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The map label for this gene is uvrD [H]

Identifier: 92113735

GI number: 92113735

Start: 1830031

End: 1832220

Strand: Direct

Name: uvrD [H]

Synonym: Csal_1611

Alternate gene names: 92113735

Gene position: 1830031-1832220 (Clockwise)

Preceding gene: 92113734

Following gene: 92113737

Centisome position: 49.51

GC content: 69.45

Gene sequence:

>2190_bases
GTGAGCGAGCCTCCCACGCCCGAACAACGCGCCGTGGTGGGGCACGGCCAGGGACATGCCCGCGTCTCGGCGGTGGCCGG
CGCCGGCAAGACCACCACGCTGGTCCAGCGGGTCCTGCACCTGCTGGCCAGTGGCGTGCCGCCCCAGCGCATTCTGGTGC
TGATGTTCAATCGCGCCGCCCGCGAGGACTTCACGGCCAAGCTGCAGCGCGAGGCGACGGGGCAGCGCCTGCCCGACGTG
CGCACCTTTCACTCCATCGGTCACCGACTGACCCAGACGCTGACGCGCTGGGGATACCTCTCGCCCCGGCAGTTGATCGC
GGCGGACTGGCAGCGCGAGCGCCTTCTGCGCCAGGCGGTGCAGATGAGCCTGGAACAGGCCGATGACAGCCAGCGTCAGG
CGGCGCTGGAAGCCGACCGGCTCGAGACGCTCGCGCAGTTCTGCGAACTCGTCAAGGCCGAGATGCGCACGCCCGAGGAG
CTTCACGAACGCCTCGACTTCGGGGACGACACCCAGCATTTCTGCGAGGCGTACGCGCATTTCGAAACCCTGATCGCCGA
TCACGGCGTGATGACCTACGCCGATCTGCTCTACCGGCCGTTGCGCTGCCTGGAGGCGACGCCCGAGGCGCGCGCCCGCG
TGCAGGGATTTCTCGACCACGTGATCGTCGACGAATACCAGGACATCAACGAAGTACAGCAGCGTCTGCTGGCCATTCTC
GCGGGGAAGCGCGCACAGGTGATGGCGGTCGGCGACGCCAACCAGTGCATCTACGAGTGGCGCGGTGCGCGCCCGGACGC
CATGTTCGAGCGTTTCGGCGCACTGTTCGGCACGGCTCACGACTACCCGTTGTCGTACACCTTCCGGCACGGTCATGTGC
TGGCGCTGGCGGCCAACCATGCGATTCGCGCCAACCGCCGGCGTCCCGATCAGCTGTGTCTCGCGGCGCCGGGCACCCCG
ACGACCCGAGCCGACGTGGCCGTGGGCAATGCGGCGCTGCTCGAGGCGCTGCGCGAATGGCAGCAGGCCGGACGCGCGCT
GAGCGAAACCTGCGTGATGGTGCGCAGTTGGGCCCTGTCGGTCTCCGTGCAGTTGCAGCTGTTGCGCGCGGGGGTCCCGT
TCCGGCTCGCCCGCGAGGACCGCTTCGTCTTTCGTCTGCCGCTGGTGCAGGCGCTGGCCGGTTACCTGGCCCTGGCGCGC
GACGGCAACCGCCTGCACGACCCCGAGCAACTCAACCTGCTGCTGTCGCAACCGACGGTGTTCGTGCCGCGCGAGACGCT
GACCGCGCTGGCCCGGCAGCTGGCGCACACCCAGCAATGGCCCGAACGTCACGACCCGTTGTTGAGCGCCTTGAAGCCCC
TGCAGCGGCGCAATCTCAAGCGGCGCTGGCAGTTGCTCTGCGAATTGCCGCGCCTGGGGCATTGGCCGCCGGCCAAGTTG
CTCGAACACGTCGTGGAAGCTACCGAGGCGGACAAGGCGCTCAAGCGTGCGGCCTCGCGCCGCGCCAAAGCGGAGGATGA
CGTGCGCCTGCTCGATGTGCTGATCGAGCAGGCGGGCGAGCTCGCCAACGATCCCGATGCCTTCATCGAGCTGCTGAGCC
AGCCGGTCGAGGGCCGCGGGGATGGCGTGCTGGTGACCACGGTGCATGGCGCGAAAGGGCTGGAATGGCCCCTGGTCGCC
TTGTGGGGCGTCAACGAAGAGGATTTTCCGCATTACACGCGGGAGACCCCGCTGGATGCCGAGCGTCTCGAGGAAGAGCG
CCGCCTCTACTATGTCGCGATCACGCGGGCGCGCGAGCGCCTGCTGGTGCTCCACGACGGCGGTGATCATCGTCCCAGCC
GCTTCATCGACGAGACTGCCTGGGACGACTGCCACCGCGCCGCCGCCGCGCTCGGCGAGGCGCCGTTTGAGTCGCTGGCG
GTGCGCGCACCGGAGGTGGTGGGGCCTTATCTGGAGCGCTGCGGCGTGCGTCTGCCCGTGACCCGCGTCGAGGAAAGCGC
GACCGCCGCGACCCGCCACTGGGAGGTGGGGCAGTGGGTGCGCCACGGGGTCTTCGGCGAGGGCGAGATCGTGGTGCTCG
AAGGTGATCCCGCCAATCCGGTCATCGAGGTGCGTTTCACCCAGGCCGGCCGCCGACGGCTGATCGCGGCAAGGGCGCCG
CTCGAGCCCGTGGCGGCGCAGGCGAGCTGA

Upstream 100 bases:

>100_bases
TCGAACTTGCCGAGCTTTGCGAAGGTGACGAAGGCACGGCACTGGGGATCTACAGCGACGGCATCTGGCAGCCGCTCGGG
TATCTTCCCGGGGAGCTGCC

Downstream 100 bases:

>100_bases
CAGGCGTCCCGCCGCCGGGCGGCTGGCGAGACGCTATCTCTCGGGCGAGGGCCTACATGTTGGGGTAGTTGGGCCCACCG
CCGCCTTCCGGCGCGACCCA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MSEPPTPEQRAVVGHGQGHARVSAVAGAGKTTTLVQRVLHLLASGVPPQRILVLMFNRAAREDFTAKLQREATGQRLPDV
RTFHSIGHRLTQTLTRWGYLSPRQLIAADWQRERLLRQAVQMSLEQADDSQRQAALEADRLETLAQFCELVKAEMRTPEE
LHERLDFGDDTQHFCEAYAHFETLIADHGVMTYADLLYRPLRCLEATPEARARVQGFLDHVIVDEYQDINEVQQRLLAIL
AGKRAQVMAVGDANQCIYEWRGARPDAMFERFGALFGTAHDYPLSYTFRHGHVLALAANHAIRANRRRPDQLCLAAPGTP
TTRADVAVGNAALLEALREWQQAGRALSETCVMVRSWALSVSVQLQLLRAGVPFRLAREDRFVFRLPLVQALAGYLALAR
DGNRLHDPEQLNLLLSQPTVFVPRETLTALARQLAHTQQWPERHDPLLSALKPLQRRNLKRRWQLLCELPRLGHWPPAKL
LEHVVEATEADKALKRAASRRAKAEDDVRLLDVLIEQAGELANDPDAFIELLSQPVEGRGDGVLVTTVHGAKGLEWPLVA
LWGVNEEDFPHYTRETPLDAERLEEERRLYYVAITRARERLLVLHDGGDHRPSRFIDETAWDDCHRAAAALGEAPFESLA
VRAPEVVGPYLERCGVRLPVTRVEESATAATRHWEVGQWVRHGVFGEGEIVVLEGDPANPVIEVRFTQAGRRRLIAARAP
LEPVAAQAS

Sequences:

>Translated_729_residues
MSEPPTPEQRAVVGHGQGHARVSAVAGAGKTTTLVQRVLHLLASGVPPQRILVLMFNRAAREDFTAKLQREATGQRLPDV
RTFHSIGHRLTQTLTRWGYLSPRQLIAADWQRERLLRQAVQMSLEQADDSQRQAALEADRLETLAQFCELVKAEMRTPEE
LHERLDFGDDTQHFCEAYAHFETLIADHGVMTYADLLYRPLRCLEATPEARARVQGFLDHVIVDEYQDINEVQQRLLAIL
AGKRAQVMAVGDANQCIYEWRGARPDAMFERFGALFGTAHDYPLSYTFRHGHVLALAANHAIRANRRRPDQLCLAAPGTP
TTRADVAVGNAALLEALREWQQAGRALSETCVMVRSWALSVSVQLQLLRAGVPFRLAREDRFVFRLPLVQALAGYLALAR
DGNRLHDPEQLNLLLSQPTVFVPRETLTALARQLAHTQQWPERHDPLLSALKPLQRRNLKRRWQLLCELPRLGHWPPAKL
LEHVVEATEADKALKRAASRRAKAEDDVRLLDVLIEQAGELANDPDAFIELLSQPVEGRGDGVLVTTVHGAKGLEWPLVA
LWGVNEEDFPHYTRETPLDAERLEEERRLYYVAITRARERLLVLHDGGDHRPSRFIDETAWDDCHRAAAALGEAPFESLA
VRAPEVVGPYLERCGVRLPVTRVEESATAATRHWEVGQWVRHGVFGEGEIVVLEGDPANPVIEVRFTQAGRRRLIAARAP
LEPVAAQAS
>Mature_728_residues
SEPPTPEQRAVVGHGQGHARVSAVAGAGKTTTLVQRVLHLLASGVPPQRILVLMFNRAAREDFTAKLQREATGQRLPDVR
TFHSIGHRLTQTLTRWGYLSPRQLIAADWQRERLLRQAVQMSLEQADDSQRQAALEADRLETLAQFCELVKAEMRTPEEL
HERLDFGDDTQHFCEAYAHFETLIADHGVMTYADLLYRPLRCLEATPEARARVQGFLDHVIVDEYQDINEVQQRLLAILA
GKRAQVMAVGDANQCIYEWRGARPDAMFERFGALFGTAHDYPLSYTFRHGHVLALAANHAIRANRRRPDQLCLAAPGTPT
TRADVAVGNAALLEALREWQQAGRALSETCVMVRSWALSVSVQLQLLRAGVPFRLAREDRFVFRLPLVQALAGYLALARD
GNRLHDPEQLNLLLSQPTVFVPRETLTALARQLAHTQQWPERHDPLLSALKPLQRRNLKRRWQLLCELPRLGHWPPAKLL
EHVVEATEADKALKRAASRRAKAEDDVRLLDVLIEQAGELANDPDAFIELLSQPVEGRGDGVLVTTVHGAKGLEWPLVAL
WGVNEEDFPHYTRETPLDAERLEEERRLYYVAITRARERLLVLHDGGDHRPSRFIDETAWDDCHRAAAALGEAPFESLAV
RAPEVVGPYLERCGVRLPVTRVEESATAATRHWEVGQWVRHGVFGEGEIVVLEGDPANPVIEVRFTQAGRRRLIAARAPL
EPVAAQAS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=766, Percent_Identity=28.9817232375979, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI48994965, Length=676, Percent_Identity=24.5562130177515, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81879; Mature: 81748

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPPTPEQRAVVGHGQGHARVSAVAGAGKTTTLVQRVLHLLASGVPPQRILVLMFNRAA
CCCCCCCCCCEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
REDFTAKLQREATGQRLPDVRTFHSIGHRLTQTLTRWGYLSPRQLIAADWQRERLLRQAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QMSLEQADDSQRQAALEADRLETLAQFCELVKAEMRTPEELHERLDFGDDTQHFCEAYAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHH
FETLIADHGVMTYADLLYRPLRCLEATPEARARVQGFLDHVIVDEYQDINEVQQRLLAIL
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGKRAQVMAVGDANQCIYEWRGARPDAMFERFGALFGTAHDYPLSYTFRHGHVLALAANH
CCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCH
AIRANRRRPDQLCLAAPGTPTTRADVAVGNAALLEALREWQQAGRALSETCVMVRSWALS
HHHCCCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVQLQLLRAGVPFRLAREDRFVFRLPLVQALAGYLALARDGNRLHDPEQLNLLLSQPTV
HHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEE
FVPRETLTALARQLAHTQQWPERHDPLLSALKPLQRRNLKRRWQLLCELPRLGHWPPAKL
EECHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEHVVEATEADKALKRAASRRAKAEDDVRLLDVLIEQAGELANDPDAFIELLSQPVEGRG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
DGVLVTTVHGAKGLEWPLVALWGVNEEDFPHYTRETPLDAERLEEERRLYYVAITRARER
CEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEECCCE
LLVLHDGGDHRPSRFIDETAWDDCHRAAAALGEAPFESLAVRAPEVVGPYLERCGVRLPV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCH
TRVEESATAATRHWEVGQWVRHGVFGEGEIVVLEGDPANPVIEVRFTQAGRRRLIAARAP
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHEEHHCCC
LEPVAAQAS
CCCCCCCCC
>Mature Secondary Structure 
SEPPTPEQRAVVGHGQGHARVSAVAGAGKTTTLVQRVLHLLASGVPPQRILVLMFNRAA
CCCCCCCCCEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
REDFTAKLQREATGQRLPDVRTFHSIGHRLTQTLTRWGYLSPRQLIAADWQRERLLRQAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QMSLEQADDSQRQAALEADRLETLAQFCELVKAEMRTPEELHERLDFGDDTQHFCEAYAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHH
FETLIADHGVMTYADLLYRPLRCLEATPEARARVQGFLDHVIVDEYQDINEVQQRLLAIL
HHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGKRAQVMAVGDANQCIYEWRGARPDAMFERFGALFGTAHDYPLSYTFRHGHVLALAANH
CCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCH
AIRANRRRPDQLCLAAPGTPTTRADVAVGNAALLEALREWQQAGRALSETCVMVRSWALS
HHHCCCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVQLQLLRAGVPFRLAREDRFVFRLPLVQALAGYLALARDGNRLHDPEQLNLLLSQPTV
HHHHHHHHHCCCCEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEE
FVPRETLTALARQLAHTQQWPERHDPLLSALKPLQRRNLKRRWQLLCELPRLGHWPPAKL
EECHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEHVVEATEADKALKRAASRRAKAEDDVRLLDVLIEQAGELANDPDAFIELLSQPVEGRG
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
DGVLVTTVHGAKGLEWPLVALWGVNEEDFPHYTRETPLDAERLEEERRLYYVAITRARER
CEEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEECCCE
LLVLHDGGDHRPSRFIDETAWDDCHRAAAALGEAPFESLAVRAPEVVGPYLERCGVRLPV
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCH
TRVEESATAATRHWEVGQWVRHGVFGEGEIVVLEGDPANPVIEVRFTQAGRRRLIAARAP
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHEEHHCCC
LEPVAAQAS
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]