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The map label for this gene is nuoL [H]

Identifier: 93005413

GI number: 93005413

Start: 695088

End: 696962

Strand: Direct

Name: nuoL [H]

Synonym: Pcryo_0583

Alternate gene names: 93005413

Gene position: 695088-696962 (Clockwise)

Preceding gene: 93005412

Following gene: 93005414

Centisome position: 22.72

GC content: 45.17

Gene sequence:

>1875_bases
ATGAGTTTATTACCATTAACCTTTATATTCCCGCTCGTTGGCTTTTTGATTTTAGCCTTTATGCGCGACAAGTTAAGCGA
GCAGGTAGCAGCGATTGTCGGTGTCGGTAGCATGCTGCTATCAGCGCTATGTACGCTGATCGTCAGCTATACCTTTTTAA
CGACGTATCCAGCCGGAACTGTTGTAGAGATTCCTCTCTGGACATGGTTCCAAGTCGGAGATTTTGCGCCAAATTTTGGC
TTAAGCTTTGATGGCTTAGCATTGACAATGACGTGTGTTATTACCGGCATTGGCTTTTTGATTCATCTGTTTGCCGCTTG
GTATATGAAAGGTGAAACAGGCTTTGCGCGCTTCTTTAGCTATATGAACTTGTTTGTCGCCAGCATGTTATTGCTGGTAT
TGGCGGATAACTTGTTCTTGCTATATCTTGGTTGGGAAGGCGTCGGTATCTGTTCTTACTTGCTGATTGGTTTTTACTAC
CATGACCGTGCGAATGGTCGTGCGGCGATAAAAGCCTTTACTGTTACCCGTGTTGGTGATGTGTTCTTAGCCTTTGGTTT
GTTTTTACTATTCCGCGAATTTGGTACGCTTAATATTCAAGAGATTATTACCCGTGCCCCGGAAGTATTTGATATTAATA
ATCCAACCATGATTCTAACTACCATGATGTTGGTTGGTGGGGCGATGGGTAAATCAGCCCAGCTGCCATTACATACATGG
CTTGCAGATGCGATGGCAGGTCCAACGCCAGTATCGGCATTGATTCACGCAGCGACCATGGTTACCGCGGGTGTTTATCT
GATTGCGCGTTTACATCCGTTATTTATATTAACACCTGGTGTACTATTGTACTGGGTTGGGGCAGTGGGTGCATTAACGC
TGGTTATTGCAGGATTCTGTGCGTTGGCACAAACGGACATCAAGCGTATCCTTGCTTATTCGACCATGAGCCAAATTGGC
TATATGTTCTTAGCACTCGGCGTTGGCGCATGGCAAGGTGCTATCTTCCATTTGATGACCCATGCTTTTTTTAAAGCGTT
GTTATTCTTATCATCAGGTGCAGTCATCCTTTCAGTACATCATGAGCAAAACATCTTTAAGATGGGCGGCTTACGTAAAA
AGATTCCGTTAGTATTCTGGTGCTATATCGTCGGTGGCGGTGCACTTGCCGCGATACCTTGGGTCACCGTTGGTTTTTAC
TCTAAAGAAGCTATTCTTTGGGAAAGTTATGCAACCGGTCATATGGTCTTATTCTATATGGGCGTATTCGGTGCTTTCTT
AACTGCGCTTTATACCTTCCGTATGATTTGGATTATCTTCTTTGGTGAAGAGAAAACGCATGCCCATAAACTATCTGGTA
TGTCATATTGGCTGCCGCTTAGTGTGTTGCTCGTATTATCTACGGCAGTGGGTGCATTTATTACCCCGCCATTGCAAGGC
GTATTGCCAGAAAGTGTTGGGCACTTATTAGAAGTGGCTGGTCAGGCGCATGCTAAGCACACCGCAGAGTATATCGCGAT
GGGTGCGATGGCAGCAGGCTTGGTATTAGCAGTGTTATTATATGTCGTTAATAAAGGTCGACTGCTGACCAGCTTTAAGC
GCACGCGTATCGGCGGTGCGCTATATCATTGGTGCTATCACGGTATGGGCTTTGACGCGCTATACGATATAGTTTTTGTA
AAACCCTTTTTGTTCATCGGCCGCTTATTTAAAGCCGACCCTATCGATAAAACGTGGCTGCTATTACCTAAGTTGGCATC
AGCAGGTAATAAGGTATTGTCTGCGACGCAAACAGGGTCACTTCGAGGTTATGCTGCAAGCTTTGGCTTGGGTATGGCTG
TATTACTCGTGCTGGTAATGATGACGGTGGTATAA

Upstream 100 bases:

>100_bases
GCAGCAGAGGCCGCTATTGGTTTAGCAATATTATTGCGTTTTTATCATCAGCGTGGGCATCTTGATGTCGACAGCGCCAA
TGAGATGAAAGGATGATGTC

Downstream 100 bases:

>100_bases
GATGATTGAGTTACAACAAACGTGGATGCTACCAGCATTAATCGCCATTCCTTTTATTGCAGGATTGCTATGCTGGCTGG
TTGAACGCTTTAATAAACGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MSLLPLTFIFPLVGFLILAFMRDKLSEQVAAIVGVGSMLLSALCTLIVSYTFLTTYPAGTVVEIPLWTWFQVGDFAPNFG
LSFDGLALTMTCVITGIGFLIHLFAAWYMKGETGFARFFSYMNLFVASMLLLVLADNLFLLYLGWEGVGICSYLLIGFYY
HDRANGRAAIKAFTVTRVGDVFLAFGLFLLFREFGTLNIQEIITRAPEVFDINNPTMILTTMMLVGGAMGKSAQLPLHTW
LADAMAGPTPVSALIHAATMVTAGVYLIARLHPLFILTPGVLLYWVGAVGALTLVIAGFCALAQTDIKRILAYSTMSQIG
YMFLALGVGAWQGAIFHLMTHAFFKALLFLSSGAVILSVHHEQNIFKMGGLRKKIPLVFWCYIVGGGALAAIPWVTVGFY
SKEAILWESYATGHMVLFYMGVFGAFLTALYTFRMIWIIFFGEEKTHAHKLSGMSYWLPLSVLLVLSTAVGAFITPPLQG
VLPESVGHLLEVAGQAHAKHTAEYIAMGAMAAGLVLAVLLYVVNKGRLLTSFKRTRIGGALYHWCYHGMGFDALYDIVFV
KPFLFIGRLFKADPIDKTWLLLPKLASAGNKVLSATQTGSLRGYAASFGLGMAVLLVLVMMTVV

Sequences:

>Translated_624_residues
MSLLPLTFIFPLVGFLILAFMRDKLSEQVAAIVGVGSMLLSALCTLIVSYTFLTTYPAGTVVEIPLWTWFQVGDFAPNFG
LSFDGLALTMTCVITGIGFLIHLFAAWYMKGETGFARFFSYMNLFVASMLLLVLADNLFLLYLGWEGVGICSYLLIGFYY
HDRANGRAAIKAFTVTRVGDVFLAFGLFLLFREFGTLNIQEIITRAPEVFDINNPTMILTTMMLVGGAMGKSAQLPLHTW
LADAMAGPTPVSALIHAATMVTAGVYLIARLHPLFILTPGVLLYWVGAVGALTLVIAGFCALAQTDIKRILAYSTMSQIG
YMFLALGVGAWQGAIFHLMTHAFFKALLFLSSGAVILSVHHEQNIFKMGGLRKKIPLVFWCYIVGGGALAAIPWVTVGFY
SKEAILWESYATGHMVLFYMGVFGAFLTALYTFRMIWIIFFGEEKTHAHKLSGMSYWLPLSVLLVLSTAVGAFITPPLQG
VLPESVGHLLEVAGQAHAKHTAEYIAMGAMAAGLVLAVLLYVVNKGRLLTSFKRTRIGGALYHWCYHGMGFDALYDIVFV
KPFLFIGRLFKADPIDKTWLLLPKLASAGNKVLSATQTGSLRGYAASFGLGMAVLLVLVMMTVV
>Mature_623_residues
SLLPLTFIFPLVGFLILAFMRDKLSEQVAAIVGVGSMLLSALCTLIVSYTFLTTYPAGTVVEIPLWTWFQVGDFAPNFGL
SFDGLALTMTCVITGIGFLIHLFAAWYMKGETGFARFFSYMNLFVASMLLLVLADNLFLLYLGWEGVGICSYLLIGFYYH
DRANGRAAIKAFTVTRVGDVFLAFGLFLLFREFGTLNIQEIITRAPEVFDINNPTMILTTMMLVGGAMGKSAQLPLHTWL
ADAMAGPTPVSALIHAATMVTAGVYLIARLHPLFILTPGVLLYWVGAVGALTLVIAGFCALAQTDIKRILAYSTMSQIGY
MFLALGVGAWQGAIFHLMTHAFFKALLFLSSGAVILSVHHEQNIFKMGGLRKKIPLVFWCYIVGGGALAAIPWVTVGFYS
KEAILWESYATGHMVLFYMGVFGAFLTALYTFRMIWIIFFGEEKTHAHKLSGMSYWLPLSVLLVLSTAVGAFITPPLQGV
LPESVGHLLEVAGQAHAKHTAEYIAMGAMAAGLVLAVLLYVVNKGRLLTSFKRTRIGGALYHWCYHGMGFDALYDIVFVK
PFLFIGRLFKADPIDKTWLLLPKLASAGNKVLSATQTGSLRGYAASFGLGMAVLLVLVMMTVV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=389, Percent_Identity=38.560411311054, Blast_Score=242, Evalue=7e-64,
Organism=Escherichia coli, GI1788614, Length=612, Percent_Identity=59.640522875817, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=32.0388349514563, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788827, Length=364, Percent_Identity=32.1428571428571, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788831, Length=435, Percent_Identity=28.5057471264368, Blast_Score=119, Evalue=9e-28,
Organism=Escherichia coli, GI1788613, Length=421, Percent_Identity=28.0285035629454, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI2367154, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693160, Length=362, Percent_Identity=25.414364640884, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68187; Mature: 68056

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLPLTFIFPLVGFLILAFMRDKLSEQVAAIVGVGSMLLSALCTLIVSYTFLTTYPAGT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVEIPLWTWFQVGDFAPNFGLSFDGLALTMTCVITGIGFLIHLFAAWYMKGETGFARFFS
EEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YMNLFVASMLLLVLADNLFLLYLGWEGVGICSYLLIGFYYHDRANGRAAIKAFTVTRVGD
HHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
VFLAFGLFLLFREFGTLNIQEIITRAPEVFDINNPTMILTTMMLVGGAMGKSAQLPLHTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARLHPLFILTPGVLLYWVGAVGALTLVIAGFC
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQTDIKRILAYSTMSQIGYMFLALGVGAWQGAIFHLMTHAFFKALLFLSSGAVILSVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKKIPLVFWCYIVGGGALAAIPWVTVGFYSKEAILWESYATGHMVLFYM
CCCCHHHHCCCCHHCHHHHHHHHHCCCHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHH
GVFGAFLTALYTFRMIWIIFFGEEKTHAHKLSGMSYWLPLSVLLVLSTAVGAFITPPLQG
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
VLPESVGHLLEVAGQAHAKHTAEYIAMGAMAAGLVLAVLLYVVNKGRLLTSFKRTRIGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LYHWCYHGMGFDALYDIVFVKPFLFIGRLFKADPIDKTWLLLPKLASAGNKVLSATQTGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCC
LRGYAASFGLGMAVLLVLVMMTVV
CCCHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SLLPLTFIFPLVGFLILAFMRDKLSEQVAAIVGVGSMLLSALCTLIVSYTFLTTYPAGT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VVEIPLWTWFQVGDFAPNFGLSFDGLALTMTCVITGIGFLIHLFAAWYMKGETGFARFFS
EEEECCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YMNLFVASMLLLVLADNLFLLYLGWEGVGICSYLLIGFYYHDRANGRAAIKAFTVTRVGD
HHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHH
VFLAFGLFLLFREFGTLNIQEIITRAPEVFDINNPTMILTTMMLVGGAMGKSAQLPLHTW
HHHHHHHHHHHHHHCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LADAMAGPTPVSALIHAATMVTAGVYLIARLHPLFILTPGVLLYWVGAVGALTLVIAGFC
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQTDIKRILAYSTMSQIGYMFLALGVGAWQGAIFHLMTHAFFKALLFLSSGAVILSVH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKKIPLVFWCYIVGGGALAAIPWVTVGFYSKEAILWESYATGHMVLFYM
CCCCHHHHCCCCHHCHHHHHHHHHCCCHHHHHHHHHEECCCCCCEEEECCCCHHHHHHHH
GVFGAFLTALYTFRMIWIIFFGEEKTHAHKLSGMSYWLPLSVLLVLSTAVGAFITPPLQG
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
VLPESVGHLLEVAGQAHAKHTAEYIAMGAMAAGLVLAVLLYVVNKGRLLTSFKRTRIGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LYHWCYHGMGFDALYDIVFVKPFLFIGRLFKADPIDKTWLLLPKLASAGNKVLSATQTGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCC
LRGYAASFGLGMAVLLVLVMMTVV
CCCHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]