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The map label for this gene is pyrC' [H]

Identifier: 93005362

GI number: 93005362

Start: 628892

End: 630073

Strand: Direct

Name: pyrC' [H]

Synonym: Pcryo_0532

Alternate gene names: 93005362

Gene position: 628892-630073 (Clockwise)

Preceding gene: 93005361

Following gene: 93005363

Centisome position: 20.55

GC content: 46.53

Gene sequence:

>1182_bases
ATGCACGACTTACTTCCAAAAGTATTTAAAGAATCACTGTCACAAATCGCCACTGCTCAGTTAGCAAAGCTGACGAGCGA
GCGCGAGACATGGATATTACCACCGCTGGTTGATTTGTGCGCCCGCTTACGTGAGCCGGGTCAACAGCAGCATGGTACAT
TAGAGTCAGAAGGGCGTGCGGCCCGTGCCAATGGTTTTTTGCATGTGGTGATTCCCCCTGATACCAATCCTATTTTAGAA
AATGGCTCGCTCTTAAAAGGCTTGCGTGAGCGTGCACTCGATGATGGCGGCATCTATTTACATATTTTGGGTGCGTTGAC
TGCTGGCTTGGAGGGTGAACGTCCGTCTAATATTGCAGGACTTAAAAAAGGCGGCTGTATTGCCGTCTCCAATGCTCGCA
GACCCTTTCAAAACGACTTAGTGCTCTTACGTACACTTGAGTATGCGGCGACGTTTGGCATGAAGGTATTCTTTTATCCT
GATGAGCCTAGTCTATCTGGTGATGGCGTTGCACATGAAGGCTATATCGCTTCTTATCATGGTCTGCAGGGTATTCCTTG
GATTGCAGAAACCGTCGCTTTATCAACGCAGTTACTTATGGTGGAAGAAACGGGCATAGCTGCTCACTTTAGCCAATTAT
CTTGTAAGTCGTCAATTGAGCTGATGCGCTGGGCGAAAGATAAAGGTTTACCAGTTACTTGTGACGTGGCAATGCATCAG
TTGTATTTAACCGATGATAATCTGGAAGGCTTTAACGCTCAAGCATATGTATTACCCCCTTTGCGTAGTAATACCGATCA
GCAAGCGATTCGCCGTGGTCTAAAAGATGGCACAATTGATGCAATTTGCAGTCATCATGAGCCGTTAAACAGTACCGCGA
AAAAAGCCCCATTTGCTGAAAGTACGCCCGGTATCTCAAATTTTGATACCTTTATGGCGCTGGCGTGCCAGCTGGTAAAA
GATGAGGTGTTAACACTTGAGCAGCTGGTCGATAAAATCTGCTTAAATCCTGCAAAAATTGCGGGTATCAGCGAGCAATA
TGAGACTATCGGGGGCGCAGTACTGGTCGATCCCAATCTTGAATGGCAGGTGACTAGCGAATCCATGTTATCAAACGGCA
AAAATACGCCATTCTTTAACCAAACACTGCAAGGGCGTGTTGTGGAGACTTTCTTTGGCTAA

Upstream 100 bases:

>100_bases
TGGTCATTAATATTTAGCTCGCCTGTTTTATTCTTATTTATCCCATTTCATTGATACGGTAATAACGCTCATGGTTCACA
TTACGAATTCAGATGTTCAT

Downstream 100 bases:

>100_bases
TTTGCCTAGGCAGGATGATAGTCTAGAGTCTTCGTCAGAGGGCAATTCATCAAAAGATAACCATCCGTCTTCAGACCCAA
GACACAATGAGCCTCGCACG

Product: putative dihydroorotase-like protein

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MHDLLPKVFKESLSQIATAQLAKLTSERETWILPPLVDLCARLREPGQQQHGTLESEGRAARANGFLHVVIPPDTNPILE
NGSLLKGLRERALDDGGIYLHILGALTAGLEGERPSNIAGLKKGGCIAVSNARRPFQNDLVLLRTLEYAATFGMKVFFYP
DEPSLSGDGVAHEGYIASYHGLQGIPWIAETVALSTQLLMVEETGIAAHFSQLSCKSSIELMRWAKDKGLPVTCDVAMHQ
LYLTDDNLEGFNAQAYVLPPLRSNTDQQAIRRGLKDGTIDAICSHHEPLNSTAKKAPFAESTPGISNFDTFMALACQLVK
DEVLTLEQLVDKICLNPAKIAGISEQYETIGGAVLVDPNLEWQVTSESMLSNGKNTPFFNQTLQGRVVETFFG

Sequences:

>Translated_393_residues
MHDLLPKVFKESLSQIATAQLAKLTSERETWILPPLVDLCARLREPGQQQHGTLESEGRAARANGFLHVVIPPDTNPILE
NGSLLKGLRERALDDGGIYLHILGALTAGLEGERPSNIAGLKKGGCIAVSNARRPFQNDLVLLRTLEYAATFGMKVFFYP
DEPSLSGDGVAHEGYIASYHGLQGIPWIAETVALSTQLLMVEETGIAAHFSQLSCKSSIELMRWAKDKGLPVTCDVAMHQ
LYLTDDNLEGFNAQAYVLPPLRSNTDQQAIRRGLKDGTIDAICSHHEPLNSTAKKAPFAESTPGISNFDTFMALACQLVK
DEVLTLEQLVDKICLNPAKIAGISEQYETIGGAVLVDPNLEWQVTSESMLSNGKNTPFFNQTLQGRVVETFFG
>Mature_393_residues
MHDLLPKVFKESLSQIATAQLAKLTSERETWILPPLVDLCARLREPGQQQHGTLESEGRAARANGFLHVVIPPDTNPILE
NGSLLKGLRERALDDGGIYLHILGALTAGLEGERPSNIAGLKKGGCIAVSNARRPFQNDLVLLRTLEYAATFGMKVFFYP
DEPSLSGDGVAHEGYIASYHGLQGIPWIAETVALSTQLLMVEETGIAAHFSQLSCKSSIELMRWAKDKGLPVTCDVAMHQ
LYLTDDNLEGFNAQAYVLPPLRSNTDQQAIRRGLKDGTIDAICSHHEPLNSTAKKAPFAESTPGISNFDTFMALACQLVK
DEVLTLEQLVDKICLNPAKIAGISEQYETIGGAVLVDPNLEWQVTSESMLSNGKNTPFFNQTLQGRVVETFFG

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=391, Percent_Identity=28.3887468030691, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786722, Length=381, Percent_Identity=20.997375328084, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=366, Percent_Identity=23.4972677595628, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=401, Percent_Identity=23.9401496259352, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24642586, Length=363, Percent_Identity=25.8953168044077, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 42884; Mature: 42884

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLLPKVFKESLSQIATAQLAKLTSERETWILPPLVDLCARLREPGQQQHGTLESEGRA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCHHHCCCCCCCCCE
ARANGFLHVVIPPDTNPILENGSLLKGLRERALDDGGIYLHILGALTAGLEGERPSNIAG
EECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCCCCC
LKKGGCIAVSNARRPFQNDLVLLRTLEYAATFGMKVFFYPDEPSLSGDGVAHEGYIASYH
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCEEEECC
GLQGIPWIAETVALSTQLLMVEETGIAAHFSQLSCKSSIELMRWAKDKGLPVTCDVAMHQ
CCCCCCHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
LYLTDDNLEGFNAQAYVLPPLRSNTDQQAIRRGLKDGTIDAICSHHEPLNSTAKKAPFAE
EEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCHHHHCCCCCC
STPGISNFDTFMALACQLVKDEVLTLEQLVDKICLNPAKIAGISEQYETIGGAVLVDPNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCEEEECCCC
EWQVTSESMLSNGKNTPFFNQTLQGRVVETFFG
CEEECHHHHHCCCCCCCCCCHHHCCCHHHHHCC
>Mature Secondary Structure
MHDLLPKVFKESLSQIATAQLAKLTSERETWILPPLVDLCARLREPGQQQHGTLESEGRA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCCHHHCCCCCCCCCE
ARANGFLHVVIPPDTNPILENGSLLKGLRERALDDGGIYLHILGALTAGLEGERPSNIAG
EECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCCCCC
LKKGGCIAVSNARRPFQNDLVLLRTLEYAATFGMKVFFYPDEPSLSGDGVAHEGYIASYH
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCEEEECC
GLQGIPWIAETVALSTQLLMVEETGIAAHFSQLSCKSSIELMRWAKDKGLPVTCDVAMHQ
CCCCCCHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
LYLTDDNLEGFNAQAYVLPPLRSNTDQQAIRRGLKDGTIDAICSHHEPLNSTAKKAPFAE
EEEECCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCCHHHHCCCCCC
STPGISNFDTFMALACQLVKDEVLTLEQLVDKICLNPAKIAGISEQYETIGGAVLVDPNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCEEEECCCC
EWQVTSESMLSNGKNTPFFNQTLQGRVVETFFG
CEEECHHHHHCCCCCCCCCCHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]