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The map label for this gene is ykkD [H]

Identifier: 92112243

GI number: 92112243

Start: 131604

End: 131924

Strand: Direct

Name: ykkD [H]

Synonym: Csal_0108

Alternate gene names: 92112243

Gene position: 131604-131924 (Clockwise)

Preceding gene: 92112242

Following gene: 92112244

Centisome position: 3.56

GC content: 63.55

Gene sequence:

>321_bases
ATGACCTGGCATTGGTTGGCCCTGTTGGGCGCGGGAATTTTCGAAGTACTCGGGGTCGTCGGTTTCGCGCGGGTGAGTCG
AGGCCGGGCGCTGGCCGGCGGCTTGCTCATGACACTAGGGTTCGGCACGGCGCTCGGCTTCCTGGCCCTGGCCATGCGCG
GCATCGACCTGGGCATCGCCTATGCCGTGTTCACCGGCATCGGGACTGTCTGTGGCACCTTGCTGGGAATGCTATACTGG
GGAGAGTCACGCCATCCCCTGCGAATCGCCTTTACCGCACTGATTGTCCTGGGTGTAGTGGGGCTCAAGCTGCTGGCTTG
A

Upstream 100 bases:

>100_bases
TGATTCTGGTGGGAGTCATCGGCCTGCATCAATTCAGCGGCAAGCCCGCCGCGCCGGCATCGGTCTCGCGTACCGACGCC
TCACGGGAAGGAGTATCGTC

Downstream 100 bases:

>100_bases
GTCACGGCGTTTTCTATCTACCCCATAGACCAAGACTATAAGTGCGATAGCAAGACTATAGTAGGATAATGTTTAGCGGG
CTAATAGAATGTGTCGTGTT

Product: small multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MTWHWLALLGAGIFEVLGVVGFARVSRGRALAGGLLMTLGFGTALGFLALAMRGIDLGIAYAVFTGIGTVCGTLLGMLYW
GESRHPLRIAFTALIVLGVVGLKLLA

Sequences:

>Translated_106_residues
MTWHWLALLGAGIFEVLGVVGFARVSRGRALAGGLLMTLGFGTALGFLALAMRGIDLGIAYAVFTGIGTVCGTLLGMLYW
GESRHPLRIAFTALIVLGVVGLKLLA
>Mature_105_residues
TWHWLALLGAGIFEVLGVVGFARVSRGRALAGGLLMTLGFGTALGFLALAMRGIDLGIAYAVFTGIGTVCGTLLGMLYWG
ESRHPLRIAFTALIVLGVVGLKLLA

Specific function: Part of a multidrug efflux pump. Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. YkkC/ykkD (TC 2.A.7.1.5) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=100, Percent_Identity=40, Blast_Score=68, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11062; Mature: 10930

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWHWLALLGAGIFEVLGVVGFARVSRGRALAGGLLMTLGFGTALGFLALAMRGIDLGIA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVFTGIGTVCGTLLGMLYWGESRHPLRIAFTALIVLGVVGLKLLA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWHWLALLGAGIFEVLGVVGFARVSRGRALAGGLLMTLGFGTALGFLALAMRGIDLGIA
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVFTGIGTVCGTLLGMLYWGESRHPLRIAFTALIVLGVVGLKLLA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8682784; 9384377 [H]