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The map label for this gene is pntAA [H]

Identifier: 93005373

GI number: 93005373

Start: 641734

End: 642891

Strand: Direct

Name: pntAA [H]

Synonym: Pcryo_0543

Alternate gene names: 93005373

Gene position: 641734-642891 (Clockwise)

Preceding gene: 93005371

Following gene: 93005374

Centisome position: 20.97

GC content: 48.19

Gene sequence:

>1158_bases
ATGAAAATTGGTGTTATTAGTGCAGAGAGCGCAAGCGAGAGTCGGGTGGCATTAACCCCAGACGCGGTAAAAAAGTTACG
CAAACTTGGGTTTGAGGTTGTCATCCAGTCAGGTGCAGGTCAAGCGTCTTATTATGCGGATGAATTATATCAGGCTGCGG
GTGCTGATATTGCCAATAGTAGCATTGACGTCGTCACACAGTCTCAGATTATTACTACCGTCAATGATTTGCCGACGTCA
ACGACTGCTAGTTTAACGTCTGGTCAAATTATTATCGGCATGCTTGATCCCTATCGTAATACCCAACTGGATACTTATGC
TGCTAAAGGGGCTACCGCCTTTGCCATGGAGCTATTGCCACGCACCTTATCACGCGCACAGAATATGGACGTCTTGTCTT
CACAAGCCAACCTTGCCGGTTACAAAGCGGTGTTGCTCGCTGCCAATGAATATTCGCGTCCGTTTCCGATGTTTATGACC
TCAGCTGGTACGGTTAAGCCTGCCAAAGTCGTTATTCTAGGTGTTGGGGTTGCGGGTTTACAAGCGATTGCGACGGCGAA
GCGTTTAGGTGCTGTCGTTGAAGCCAGTGATTTACGTCCGACCGCTCGCGAGCAAGTGGAATCATTAGGTGGTAAATGGC
TTGATGTCCCGATGAGTGCGGAGGAGGCTGAGACAGCTAAATCTACAGGCGGCTATGCGTGGACGCCATCTGAGCAATAT
ATCAAAGACCAAGCTGCTATTGTTGATAAAGCCTTGAGCAATGCTGACATCGTCATTACGACTGCACAGATTCCGGGTCG
TCAAGCGCCGCGTTTGGTACACCAATCAACCATTGCTAAGATGAAAGCTGGTTCGGTACTGATCGATATGGCTGCTGGCA
CTGGTGGAAACGTTGAAGGCAGTGTCCCTGATGAAACGATTACGACGTCAAATGGCGTGCGTATTGTCGGTGCAGCTAAT
ATTCCATCGCAACTGGCAGCGCAGTCTTCAGACTTATATGCCAATAACCTCGTTAATTTTATCACCACTTTAATTGCGTC
TGCCGCTACAGATGACGCTACAGCAAACACAATGGCACTCAACTTAGACATGGAAGATGAGATTCAAGGCGCATTAGCGG
TAACGCATGACAATCAAGTACGTCTTGCTAAACGCTAA

Upstream 100 bases:

>100_bases
TAAGTATTAAGCTAACCCTGACCAAAGATTTTTTTGTCCCCTGTGCTTTTTAGAGGTGCGTTAGGGTATTAAAAGTAGTC
ATTAGACGTAAGGAGACGGT

Downstream 100 bases:

>100_bases
GTGCTAAATGCCAAATTTCAAGTCTTGATACTTTCATTATCGTACATTTGCCAGACACGAACAAATTTTAGGAGGATAAG
ATGATTGCCACTATTTTAGC

Product: alanine dehydrogenase/PNT-like

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKIGVISAESASESRVALTPDAVKKLRKLGFEVVIQSGAGQASYYADELYQAAGADIANSSIDVVTQSQIITTVNDLPTS
TTASLTSGQIIIGMLDPYRNTQLDTYAAKGATAFAMELLPRTLSRAQNMDVLSSQANLAGYKAVLLAANEYSRPFPMFMT
SAGTVKPAKVVILGVGVAGLQAIATAKRLGAVVEASDLRPTAREQVESLGGKWLDVPMSAEEAETAKSTGGYAWTPSEQY
IKDQAAIVDKALSNADIVITTAQIPGRQAPRLVHQSTIAKMKAGSVLIDMAAGTGGNVEGSVPDETITTSNGVRIVGAAN
IPSQLAAQSSDLYANNLVNFITTLIASAATDDATANTMALNLDMEDEIQGALAVTHDNQVRLAKR

Sequences:

>Translated_385_residues
MKIGVISAESASESRVALTPDAVKKLRKLGFEVVIQSGAGQASYYADELYQAAGADIANSSIDVVTQSQIITTVNDLPTS
TTASLTSGQIIIGMLDPYRNTQLDTYAAKGATAFAMELLPRTLSRAQNMDVLSSQANLAGYKAVLLAANEYSRPFPMFMT
SAGTVKPAKVVILGVGVAGLQAIATAKRLGAVVEASDLRPTAREQVESLGGKWLDVPMSAEEAETAKSTGGYAWTPSEQY
IKDQAAIVDKALSNADIVITTAQIPGRQAPRLVHQSTIAKMKAGSVLIDMAAGTGGNVEGSVPDETITTSNGVRIVGAAN
IPSQLAAQSSDLYANNLVNFITTLIASAATDDATANTMALNLDMEDEIQGALAVTHDNQVRLAKR
>Mature_385_residues
MKIGVISAESASESRVALTPDAVKKLRKLGFEVVIQSGAGQASYYADELYQAAGADIANSSIDVVTQSQIITTVNDLPTS
TTASLTSGQIIIGMLDPYRNTQLDTYAAKGATAFAMELLPRTLSRAQNMDVLSSQANLAGYKAVLLAANEYSRPFPMFMT
SAGTVKPAKVVILGVGVAGLQAIATAKRLGAVVEASDLRPTAREQVESLGGKWLDVPMSAEEAETAKSTGGYAWTPSEQY
IKDQAAIVDKALSNADIVITTAQIPGRQAPRLVHQSTIAKMKAGSVLIDMAAGTGGNVEGSVPDETITTSNGVRIVGAAN
IPSQLAAQSSDLYANNLVNFITTLIASAATDDATANTMALNLDMEDEIQGALAVTHDNQVRLAKR

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=346, Percent_Identity=38.150289017341, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI122939153, Length=346, Percent_Identity=38.150289017341, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1787887, Length=345, Percent_Identity=43.1884057971014, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17550456, Length=382, Percent_Identity=37.9581151832461, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40237; Mature: 40237

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVISAESASESRVALTPDAVKKLRKLGFEVVIQSGAGQASYYADELYQAAGADIANS
CEEEEEECCCCCCCEEEECHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
SIDVVTQSQIITTVNDLPTSTTASLTSGQIIIGMLDPYRNTQLDTYAAKGATAFAMELLP
CEEEEEHHHHEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHH
RTLSRAQNMDVLSSQANLAGYKAVLLAANEYSRPFPMFMTSAGTVKPAKVVILGVGVAGL
HHHHHHCCCHHHHCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCEEEEEEECCHHHH
QAIATAKRLGAVVEASDLRPTAREQVESLGGKWLDVPMSAEEAETAKSTGGYAWTPSEQY
HHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCEEECCCHHH
IKDQAAIVDKALSNADIVITTAQIPGRQAPRLVHQSTIAKMKAGSVLIDMAAGTGGNVEG
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
SVPDETITTSNGVRIVGAANIPSQLAAQSSDLYANNLVNFITTLIASAATDDATANTMAL
CCCCCEEECCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
NLDMEDEIQGALAVTHDNQVRLAKR
ECCCHHHCCCEEEEEECCCEEEECC
>Mature Secondary Structure
MKIGVISAESASESRVALTPDAVKKLRKLGFEVVIQSGAGQASYYADELYQAAGADIANS
CEEEEEECCCCCCCEEEECHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
SIDVVTQSQIITTVNDLPTSTTASLTSGQIIIGMLDPYRNTQLDTYAAKGATAFAMELLP
CEEEEEHHHHEEEHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHCCHHHHHHHHHH
RTLSRAQNMDVLSSQANLAGYKAVLLAANEYSRPFPMFMTSAGTVKPAKVVILGVGVAGL
HHHHHHCCCHHHHCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCEEEEEEECCHHHH
QAIATAKRLGAVVEASDLRPTAREQVESLGGKWLDVPMSAEEAETAKSTGGYAWTPSEQY
HHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCEEECCCHHH
IKDQAAIVDKALSNADIVITTAQIPGRQAPRLVHQSTIAKMKAGSVLIDMAAGTGGNVEG
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCC
SVPDETITTSNGVRIVGAANIPSQLAAQSSDLYANNLVNFITTLIASAATDDATANTMAL
CCCCCEEECCCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
NLDMEDEIQGALAVTHDNQVRLAKR
ECCCHHHCCCEEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]