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The map label for this gene is rnc [H]

Identifier: 93005197

GI number: 93005197

Start: 445592

End: 446389

Strand: Direct

Name: rnc [H]

Synonym: Pcryo_0367

Alternate gene names: 93005197

Gene position: 445592-446389 (Clockwise)

Preceding gene: 93005196

Following gene: 93005198

Centisome position: 14.56

GC content: 42.61

Gene sequence:

>798_bases
ATGAAACCAACTTCGCAGTATCCTCAGGCGGTTCCTAATCCACCAAAAAATAGCCTGTCTGATGACACGCTTATTATTAG
CTCAGAATTTATTCAACGCTTAGCAGTATTAACGCGCAAGTTGGGTTATGTGTTTAATGATTTAAGTCTACCTAAGCTGG
CACTCACGCATCGCTCGTTTGATAGTAAAAAGAACTATGAACGCTTAGAGTTTTTGGGTGATGCATTGCTAGGTATGATA
GTCGGTGAAGCGCTATATCATCGTTATCCAACCCAAAATGAAGGTCGTCTGACCCGTATGCGAGCGACGCTCGTGAGGCA
AGAATCCTTGGTCATTATCGCTCAAAATCTAGAGCTGTCTAATCAGCTAATATTGGGTGTGGGTGAGCGTAAAGGTGGCG
GACGCAATCGTGCTTCTATATTGGCGGACGCCGTCGAATCCTTGATTGGTGCTATTTATCTAGACAGTCAAGATATGAAT
ATCACACGAGAATGTGTATTGTCTTGGTATGGTGATTTAATTGATAATGTCAATGATCAAAAAGCCCTAAAAGATGCCAA
GAGCCGTTTACAAGAATGGCTGCAGTCGAAGCAATTTGACTTACCACATTATGAGTTGATGGAAACACGCGGTAATGCCC
CGCATCAAATATTTGTGGTACGCTGTCAGGTAAACATTCTTAACTGTCCTGATATTACCGAATCTGGTGAAAGCCGCCGT
ATTGCTGAGCAAAAAGCAGCAGAATTGATGATTAACCAACTTCATAAGCTACCAAGTGTGCCCAAAAAACGCAGCTAA

Upstream 100 bases:

>100_bases
AACAGTTCTTTATGAGCTGGTTTTTTGTATTTAATATTTTTAAACGTTACTATTTAATGACCTTAAATAGTACAACAAAA
GGGATAATCATAAGCCACGC

Downstream 100 bases:

>100_bases
TGGCTTTTGTAATATTACCCTGATTTTATATTGATGACTTGATAGTAATGCCTTTAAGACTATCATTTCTATATTATAAA
AATGCTCATTCTTTAACGAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKPTSQYPQAVPNPPKNSLSDDTLIISSEFIQRLAVLTRKLGYVFNDLSLPKLALTHRSFDSKKNYERLEFLGDALLGMI
VGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELSNQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMN
ITRECVLSWYGDLIDNVNDQKALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQIFVVRCQVNILNCPDITESGESRR
IAEQKAAELMINQLHKLPSVPKKRS

Sequences:

>Translated_265_residues
MKPTSQYPQAVPNPPKNSLSDDTLIISSEFIQRLAVLTRKLGYVFNDLSLPKLALTHRSFDSKKNYERLEFLGDALLGMI
VGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELSNQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMN
ITRECVLSWYGDLIDNVNDQKALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQIFVVRCQVNILNCPDITESGESRR
IAEQKAAELMINQLHKLPSVPKKRS
>Mature_265_residues
MKPTSQYPQAVPNPPKNSLSDDTLIISSEFIQRLAVLTRKLGYVFNDLSLPKLALTHRSFDSKKNYERLEFLGDALLGMI
VGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELSNQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMN
ITRECVLSWYGDLIDNVNDQKALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQIFVVRCQVNILNCPDITESGESRR
IAEQKAAELMINQLHKLPSVPKKRS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=210, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI155030236, Length=210, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1788920, Length=204, Percent_Identity=49.0196078431373, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17506883, Length=237, Percent_Identity=27.0042194092827, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=237, Percent_Identity=27.0042194092827, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17137682, Length=240, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 30017; Mature: 30017

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTSQYPQAVPNPPKNSLSDDTLIISSEFIQRLAVLTRKLGYVFNDLSLPKLALTHRSF
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
DSKKNYERLEFLGDALLGMIVGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCC
NQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMNITRECVLSWYGDLIDNVNDQ
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
KALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQIFVVRCQVNILNCPDITESGESRR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCHHH
IAEQKAAELMINQLHKLPSVPKKRS
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKPTSQYPQAVPNPPKNSLSDDTLIISSEFIQRLAVLTRKLGYVFNDLSLPKLALTHRSF
CCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
DSKKNYERLEFLGDALLGMIVGEALYHRYPTQNEGRLTRMRATLVRQESLVIIAQNLELS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCC
NQLILGVGERKGGGRNRASILADAVESLIGAIYLDSQDMNITRECVLSWYGDLIDNVNDQ
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
KALKDAKSRLQEWLQSKQFDLPHYELMETRGNAPHQIFVVRCQVNILNCPDITESGESRR
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCHHH
IAEQKAAELMINQLHKLPSVPKKRS
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA