Click here to switch to the map view.

The map label for this gene is hutC [H]

Identifier: 91787062

GI number: 91787062

Start: 1208040

End: 1208750

Strand: Direct

Name: hutC [H]

Synonym: Bpro_1165

Alternate gene names: 91787062

Gene position: 1208040-1208750 (Clockwise)

Preceding gene: 91787056

Following gene: 91787063

Centisome position: 23.23

GC content: 63.01

Gene sequence:

>711_bases
ATGGCAACCACTCCGCTGCCTGCTTATGGGCAGGTCAAGGCATTCATCAAAACGCGCATCAGTGCCGGCACCTGGAGGCC
CGGTGATCCGGTGCCCAGCGAGGCCGTGCTGATGGCGCAATTTGGCGTCAGCCGCATGACGGTCAACCGTGCGCTGCGCG
AGCTGATGGGCGAGGGCCTGGTCACGCGAATCCAGGGCTCGGGAACCTTTGTGGCTGAGCTGCACCGCATTTCTTCCACG
CTGACCATTCGTGATATTCATGAGGAAGTCATTGAGCGGGGCCACACCCATAGCTCGCGGGTGTTGCGGGCGGAGTCCGA
AAAAGCCAGCGCCGACGTGGCGCGCACCCTGGGCCTGCGCACGGGCGGGCGTGTGTTCCACACCATATTGATTCATCTGG
AAAACGGTGTGCCCATCCAGTACGAAGACCGCTATGTCAACCCGGCGGCGGCACCCAACTACCTGAAGACCGACTTCACG
CAGACCACGCCCACCTACCACCTGCTGGAAGAAGCGCCGCTCACCGAAGCCAGCTATTCGATCGAGGCCTGCCTGCCGAC
AGCACTGGAGGCCAGGCACCTCGATATCAAGCCAGGCGAAGCCTGTCTGGCGATGATGCGCCGCACCGTGAGCGGCGCCC
ACATTGCCAGCGTGGCACGGCTGGTGTACCCCGGTTCGCGCTACAGCTTTGCCGGAAAGTTCCAGGCATGA

Upstream 100 bases:

>100_bases
TCGTAGTTGTCTATACAACTTGTGTCAACTGGAGTAATCTACGGCCTGCGACAGCGCCTTTTAGAGGGCGCCAATTGTTT
TTTCTTACTTCGGCATAAAA

Downstream 100 bases:

>100_bases
GACCGCCGCCGCGGCGTCAAACTGTATTTGAGGAAGCAGTGAAATGAGCGGGGCGAGTGACCTTGTCAGTATCAATGATC
AATGGAGTCAGTGAGATGAA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MATTPLPAYGQVKAFIKTRISAGTWRPGDPVPSEAVLMAQFGVSRMTVNRALRELMGEGLVTRIQGSGTFVAELHRISST
LTIRDIHEEVIERGHTHSSRVLRAESEKASADVARTLGLRTGGRVFHTILIHLENGVPIQYEDRYVNPAAAPNYLKTDFT
QTTPTYHLLEEAPLTEASYSIEACLPTALEARHLDIKPGEACLAMMRRTVSGAHIASVARLVYPGSRYSFAGKFQA

Sequences:

>Translated_236_residues
MATTPLPAYGQVKAFIKTRISAGTWRPGDPVPSEAVLMAQFGVSRMTVNRALRELMGEGLVTRIQGSGTFVAELHRISST
LTIRDIHEEVIERGHTHSSRVLRAESEKASADVARTLGLRTGGRVFHTILIHLENGVPIQYEDRYVNPAAAPNYLKTDFT
QTTPTYHLLEEAPLTEASYSIEACLPTALEARHLDIKPGEACLAMMRRTVSGAHIASVARLVYPGSRYSFAGKFQA
>Mature_235_residues
ATTPLPAYGQVKAFIKTRISAGTWRPGDPVPSEAVLMAQFGVSRMTVNRALRELMGEGLVTRIQGSGTFVAELHRISSTL
TIRDIHEEVIERGHTHSSRVLRAESEKASADVARTLGLRTGGRVFHTILIHLENGVPIQYEDRYVNPAAAPNYLKTDFTQ
TTPTYHLLEEAPLTEASYSIEACLPTALEARHLDIKPGEACLAMMRRTVSGAHIASVARLVYPGSRYSFAGKFQA

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=228, Percent_Identity=27.1929824561404, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082252, Length=163, Percent_Identity=24.5398773006135, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790118, Length=138, Percent_Identity=26.8115942028986, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 25873; Mature: 25742

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTPLPAYGQVKAFIKTRISAGTWRPGDPVPSEAVLMAQFGVSRMTVNRALRELMGEGL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCC
VTRIQGSGTFVAELHRISSTLTIRDIHEEVIERGHTHSSRVLRAESEKASADVARTLGLR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCHHHHHHHHHHHCCC
TGGRVFHTILIHLENGVPIQYEDRYVNPAAAPNYLKTDFTQTTPTYHLLEEAPLTEASYS
CCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCHHCCCCCCCCCHHHHHCCCCCCCCCH
IEACLPTALEARHLDIKPGEACLAMMRRTVSGAHIASVARLVYPGSRYSFAGKFQA
HHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATTPLPAYGQVKAFIKTRISAGTWRPGDPVPSEAVLMAQFGVSRMTVNRALRELMGEGL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCC
VTRIQGSGTFVAELHRISSTLTIRDIHEEVIERGHTHSSRVLRAESEKASADVARTLGLR
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCHHHHHHHHHHHCCC
TGGRVFHTILIHLENGVPIQYEDRYVNPAAAPNYLKTDFTQTTPTYHLLEEAPLTEASYS
CCCCEEEEEEEEECCCCCEEECCCCCCCCCCCCCHHCCCCCCCCCHHHHHCCCCCCCCCH
IEACLPTALEARHLDIKPGEACLAMMRRTVSGAHIASVARLVYPGSRYSFAGKFQA
HHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]