Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 91787081

GI number: 91787081

Start: 1223570

End: 1224760

Strand: Direct

Name: macA [H]

Synonym: Bpro_1184

Alternate gene names: 91787081

Gene position: 1223570-1224760 (Clockwise)

Preceding gene: 91787080

Following gene: 91787082

Centisome position: 23.53

GC content: 68.01

Gene sequence:

>1191_bases
ATGAGGCTGCCCTTCACCTTGCCCAGATGGGTCTGGTTGACAGCTGCCGGGGTGGCGGTGCTACTGGCCTTCGGCTGGGT
GGCCACGGCAAGTGGGCCGCTCGCGCCGATCAAGGTGACTGTGACCCAGGTGGCCACGGGGACGGTGGCGCCGTCGCTGT
TCGGCATTGGCACGGTCGAGGCGAGACGCGCGTATCTCATTGGGCCGACCACAGCCGGTCGGGTCAAGCGCGTGCTGGTC
GACGTGGGCGACAGGGTGAGGGCCGGCCAGTTGCTGGCAGAAATGGATCCGGTGGATCTGGATGCGCGGGTTGGCTCGTC
GGCTGCGGCGGCGGCCCGCGCCCAAAGTGCGGTGGCGACAGCGCAGGCCCAGGTGCGCGATGCGCAGAGCCGCCAGGCCT
TGGCCGCCGGTGAGGCGCGGCGCTACATCGACCTCGGAAAACAGAACTTCATTAGCCCGAGCGTCGTGGAGGGCAAGCTG
CAGCAACAACAATCGGCCGATGCCCAGCTGGTCGCCGCCCGATCGGTTCAGACGAGCGCCCGGCAGGACGTGAGCCGTCT
GGAGGCCGAGCGTGAGGGGGCGCGACAGCAACGCGGGAATATCCGCCTGGAGGCACCGATTGACGGGGTGGTGACATCAC
GCGATGCGGAGCCGGGCTCCACAGTCGTGGCGGGTCAGGCGGTACTCAAGCTGATCGACCCCGCCAGCCTGTGGGTAACG
ACGCGGCTGGACCAGAGTCGATCCGCGGGATTGCATGAGGGGCTGCCCGCCGAAATCACGCTGCGGTCCAGCGCGCAAGG
GAGCGTGCCTGGCAAGGTAGTGCGGCTTGAGCTCGTCAGCGACAGCGTCACCGAGGAGCGGATTGCGCGGGTGACGTTCG
AGAGGCTGCCTGCTGGCGTGTCGACCGGCGAAATGGCCGAGGTTATCGTCCGACTGCCTCCCGTGCGCGACGCGTTGTTG
ATCCCCAATGCGGCGCTGCGCCAGCGTGGCGCCCGGGCGGGGGTGTGGCTGCATGACGATGGCAAGCTGCGCTTCGTCAG
CGTCAAGACGGGCGCTGAAGGCCCGGACGGCATGGTGCAGATCATCGATGGCCTGAAGGCCGGCAACGAGGTGGTGGTCT
ACAGCGGGCGCGAACTGGAGGCCGGCAGTCGAATCAAGGTCGTGCCCTCGCTGGTCGAGGCTGCAAAGTGA

Upstream 100 bases:

>100_bases
AGAGGCGCGTTCGAATCATGCGTGAACGGCTGGACAAGTCCCCATCGCAGCCGGTCCGGCTGGCGATATCGTCTGTGGTG
CAACGATTGAGAGAAACACA

Downstream 100 bases:

>100_bases
TCAGCCTGGCCGGCCGCGACATCCTGCACGCTTGGGGAAAGTTCGTTCTCACGGGCTTTGGGTTGGGGTTGCTGATCGGC
GTCACACTGACCTTTGCCGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MRLPFTLPRWVWLTAAGVAVLLAFGWVATASGPLAPIKVTVTQVATGTVAPSLFGIGTVEARRAYLIGPTTAGRVKRVLV
DVGDRVRAGQLLAEMDPVDLDARVGSSAAAAARAQSAVATAQAQVRDAQSRQALAAGEARRYIDLGKQNFISPSVVEGKL
QQQQSADAQLVAARSVQTSARQDVSRLEAEREGARQQRGNIRLEAPIDGVVTSRDAEPGSTVVAGQAVLKLIDPASLWVT
TRLDQSRSAGLHEGLPAEITLRSSAQGSVPGKVVRLELVSDSVTEERIARVTFERLPAGVSTGEMAEVIVRLPPVRDALL
IPNAALRQRGARAGVWLHDDGKLRFVSVKTGAEGPDGMVQIIDGLKAGNEVVVYSGRELEAGSRIKVVPSLVEAAK

Sequences:

>Translated_396_residues
MRLPFTLPRWVWLTAAGVAVLLAFGWVATASGPLAPIKVTVTQVATGTVAPSLFGIGTVEARRAYLIGPTTAGRVKRVLV
DVGDRVRAGQLLAEMDPVDLDARVGSSAAAAARAQSAVATAQAQVRDAQSRQALAAGEARRYIDLGKQNFISPSVVEGKL
QQQQSADAQLVAARSVQTSARQDVSRLEAEREGARQQRGNIRLEAPIDGVVTSRDAEPGSTVVAGQAVLKLIDPASLWVT
TRLDQSRSAGLHEGLPAEITLRSSAQGSVPGKVVRLELVSDSVTEERIARVTFERLPAGVSTGEMAEVIVRLPPVRDALL
IPNAALRQRGARAGVWLHDDGKLRFVSVKTGAEGPDGMVQIIDGLKAGNEVVVYSGRELEAGSRIKVVPSLVEAAK
>Mature_396_residues
MRLPFTLPRWVWLTAAGVAVLLAFGWVATASGPLAPIKVTVTQVATGTVAPSLFGIGTVEARRAYLIGPTTAGRVKRVLV
DVGDRVRAGQLLAEMDPVDLDARVGSSAAAAARAQSAVATAQAQVRDAQSRQALAAGEARRYIDLGKQNFISPSVVEGKL
QQQQSADAQLVAARSVQTSARQDVSRLEAEREGARQQRGNIRLEAPIDGVVTSRDAEPGSTVVAGQAVLKLIDPASLWVT
TRLDQSRSAGLHEGLPAEITLRSSAQGSVPGKVVRLELVSDSVTEERIARVTFERLPAGVSTGEMAEVIVRLPPVRDALL
IPNAALRQRGARAGVWLHDDGKLRFVSVKTGAEGPDGMVQIIDGLKAGNEVVVYSGRELEAGSRIKVVPSLVEAAK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=340, Percent_Identity=27.6470588235294, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082036, Length=374, Percent_Identity=25.9358288770053, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789041, Length=345, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41793; Mature: 41793

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPFTLPRWVWLTAAGVAVLLAFGWVATASGPLAPIKVTVTQVATGTVAPSLFGIGTVE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHCCCCCC
ARRAYLIGPTTAGRVKRVLVDVGDRVRAGQLLAEMDPVDLDARVGSSAAAAARAQSAVAT
CCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHH
AQAQVRDAQSRQALAAGEARRYIDLGKQNFISPSVVEGKLQQQQSADAQLVAARSVQTSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHEEHHHHHHHHH
RQDVSRLEAEREGARQQRGNIRLEAPIDGVVTSRDAEPGSTVVAGQAVLKLIDPASLWVT
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCEEEE
TRLDQSRSAGLHEGLPAEITLRSSAQGSVPGKVVRLELVSDSVTEERIARVTFERLPAGV
EECCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCC
STGEMAEVIVRLPPVRDALLIPNAALRQRGARAGVWLHDDGKLRFVSVKTGAEGPDGMVQ
CCCHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCHHHH
IIDGLKAGNEVVVYSGRELEAGSRIKVVPSLVEAAK
HHHHHCCCCEEEEEECCEECCCCEEEEHHHHHHHCC
>Mature Secondary Structure
MRLPFTLPRWVWLTAAGVAVLLAFGWVATASGPLAPIKVTVTQVATGTVAPSLFGIGTVE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHCCCCCC
ARRAYLIGPTTAGRVKRVLVDVGDRVRAGQLLAEMDPVDLDARVGSSAAAAARAQSAVAT
CCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHH
AQAQVRDAQSRQALAAGEARRYIDLGKQNFISPSVVEGKLQQQQSADAQLVAARSVQTSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHEEHHHHHHHHH
RQDVSRLEAEREGARQQRGNIRLEAPIDGVVTSRDAEPGSTVVAGQAVLKLIDPASLWVT
HHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCEEEE
TRLDQSRSAGLHEGLPAEITLRSSAQGSVPGKVVRLELVSDSVTEERIARVTFERLPAGV
EECCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCC
STGEMAEVIVRLPPVRDALLIPNAALRQRGARAGVWLHDDGKLRFVSVKTGAEGPDGMVQ
CCCHHHHHHHCCCCCCCEEECCCHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCHHHH
IIDGLKAGNEVVVYSGRELEAGSRIKVVPSLVEAAK
HHHHHCCCCEEEEEECCEECCCCEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]