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The map label for this gene is cls [H]

Identifier: 92113958

GI number: 92113958

Start: 2091702

End: 2093126

Strand: Direct

Name: cls [H]

Synonym: Csal_1835

Alternate gene names: 92113958

Gene position: 2091702-2093126 (Clockwise)

Preceding gene: 92113957

Following gene: 92113959

Centisome position: 56.58

GC content: 61.33

Gene sequence:

>1425_bases
ATGACATCCGGGGTAATTGGCATCCTGATCGTTGTCATCCATGTGCTGGGTGTGCTGTCCGCGCTCATGGCGCTGATGTC
GAGCCGTACCTCGCAGGGCGCCGTGGCCTGGATCGTCACGTTGCTGACGTTCCCTTATCTGGCGGTGCCCATCTACTGGA
TTTTCGGCCGCCCCCGTTTCTACGGTTACACCTCTGCGCGCGGTGAGCGTGACAGCGTATTGCGTCAGGTGCTGTTACGC
TTCCGGCCGCGTCTGGAGCCTTATTTCTCGCGTCCCTCGCATGATGTCGCCCGCATCCAGGCAGTGGAGCGTCTGGCGAT
GATGCCCATGAGTACCGGCAATCGGGCGGAATTGCTCATCGACGGTGAAGCGACCTTCAAGAGCCTGTTGGCAGGGATCG
ATTCGGCGCGAGAGTACATCCTCGTCCAGTTCTTCATCTTCCGCGCCGATGAAATCGGCACGCTGTTCAAGCAGCATTTG
ATCCAGCAAGCCGAGCGCGGCGTTCGCGTCTGCCTGCTTTACGATGAAATCGGCAGCCGCAGCCTGTCCGGAGGCTACCT
GCGCGAACTGTCGGAAGCGGGCGTCGAGGTCACGGCCTTCAACTCCTCGCGTGGATGGCGTCATCGCTTCCAGATCAATT
TCCGCAACCACCGCAAGATCCTGGTCGTCGATGGACGGGAAGGATGGACGGGCGGCTTCAACGTGGCCGACGAGTACCTG
GGGCGCGTCCCGCGATACGGACCCTGGCGCGATACGCATCTCAAGCTGACCGGCCCGAGCGTGATGGGGTTGCAGGAAGC
CTTCTGGGAGGACTGGTACTGGGCGACCGGCGACATTCTGTCGCTGGAGTGGGAGCCCTCGGTCACCTGTAACGAATGCC
AGCATGTGGTCATCGTCCCCTCGGGCCCCGCGGACCGCTGCGAGACAGCCAGCCTGTTGATCCAGCACGTGATCCACGGG
GCGCACGAGCGCCTTTGGGTGACCAGCCCCTATTTCGTCCCCGACCAGGGGGTGCAGGACGCACTGAAGCTGGCGGCGTT
GCGCGGCGTCGACGTGAGAGTGATGATCCCGGAGCGTCCCGATCATCTGCTGGTCTTTCTCTCGGCCTTTTCTTTCTTGC
CGGAGATGATCCGTCATGGCGTACGGATCTTTCGCTACCAGCCGGGCTTCTTGCATCAGAAAGCGGTGCTGGTCGACGAC
CATACCGCGCTGCTGGGATCGGTCAATCTCGACAATCGCTCGTTTCGGCTCAATTTCGAGATCACTGCCTATATTCCCGA
CGCGGCCTTCGCACACGATGTCGAGACCATGCTGCTGCACGATTTCGAATCATGTCGCGAGGTCACGCTGCAGGAACTCG
ACGACAGGCCTGCATGGCGCAAGCTGGTCTCGCGCGCCGCCTATTTGCTGGCTCCGATACAATGA

Upstream 100 bases:

>100_bases
AGCGCCTGAAGCGTGAGATGATCACTCGTGCCAGGCCCCGCACTCGCGGGGCCTGATTTTTAGCCGCCGAGCGATTGCGA
GGGGCCAGGGAGGCGCCATC

Downstream 100 bases:

>100_bases
GTGAAGCATGACGACGTCGCATCGCCAGGTCCATGTCATCCATCCACCATGCCCGCCGTGATCAGGAGTGCCGGTGAACC
TTGAAACCAAGTGGCTCGAA

Product: cardiolipin synthetase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTSGVIGILIVVIHVLGVLSALMALMSSRTSQGAVAWIVTLLTFPYLAVPIYWIFGRPRFYGYTSARGERDSVLRQVLLR
FRPRLEPYFSRPSHDVARIQAVERLAMMPMSTGNRAELLIDGEATFKSLLAGIDSAREYILVQFFIFRADEIGTLFKQHL
IQQAERGVRVCLLYDEIGSRSLSGGYLRELSEAGVEVTAFNSSRGWRHRFQINFRNHRKILVVDGREGWTGGFNVADEYL
GRVPRYGPWRDTHLKLTGPSVMGLQEAFWEDWYWATGDILSLEWEPSVTCNECQHVVIVPSGPADRCETASLLIQHVIHG
AHERLWVTSPYFVPDQGVQDALKLAALRGVDVRVMIPERPDHLLVFLSAFSFLPEMIRHGVRIFRYQPGFLHQKAVLVDD
HTALLGSVNLDNRSFRLNFEITAYIPDAAFAHDVETMLLHDFESCREVTLQELDDRPAWRKLVSRAAYLLAPIQ

Sequences:

>Translated_474_residues
MTSGVIGILIVVIHVLGVLSALMALMSSRTSQGAVAWIVTLLTFPYLAVPIYWIFGRPRFYGYTSARGERDSVLRQVLLR
FRPRLEPYFSRPSHDVARIQAVERLAMMPMSTGNRAELLIDGEATFKSLLAGIDSAREYILVQFFIFRADEIGTLFKQHL
IQQAERGVRVCLLYDEIGSRSLSGGYLRELSEAGVEVTAFNSSRGWRHRFQINFRNHRKILVVDGREGWTGGFNVADEYL
GRVPRYGPWRDTHLKLTGPSVMGLQEAFWEDWYWATGDILSLEWEPSVTCNECQHVVIVPSGPADRCETASLLIQHVIHG
AHERLWVTSPYFVPDQGVQDALKLAALRGVDVRVMIPERPDHLLVFLSAFSFLPEMIRHGVRIFRYQPGFLHQKAVLVDD
HTALLGSVNLDNRSFRLNFEITAYIPDAAFAHDVETMLLHDFESCREVTLQELDDRPAWRKLVSRAAYLLAPIQ
>Mature_473_residues
TSGVIGILIVVIHVLGVLSALMALMSSRTSQGAVAWIVTLLTFPYLAVPIYWIFGRPRFYGYTSARGERDSVLRQVLLRF
RPRLEPYFSRPSHDVARIQAVERLAMMPMSTGNRAELLIDGEATFKSLLAGIDSAREYILVQFFIFRADEIGTLFKQHLI
QQAERGVRVCLLYDEIGSRSLSGGYLRELSEAGVEVTAFNSSRGWRHRFQINFRNHRKILVVDGREGWTGGFNVADEYLG
RVPRYGPWRDTHLKLTGPSVMGLQEAFWEDWYWATGDILSLEWEPSVTCNECQHVVIVPSGPADRCETASLLIQHVIHGA
HERLWVTSPYFVPDQGVQDALKLAALRGVDVRVMIPERPDHLLVFLSAFSFLPEMIRHGVRIFRYQPGFLHQKAVLVDDH
TALLGSVNLDNRSFRLNFEITAYIPDAAFAHDVETMLLHDFESCREVTLQELDDRPAWRKLVSRAAYLLAPIQ

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=464, Percent_Identity=28.0172413793103, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1787007, Length=367, Percent_Identity=29.1553133514986, Blast_Score=131, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 53883; Mature: 53752

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGVIGILIVVIHVLGVLSALMALMSSRTSQGAVAWIVTLLTFPYLAVPIYWIFGRPRF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCEE
YGYTSARGERDSVLRQVLLRFRPRLEPYFSRPSHDVARIQAVERLAMMPMSTGNRAELLI
EEECCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
DGEATFKSLLAGIDSAREYILVQFFIFRADEIGTLFKQHLIQQAERGVRVCLLYDEIGSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
SLSGGYLRELSEAGVEVTAFNSSRGWRHRFQINFRNHRKILVVDGREGWTGGFNVADEYL
CCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHH
GRVPRYGPWRDTHLKLTGPSVMGLQEAFWEDWYWATGDILSLEWEPSVTCNECQHVVIVP
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCEEEEECCCCCCHHHCCEEEEEE
SGPADRCETASLLIQHVIHGAHERLWVTSPYFVPDQGVQDALKLAALRGVDVRVMIPERP
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCC
DHLLVFLSAFSFLPEMIRHGVRIFRYQPGFLHQKAVLVDDHTALLGSVNLDNRSFRLNFE
CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEE
ITAYIPDAAFAHDVETMLLHDFESCREVTLQELDDRPAWRKLVSRAAYLLAPIQ
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSGVIGILIVVIHVLGVLSALMALMSSRTSQGAVAWIVTLLTFPYLAVPIYWIFGRPRF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCEE
YGYTSARGERDSVLRQVLLRFRPRLEPYFSRPSHDVARIQAVERLAMMPMSTGNRAELLI
EEECCCCCCHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEE
DGEATFKSLLAGIDSAREYILVQFFIFRADEIGTLFKQHLIQQAERGVRVCLLYDEIGSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
SLSGGYLRELSEAGVEVTAFNSSRGWRHRFQINFRNHRKILVVDGREGWTGGFNVADEYL
CCCCHHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHH
GRVPRYGPWRDTHLKLTGPSVMGLQEAFWEDWYWATGDILSLEWEPSVTCNECQHVVIVP
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCEEEEECCCCCCHHHCCEEEEEE
SGPADRCETASLLIQHVIHGAHERLWVTSPYFVPDQGVQDALKLAALRGVDVRVMIPERP
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCC
DHLLVFLSAFSFLPEMIRHGVRIFRYQPGFLHQKAVLVDDHTALLGSVNLDNRSFRLNFE
CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCEEEEEEE
ITAYIPDAAFAHDVETMLLHDFESCREVTLQELDDRPAWRKLVSRAAYLLAPIQ
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]