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The map label for this gene is msrA [H]

Identifier: 92113989

GI number: 92113989

Start: 2123198

End: 2123833

Strand: Direct

Name: msrA [H]

Synonym: Csal_1866

Alternate gene names: 92113989

Gene position: 2123198-2123833 (Clockwise)

Preceding gene: 92113987

Following gene: 92113998

Centisome position: 57.44

GC content: 62.11

Gene sequence:

>636_bases
ATGTGGCCACATGAATCGCTCGAGCTTCCCACGCCGGCAACGGCTCTCGAAGGGCGCGATACGCCCATACGTATCAGCGG
CGTCCATTATGTCAACGGGCGCACGATGCTGCCTCCTTTCCCCGAGGAGTACGAGGAAATCGTGCTGGGACTGGGCTGCT
TCTGGGGTGCCGAACGACTGTTCTGGGAAATGCCCGGCGTGTACGTCACCGCAGTGGGTTACGCGGGCGGCCAGACACCC
AATCCCACCTACGAAGAGACCTGCACCGGACGCACCGGGCACGCCGAAGTGGTGCGCGTGATCTTCGATCCTACCGAGAT
CGGGTTACCCGAGCTGCTGCGAGCCTTCTGGGAAGCGCACGACCCGACCCAGGGCATGCGCCAGGGCAACGATATCGGCA
CGCAGTATCGCAGTGTCATCTACACCACCAATGAGTTGCAGCGCCCGCTGGTCGACAAGAGCCTGCAGGAGTACGACCAG
GCCTTGCAGCAGCAGGGAATGGGCAACGTCACCACGGAAGTCGCGCCACTCGATGCCTTCTATTACGCGGAAGAGTATCA
CCAACAGTACCTGGCCAAGAATCCGGCCGGCTACTGCGGCTTGAAAGGGACCGGTGTCGCCTGTCCGGTCACCTGA

Upstream 100 bases:

>100_bases
GTCCGCATGGATCGGTGCACAGCATTCAGCGAAGCGCCGTGGCTGCCCGCATGGGCAGGGCCCCGGTGTTTCTTTACTCA
TCGTCATACGAGATTGTCCT

Downstream 100 bases:

>100_bases
GCCCCGCTCGCGGCGTCGTCACTCCTTGGGTCCTGCCGCGAGCGAGCGGTGGGGCCTCGCATGCGAGGCCCAGTTTTCCA
ACTGCCAGGCGAGACGCCGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MWPHESLELPTPATALEGRDTPIRISGVHYVNGRTMLPPFPEEYEEIVLGLGCFWGAERLFWEMPGVYVTAVGYAGGQTP
NPTYEETCTGRTGHAEVVRVIFDPTEIGLPELLRAFWEAHDPTQGMRQGNDIGTQYRSVIYTTNELQRPLVDKSLQEYDQ
ALQQQGMGNVTTEVAPLDAFYYAEEYHQQYLAKNPAGYCGLKGTGVACPVT

Sequences:

>Translated_211_residues
MWPHESLELPTPATALEGRDTPIRISGVHYVNGRTMLPPFPEEYEEIVLGLGCFWGAERLFWEMPGVYVTAVGYAGGQTP
NPTYEETCTGRTGHAEVVRVIFDPTEIGLPELLRAFWEAHDPTQGMRQGNDIGTQYRSVIYTTNELQRPLVDKSLQEYDQ
ALQQQGMGNVTTEVAPLDAFYYAEEYHQQYLAKNPAGYCGLKGTGVACPVT
>Mature_211_residues
MWPHESLELPTPATALEGRDTPIRISGVHYVNGRTMLPPFPEEYEEIVLGLGCFWGAERLFWEMPGVYVTAVGYAGGQTP
NPTYEETCTGRTGHAEVVRVIFDPTEIGLPELLRAFWEAHDPTQGMRQGNDIGTQYRSVIYTTNELQRPLVDKSLQEYDQ
ALQQQGMGNVTTEVAPLDAFYYAEEYHQQYLAKNPAGYCGLKGTGVACPVT

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=200, Percent_Identity=56, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI208609995, Length=182, Percent_Identity=58.7912087912088, Blast_Score=235, Evalue=2e-62,
Organism=Homo sapiens, GI208609993, Length=200, Percent_Identity=43, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1790665, Length=192, Percent_Identity=52.6041666666667, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.986301369863, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320881, Length=178, Percent_Identity=35.9550561797753, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=37.5, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=36.9047619047619, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=39.2857142857143, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23523; Mature: 23523

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPHESLELPTPATALEGRDTPIRISGVHYVNGRTMLPPFPEEYEEIVLGLGCFWGAERL
CCCCCCCCCCCCCHHCCCCCCCEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHH
FWEMPGVYVTAVGYAGGQTPNPTYEETCTGRTGHAEVVRVIFDPTEIGLPELLRAFWEAH
HHHCCCEEEEEEECCCCCCCCCCHHHHCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHCC
DPTQGMRQGNDIGTQYRSVIYTTNELQRPLVDKSLQEYDQALQQQGMGNVTTEVAPLDAF
CCHHHHHCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHH
YYAEEYHQQYLAKNPAGYCGLKGTGVACPVT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MWPHESLELPTPATALEGRDTPIRISGVHYVNGRTMLPPFPEEYEEIVLGLGCFWGAERL
CCCCCCCCCCCCCHHCCCCCCCEEEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHH
FWEMPGVYVTAVGYAGGQTPNPTYEETCTGRTGHAEVVRVIFDPTEIGLPELLRAFWEAH
HHHCCCEEEEEEECCCCCCCCCCHHHHCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHCC
DPTQGMRQGNDIGTQYRSVIYTTNELQRPLVDKSLQEYDQALQQQGMGNVTTEVAPLDAF
CCHHHHHCCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHHHHH
YYAEEYHQQYLAKNPAGYCGLKGTGVACPVT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA