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The map label for this gene is icd [H]

Identifier: 91788802

GI number: 91788802

Start: 3104732

End: 3105985

Strand: Reverse

Name: icd [H]

Synonym: Bpro_2942

Alternate gene names: 91788802

Gene position: 3105985-3104732 (Counterclockwise)

Preceding gene: 91788805

Following gene: 91788801

Centisome position: 59.73

GC content: 59.57

Gene sequence:

>1254_bases
ATGTACCAGCACATCAAGGTGCCCGCCCAAGGCCAGAAAATCACCGTCAATGCCGACAATTCACTGAATGTGCCTGACGA
GCCGGTCATTCCGTTCATTGAGGGCGACGGTACCGGCGCAGACATTACGCCGGTCATGCTGAAAGTGGTGGATGCAGCCG
TGGCCAAAGCCTACGGCGGCAAGAAGAAGATCCACTGGATGGAAGTGTTTGCAGGTGAGAAGTCCACCAAGGTGTACGGC
CCGGACGTCTGGCTGCCGGAAGAAACGCTGCACGCCGTGCGCGACTACGTGGTGTCCATCAAGGGCCCGCTGACGACCCC
CGTGGGCGGCGGTATCCGCAGCCTGAACGTGGCATTGCGCCAGGAGCTGGACCTGTACGTCTGCCTGCGCCCCATCCAGT
ACTTTGCCGGCGTGCCTTCCCCCGTGAAAGAGCCGCAAAAGACCAACATGGTCATCTTCCGTGAAAACTCGGAAGACATC
TACGCCGGTATCGAGTTCGAATCGGGCAGCGACAAGGCCAAGAAACTCATCAAGTTCCTGCAGGATGAACTGGGCGTCAA
GAAGATCCGCTTCCCCAACACCTCCGGCATCGGCATCAAGCCGGTCTCCAGCGAAGGTACCGAGCGCCTGGTGCGCAAGG
CCATCCAGTACGCGATTGACAATGACAAGCCCAGCGTGACCATCGTTCACAAGGGCAACATCATGAAATTCACCGAAGGC
GGTTTCCGTGACTGGGCCTACGCCCTGGCGCAAAAGGAATTCGGTGCCGAACTGATCGACGGCGGCCCATGGTGCAAGTT
CAAGAACCCGAAGACCGGCAAGGACGTCATCGTCAAGGACAGCATTGCCGACGCCTTCCTGCAGCAAATCCTGCTGCGCC
CGGCCGAGTACAGCGTGATTGCGACGCTGAACCTGAACGGCGACTATGTGTCCGACGCCCTGGCTGCACAGGTCGGCGGT
ATCGGCATTGCCCCCGGCGCCAACCTGAGCGACACCGTGGCCATGTTCGAGGCCACCCACGGTACCGCTCCGAAATATGC
TGGCAAGGACTATGTGAACCCCGGCTCCGAGATCCTGTCCGCAGAAATGATGCTGCGCCACATGGGCTGGACCGAGGCGG
CCGACCTGATCATCAGCTCGATGGAAAAGTCGATTGAATCCAAGAAAGTCACCTACGACTTTGCCCGCCTGATGGAGGGC
GCGACCCAGGTCAGCTGCTCCGGTTTCGGCCAGGTGATGATCGATCACATGTAA

Upstream 100 bases:

>100_bases
GCAATATTGATTTGCGGCTAGAATTTAGGGGTTTTTACCTAACTGCTGAAAGCGGCGTTTTTTGTTGACGCCATCAGCGC
TCACCGGAGACTTCTTAAAC

Downstream 100 bases:

>100_bases
GCCAGCCAGGCTTGCCCCTACCAACCGCCCGGGAGCGATTCCGAGGCGGTTTTTTTTATGGGCGCAGAATAGCCGAATGA
GTCACGATTGAATGTCGCGT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MYQHIKVPAQGQKITVNADNSLNVPDEPVIPFIEGDGTGADITPVMLKVVDAAVAKAYGGKKKIHWMEVFAGEKSTKVYG
PDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFAGVPSPVKEPQKTNMVIFRENSEDI
YAGIEFESGSDKAKKLIKFLQDELGVKKIRFPNTSGIGIKPVSSEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEG
GFRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKDVIVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQVGG
IGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKSIESKKVTYDFARLMEG
ATQVSCSGFGQVMIDHM

Sequences:

>Translated_417_residues
MYQHIKVPAQGQKITVNADNSLNVPDEPVIPFIEGDGTGADITPVMLKVVDAAVAKAYGGKKKIHWMEVFAGEKSTKVYG
PDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFAGVPSPVKEPQKTNMVIFRENSEDI
YAGIEFESGSDKAKKLIKFLQDELGVKKIRFPNTSGIGIKPVSSEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEG
GFRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKDVIVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQVGG
IGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKSIESKKVTYDFARLMEG
ATQVSCSGFGQVMIDHM
>Mature_417_residues
MYQHIKVPAQGQKITVNADNSLNVPDEPVIPFIEGDGTGADITPVMLKVVDAAVAKAYGGKKKIHWMEVFAGEKSTKVYG
PDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFAGVPSPVKEPQKTNMVIFRENSEDI
YAGIEFESGSDKAKKLIKFLQDELGVKKIRFPNTSGIGIKPVSSEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEG
GFRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKDVIVKDSIADAFLQQILLRPAEYSVIATLNLNGDYVSDALAAQVGG
IGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSMEKSIESKKVTYDFARLMEG
ATQVSCSGFGQVMIDHM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=386, Percent_Identity=31.0880829015544, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=26.7045454545455, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=26.7045454545455, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI28178838, Length=304, Percent_Identity=26.9736842105263, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4758582, Length=302, Percent_Identity=26.8211920529801, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=32.0441988950276, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=71.9424460431655, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=26.525198938992, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986051, Length=350, Percent_Identity=31.4285714285714, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=28.8524590163934, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505779, Length=297, Percent_Identity=28.956228956229, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550882, Length=345, Percent_Identity=24.0579710144928, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324709, Length=366, Percent_Identity=29.5081967213115, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=27.2972972972973, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=26.7029972752044, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24643270, Length=383, Percent_Identity=33.6814621409922, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24643268, Length=383, Percent_Identity=33.6814621409922, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=29.0488431876607, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161078635, Length=275, Percent_Identity=29.8181818181818, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI161078637, Length=275, Percent_Identity=29.8181818181818, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI161078633, Length=275, Percent_Identity=29.8181818181818, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24650122, Length=275, Percent_Identity=29.8181818181818, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161078639, Length=275, Percent_Identity=29.8181818181818, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI20130355, Length=390, Percent_Identity=23.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281362242, Length=329, Percent_Identity=27.9635258358663, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648872, Length=329, Percent_Identity=27.9635258358663, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45467; Mature: 45467

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAQGQKITVNADNSLNVPDEPVIPFIEGDGTGADITPVMLKVVDAAVAKAYGG
CCCEEECCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
KKKIHWMEVFAGEKSTKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALR
CCEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHH
QELDLYVCLRPIQYFAGVPSPVKEPQKTNMVIFRENSEDIYAGIEFESGSDKAKKLIKFL
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
QDELGVKKIRFPNTSGIGIKPVSSEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEG
HHHCCCEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCC
GFRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKDVIVKDSIADAFLQQILLRPAEYSVI
CHHHHHHHHHHHHHCCHHHCCCCCEECCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEE
ATLNLNGDYVSDALAAQVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSEILS
EEEECCCCHHHHHHHHHHCCEECCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCHHHHH
AEMMLRHMGWTEAADLIISSMEKSIESKKVTYDFARLMEGATQVSCSGFGQVMIDHM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC
>Mature Secondary Structure
MYQHIKVPAQGQKITVNADNSLNVPDEPVIPFIEGDGTGADITPVMLKVVDAAVAKAYGG
CCCEEECCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
KKKIHWMEVFAGEKSTKVYGPDVWLPEETLHAVRDYVVSIKGPLTTPVGGGIRSLNVALR
CCEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHH
QELDLYVCLRPIQYFAGVPSPVKEPQKTNMVIFRENSEDIYAGIEFESGSDKAKKLIKFL
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
QDELGVKKIRFPNTSGIGIKPVSSEGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEG
HHHCCCEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCC
GFRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKDVIVKDSIADAFLQQILLRPAEYSVI
CHHHHHHHHHHHHHCCHHHCCCCCEECCCCCCCCCEEEEHHHHHHHHHHHHCCCCCEEEE
ATLNLNGDYVSDALAAQVGGIGIAPGANLSDTVAMFEATHGTAPKYAGKDYVNPGSEILS
EEEECCCCHHHHHHHHHHCCEECCCCCCCCHHHHEEECCCCCCCCCCCCCCCCCCHHHHH
AEMMLRHMGWTEAADLIISSMEKSIESKKVTYDFARLMEGATQVSCSGFGQVMIDHM
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]