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The map label for this gene is nuoI [H]

Identifier: 93005410

GI number: 93005410

Start: 693388

End: 693936

Strand: Direct

Name: nuoI [H]

Synonym: Pcryo_0580

Alternate gene names: 93005410

Gene position: 693388-693936 (Clockwise)

Preceding gene: 93005409

Following gene: 93005411

Centisome position: 22.66

GC content: 47.18

Gene sequence:

>549_bases
ATGTTTACTACGATAAAAAAGACCGTCATTGGACTATTTACCATTGTCCGCAGCATGTGGATGGTCAATAGTCATGCGCT
CAGACCACGCGACACCATTCTTTATCCTGAGGTGCCAGTACCAGTGCCGCCACGTTTTCGTGGACGTATTATCTTGTCGC
GTGACCCTGACGGCGATGAGCGCTGCGTTGCTTGTAACTTGTGCGCTGTGGCATGTCCAGTTGGTTGTATCTCCCTGCAA
AAAGCGGAACGTGAAGATGGACGCTGGTATCCAGAGTTCTTCCGTATTAACTTTTCACGTTGTATTTTTTGTGGCTTGTG
TGAAGAAGCTTGTCCTACAACAGCTATTCAGATGACTCCTGATTTTGAGATGGGCGAATACGTCCGTCAAGACTTGGTCT
ATGAAAAAGAGCATTTGCTGATTTCAGGACCGGGTAAATATCCCGATTATAACTATTATCGCGTGACGGGTATGGCGGTA
GCAGATAAACCAAAAGGCGCAGCGCAAAATGAAGCGGCACCGATTGATCTAAGGAGCTTGCTACCATGA

Upstream 100 bases:

>100_bases
TTGGTTACTGCTGCAGTCATTTTGATTTTTTCCCCAACGTTGTAATCATCACTAGCCATCACTGATGAACTAGGGTAAAG
CTGAGAAGGATAATAATCCC

Downstream 100 bases:

>100_bases
TGAATATTTTAAATAATCCTGAATTGGCAGGGTTTTACTCATTAGCAGCGGTAGCAATATTTGCCAGTTTGCGCGTGGTA
ACCCAAGCCAATCCAGTGCA

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MFTTIKKTVIGLFTIVRSMWMVNSHALRPRDTILYPEVPVPVPPRFRGRIILSRDPDGDERCVACNLCAVACPVGCISLQ
KAEREDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQMTPDFEMGEYVRQDLVYEKEHLLISGPGKYPDYNYYRVTGMAV
ADKPKGAAQNEAAPIDLRSLLP

Sequences:

>Translated_182_residues
MFTTIKKTVIGLFTIVRSMWMVNSHALRPRDTILYPEVPVPVPPRFRGRIILSRDPDGDERCVACNLCAVACPVGCISLQ
KAEREDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQMTPDFEMGEYVRQDLVYEKEHLLISGPGKYPDYNYYRVTGMAV
ADKPKGAAQNEAAPIDLRSLLP
>Mature_182_residues
MFTTIKKTVIGLFTIVRSMWMVNSHALRPRDTILYPEVPVPVPPRFRGRIILSRDPDGDERCVACNLCAVACPVGCISLQ
KAEREDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQMTPDFEMGEYVRQDLVYEKEHLLISGPGKYPDYNYYRVTGMAV
ADKPKGAAQNEAAPIDLRSLLP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=129, Percent_Identity=41.0852713178295, Blast_Score=110, Evalue=5e-25,
Organism=Escherichia coli, GI1788617, Length=179, Percent_Identity=75.9776536312849, Blast_Score=297, Evalue=3e-82,
Organism=Escherichia coli, GI1789075, Length=143, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555194, Length=129, Percent_Identity=39.5348837209302, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17864306, Length=129, Percent_Identity=40.3100775193798, Blast_Score=113, Evalue=8e-26,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 20629; Mature: 20629

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTTIKKTVIGLFTIVRSMWMVNSHALRPRDTILYPEVPVPVPPRFRGRIILSRDPDGDE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCC
RCVACNLCAVACPVGCISLQKAEREDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQMTP
EEEEEHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEECHHHHEEEHHHHHHCCCCEEEECC
DFEMGEYVRQDLVYEKEHLLISGPGKYPDYNYYRVTGMAVADKPKGAAQNEAAPIDLRSL
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHH
LP
CC
>Mature Secondary Structure
MFTTIKKTVIGLFTIVRSMWMVNSHALRPRDTILYPEVPVPVPPRFRGRIILSRDPDGDE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCCCCC
RCVACNLCAVACPVGCISLQKAEREDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQMTP
EEEEEHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEECHHHHEEEHHHHHHCCCCEEEECC
DFEMGEYVRQDLVYEKEHLLISGPGKYPDYNYYRVTGMAVADKPKGAAQNEAAPIDLRSL
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHH
LP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA