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The map label for this gene is purE [H]

Identifier: 93005134

GI number: 93005134

Start: 364101

End: 364661

Strand: Reverse

Name: purE [H]

Synonym: Pcryo_0303

Alternate gene names: 93005134

Gene position: 364661-364101 (Counterclockwise)

Preceding gene: 93005135

Following gene: 93005133

Centisome position: 11.92

GC content: 48.31

Gene sequence:

>561_bases
ATGAGCATTATCTCAGCGACGATTAACGCTACTGATCAGAACGCACCTATCACCTCCCCTGTTGGTCAACCAAAAGTTGG
CATTATCATGGGTTCGCAGTCTGATTGGGCAACCATGAGCGCAGCAGCACAATTGCTTGCAGACTTTGATATCGCCTTTG
AATGTGAAGTGGTTTCAGCACATCGTACGCCTGACAGATTATTCGATTATGCTAAAAGCGCAAAAGGCAACGGCTTGCAA
GTGATTATCGCTGGCGCTGGCGGAGCAGCTCATCTGCCCGGTATGTGTGCCAGTCAAACGCCGCTACCTGTCTTTGGTGT
CCCTGTAAAATCCTCTATGCTGAGTGGTTGGGACAGCTTACTATCTATCGTTCAGATGCCCAAAGGCGTTGCAGTTGGCA
CATTAGCTATTGGATCCGCTGGCGCTTATAATGCTGCGCTGCTTGCTATTCAAGTGCTTGCCTTGCATGATGAGTCGATT
GCTACTAAACTTGACCATCTGCGTAATACCCAAACCAATACTATCCTTGCCAGTCCAACACCCGGTATTATCAATCCTTA
G

Upstream 100 bases:

>100_bases
GTATGATGTTTTATACGCGTGATTTGGCATTAAAGCACAAACTTGGCTTTACGAATACAGCAAAATTTTTGTATGATGGT
CTTTTTGAGGATATCAAAGC

Downstream 100 bases:

>100_bases
TATTTAGCTTAAGTGAATGGTAAATAATTATTATATTTACCATTTTTATCGTTAATTTTAAATATAAGCGGGTTTACTTG
ATATTTATTTTTAGATAAGT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSIISATINATDQNAPITSPVGQPKVGIIMGSQSDWATMSAAAQLLADFDIAFECEVVSAHRTPDRLFDYAKSAKGNGLQ
VIIAGAGGAAHLPGMCASQTPLPVFGVPVKSSMLSGWDSLLSIVQMPKGVAVGTLAIGSAGAYNAALLAIQVLALHDESI
ATKLDHLRNTQTNTILASPTPGIINP

Sequences:

>Translated_186_residues
MSIISATINATDQNAPITSPVGQPKVGIIMGSQSDWATMSAAAQLLADFDIAFECEVVSAHRTPDRLFDYAKSAKGNGLQ
VIIAGAGGAAHLPGMCASQTPLPVFGVPVKSSMLSGWDSLLSIVQMPKGVAVGTLAIGSAGAYNAALLAIQVLALHDESI
ATKLDHLRNTQTNTILASPTPGIINP
>Mature_185_residues
SIISATINATDQNAPITSPVGQPKVGIIMGSQSDWATMSAAAQLLADFDIAFECEVVSAHRTPDRLFDYAKSAKGNGLQV
IIAGAGGAAHLPGMCASQTPLPVFGVPVKSSMLSGWDSLLSIVQMPKGVAVGTLAIGSAGAYNAALLAIQVLALHDESIA
TKLDHLRNTQTNTILASPTPGIINP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=61.1464968152866, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=154, Percent_Identity=57.1428571428571, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 19075; Mature: 18944

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIISATINATDQNAPITSPVGQPKVGIIMGSQSDWATMSAAAQLLADFDIAFECEVVSA
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEC
HRTPDRLFDYAKSAKGNGLQVIIAGAGGAAHLPGMCASQTPLPVFGVPVKSSMLSGWDSL
CCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHH
LSIVQMPKGVAVGTLAIGSAGAYNAALLAIQVLALHDESIATKLDHLRNTQTNTILASPT
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCC
PGIINP
CCCCCC
>Mature Secondary Structure 
SIISATINATDQNAPITSPVGQPKVGIIMGSQSDWATMSAAAQLLADFDIAFECEVVSA
CEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEC
HRTPDRLFDYAKSAKGNGLQVIIAGAGGAAHLPGMCASQTPLPVFGVPVKSSMLSGWDSL
CCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHH
LSIVQMPKGVAVGTLAIGSAGAYNAALLAIQVLALHDESIATKLDHLRNTQTNTILASPT
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEECCC
PGIINP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]