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The map label for this gene is catF [H]

Identifier: 91787128

GI number: 91787128

Start: 1276523

End: 1277725

Strand: Direct

Name: catF [H]

Synonym: Bpro_1231

Alternate gene names: 91787128

Gene position: 1276523-1277725 (Clockwise)

Preceding gene: 91787127

Following gene: 91787129

Centisome position: 24.55

GC content: 67.25

Gene sequence:

>1203_bases
ATGAACCAGGCTTTTATCTGCGATGCCATTCGCACCCCCTTCGGCCGCTACGGCGGCGCCTTGAGCAGCGTGCGTGCTGA
TGACCTTGGCGCGATTCCGCTCAAGGCCCTGATGGCGCGCAACTCCAACGTCGACTGGCAACTGGTGAGCGACGTGATCT
TCGGCTGCGCCAACCAGGCCGGCGAAGACAACCGCAACGTGGCGCGCATGTCCAGCCTGCTGGCCGGCCTGCCGCTGGAG
CTGCCCGGCGCCACCATCAACCGCCTGTGCGGCTCCGGCCTGGACGCCCTGGGCACGGCCGCCCGCGCCATCAAGTCGGG
CGAGGCCCAACTGATGATCGCCGGAGGCGTCGAAAGCATGAGCCGCGCACCGTTCGTCATGCCCAAAGCCGAAAGCGCCT
TCAGCCGCGCCAACGCTGTGTATGACACCACCATAGGCTGGCGCTTCGTCAACAAGCTGATGAAGGAAAAGTACGGCGTC
GACGCCATGCCCGAAACCGCCGAGAACGTGGCCACCGACTACAAGATCAGCCGCGAAGACCAGGACAAGATGGCCCTGGC
CAGCCAGCTCAAGGCCGTGGCGGCCCAAAAAGCAGGCTACTTCGATGCCGAAATCACGCCCGTGACGATCGCGCAGAAAA
AGGGCGATCCCATCATCGTGAACAAGGACGAGCATCCGCGCGAGACCTCGATGGAAACGCTGGCCCGGCTCAAGGGCGTG
GTGCGTCCCGATGGCTCCGTTACCGCCGGCAATGCCAGCGGCGTCAACGACGGCGCCTGCGCGCTGCTGCTCGCCGATGA
GGCCAGCGCGGCCAAGAACGGCCTGACGCCCAGGGCCCGCATCGTCGGCATGGCCACGGCGGGCGTGGCGCCGCGCATCA
TGGGCATAGGCCCCGCGCCGGCCACGCAAAAAGTGCTGGCGCTCACCGGCCTGACGCTGGCGCAGATGGACGTGATCGAG
CTCAACGAAGCCTTTGCCGCGCAGGGCCTGGCGGTGCTGCGCCTGCTCGGCGTGCGTGATGACGACCCGCGCGTCAACCC
CAATGGCGGCGCCATTGCGCTGGGCCACCCGCTGGGCGCCAGCGGTGCCCGCCTGGCCACCACGGCGGTCAACCAGCTGC
ACAAGGGCGGCGGGCGCTATGCGCTGTGCACCATGTGCATTGGCGTGGGGCAGGGCATTGCGGTGATTCTTGAGCGGGTT
TGA

Upstream 100 bases:

>100_bases
CCGATAGCCGTTTAATTTTTTAATTAACCAATCCGTTCGGGCTTGAAGGGCTCAGGTCCTGCTCAGGTCCTGTATTGAAC
GGAAATTCAGGAGACATTTC

Downstream 100 bases:

>100_bases
TCGACTTGCCCTTGGGCCGTCATTGAGCAGCCAATGAGCTGCCATGTCACTGTTTGATTTGCTATTTATTTAATAGCAAT
CTGCGCATTTCTCTTTCTAT

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNQAFICDAIRTPFGRYGGALSSVRADDLGAIPLKALMARNSNVDWQLVSDVIFGCANQAGEDNRNVARMSSLLAGLPLE
LPGATINRLCGSGLDALGTAARAIKSGEAQLMIAGGVESMSRAPFVMPKAESAFSRANAVYDTTIGWRFVNKLMKEKYGV
DAMPETAENVATDYKISREDQDKMALASQLKAVAAQKAGYFDAEITPVTIAQKKGDPIIVNKDEHPRETSMETLARLKGV
VRPDGSVTAGNASGVNDGACALLLADEASAAKNGLTPRARIVGMATAGVAPRIMGIGPAPATQKVLALTGLTLAQMDVIE
LNEAFAAQGLAVLRLLGVRDDDPRVNPNGGAIALGHPLGASGARLATTAVNQLHKGGGRYALCTMCIGVGQGIAVILERV

Sequences:

>Translated_400_residues
MNQAFICDAIRTPFGRYGGALSSVRADDLGAIPLKALMARNSNVDWQLVSDVIFGCANQAGEDNRNVARMSSLLAGLPLE
LPGATINRLCGSGLDALGTAARAIKSGEAQLMIAGGVESMSRAPFVMPKAESAFSRANAVYDTTIGWRFVNKLMKEKYGV
DAMPETAENVATDYKISREDQDKMALASQLKAVAAQKAGYFDAEITPVTIAQKKGDPIIVNKDEHPRETSMETLARLKGV
VRPDGSVTAGNASGVNDGACALLLADEASAAKNGLTPRARIVGMATAGVAPRIMGIGPAPATQKVLALTGLTLAQMDVIE
LNEAFAAQGLAVLRLLGVRDDDPRVNPNGGAIALGHPLGASGARLATTAVNQLHKGGGRYALCTMCIGVGQGIAVILERV
>Mature_400_residues
MNQAFICDAIRTPFGRYGGALSSVRADDLGAIPLKALMARNSNVDWQLVSDVIFGCANQAGEDNRNVARMSSLLAGLPLE
LPGATINRLCGSGLDALGTAARAIKSGEAQLMIAGGVESMSRAPFVMPKAESAFSRANAVYDTTIGWRFVNKLMKEKYGV
DAMPETAENVATDYKISREDQDKMALASQLKAVAAQKAGYFDAEITPVTIAQKKGDPIIVNKDEHPRETSMETLARLKGV
VRPDGSVTAGNASGVNDGACALLLADEASAAKNGLTPRARIVGMATAGVAPRIMGIGPAPATQKVLALTGLTLAQMDVIE
LNEAFAAQGLAVLRLLGVRDDDPRVNPNGGAIALGHPLGASGARLATTAVNQLHKGGGRYALCTMCIGVGQGIAVILERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=44.25, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI148539872, Length=398, Percent_Identity=41.4572864321608, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=40.2010050251256, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=34.320987654321, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=33.0232558139535, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.4347826086957, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=68.3291770573566, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=47.1464019851117, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=45.3865336658354, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=42.962962962963, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=31.1475409836066, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=43.3915211970075, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25147385, Length=405, Percent_Identity=33.5802469135802, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=33.6609336609337, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.8604651162791, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=28, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=37.1571072319202, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=36.9346733668342, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=44.8877805486284, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17648125, Length=406, Percent_Identity=41.1330049261084, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=33.2506203473945, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.7647058823529, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 41638; Mature: 41638

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAFICDAIRTPFGRYGGALSSVRADDLGAIPLKALMARNSNVDWQLVSDVIFGCANQA
CCCCEEHHHHHCCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
GEDNRNVARMSSLLAGLPLELPGATINRLCGSGLDALGTAARAIKSGEAQLMIAGGVESM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPFVMPKAESAFSRANAVYDTTIGWRFVNKLMKEKYGVDAMPETAENVATDYKISRED
CCCCEECCCCHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEECCCC
QDKMALASQLKAVAAQKAGYFDAEITPVTIAQKKGDPIIVNKDEHPRETSMETLARLKGV
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCC
VRPDGSVTAGNASGVNDGACALLLADEASAAKNGLTPRARIVGMATAGVAPRIMGIGPAP
CCCCCCEECCCCCCCCCCEEEEEEECCHHHHHCCCCCCHHEEEEECCCCCCCEEECCCCC
ATQKVLALTGLTLAQMDVIELNEAFAAQGLAVLRLLGVRDDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLATTAVNQLHKGGGRYALCTMCIGVGQGIAVILERV
CCCHHHHHHHHHHHHCCCCEEHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MNQAFICDAIRTPFGRYGGALSSVRADDLGAIPLKALMARNSNVDWQLVSDVIFGCANQA
CCCCEEHHHHHCCHHHHCCHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
GEDNRNVARMSSLLAGLPLELPGATINRLCGSGLDALGTAARAIKSGEAQLMIAGGVESM
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPFVMPKAESAFSRANAVYDTTIGWRFVNKLMKEKYGVDAMPETAENVATDYKISRED
CCCCEECCCCHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEECCCC
QDKMALASQLKAVAAQKAGYFDAEITPVTIAQKKGDPIIVNKDEHPRETSMETLARLKGV
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCC
VRPDGSVTAGNASGVNDGACALLLADEASAAKNGLTPRARIVGMATAGVAPRIMGIGPAP
CCCCCCEECCCCCCCCCCEEEEEEECCHHHHHCCCCCCHHEEEEECCCCCCCEEECCCCC
ATQKVLALTGLTLAQMDVIELNEAFAAQGLAVLRLLGVRDDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLATTAVNQLHKGGGRYALCTMCIGVGQGIAVILERV
CCCHHHHHHHHHHHHCCCCEEHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]