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The map label for this gene is hemC [H]

Identifier: 93004929

GI number: 93004929

Start: 113639

End: 114676

Strand: Direct

Name: hemC [H]

Synonym: Pcryo_0098

Alternate gene names: 93004929

Gene position: 113639-114676 (Clockwise)

Preceding gene: 93004928

Following gene: 93004930

Centisome position: 3.71

GC content: 46.24

Gene sequence:

>1038_bases
ATGAGCACCATGCAGCAACCTGCTTTGACTACCTTAAATATCGCTACGCGCCAGAGCCCACTAGCATTATGGCAAGCTGA
GCATATTCGTAATCGATTACTAGCTTTGTATCCTGAGATGACAATTAATCTGCTAAAAATCGTGACTAAAGGTGACAAAA
TTTTGGATACGCCACTGGCTAAAATTGGCGGCAAAGGTTTATTTGTTAAAGAGCTTGAGCAAGCACTGTATGACAAGCAA
GCAGATATCGCGGTGCACTCACTCAAAGACGTGCCCATGGATTTACCAGAAGGGTTGACGCTAGGCGTTTATTGCAAACG
TGCTTCACCAACCGACGCTTTTGTATCGAATACTTATCATAGTATCGCTGAGTTGCCACAAGGGGCGGTAGTCGGTACTG
CAAGTTTGCGTCGTCAGTGTCAAATCAAAGCTTATCGTCCCGATTTGCAAATTAAAACCCTACGCGGCAATGTCGGCACG
CGACTAAGCAAGTTAGATGCGGGCGAGTATGATGCGATTATTTTGGCGACTAGTGGTCTAAAGCGCATTGAGCTTGATGC
ACGTATTCGTAGTGAGTTAGATATCAATATTTGCTTGCCAGCGGTTGGGCAAGGCGCGTTAGCAATTGAATGTCGTGAAG
ATGATGCCGACGTATTAAAATTATTGGCACCACTTAATGACGACAAAGCTCGTATCCGCTTAATCGCTGAGCGCGCATTA
AATCGTCATCTGCAGGGCGGTTGCCAAGTACCTATCGCCGCTTATGCTGTATTACAAAAGGCAGATGCATTGGCTGCTGA
TAATGATAGCAATGATAATGACAATGGTAACAACGATGCTGGCGATACCTTATGGCTGCGCGGTCGCGTTGGTCAAGAAG
ATGGTAGCGAGCTGCTTAAGGTGGACAAGCGCCAGACGTTAACAGGCAGTCAAGCTGAGCAAGAAGCCCAAGCAAACCAG
TTGGGTATCGAAGTTGCTGAGATGTTATTGCAAGCTGGTGCTGGTGAGATTCTATCAGCGATCTATCATCCTGAATAA

Upstream 100 bases:

>100_bases
TTATTATCGTTATAAACCATTTTTACGCCCCATCTTGGGCGAAAAACTCACATTATCGTCGAGCAATGACCGTTTAGTAT
TAAAATTATTGAGGCCTTTT

Downstream 100 bases:

>100_bases
TAGCTAGTCTGTATAACACTGGATCACCATTATCAACTCAGTCATAGAGTTATCATGGTTTAGATGACTCTATGATGGTG
CTAACTCTATTTGCTTTTTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTMQQPALTTLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLAKIGGKGLFVKELEQALYDKQ
ADIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSNTYHSIAELPQGAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGT
RLSKLDAGEYDAIILATSGLKRIELDARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERAL
NRHLQGGCQVPIAAYAVLQKADALAADNDSNDNDNGNNDAGDTLWLRGRVGQEDGSELLKVDKRQTLTGSQAEQEAQANQ
LGIEVAEMLLQAGAGEILSAIYHPE

Sequences:

>Translated_345_residues
MSTMQQPALTTLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLAKIGGKGLFVKELEQALYDKQ
ADIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSNTYHSIAELPQGAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGT
RLSKLDAGEYDAIILATSGLKRIELDARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERAL
NRHLQGGCQVPIAAYAVLQKADALAADNDSNDNDNGNNDAGDTLWLRGRVGQEDGSELLKVDKRQTLTGSQAEQEAQANQ
LGIEVAEMLLQAGAGEILSAIYHPE
>Mature_344_residues
STMQQPALTTLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLAKIGGKGLFVKELEQALYDKQA
DIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSNTYHSIAELPQGAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGTR
LSKLDAGEYDAIILATSGLKRIELDARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERALN
RHLQGGCQVPIAAYAVLQKADALAADNDSNDNDNGNNDAGDTLWLRGRVGQEDGSELLKVDKRQTLTGSQAEQEAQANQL
GIEVAEMLLQAGAGEILSAIYHPE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=340, Percent_Identity=40.5882352941176, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI66933009, Length=338, Percent_Identity=40.5325443786982, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI48994974, Length=334, Percent_Identity=53.8922155688623, Blast_Score=349, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6319996, Length=340, Percent_Identity=37.3529411764706, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20130425, Length=315, Percent_Identity=39.6825396825397, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 37488; Mature: 37357

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTMQQPALTTLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLA
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHH
KIGGKGLFVKELEQALYDKQADIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSNTYH
HHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
SIAELPQGAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGTRLSKLDAGEYDAIILATSGL
HHHHCCCCCEEECHHHHHHHEEEEECCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
KRIELDARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERAL
CEEEEHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHH
NRHLQGGCQVPIAAYAVLQKADALAADNDSNDNDNGNNDAGDTLWLRGRVGQEDGSELLK
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
VDKRQTLTGSQAEQEAQANQLGIEVAEMLLQAGAGEILSAIYHPE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
STMQQPALTTLNIATRQSPLALWQAEHIRNRLLALYPEMTINLLKIVTKGDKILDTPLA
CCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHH
KIGGKGLFVKELEQALYDKQADIAVHSLKDVPMDLPEGLTLGVYCKRASPTDAFVSNTYH
HHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
SIAELPQGAVVGTASLRRQCQIKAYRPDLQIKTLRGNVGTRLSKLDAGEYDAIILATSGL
HHHHCCCCCEEECHHHHHHHEEEEECCCCEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
KRIELDARIRSELDINICLPAVGQGALAIECREDDADVLKLLAPLNDDKARIRLIAERAL
CEEEEHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHH
NRHLQGGCQVPIAAYAVLQKADALAADNDSNDNDNGNNDAGDTLWLRGRVGQEDGSELLK
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHH
VDKRQTLTGSQAEQEAQANQLGIEVAEMLLQAGAGEILSAIYHPE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA