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The map label for this gene is gor [H]

Identifier: 92113998

GI number: 92113998

Start: 2132690

End: 2134054

Strand: Direct

Name: gor [H]

Synonym: Csal_1875

Alternate gene names: 92113998

Gene position: 2132690-2134054 (Clockwise)

Preceding gene: 92113989

Following gene: 92113999

Centisome position: 57.69

GC content: 65.05

Gene sequence:

>1365_bases
GTGGCTCAGTACGATTACGACCTATTTGTCATCGGCGCGGGCTCCGGTGGTGTGCGTGCCGCGCGTACGGCCGCCGCCAC
GGGGGCGCGCGTCGCCATCGCCGAAGATCGCTATCTGGGCGGCACCTGCGTGAACGTGGGGTGCGTGCCCAAGAAGCTTT
ATTCCTATGCCGCGCACTTTCACGATGCCTTCGATGACAGCGCCGGCTTCGGCTGGACGCTGCCCGAGCCCCCGCGTTTC
GACTGGGCCACGCTGCGCGACAACAAGAGCGAGGAAATCAAGCGTCTCAATGGCATCTACGGGCGTCTGCTGGAGGGAGC
CAACGTCGCTCTGCTCAATGGCCGAGCGCGCATCGCCGGTCCGCACAGCGTCGAGATCAACGGCGAGACGATCACCGCCG
AGAAGATTCTGGTCGCCACCGGTGGCTGGCCCTGGGTACCCGACATCGAGGGCGCGGAGCATGCGCTGGATTCCAACCGC
GTCTTCGATCTCGACACCTTCCCCGAGCGCTTTCTCGTGCTGGGGGGCGGCTATATCGCCGTCGAGTTCGCCAGCATCTT
CAACGGGCTGGGCAGCGATGCCCATCTGGTCTATCGCGGCGAGCTGTTCCTGCGCGGCTTCGACCGCGAAGTGCGCGAAT
TCACGCGTGACGAAATGCAGAAGAAGGGCGTCAACCTGCACTTCGAGGCAACCATCGAACGCATCGAACCCGTGGATGAC
GCCTACCGCGTCACGCTGAGCAACGGCGAAATCCTGGACGTCGATGTCGTGCTGGCGGCCACCGGCCGGCGCCCGAATCT
CGCCGGACTCGGTCTCGACGAGCTGGGCGTGGCCCTCAATCCCGATGGCACCGTGAAGGTCGACGAGCGCTACCAGACGT
CGGAACCCTCGATCCTCGCGCTCGGCGATGTCACCGGCGGCCCCGAACTCACGCCGGTCGCCCTCGCCGAAGCCATGCAC
CTGGTGCAGCATCACTATGGTGACACGCCGCCGCGCCCGCTGGACTACCAAAACATCGCCACGGCAGTGTTCTGTCATCC
CAACATCGGCACCGTCGGCTTGAGCGAGGAAGAAGCGCGCGAGCAATGCCAGAGCGGCGTGCGCATCTATCGCACCGATT
TCCGCCCGATGAAGCACACGCTGTCGGGCAGTCAGGAACGTTGCCTGATGAAGCTGGTGGTCGACGATGCCACCGACCGC
GTGGTTGGCGCGCACATGGTGGGCGACGAAGCAGGAGAGCTCATCCAGGGGATCGCCATCGCCGTGCGAGCCGGCCTGAC
CAAGACCGATTTCGACGCCACGGTGGGCATCCATCCCACCAGCGCCGAGGAATTCGTCACCATGCGGTCGCTGTCACGGC
ACTGA

Upstream 100 bases:

>100_bases
GCAACTTTTACCCCGTGTGCTTCCGGGCGTCAATCCGGCCCCTCCCTGAGCCTTCGAGGGACTGTTATCATCTGCGCCAT
CGCAAACTCAGGAGATCGAT

Downstream 100 bases:

>100_bases
TGCTCCTGACGCATGCGTCACACGAACGGGCCACCCCTGGGTGGCCCGTTTGCGTTGCAGGAACCACTCACGTCATGCAG
GCGTCACATCATTGACTAGA

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAQYDYDLFVIGAGSGGVRAARTAAATGARVAIAEDRYLGGTCVNVGCVPKKLYSYAAHFHDAFDDSAGFGWTLPEPPRF
DWATLRDNKSEEIKRLNGIYGRLLEGANVALLNGRARIAGPHSVEINGETITAEKILVATGGWPWVPDIEGAEHALDSNR
VFDLDTFPERFLVLGGGYIAVEFASIFNGLGSDAHLVYRGELFLRGFDREVREFTRDEMQKKGVNLHFEATIERIEPVDD
AYRVTLSNGEILDVDVVLAATGRRPNLAGLGLDELGVALNPDGTVKVDERYQTSEPSILALGDVTGGPELTPVALAEAMH
LVQHHYGDTPPRPLDYQNIATAVFCHPNIGTVGLSEEEAREQCQSGVRIYRTDFRPMKHTLSGSQERCLMKLVVDDATDR
VVGAHMVGDEAGELIQGIAIAVRAGLTKTDFDATVGIHPTSAEEFVTMRSLSRH

Sequences:

>Translated_454_residues
MAQYDYDLFVIGAGSGGVRAARTAAATGARVAIAEDRYLGGTCVNVGCVPKKLYSYAAHFHDAFDDSAGFGWTLPEPPRF
DWATLRDNKSEEIKRLNGIYGRLLEGANVALLNGRARIAGPHSVEINGETITAEKILVATGGWPWVPDIEGAEHALDSNR
VFDLDTFPERFLVLGGGYIAVEFASIFNGLGSDAHLVYRGELFLRGFDREVREFTRDEMQKKGVNLHFEATIERIEPVDD
AYRVTLSNGEILDVDVVLAATGRRPNLAGLGLDELGVALNPDGTVKVDERYQTSEPSILALGDVTGGPELTPVALAEAMH
LVQHHYGDTPPRPLDYQNIATAVFCHPNIGTVGLSEEEAREQCQSGVRIYRTDFRPMKHTLSGSQERCLMKLVVDDATDR
VVGAHMVGDEAGELIQGIAIAVRAGLTKTDFDATVGIHPTSAEEFVTMRSLSRH
>Mature_453_residues
AQYDYDLFVIGAGSGGVRAARTAAATGARVAIAEDRYLGGTCVNVGCVPKKLYSYAAHFHDAFDDSAGFGWTLPEPPRFD
WATLRDNKSEEIKRLNGIYGRLLEGANVALLNGRARIAGPHSVEINGETITAEKILVATGGWPWVPDIEGAEHALDSNRV
FDLDTFPERFLVLGGGYIAVEFASIFNGLGSDAHLVYRGELFLRGFDREVREFTRDEMQKKGVNLHFEATIERIEPVDDA
YRVTLSNGEILDVDVVLAATGRRPNLAGLGLDELGVALNPDGTVKVDERYQTSEPSILALGDVTGGPELTPVALAEAMHL
VQHHYGDTPPRPLDYQNIATAVFCHPNIGTVGLSEEEAREQCQSGVRIYRTDFRPMKHTLSGSQERCLMKLVVDDATDRV
VGAHMVGDEAGELIQGIAIAVRAGLTKTDFDATVGIHPTSAEEFVTMRSLSRH

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=39.3478260869565, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI22035672, Length=478, Percent_Identity=35.9832635983264, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=34.446764091858, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=34.446764091858, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=34.446764091858, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=34.446764091858, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=34.446764091858, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=34.8101265822785, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=31.8181818181818, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=32.1353065539112, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=42.2273781902552, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=29.9349240780911, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=29.5404814004376, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=28.3842794759825, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1789065, Length=213, Percent_Identity=30.5164319248826, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=42.2222222222222, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=42.2222222222222, Blast_Score=307, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=32.1353065539112, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=34.1614906832298, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=31.0869565217391, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=39.4793926247288, Blast_Score=309, Evalue=7e-85,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=27.991452991453, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=30.2713987473904, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=36.5546218487395, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=36.5546218487395, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=36.5546218487395, Blast_Score=258, Evalue=8e-69,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=34.9372384937238, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=29.2207792207792, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49378; Mature: 49247

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYDYDLFVIGAGSGGVRAARTAAATGARVAIAEDRYLGGTCVNVGCVPKKLYSYAAHF
CCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
HDAFDDSAGFGWTLPEPPRFDWATLRDNKSEEIKRLNGIYGRLLEGANVALLNGRARIAG
HHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEECC
PHSVEINGETITAEKILVATGGWPWVPDIEGAEHALDSNRVFDLDTFPERFLVLGGGYIA
CCEEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHCCCCCEEECCCCCCEEEEECCCEEE
VEFASIFNGLGSDAHLVYRGELFLRGFDREVREFTRDEMQKKGVNLHFEATIERIEPVDD
EEHHHHHCCCCCCCEEEEECEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCC
AYRVTLSNGEILDVDVVLAATGRRPNLAGLGLDELGVALNPDGTVKVDERYQTSEPSILA
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCCCCCCCCCEEE
LGDVTGGPELTPVALAEAMHLVQHHYGDTPPRPLDYQNIATAVFCHPNIGTVGLSEEEAR
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCEEEEEECCCCCCCCCCHHHHH
EQCQSGVRIYRTDFRPMKHTLSGSQERCLMKLVVDDATDRVVGAHMVGDEAGELIQGIAI
HHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
AVRAGLTKTDFDATVGIHPTSAEEFVTMRSLSRH
HHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AQYDYDLFVIGAGSGGVRAARTAAATGARVAIAEDRYLGGTCVNVGCVPKKLYSYAAHF
CCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEECCCCHHHHHHHHHHH
HDAFDDSAGFGWTLPEPPRFDWATLRDNKSEEIKRLNGIYGRLLEGANVALLNGRARIAG
HHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEECC
PHSVEINGETITAEKILVATGGWPWVPDIEGAEHALDSNRVFDLDTFPERFLVLGGGYIA
CCEEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHCCCCCEEECCCCCCEEEEECCCEEE
VEFASIFNGLGSDAHLVYRGELFLRGFDREVREFTRDEMQKKGVNLHFEATIERIEPVDD
EEHHHHHCCCCCCCEEEEECEEEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCC
AYRVTLSNGEILDVDVVLAATGRRPNLAGLGLDELGVALNPDGTVKVDERYQTSEPSILA
EEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCCCCCCCCCEEE
LGDVTGGPELTPVALAEAMHLVQHHYGDTPPRPLDYQNIATAVFCHPNIGTVGLSEEEAR
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHCCEEEEEECCCCCCCCCCHHHHH
EQCQSGVRIYRTDFRPMKHTLSGSQERCLMKLVVDDATDRVVGAHMVGDEAGELIQGIAI
HHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHH
AVRAGLTKTDFDATVGIHPTSAEEFVTMRSLSRH
HHHCCCCCCCCCEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]