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The map label for this gene is groEL

Identifier: 93005371

GI number: 93005371

Start: 638605

End: 640254

Strand: Direct

Name: groEL

Synonym: Pcryo_0541

Alternate gene names: 93005371

Gene position: 638605-640254 (Clockwise)

Preceding gene: 93005370

Following gene: 93005373

Centisome position: 20.87

GC content: 46.24

Gene sequence:

>1650_bases
ATGGCAAAAGACGTAAAATTCGGCATAGATGCCCGTAAACAAATGATGGACGGCGTGAACGTTCTAGCAAACGCAGTACG
AGTCACACTAGGCCCTAAAGGTCGTAACGTGGTAATCGATAAGTCGTTTGGCGCACCTACTATTACTAAAGATGGTGTTT
CAGTTGCTAAAGAAATCGAGCTTGAAAACAAATTTGAAAACATGGGCGCGCAATTGGTTCGTGAAGTCGCTAGCCGTACC
AACGATGTTGCTGGTGATGGTACGACTACTGCGACGGTATTGGCTCAGTCAATCTTGCAAGAAGGCATGAAATCAGTTGC
CGCTGGCATGAACCCAATGGATCTAAAACGCGGTATCGATAAAGCGGTACGTGCAGCTGTTGAGCAAATCCATTTGCTAT
CTACCCCAGCTGACGATTCAAAAGCGATTGCTCAAGTTGGTTCTATCTCTGCCAACTCAGACACCAAAATCGGTGAATTG
ATTGCTCAAGCGATGGAAAAAGTCGGTAAGCAAGGCGTTATCACCGTTGAAGAAGGTTCAAGCTTTGAAGATACCCTAGA
AGTTGTCGAAGGTATGCAGTTTGATCGTGGTTATATCAGCCCGTACTTTGCAAATAAGCAAGACAGCTTAACTGCTGAGT
TTGAAAACCCATATATCTTATTGGTTGATAAAAAAATCAGCAATATCCGTGAAATCGTGCCATTACTTGAGCAAGTCATG
CAGCAAAGCAAGCCATTGCTAATCATCGCTGAAGACGTAGAAAACGAAGCATTGGCGACATTGGTTGTCAACAACATGCG
TGGCGGCTTAAAAACTTGTGCCGTTAAAGCACCCGGTTTTGGCGATCGTCGTAAAGCGATGTTAGAAGATATCGCAACGC
TAACTGGCGGTACGGTTATCTCTGAAGAGATTGGTCTAAGTTTAGAGACTGCTACTTTAGAGCAACTTGGTACGGCTAAA
AAAGTCACTGTCGGTAAAGAAAACACCGTTATCGTTGATGGCGCTGGCAACTCTGCGGATATCGAAAACCGTGTTGAATC
TATCAAACGTCAAGTAGAAGAATCAACGTCTGACTACGATAAAGAAAAGCTTCAAGAGCGTATGGCTAAACTGGCTGGCG
GCGTTGCCGTTATCAAAGTTGGCGCTGCGACTGAAACTGAAATGAAAGAGAAGAAAGACCGTGTTGATGATGCGTTACAT
GCCACTCGTGCAGCGGTTGAAGAAGGCGTTGTCCCTGGTGGCGGTGTTGCGCTAGTTCGTGCCATGAATGCATTGTCTGA
GCTACGCGGTGATAATGACGACCAAAACGCTGGTATCAATATCTTACGTCGCGCAATGGAAGCACCATTACGTCAAATCG
TGACCAACTCTGGCGAAGAAGCTTCAGTGGTAGTAAATGAAGTGAAGAGCGGTACTGGTAACTACGGTTACAACGCAGCT
TCTGGCGAATATGGCGATATGCTAGAGATGGGTATTCTTGATCCAGCCAAAGTAGCACGTTCAGCGCTAGAAAACGCAGC
ATCTGTTGCCGGTCTAATGCTAACCACTGAAGTCATGATTACTGATTTACCGCAAGGCGATGACGGTATGGCTGGCATGG
GCGGTGCTGGTGGAATGGGCGGTATGGGTGGAATGGGCGGTATGATGTAA

Upstream 100 bases:

>100_bases
GGCTAGTCCTTTTTGAGTATTTTTATACTCAGCGCATTTTGACAATATCATTGAAACATTTAATTGCATTCTCATACTTA
TAATAGTGGAGTAATTTAAC

Downstream 100 bases:

>100_bases
TTTTACTTCTACTACAAAGCGATTTCTCTTTGTCAGACGTGCTCAATGTACAATAGGTACTATTTTCGCGCGTCTTCCTC
GACAAATCGATTTTTGCTAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MAKDVKFGIDARKQMMDGVNVLANAVRVTLGPKGRNVVIDKSFGAPTITKDGVSVAKEIELENKFENMGAQLVREVASRT
NDVAGDGTTTATVLAQSILQEGMKSVAAGMNPMDLKRGIDKAVRAAVEQIHLLSTPADDSKAIAQVGSISANSDTKIGEL
IAQAMEKVGKQGVITVEEGSSFEDTLEVVEGMQFDRGYISPYFANKQDSLTAEFENPYILLVDKKISNIREIVPLLEQVM
QQSKPLLIIAEDVENEALATLVVNNMRGGLKTCAVKAPGFGDRRKAMLEDIATLTGGTVISEEIGLSLETATLEQLGTAK
KVTVGKENTVIVDGAGNSADIENRVESIKRQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATETEMKEKKDRVDDALH
ATRAAVEEGVVPGGGVALVRAMNALSELRGDNDDQNAGINILRRAMEAPLRQIVTNSGEEASVVVNEVKSGTGNYGYNAA
SGEYGDMLEMGILDPAKVARSALENAASVAGLMLTTEVMITDLPQGDDGMAGMGGAGGMGGMGGMGGMM

Sequences:

>Translated_549_residues
MAKDVKFGIDARKQMMDGVNVLANAVRVTLGPKGRNVVIDKSFGAPTITKDGVSVAKEIELENKFENMGAQLVREVASRT
NDVAGDGTTTATVLAQSILQEGMKSVAAGMNPMDLKRGIDKAVRAAVEQIHLLSTPADDSKAIAQVGSISANSDTKIGEL
IAQAMEKVGKQGVITVEEGSSFEDTLEVVEGMQFDRGYISPYFANKQDSLTAEFENPYILLVDKKISNIREIVPLLEQVM
QQSKPLLIIAEDVENEALATLVVNNMRGGLKTCAVKAPGFGDRRKAMLEDIATLTGGTVISEEIGLSLETATLEQLGTAK
KVTVGKENTVIVDGAGNSADIENRVESIKRQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATETEMKEKKDRVDDALH
ATRAAVEEGVVPGGGVALVRAMNALSELRGDNDDQNAGINILRRAMEAPLRQIVTNSGEEASVVVNEVKSGTGNYGYNAA
SGEYGDMLEMGILDPAKVARSALENAASVAGLMLTTEVMITDLPQGDDGMAGMGGAGGMGGMGGMGGMM
>Mature_548_residues
AKDVKFGIDARKQMMDGVNVLANAVRVTLGPKGRNVVIDKSFGAPTITKDGVSVAKEIELENKFENMGAQLVREVASRTN
DVAGDGTTTATVLAQSILQEGMKSVAAGMNPMDLKRGIDKAVRAAVEQIHLLSTPADDSKAIAQVGSISANSDTKIGELI
AQAMEKVGKQGVITVEEGSSFEDTLEVVEGMQFDRGYISPYFANKQDSLTAEFENPYILLVDKKISNIREIVPLLEQVMQ
QSKPLLIIAEDVENEALATLVVNNMRGGLKTCAVKAPGFGDRRKAMLEDIATLTGGTVISEEIGLSLETATLEQLGTAKK
VTVGKENTVIVDGAGNSADIENRVESIKRQVEESTSDYDKEKLQERMAKLAGGVAVIKVGAATETEMKEKKDRVDDALHA
TRAAVEEGVVPGGGVALVRAMNALSELRGDNDDQNAGINILRRAMEAPLRQIVTNSGEEASVVVNEVKSGTGNYGYNAAS
GEYGDMLEMGILDPAKVARSALENAASVAGLMLTTEVMITDLPQGDDGMAGMGGAGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=51.6190476190476, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=51.6190476190476, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI5453607, Length=527, Percent_Identity=22.3908918406072, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI24307939, Length=376, Percent_Identity=24.2021276595745, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=74.1444866920152, Blast_Score=788, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=50.7547169811321, Blast_Score=543, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI193210679, Length=223, Percent_Identity=50.2242152466368, Blast_Score=227, Evalue=9e-60,
Organism=Caenorhabditis elegans, GI25144674, Length=234, Percent_Identity=24.7863247863248, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=55.7251908396947, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.7175572519084, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.7175572519084, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.7175572519084, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.2333965844402, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.2333965844402, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=539, Percent_Identity=43.2282003710575, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=40.607210626186, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=40.607210626186, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24583944, Length=211, Percent_Identity=28.436018957346, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24645179, Length=533, Percent_Identity=21.3883677298311, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_PSYCK (Q1QDC9)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_579808.1
- ProteinModelPortal:   Q1QDC9
- SMR:   Q1QDC9
- STRING:   Q1QDC9
- GeneID:   4035710
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_0541
- NMPDR:   fig|335284.3.peg.1331
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   ENRVESI
- PhylomeDB:   Q1QDC9
- ProtClustDB:   PRK00013
- BioCyc:   PCRY335284:PCRYO_0541-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57903; Mature: 57772

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDVKFGIDARKQMMDGVNVLANAVRVTLGPKGRNVVIDKSFGAPTITKDGVSVAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
LENKFENMGAQLVREVASRTNDVAGDGTTTATVLAQSILQEGMKSVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVRAAVEQIHLLSTPADDSKAIAQVGSISANSDTKIGELIAQAMEKVGKQGVITVEEGS
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
SFEDTLEVVEGMQFDRGYISPYFANKQDSLTAEFENPYILLVDKKISNIREIVPLLEQVM
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHH
QQSKPLLIIAEDVENEALATLVVNNMRGGLKTCAVKAPGFGDRRKAMLEDIATLTGGTVI
HCCCCEEEEECCCCCHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCEE
SEEIGLSLETATLEQLGTAKKVTVGKENTVIVDGAGNSADIENRVESIKRQVEESTSDYD
HHHHCCEEHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCH
KEKLQERMAKLAGGVAVIKVGAATETEMKEKKDRVDDALHATRAAVEEGVVPGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AMNALSELRGDNDDQNAGINILRRAMEAPLRQIVTNSGEEASVVVNEVKSGTGNYGYNAA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
SGEYGDMLEMGILDPAKVARSALENAASVAGLMLTTEVMITDLPQGDDGMAGMGGAGGMG
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GMGGMGGMM
CCCCCCCCC
>Mature Secondary Structure 
AKDVKFGIDARKQMMDGVNVLANAVRVTLGPKGRNVVIDKSFGAPTITKDGVSVAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
LENKFENMGAQLVREVASRTNDVAGDGTTTATVLAQSILQEGMKSVAAGMNPMDLKRGID
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KAVRAAVEQIHLLSTPADDSKAIAQVGSISANSDTKIGELIAQAMEKVGKQGVITVEEGS
HHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
SFEDTLEVVEGMQFDRGYISPYFANKQDSLTAEFENPYILLVDKKISNIREIVPLLEQVM
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCHHHHHHHHHHHHHHHH
QQSKPLLIIAEDVENEALATLVVNNMRGGLKTCAVKAPGFGDRRKAMLEDIATLTGGTVI
HCCCCEEEEECCCCCHHHHHHHHHHHCCCHHEEEEECCCCCHHHHHHHHHHHHHCCCCEE
SEEIGLSLETATLEQLGTAKKVTVGKENTVIVDGAGNSADIENRVESIKRQVEESTSDYD
HHHHCCEEHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCH
KEKLQERMAKLAGGVAVIKVGAATETEMKEKKDRVDDALHATRAAVEEGVVPGGGVALVR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AMNALSELRGDNDDQNAGINILRRAMEAPLRQIVTNSGEEASVVVNEVKSGTGNYGYNAA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCC
SGEYGDMLEMGILDPAKVARSALENAASVAGLMLTTEVMITDLPQGDDGMAGMGGAGGMG
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCC
GMGGMGGMM
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA