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The map label for this gene is hmp [H]

Identifier: 91789263

GI number: 91789263

Start: 3604454

End: 3605635

Strand: Direct

Name: hmp [H]

Synonym: Bpro_3408

Alternate gene names: 91789263

Gene position: 3604454-3605635 (Clockwise)

Preceding gene: 91789261

Following gene: 91789264

Centisome position: 69.31

GC content: 65.48

Gene sequence:

>1182_bases
ATGCTGACCGCGCAACAACGTGCCATCGTCAAATCCACCGTACCGCTGCTGGAAAGTGGCGGCGAGGCACTGACCACCCA
CTTCTACCAAATCCTGCTGACCGAACATCCCGAAGTGCGCCCCTTCTTCAACCAGGCGCACCAGGCCAACGGTGACCAGC
CCCGGGCGCTGGCCAACGGTGTGCTGATGTACGCCCGCCACATCGACAAGCTGGAGCAGCTGGGCGGGCTGGTGGCGCAA
ATCATCAACAAGCATGTGTCGCTGCAGATCGAGCCGGCGCACTACCCCATCGTCGGCGCCTGCCTGTTGCGCGCGATTCG
CGAAGTGCTGGGTGCGGAGATCGCCACCGGCGAGGTGCTGGCCGCCTGGGGCGCCGCTTACGGGCAACTCGCCGACATCC
TGATCGGCGCCGAAGAGAAAATTTATGCGGAAACGGCCGCTGCGCCGGGCGGCTGGCGCGGTGCGCGCCGTTTTATCGTG
GCGCGCAAGGTCGCCGAAAGCGCGGAAATCACCTCCTTCTACCTGCAGCCCGAAGACGGCGCAGCGCTGGCAGCCTTTCA
ACCGGGCCAGTACCTTGGCCTGAAACTGGTGATCAACGGCGAGGAAATCCGCCGCAACTATTCGCTCTCGGCAGCGCCCA
ACGGCCGCGACTACCGCATCAGCGTGAAACGCGAGCCGGGCGGCGTGGCGTCGTGCTATCTGCATGACGAGTTGCAGGAA
GGCGGCGGGCTGGACGTGTTTCCGCCCGCCGGCGAGTTTGTGCTGGCGGACGGCGACAGGCCGGTAGTGCTGATCAGCGG
CGGCGTCGGCATTACACCGACGCTGGCCATGCTGGACGCCGCACTGGAACGCCAGCGGCCGGTGCACTTCATCCACTTTG
CGCGCAACAAATCGGTCCACGCCTTTCGCGACGCGCTGGCCACGCGGCAAGCCAGGCATGCGCAACTGCGGCACTTTTAC
GTCTATGACGAACATGCCGGCGAAGCCGACGCGCCGCACGCCACCGGTCTCGTCGACAGCGGGCAACTGGCTCAATGGCT
GCCGGCTTCGCGCGATGTGGATGCCTATTTCCTGGGCCCCAAGCCCTTCATGCGCCGGGTCAGGCAACAGCTGCGCGAAC
TGGGCGTGCCTGAATCGCAGACCCGTTACGAGTTTTTTGGCCCGGCCAGCGCGCTGGACTGA

Upstream 100 bases:

>100_bases
GTAGACGAGCTGGCACAAGTATTGAATACAGGGTGTCGGCAATCACCGGCAGGGCTTCGTTTCGCATCGTGCGGGGCGCC
CTGCCCCTACAGGAGAATTC

Downstream 100 bases:

>100_bases
GGCCACGCCGTCGCGAAGCCACGCCGGCGCGTGCATGCCGCCGGCGTGCTGAAACGCGTGTAAATATTCACAAAAAACAC
GATTGCACAGCACTGCAACA

Product: nitric oxide dioxygenase

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MLTAQQRAIVKSTVPLLESGGEALTTHFYQILLTEHPEVRPFFNQAHQANGDQPRALANGVLMYARHIDKLEQLGGLVAQ
IINKHVSLQIEPAHYPIVGACLLRAIREVLGAEIATGEVLAAWGAAYGQLADILIGAEEKIYAETAAAPGGWRGARRFIV
ARKVAESAEITSFYLQPEDGAALAAFQPGQYLGLKLVINGEEIRRNYSLSAAPNGRDYRISVKREPGGVASCYLHDELQE
GGGLDVFPPAGEFVLADGDRPVVLISGGVGITPTLAMLDAALERQRPVHFIHFARNKSVHAFRDALATRQARHAQLRHFY
VYDEHAGEADAPHATGLVDSGQLAQWLPASRDVDAYFLGPKPFMRRVRQQLRELGVPESQTRYEFFGPASALD

Sequences:

>Translated_393_residues
MLTAQQRAIVKSTVPLLESGGEALTTHFYQILLTEHPEVRPFFNQAHQANGDQPRALANGVLMYARHIDKLEQLGGLVAQ
IINKHVSLQIEPAHYPIVGACLLRAIREVLGAEIATGEVLAAWGAAYGQLADILIGAEEKIYAETAAAPGGWRGARRFIV
ARKVAESAEITSFYLQPEDGAALAAFQPGQYLGLKLVINGEEIRRNYSLSAAPNGRDYRISVKREPGGVASCYLHDELQE
GGGLDVFPPAGEFVLADGDRPVVLISGGVGITPTLAMLDAALERQRPVHFIHFARNKSVHAFRDALATRQARHAQLRHFY
VYDEHAGEADAPHATGLVDSGQLAQWLPASRDVDAYFLGPKPFMRRVRQQLRELGVPESQTRYEFFGPASALD
>Mature_393_residues
MLTAQQRAIVKSTVPLLESGGEALTTHFYQILLTEHPEVRPFFNQAHQANGDQPRALANGVLMYARHIDKLEQLGGLVAQ
IINKHVSLQIEPAHYPIVGACLLRAIREVLGAEIATGEVLAAWGAAYGQLADILIGAEEKIYAETAAAPGGWRGARRFIV
ARKVAESAEITSFYLQPEDGAALAAFQPGQYLGLKLVINGEEIRRNYSLSAAPNGRDYRISVKREPGGVASCYLHDELQE
GGGLDVFPPAGEFVLADGDRPVVLISGGVGITPTLAMLDAALERQRPVHFIHFARNKSVHAFRDALATRQARHAQLRHFY
VYDEHAGEADAPHATGLVDSGQLAQWLPASRDVDAYFLGPKPFMRRVRQQLRELGVPESQTRYEFFGPASALD

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=404, Percent_Identity=42.5742574257426, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1787658, Length=217, Percent_Identity=31.3364055299539, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788104, Length=224, Percent_Identity=26.3392857142857, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321673, Length=413, Percent_Identity=35.8353510895884, Blast_Score=216, Evalue=4e-57,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR000951
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 42925; Mature: 42925

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTAQQRAIVKSTVPLLESGGEALTTHFYQILLTEHPEVRPFFNQAHQANGDQPRALANG
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
VLMYARHIDKLEQLGGLVAQIINKHVSLQIEPAHYPIVGACLLRAIREVLGAEIATGEVL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
AAWGAAYGQLADILIGAEEKIYAETAAAPGGWRGARRFIVARKVAESAEITSFYLQPEDG
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCC
AALAAFQPGQYLGLKLVINGEEIRRNYSLSAAPNGRDYRISVKREPGGVASCYLHDELQE
CEEEEECCCCEEEEEEEECHHHHHHCCCEECCCCCCEEEEEEEECCCCEEEEEEEHHHHC
GGGLDVFPPAGEFVLADGDRPVVLISGGVGITPTLAMLDAALERQRPVHFIHFARNKSVH
CCCEECCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHH
AFRDALATRQARHAQLRHFYVYDEHAGEADAPHATGLVDSGQLAQWLPASRDVDAYFLGP
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECC
KPFMRRVRQQLRELGVPESQTRYEFFGPASALD
HHHHHHHHHHHHHCCCCCCCCCEEEECCHHCCC
>Mature Secondary Structure
MLTAQQRAIVKSTVPLLESGGEALTTHFYQILLTEHPEVRPFFNQAHQANGDQPRALANG
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHH
VLMYARHIDKLEQLGGLVAQIINKHVSLQIEPAHYPIVGACLLRAIREVLGAEIATGEVL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHH
AAWGAAYGQLADILIGAEEKIYAETAAAPGGWRGARRFIVARKVAESAEITSFYLQPEDG
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCC
AALAAFQPGQYLGLKLVINGEEIRRNYSLSAAPNGRDYRISVKREPGGVASCYLHDELQE
CEEEEECCCCEEEEEEEECHHHHHHCCCEECCCCCCEEEEEEEECCCCEEEEEEEHHHHC
GGGLDVFPPAGEFVLADGDRPVVLISGGVGITPTLAMLDAALERQRPVHFIHFARNKSVH
CCCEECCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHH
AFRDALATRQARHAQLRHFYVYDEHAGEADAPHATGLVDSGQLAQWLPASRDVDAYFLGP
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECC
KPFMRRVRQQLRELGVPESQTRYEFFGPASALD
HHHHHHHHHHHHHCCCCCCCCCEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12270830 [H]