
CEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHH
ELIQRYRAAEKHTPVLFLTAKDDLSDRIKGIEIGGDDYLTKPFAFAELIVRIKSLLRRAN
HHHHHHHHHHCCCCEEEEEECCCHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCC
QSDYKSTVIHTADLKMDIAKRTVYRGDTLIKLTAKEFALLQFFLERQGEVLPRTVIASQV
CCCHHHHEEEECCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHH
WDINFDSDTNVIDVAIRRLRIKIDDGFDTKLIHTVRGMGYRLEPLAVGVGDDDKDDPK
EEECCCCCCCHHHHHHHHHEEEECCCCCHHHHHHHHCCCEEECEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]