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The map label for this gene is 91788856

Identifier: 91788856

GI number: 91788856

Start: 3155989

End: 3157266

Strand: Reverse

Name: 91788856

Synonym: Bpro_2996

Alternate gene names: NA

Gene position: 3157266-3155989 (Counterclockwise)

Preceding gene: 91788857

Following gene: 91788855

Centisome position: 60.71

GC content: 64.71

Gene sequence:

>1278_bases
ATGAATGATTCGCTCAATGCCACCCACGACCCGGCGCTTCGCAGCTGGGTGACTTCCGCCAACGCGGCGGACACCGACTT
TCCGATCCAGAATCTGCCCTTCGGCCGTTTTCGGCGCGTCGGCAGCGCTGAAGCCTTTCGCATCGGTGTTGCCATTGGCG
ACCAGGCGCTTGATTTGAAAGCGGCCGGTCTCATCGCCACGGATGACATGAATGTGCTGATGGCCATGGGCGCTGCAGAG
CGCCAGGCCCTGCGCGCAGCGATCTCTGAAGGCCTGCGCGAAGGCAGCCCAAGCCAGTCCGCATGGCTCAGCGCGCTGTT
GCCGCAGGCGGGGCTTGAAATGACCTTGCCTTGCCGTATCGGCGACTACACCGACTTCTACACCGGCATTCATCACGCCA
CCACCGTCGGCAAGCTGTTTCGCCCCGATGCGCCACTGTTGCCCAACTACAAGTGGGTACCGATTGGCTACCACGGCCGT
GCATCGTCCATCGGGGTCAGCGGCCAGTCGTTTCCCCGACCGCTGGGCCAGACCAAAGGCCCCAACGAAGAAGTACCGGT
TTTGCGGCCCAGTCACCGGATGGACTACGAGCTGGAGCTGGGCGTTTTCATGGGGCAGGGCAATGCGCCGGGCGACCGGC
TCACGATGGACCAGGCGGAGGCCCACGCCTTTGGCATGGTGCTGCTCAATGACTGGTCGGCGCGCGATGTGCAGGCCTGG
GAATACCAGCCGCTGGGGCCCTTCCTGGCCAAAAACTTTGCCAGCACCATCTCGCCCTGGATCGTGACGATGGAGGCCCT
GGCGCCTTTTCGTGCGCCCTTCGTGCGGCCCGAGGGTGACCCGCAACCTTTGCCGTACCTCGACTCAGCAGGCAACCGGC
AGCAAGGCGGTATCGACGTGGAACTCGAGGTCTGGCTGCAGACCCTGGCCATGCGCGATGCCGGCCAGGGTCCGGTGCGC
CTGTCGCAGTCGAGCTTTCGCGATGCCTACTGGACAGTGGCGCAAATGATCACGCACCACACCGTGAACGGCTGCAACCT
GCAGCCGGGCGACCTGTTAGGCTCCGGCACGCTGTCGGGCGCCAGGCCCGAGCAGGCTGGCTCGCTGCTGGAACTGAGTT
CGGGCGGAAAGAACCCGCTGACGCTGGCCAATGGGGAAACGCGCACCTTCCTCGAAGACGGTGACTCCATCATCCTGCGC
GGTTACTGCGCGCGCGCCGGTTTCCGTCGTATCGGCTTTGGCGATTGCCAGGGCCGGCTGTTGCCCGCGCGCAGCTAA

Upstream 100 bases:

>100_bases
ACCTCAGCTGCTGGGCGGGCCTCAAGGATCAATTCAAGCCCTGAGTTTTCGCACGGCTCATCACCCCTTTCACGGCGCCC
TGGCGTCAAGGATTTGCACC

Downstream 100 bases:

>100_bases
CTGCCCGCTGATCCTGGCCCGGCGAATGCTATCGAGTTGATAGCGTATGAATCCCGTATCCATTGGGATGAAGGTTTATT
CAATGGACGAGTCTGGCCCT

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNDSLNATHDPALRSWVTSANAADTDFPIQNLPFGRFRRVGSAEAFRIGVAIGDQALDLKAAGLIATDDMNVLMAMGAAE
RQALRAAISEGLREGSPSQSAWLSALLPQAGLEMTLPCRIGDYTDFYTGIHHATTVGKLFRPDAPLLPNYKWVPIGYHGR
ASSIGVSGQSFPRPLGQTKGPNEEVPVLRPSHRMDYELELGVFMGQGNAPGDRLTMDQAEAHAFGMVLLNDWSARDVQAW
EYQPLGPFLAKNFASTISPWIVTMEALAPFRAPFVRPEGDPQPLPYLDSAGNRQQGGIDVELEVWLQTLAMRDAGQGPVR
LSQSSFRDAYWTVAQMITHHTVNGCNLQPGDLLGSGTLSGARPEQAGSLLELSSGGKNPLTLANGETRTFLEDGDSIILR
GYCARAGFRRIGFGDCQGRLLPARS

Sequences:

>Translated_425_residues
MNDSLNATHDPALRSWVTSANAADTDFPIQNLPFGRFRRVGSAEAFRIGVAIGDQALDLKAAGLIATDDMNVLMAMGAAE
RQALRAAISEGLREGSPSQSAWLSALLPQAGLEMTLPCRIGDYTDFYTGIHHATTVGKLFRPDAPLLPNYKWVPIGYHGR
ASSIGVSGQSFPRPLGQTKGPNEEVPVLRPSHRMDYELELGVFMGQGNAPGDRLTMDQAEAHAFGMVLLNDWSARDVQAW
EYQPLGPFLAKNFASTISPWIVTMEALAPFRAPFVRPEGDPQPLPYLDSAGNRQQGGIDVELEVWLQTLAMRDAGQGPVR
LSQSSFRDAYWTVAQMITHHTVNGCNLQPGDLLGSGTLSGARPEQAGSLLELSSGGKNPLTLANGETRTFLEDGDSIILR
GYCARAGFRRIGFGDCQGRLLPARS
>Mature_425_residues
MNDSLNATHDPALRSWVTSANAADTDFPIQNLPFGRFRRVGSAEAFRIGVAIGDQALDLKAAGLIATDDMNVLMAMGAAE
RQALRAAISEGLREGSPSQSAWLSALLPQAGLEMTLPCRIGDYTDFYTGIHHATTVGKLFRPDAPLLPNYKWVPIGYHGR
ASSIGVSGQSFPRPLGQTKGPNEEVPVLRPSHRMDYELELGVFMGQGNAPGDRLTMDQAEAHAFGMVLLNDWSARDVQAW
EYQPLGPFLAKNFASTISPWIVTMEALAPFRAPFVRPEGDPQPLPYLDSAGNRQQGGIDVELEVWLQTLAMRDAGQGPVR
LSQSSFRDAYWTVAQMITHHTVNGCNLQPGDLLGSGTLSGARPEQAGSLLELSSGGKNPLTLANGETRTFLEDGDSIILR
GYCARAGFRRIGFGDCQGRLLPARS

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=423, Percent_Identity=46.3356973995272, Blast_Score=358, Evalue=7e-99,
Organism=Caenorhabditis elegans, GI17568863, Length=421, Percent_Identity=46.3182897862233, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI24657182, Length=417, Percent_Identity=45.083932853717, Blast_Score=342, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45961; Mature: 45961

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSLNATHDPALRSWVTSANAADTDFPIQNLPFGRFRRVGSAEAFRIGVAIGDQALDLK
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCEE
AAGLIATDDMNVLMAMGAAERQALRAAISEGLREGSPSQSAWLSALLPQAGLEMTLPCRI
ECCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECEEC
GDYTDFYTGIHHATTVGKLFRPDAPLLPNYKWVPIGYHGRASSIGVSGQSFPRPLGQTKG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
PNEEVPVLRPSHRMDYELELGVFMGQGNAPGDRLTMDQAEAHAFGMVLLNDWSARDVQAW
CCCCCCEECCCCCCCEEEEEEEEEECCCCCCCCEEHHHHHHHEEEEEEEECCCCCCCCCC
EYQPLGPFLAKNFASTISPWIVTMEALAPFRAPFVRPEGDPQPLPYLDSAGNRQQGGIDV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ELEVWLQTLAMRDAGQGPVRLSQSSFRDAYWTVAQMITHHTVNGCNLQPGDLLGSGTLSG
EHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ARPEQAGSLLELSSGGKNPLTLANGETRTFLEDGDSIILRGYCARAGFRRIGFGDCQGRL
CCHHHCCCEEEECCCCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCE
LPARS
ECCCC
>Mature Secondary Structure
MNDSLNATHDPALRSWVTSANAADTDFPIQNLPFGRFRRVGSAEAFRIGVAIGDQALDLK
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCEE
AAGLIATDDMNVLMAMGAAERQALRAAISEGLREGSPSQSAWLSALLPQAGLEMTLPCRI
ECCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECEEC
GDYTDFYTGIHHATTVGKLFRPDAPLLPNYKWVPIGYHGRASSIGVSGQSFPRPLGQTKG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
PNEEVPVLRPSHRMDYELELGVFMGQGNAPGDRLTMDQAEAHAFGMVLLNDWSARDVQAW
CCCCCCEECCCCCCCEEEEEEEEEECCCCCCCCEEHHHHHHHEEEEEEEECCCCCCCCCC
EYQPLGPFLAKNFASTISPWIVTMEALAPFRAPFVRPEGDPQPLPYLDSAGNRQQGGIDV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ELEVWLQTLAMRDAGQGPVRLSQSSFRDAYWTVAQMITHHTVNGCNLQPGDLLGSGTLSG
EHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ARPEQAGSLLELSSGGKNPLTLANGETRTFLEDGDSIILRGYCARAGFRRIGFGDCQGRL
CCHHHCCCEEEECCCCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCE
LPARS
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA