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The map label for this gene is mutY [H]

Identifier: 91787195

GI number: 91787195

Start: 1342705

End: 1343778

Strand: Direct

Name: mutY [H]

Synonym: Bpro_1299

Alternate gene names: 91787195

Gene position: 1342705-1343778 (Clockwise)

Preceding gene: 91787194

Following gene: 91787199

Centisome position: 25.82

GC content: 64.53

Gene sequence:

>1074_bases
GTGCCATCGACCCTGGTAGGGTTTTCCGGTGAAATCGTGCGCTGGCAGGCCACGCATGGGCGCAATAGCCTGCCCTGGCA
AAACACGCGCGACCCCTACCGCGTGTGGCTGTCGGAGATCATGCTCCAGCAGACCCAGGTCGCGACCGTGCTCGACTACT
ACGCCCGGTTTTTGCAGCATTTCCCCGCAGTCAGCGACCTGGCCGCTGCCTCGCAGGATGAGGTGCTGGCCTTGTGGAGC
GGCCTGGGCTACTACAGCCGGGCGCGCAACCTGCACCGGTGCGCACAGGACGTCATGCTGCTGCATGCGGGGCAGTTTCC
GCGTACCGCCGAACAGCTTCAGACCTTGCCAGGTATAGGCCGTTCGACCGCAGCTGCCATTGCGTCATTCTGTTTTGGAG
AGCGCGTCGCGATTCTGGATGGCAACGTCAAACGGGTGCTCACGCGGGTGCTCGGTTTTTCGGCGGATCTTGCGCAAAGC
GCCAATGAACGTGCGCTGTGGGATATGGCGACCAACTTGTTGCCCACACAGGATTTGCCGGACAGCATGCCGCGTTACAC
GCAAGGGCTGATGGATCTGGGCGCCACGATTTGCGCTGGCCGGCAGCCGCAGTGCCTGCTGTGCCCGGTGCAGAATCTGT
GCGGCGGCCGTGCGAGCGGTGAGCCCGAAAAATACCCCGTCAAGACGCGAACGCTCAAGCGCAGTTCGCGGGCGCTGAGC
CTGCTATGGGCGCAGAGGCCGGACGGCTCGGTCTGGCTTGAAAAGCGCCCTGCGTCGGGCATCTGGGGCGGGCTGTATTG
CCTGCCGGTTTTTGACAGCGAGGACGCGCTGAAGGATTTTTTGCCACCCAGCGTGCACGGCCGGCTGGAGCCTCTGCCGC
ATTTTGTTCATGTGCTGACGCACAGGGATTTGCATCTGGCCCCGTGGATCGCGGGCTTCCGGGCGGGCCAGGCCATGCCG
AAAGCGATGGATGCGGGGGCGCGTGCCGGTGCGTGGTTTGGCCCGGCGCAATGGCCGGGTTTGGGCTTGCCTGCGCCCAT
CCGCAAACTGCTGCTGCAGGATGCACCGGCGTGA

Upstream 100 bases:

>100_bases
GACCCGTGGTCCCTCACCGCTGATGAAGGCCGCAGGCGTTACGCGCAAAGGCCGGCCGACGAATCCGCCTGCTCGTGAGC
CACGCGGGAATCCGGACGTT

Downstream 100 bases:

>100_bases
GCGGGATTTTGGCGATGTACCGGACCGTTGCTGCCTGATCAGCCGGCATCCAGTTCGCGGTGCCGTTTCAGGGTGGGCCA
CTGCCTGCCAAACGACTCGG

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MPSTLVGFSGEIVRWQATHGRNSLPWQNTRDPYRVWLSEIMLQQTQVATVLDYYARFLQHFPAVSDLAAASQDEVLALWS
GLGYYSRARNLHRCAQDVMLLHAGQFPRTAEQLQTLPGIGRSTAAAIASFCFGERVAILDGNVKRVLTRVLGFSADLAQS
ANERALWDMATNLLPTQDLPDSMPRYTQGLMDLGATICAGRQPQCLLCPVQNLCGGRASGEPEKYPVKTRTLKRSSRALS
LLWAQRPDGSVWLEKRPASGIWGGLYCLPVFDSEDALKDFLPPSVHGRLEPLPHFVHVLTHRDLHLAPWIAGFRAGQAMP
KAMDAGARAGAWFGPAQWPGLGLPAPIRKLLLQDAPA

Sequences:

>Translated_357_residues
MPSTLVGFSGEIVRWQATHGRNSLPWQNTRDPYRVWLSEIMLQQTQVATVLDYYARFLQHFPAVSDLAAASQDEVLALWS
GLGYYSRARNLHRCAQDVMLLHAGQFPRTAEQLQTLPGIGRSTAAAIASFCFGERVAILDGNVKRVLTRVLGFSADLAQS
ANERALWDMATNLLPTQDLPDSMPRYTQGLMDLGATICAGRQPQCLLCPVQNLCGGRASGEPEKYPVKTRTLKRSSRALS
LLWAQRPDGSVWLEKRPASGIWGGLYCLPVFDSEDALKDFLPPSVHGRLEPLPHFVHVLTHRDLHLAPWIAGFRAGQAMP
KAMDAGARAGAWFGPAQWPGLGLPAPIRKLLLQDAPA
>Mature_356_residues
PSTLVGFSGEIVRWQATHGRNSLPWQNTRDPYRVWLSEIMLQQTQVATVLDYYARFLQHFPAVSDLAAASQDEVLALWSG
LGYYSRARNLHRCAQDVMLLHAGQFPRTAEQLQTLPGIGRSTAAAIASFCFGERVAILDGNVKRVLTRVLGFSADLAQSA
NERALWDMATNLLPTQDLPDSMPRYTQGLMDLGATICAGRQPQCLLCPVQNLCGGRASGEPEKYPVKTRTLKRSSRALSL
LWAQRPDGSVWLEKRPASGIWGGLYCLPVFDSEDALKDFLPPSVHGRLEPLPHFVHVLTHRDLHLAPWIAGFRAGQAMPK
AMDAGARAGAWFGPAQWPGLGLPAPIRKLLLQDAPA

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI6912520, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI190358497, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298654, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298652, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI115298650, Length=231, Percent_Identity=43.7229437229437, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1789331, Length=349, Percent_Identity=44.4126074498567, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39297; Mature: 39165

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTLVGFSGEIVRWQATHGRNSLPWQNTRDPYRVWLSEIMLQQTQVATVLDYYARFLQH
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPAVSDLAAASQDEVLALWSGLGYYSRARNLHRCAQDVMLLHAGQFPRTAEQLQTLPGIG
CCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
RSTAAAIASFCFGERVAILDGNVKRVLTRVLGFSADLAQSANERALWDMATNLLPTQDLP
HHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCCC
DSMPRYTQGLMDLGATICAGRQPQCLLCPVQNLCGGRASGEPEKYPVKTRTLKRSSRALS
CHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLWAQRPDGSVWLEKRPASGIWGGLYCLPVFDSEDALKDFLPPSVHGRLEPLPHFVHVLT
HHEEECCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHH
HRDLHLAPWIAGFRAGQAMPKAMDAGARAGAWFGPAQWPGLGLPAPIRKLLLQDAPA
CCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
PSTLVGFSGEIVRWQATHGRNSLPWQNTRDPYRVWLSEIMLQQTQVATVLDYYARFLQH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPAVSDLAAASQDEVLALWSGLGYYSRARNLHRCAQDVMLLHAGQFPRTAEQLQTLPGIG
CCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
RSTAAAIASFCFGERVAILDGNVKRVLTRVLGFSADLAQSANERALWDMATNLLPTQDLP
HHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCCC
DSMPRYTQGLMDLGATICAGRQPQCLLCPVQNLCGGRASGEPEKYPVKTRTLKRSSRALS
CHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
LLWAQRPDGSVWLEKRPASGIWGGLYCLPVFDSEDALKDFLPPSVHGRLEPLPHFVHVLT
HHEEECCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHHHH
HRDLHLAPWIAGFRAGQAMPKAMDAGARAGAWFGPAQWPGLGLPAPIRKLLLQDAPA
CCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]