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The map label for this gene is guaA [H]

Identifier: 93004847

GI number: 93004847

Start: 20495

End: 22090

Strand: Direct

Name: guaA [H]

Synonym: Pcryo_0016

Alternate gene names: 93004847

Gene position: 20495-22090 (Clockwise)

Preceding gene: 93004843

Following gene: 93004852

Centisome position: 0.67

GC content: 47.37

Gene sequence:

>1596_bases
ATGACAACTGCTGCCAACGTTCCTACTATTAAAGAAGATCGCATCTTAATTCTCGATTTTGGCTCGCAGTACAGCCAGCT
TATCGCCCGCCGTGTCCGTGATTCAGGCGTATTCTGTGAGATGTTCCCTTATGATATCGACACTCAGCGCATCATCGATT
TTGGCGCAAAAGGCGTTATCTTATCTGGTGGTCCTGAGAGCGTCCACGCAGATGACAGCCCACGCATCAACGATGCTGTA
TTTGATATAGGCGTACCAGTATTAGGTATCTGCTATGGTATGCAAGCGATGGCAGAGCGTTTCGGTGGTAAAGTTCACGC
CAGTGATATCCATGAATTTGGCGCAGCAACCATCAATATCGATGGCAAATCAACGCTGACTGATGGTATCGAAGACGCAG
CAGCGAAGCTAAATGTCTGGATGAGTCATGGCGATAAAGTAGTCGACGCCCCACAAGGTTTCGATATCGTCGCCAGTACG
CCAAGCTGCCCGATTGCGATCATGGCAGATGATTCGCGCCATTATTATGGGCTACAGTTCCATCCTGAAGTGACGCATAC
CGCACAAGGTCAGGCATTGCTAGGACGTTTTGTCCATCAAATCTGTGACTGCGCGGGTAGCTGGACGCCTGATAACATCA
TCGATATGCGTATCGAGCAACTCAAAAAGCAAATCGGTGATAAGCAAGTATTGCTAGGTCTTTCAGGTGGTGTAGACAGC
TCAGTTGTCGCAGCATTATTGCATAAAGCCATCGGCGATCAATTAACGTGCGTGTTTGTCGATACTGGTCTGCTTCGTCT
GCATGAAGGCGATCAAGTGATGCAAATTTTTGCAGAAAACATGGGCGTAAAAGTCATTCGTGTTGATGCCGAAGAGTTAT
TCTTAACGGCATTGGCTGGCGAGTCTGATCCAGAAGCCAAGCGTAAAATCATCGGTAAAACCTTTATCGATGTATTTGCC
AATAGTGCTCGTGAAGTCAGCGAGCAGAGCGATGGTAAAGTCATCGAATTCTTAGCGCAAGGTACGATTTATCCAGACGT
GATTGAATCTGCCAAGTCGCATCAAGGTAAAGCGCACGTCATTAAGAGTCATCATAACGTTGGTGGTTTGCCAGATGATT
TAGCGTTTGAATTGGTTGAGCCGTTACGTGATTTGTTCAAAGATGAAGTACGTAAATTGGGTATTACCCTAGGTTTGCCT
GCCAAAATGATTAACCGTCATCCGTTCCCAGGACCGGGTTTGGGCGTGCGTATCTTGGGCAAAGTGACCAAAGAGTTTGC
TGATATCCTACGTTCTGCTGATGCTATCTTTATGGAAGAGCTTGAGCGTTCAGGTTGGTATGAGAAAACCGCGCAAGCAT
TTGCGGTATTCCAACCAATCAAATCGGTTGGTGTGGTCGGTGATGGTCGCCGCTATGCGTGGGTGATTGCGCTACGTGCC
GTTGAGACTGTTGACTTTATGACCGCACGCTTTGCGCATCTGCCGTATGATTTGATTGAAACGGTATCGAATCGAATCAT
GAACGAAATCGCTGAAGTTTCACGCGTGACTTATGATGTGTCGAGCAAGCCACCTGCGACGATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
ATTAAAAAATAGACAATAATAAACGTATATCTAACCGCCACTACATTCGTGAAACTTGTTAAAATAGCGCACCAATTTAT
TTATTGATGGACACTACGTT

Downstream 100 bases:

>100_bases
TTCTCCGCTTGATATTCAGATGAAATAAAAAAAGCACTCAACTTGGTTGGGTGTTTTTTTAGTTTAAAATTAAGTGTTTT
ACTCACTAAATTCTGCTTCG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTTAANVPTIKEDRILILDFGSQYSQLIARRVRDSGVFCEMFPYDIDTQRIIDFGAKGVILSGGPESVHADDSPRINDAV
FDIGVPVLGICYGMQAMAERFGGKVHASDIHEFGAATINIDGKSTLTDGIEDAAAKLNVWMSHGDKVVDAPQGFDIVAST
PSCPIAIMADDSRHYYGLQFHPEVTHTAQGQALLGRFVHQICDCAGSWTPDNIIDMRIEQLKKQIGDKQVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDTGLLRLHEGDQVMQIFAENMGVKVIRVDAEELFLTALAGESDPEAKRKIIGKTFIDVFA
NSAREVSEQSDGKVIEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGITLGLP
AKMINRHPFPGPGLGVRILGKVTKEFADILRSADAIFMEELERSGWYEKTAQAFAVFQPIKSVGVVGDGRRYAWVIALRA
VETVDFMTARFAHLPYDLIETVSNRIMNEIAEVSRVTYDVSSKPPATIEWE

Sequences:

>Translated_531_residues
MTTAANVPTIKEDRILILDFGSQYSQLIARRVRDSGVFCEMFPYDIDTQRIIDFGAKGVILSGGPESVHADDSPRINDAV
FDIGVPVLGICYGMQAMAERFGGKVHASDIHEFGAATINIDGKSTLTDGIEDAAAKLNVWMSHGDKVVDAPQGFDIVAST
PSCPIAIMADDSRHYYGLQFHPEVTHTAQGQALLGRFVHQICDCAGSWTPDNIIDMRIEQLKKQIGDKQVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDTGLLRLHEGDQVMQIFAENMGVKVIRVDAEELFLTALAGESDPEAKRKIIGKTFIDVFA
NSAREVSEQSDGKVIEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGITLGLP
AKMINRHPFPGPGLGVRILGKVTKEFADILRSADAIFMEELERSGWYEKTAQAFAVFQPIKSVGVVGDGRRYAWVIALRA
VETVDFMTARFAHLPYDLIETVSNRIMNEIAEVSRVTYDVSSKPPATIEWE
>Mature_530_residues
TTAANVPTIKEDRILILDFGSQYSQLIARRVRDSGVFCEMFPYDIDTQRIIDFGAKGVILSGGPESVHADDSPRINDAVF
DIGVPVLGICYGMQAMAERFGGKVHASDIHEFGAATINIDGKSTLTDGIEDAAAKLNVWMSHGDKVVDAPQGFDIVASTP
SCPIAIMADDSRHYYGLQFHPEVTHTAQGQALLGRFVHQICDCAGSWTPDNIIDMRIEQLKKQIGDKQVLLGLSGGVDSS
VVAALLHKAIGDQLTCVFVDTGLLRLHEGDQVMQIFAENMGVKVIRVDAEELFLTALAGESDPEAKRKIIGKTFIDVFAN
SAREVSEQSDGKVIEFLAQGTIYPDVIESAKSHQGKAHVIKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGITLGLPA
KMINRHPFPGPGLGVRILGKVTKEFADILRSADAIFMEELERSGWYEKTAQAFAVFQPIKSVGVVGDGRRYAWVIALRAV
ETVDFMTARFAHLPYDLIETVSNRIMNEIAEVSRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=530, Percent_Identity=36.7924528301887, Blast_Score=311, Evalue=1e-84,
Organism=Escherichia coli, GI1788854, Length=528, Percent_Identity=60.0378787878788, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=588, Percent_Identity=35.7142857142857, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI133901714, Length=588, Percent_Identity=35.7142857142857, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI71992710, Length=588, Percent_Identity=35.7142857142857, Blast_Score=307, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6323873, Length=523, Percent_Identity=49.7131931166348, Blast_Score=529, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281365319, Length=515, Percent_Identity=34.7572815533981, Blast_Score=284, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58134; Mature: 58003

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAANVPTIKEDRILILDFGSQYSQLIARRVRDSGVFCEMFPYDIDTQRIIDFGAKGVI
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCEEE
LSGGPESVHADDSPRINDAVFDIGVPVLGICYGMQAMAERFGGKVHASDIHEFGAATINI
EECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHCCEEEEE
DGKSTLTDGIEDAAAKLNVWMSHGDKVVDAPQGFDIVASTPSCPIAIMADDSRHYYGLQF
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEECCCCCEEEEEE
HPEVTHTAQGQALLGRFVHQICDCAGSWTPDNIIDMRIEQLKKQIGDKQVLLGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDTGLLRLHEGDQVMQIFAENMGVKVIRVDAEELFLTALAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHHHHHHCCCEEEEEECHHHHHHHHHCC
ESDPEAKRKIIGKTFIDVFANSAREVSEQSDGKVIEFLAQGTIYPDVIESAKSHQGKAHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEE
IKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGITLGLPAKMINRHPFPGPGLGVRILG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCHHHHH
KVTKEFADILRSADAIFMEELERSGWYEKTAQAFAVFQPIKSVGVVGDGRRYAWVIALRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
VETVDFMTARFAHLPYDLIETVSNRIMNEIAEVSRVTYDVSSKPPATIEWE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC
>Mature Secondary Structure 
TTAANVPTIKEDRILILDFGSQYSQLIARRVRDSGVFCEMFPYDIDTQRIIDFGAKGVI
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCEEE
LSGGPESVHADDSPRINDAVFDIGVPVLGICYGMQAMAERFGGKVHASDIHEFGAATINI
EECCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEHHHHHHHCCEEEEE
DGKSTLTDGIEDAAAKLNVWMSHGDKVVDAPQGFDIVASTPSCPIAIMADDSRHYYGLQF
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCEEEEECCCCCEEEEEE
HPEVTHTAQGQALLGRFVHQICDCAGSWTPDNIIDMRIEQLKKQIGDKQVLLGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDTGLLRLHEGDQVMQIFAENMGVKVIRVDAEELFLTALAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCHHHHHHHHHCCCEEEEEECHHHHHHHHHCC
ESDPEAKRKIIGKTFIDVFANSAREVSEQSDGKVIEFLAQGTIYPDVIESAKSHQGKAHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCCEEE
IKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGITLGLPAKMINRHPFPGPGLGVRILG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCHHHHH
KVTKEFADILRSADAIFMEELERSGWYEKTAQAFAVFQPIKSVGVVGDGRRYAWVIALRA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
VETVDFMTARFAHLPYDLIETVSNRIMNEIAEVSRVTYDVSSKPPATIEWE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA