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The map label for this gene is patB [H]

Identifier: 93004843

GI number: 93004843

Start: 13540

End: 14724

Strand: Direct

Name: patB [H]

Synonym: Pcryo_0012

Alternate gene names: 93004843

Gene position: 13540-14724 (Clockwise)

Preceding gene: 93004841

Following gene: 93004847

Centisome position: 0.44

GC content: 43.54

Gene sequence:

>1185_bases
ATGCTGGTGTTGTACAACTTTGATGAAATAATAGACAGGTGTAACACGGGGTCGTTTAAATGGCATTATACCGATGAGAC
AATTCCGCTGTGGGTCGCGGATATGGACTTTAAGGCCGCCCAGCCTATTTTAGCGGCGATTGAGCAAGTAACGCAGCATG
GCATATTGGGTTACACCGTGCCGACCGAGCCGTTGTATCAAGCGATTATCGACTGGCATGGCAGTCGTTATGACTTGTGG
CTGGATCAACAGGATATCCTGTTTTCTCCGGGTGTCGTGCCAAGTTTGGTGCTGATGATGAAGGTATTTACCGAGGTAGG
GGATGCGGTACTCATCAATGACCCTATTTATACGCCTTTTATGACCAAGGTTTTAGACAATGATCGTAAGCTGGTGACTT
CTGCATTACAGGAGGTTGAGGGCCGATATCATCTAGATTTAGTCGATATCGAAGCCAAAATTATCGAGCATAAAGTTAAG
CTATATTTGTTCTGCAATCCGCATAATCCGGGCGGGCGGGTATGGACAGCGGATGAGCTTGAAGCGCTGCTTTTCATCTG
CAAAAAGCACGATGTGGCGATTGTGAGTGATGAGATTCATCAAGATTTAACTTTGAGTGGGCATACATTCACGCCTTTTT
TAACCCTAGCAAAAGACTATGAACACAAAGTAGTAAACCTAACCTCGATGACCAAAACCTTTAATATTGCCGGTATCAAA
GGCTCGATGATATTTGCTAAAGACAGCGGATTACTGAGTAAAATTAACCAGCAGCAGCGTTTAAGTGACGAACATGAGCT
AAATTTATTTGCTTATACAGCGATGCGTAGTGCTTATGAGCAAGGTGACGAGTGGTTGGCGCAGGCGCTGACTTATATTG
AAGCCAATATTGACTTAACGCTACAGTTTTTAGAAGAGCATTTGCCTAAAATTAAGGTGATGCGTCCAGAAGCTTCGTAT
TTGATTTGGCTAGATTGTTCGGCATATGCGCAAGACGATCAAATGCTTTATGACAAATTGAGAGCTGCTAAGGTTGAGCT
GAGTGCAGGGATTAAATATGGTGGTGAAGGCCATCTTAAAATGCGCCTCAATGTGGCGTGTCCTAAAGCGCTGCTGATAG
AAGGGCTAAACCGTATGCAAACAGCATTAAATAGCGATGTTTTTAATATAGTCGATTCAATTTAA

Upstream 100 bases:

>100_bases
TAATTTTTAGCCATTATTCAAATAATGATGATGTTATATTTTTAAATATCATTTAAGCCGACGGATGAACAGTTATAATA
TAAAGCAATCGTAAAGGGGA

Downstream 100 bases:

>100_bases
AAAGAATACGGTGTTGCTGGGATAAATTTTGCGAAGCTTCTGGAGTGCGAAGTGCACAGCAAGCGAGGAAAGTTTATCCC
AGCATAACGCTATTTTTAAC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLVLYNFDEIIDRCNTGSFKWHYTDETIPLWVADMDFKAAQPILAAIEQVTQHGILGYTVPTEPLYQAIIDWHGSRYDLW
LDQQDILFSPGVVPSLVLMMKVFTEVGDAVLINDPIYTPFMTKVLDNDRKLVTSALQEVEGRYHLDLVDIEAKIIEHKVK
LYLFCNPHNPGGRVWTADELEALLFICKKHDVAIVSDEIHQDLTLSGHTFTPFLTLAKDYEHKVVNLTSMTKTFNIAGIK
GSMIFAKDSGLLSKINQQQRLSDEHELNLFAYTAMRSAYEQGDEWLAQALTYIEANIDLTLQFLEEHLPKIKVMRPEASY
LIWLDCSAYAQDDQMLYDKLRAAKVELSAGIKYGGEGHLKMRLNVACPKALLIEGLNRMQTALNSDVFNIVDSI

Sequences:

>Translated_394_residues
MLVLYNFDEIIDRCNTGSFKWHYTDETIPLWVADMDFKAAQPILAAIEQVTQHGILGYTVPTEPLYQAIIDWHGSRYDLW
LDQQDILFSPGVVPSLVLMMKVFTEVGDAVLINDPIYTPFMTKVLDNDRKLVTSALQEVEGRYHLDLVDIEAKIIEHKVK
LYLFCNPHNPGGRVWTADELEALLFICKKHDVAIVSDEIHQDLTLSGHTFTPFLTLAKDYEHKVVNLTSMTKTFNIAGIK
GSMIFAKDSGLLSKINQQQRLSDEHELNLFAYTAMRSAYEQGDEWLAQALTYIEANIDLTLQFLEEHLPKIKVMRPEASY
LIWLDCSAYAQDDQMLYDKLRAAKVELSAGIKYGGEGHLKMRLNVACPKALLIEGLNRMQTALNSDVFNIVDSI
>Mature_394_residues
MLVLYNFDEIIDRCNTGSFKWHYTDETIPLWVADMDFKAAQPILAAIEQVTQHGILGYTVPTEPLYQAIIDWHGSRYDLW
LDQQDILFSPGVVPSLVLMMKVFTEVGDAVLINDPIYTPFMTKVLDNDRKLVTSALQEVEGRYHLDLVDIEAKIIEHKVK
LYLFCNPHNPGGRVWTADELEALLFICKKHDVAIVSDEIHQDLTLSGHTFTPFLTLAKDYEHKVVNLTSMTKTFNIAGIK
GSMIFAKDSGLLSKINQQQRLSDEHELNLFAYTAMRSAYEQGDEWLAQALTYIEANIDLTLQFLEEHLPKIKVMRPEASY
LIWLDCSAYAQDDQMLYDKLRAAKVELSAGIKYGGEGHLKMRLNVACPKALLIEGLNRMQTALNSDVFNIVDSI

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=268, Percent_Identity=21.6417910447761, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI169881279, Length=268, Percent_Identity=21.6417910447761, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI56713254, Length=214, Percent_Identity=26.1682242990654, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI56713256, Length=214, Percent_Identity=26.1682242990654, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=394, Percent_Identity=29.6954314720812, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788722, Length=328, Percent_Identity=22.5609756097561, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994476, Length=225, Percent_Identity=28, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=225, Percent_Identity=28, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=379, Percent_Identity=21.3720316622691, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=198, Percent_Identity=25.2525252525253, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573069, Length=163, Percent_Identity=30.0613496932515, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24646114, Length=163, Percent_Identity=30.0613496932515, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573067, Length=163, Percent_Identity=30.0613496932515, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573065, Length=163, Percent_Identity=30.0613496932515, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44793; Mature: 44793

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLYNFDEIIDRCNTGSFKWHYTDETIPLWVADMDFKAAQPILAAIEQVTQHGILGYTV
CEEEECHHHHHHHCCCCCEEEEEECCCEEEEEECCCCHHCCHHHHHHHHHHHCCCEEEEC
PTEPLYQAIIDWHGSRYDLWLDQQDILFSPGVVPSLVLMMKVFTEVGDAVLINDPIYTPF
CCHHHHHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHH
MTKVLDNDRKLVTSALQEVEGRYHLDLVDIEAKIIEHKVKLYLFCNPHNPGGRVWTADEL
HHHHHCCCHHHHHHHHHHCCCCEEEEEEEHHHHHEEEEEEEEEEECCCCCCCCEEEHHHH
EALLFICKKHDVAIVSDEIHQDLTLSGHTFTPFLTLAKDYEHKVVNLTSMTKTFNIAGIK
HHHHHHHCCCCEEEEEHHHCCCEEECCCCCCHHHHHHHCCCCCEEEEEHHHEEEEEEECC
GSMIFAKDSGLLSKINQQQRLSDEHELNLFAYTAMRSAYEQGDEWLAQALTYIEANIDLT
CCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LQFLEEHLPKIKVMRPEASYLIWLDCSAYAQDDQMLYDKLRAAKVELSAGIKYGGEGHLK
HHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEEECCCEECCCCEEE
MRLNVACPKALLIEGLNRMQTALNSDVFNIVDSI
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MLVLYNFDEIIDRCNTGSFKWHYTDETIPLWVADMDFKAAQPILAAIEQVTQHGILGYTV
CEEEECHHHHHHHCCCCCEEEEEECCCEEEEEECCCCHHCCHHHHHHHHHHHCCCEEEEC
PTEPLYQAIIDWHGSRYDLWLDQQDILFSPGVVPSLVLMMKVFTEVGDAVLINDPIYTPF
CCHHHHHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCHH
MTKVLDNDRKLVTSALQEVEGRYHLDLVDIEAKIIEHKVKLYLFCNPHNPGGRVWTADEL
HHHHHCCCHHHHHHHHHHCCCCEEEEEEEHHHHHEEEEEEEEEEECCCCCCCCEEEHHHH
EALLFICKKHDVAIVSDEIHQDLTLSGHTFTPFLTLAKDYEHKVVNLTSMTKTFNIAGIK
HHHHHHHCCCCEEEEEHHHCCCEEECCCCCCHHHHHHHCCCCCEEEEEHHHEEEEEEECC
GSMIFAKDSGLLSKINQQQRLSDEHELNLFAYTAMRSAYEQGDEWLAQALTYIEANIDLT
CCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LQFLEEHLPKIKVMRPEASYLIWLDCSAYAQDDQMLYDKLRAAKVELSAGIKYGGEGHLK
HHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHEEEECCCEECCCCEEE
MRLNVACPKALLIEGLNRMQTALNSDVFNIVDSI
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]