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The map label for this gene is accC [H]

Identifier: 91786998

GI number: 91786998

Start: 1133083

End: 1134432

Strand: Direct

Name: accC [H]

Synonym: Bpro_1100

Alternate gene names: 91786998

Gene position: 1133083-1134432 (Clockwise)

Preceding gene: 91786997

Following gene: 91786999

Centisome position: 21.79

GC content: 61.04

Gene sequence:

>1350_bases
ATGTTCAAAAAAATACTGATCGCCAACCGGGGTGAGATTGCCCTCCGGATCCAGCGTGCCTGCCGGGAACTCGGCGTCAA
GGCCGTGATGGTCTACTCCGAGGCCGACCGGGAAGCCAAATACATCAAGCTGGCCGATGAGTCGGTGTGTATCGGTCCCG
CCCCTTCCTCCCACAGCTACCTCAACATGCCCGCGATCATCTCGGCGGCCGAGGTCACTGACGCCGAGGCGATTCACCCG
GGCTATGGTTTCCTGAGCGAAAACGCCGATTTCGCCGAACGGGTTGAAAAGAGCGGTTTCAAGTTCATTGGCCCCACACC
CGAGTCGATTCGCATCATGGGCGACAAGGTGTCGGCCAAGCAGACCATGATCAAGGCGGGTGTTCCCTGCGTGCCTGGTT
CCGAGGGTGCACTGCCGGATGACCCCGTGGTCATCAAGCGGATCGCCAAACAGGTCGGCTACCCCGTGATCATCAAGGCC
GCCGGCGGCGGCGGTGGCCGCGGCATGCGTGTGGTGCACACCGAAGCGGCCTTGCTCCATGCGGTGCAGACCACCAAGGC
CGAAGCCGGTGCGGCGTTCGGCAATCCCGAGGTCTACATGGAGAAATTCCTGCAGAATCCGCGACACGTCGAAATCCAGA
TCCTGGCCGATCAGCACAGGAACGCGGTCTGGCTTGGCGAGCGCGACTGCTCCATGCAGCGGCGCCACCAGAAGGTCATT
GAAGAGGCGCCGGCGCCGGGCATTCCGCGCAAGCTGATAGAAAAAATCGGCGAGCGCTGCGTGGCTGCCGTCAAGAAAAT
CAACTACCGTGGTGCCGGCACCTTCGAATTTCTCTACGAGAACGGCGAGTTTTATTTCATCGAAATGAACACCCGCGTGC
AGGTGGAGCATCCGGTGACGGAGTGGATCACGGGCGTGGACATCGTGAAAACCCAGATCATGGTGGCCGCCGGCGAAAAG
CTGCCCTTTTTGCAGCGCGACATCCAGTTCAAGGGCCATGCGATCGAATGCCGCATCAACGCGGAAGATCCCTACAAGTT
CATCCCTTCACCAGGGCGTATCACGACCTGGCACACGCCGGGCGGCCCCGGGGTGCGGGTGGACTCGCATATTTATGCCA
ACTACTTCGTGCCGCCCAACTACGACTCCATGATCGGCAAGATCATCGTTCACGGGGACACGCGCGAGCAGGCCCTGGCG
CGCATGCGCACGGCGCTGGCCGAGACCGTGGTGGAAGGCATCAACACCAACATCCCGCTGCACCGCGAACTCATGGTGGA
CGCCAAATTCATGGACGGCGGCACCAACATCCACTACCTCGAAGAGTGGCTGTCCAAGCGTGACCGATAG

Upstream 100 bases:

>100_bases
TACTCTCGGAAAACGGCCAGGCTGTGGAATACGGGCAGCCCCTCTTCATCATTGAGTAAGCAGGCTCCAGCCCTCCTTGC
CGAACCAGGCCCATCGACGC

Downstream 100 bases:

>100_bases
CTTGAGTTTCACTGCAATGAAAGATCGTGTGACCTTGCGCCGCGCCGGGCCGCCCCAGGCAAGCCCAGCCCCCTCGGGGG
GCAGAGAGCTACACGGAGTG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFKKILIANRGEIALRIQRACRELGVKAVMVYSEADREAKYIKLADESVCIGPAPSSHSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFKFIGPTPESIRIMGDKVSAKQTMIKAGVPCVPGSEGALPDDPVVIKRIAKQVGYPVIIKA
AGGGGGRGMRVVHTEAALLHAVQTTKAEAGAAFGNPEVYMEKFLQNPRHVEIQILADQHRNAVWLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAAVKKINYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFLQRDIQFKGHAIECRINAEDPYKFIPSPGRITTWHTPGGPGVRVDSHIYANYFVPPNYDSMIGKIIVHGDTREQALA
RMRTALAETVVEGINTNIPLHRELMVDAKFMDGGTNIHYLEEWLSKRDR

Sequences:

>Translated_449_residues
MFKKILIANRGEIALRIQRACRELGVKAVMVYSEADREAKYIKLADESVCIGPAPSSHSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFKFIGPTPESIRIMGDKVSAKQTMIKAGVPCVPGSEGALPDDPVVIKRIAKQVGYPVIIKA
AGGGGGRGMRVVHTEAALLHAVQTTKAEAGAAFGNPEVYMEKFLQNPRHVEIQILADQHRNAVWLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAAVKKINYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFLQRDIQFKGHAIECRINAEDPYKFIPSPGRITTWHTPGGPGVRVDSHIYANYFVPPNYDSMIGKIIVHGDTREQALA
RMRTALAETVVEGINTNIPLHRELMVDAKFMDGGTNIHYLEEWLSKRDR
>Mature_449_residues
MFKKILIANRGEIALRIQRACRELGVKAVMVYSEADREAKYIKLADESVCIGPAPSSHSYLNMPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFKFIGPTPESIRIMGDKVSAKQTMIKAGVPCVPGSEGALPDDPVVIKRIAKQVGYPVIIKA
AGGGGGRGMRVVHTEAALLHAVQTTKAEAGAAFGNPEVYMEKFLQNPRHVEIQILADQHRNAVWLGERDCSMQRRHQKVI
EEAPAPGIPRKLIEKIGERCVAAVKKINYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTEWITGVDIVKTQIMVAAGEK
LPFLQRDIQFKGHAIECRINAEDPYKFIPSPGRITTWHTPGGPGVRVDSHIYANYFVPPNYDSMIGKIIVHGDTREQALA
RMRTALAETVVEGINTNIPLHRELMVDAKFMDGGTNIHYLEEWLSKRDR

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=47.1910112359551, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=47.1910112359551, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=47.1910112359551, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.7272727272727, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=45.0110864745011, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=45.0110864745011, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=45.0110864745011, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.1023622047244, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.1023622047244, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.1023622047244, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.1023622047244, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.1023622047244, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=30.5882352941176, Blast_Score=223, Evalue=4e-58,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=66.369710467706, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1786216, Length=243, Percent_Identity=23.8683127572016, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=445, Percent_Identity=47.1910112359551, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=46.7120181405896, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=43.9732142857143, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=29.3877551020408, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=27.4509803921569, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=27.4509803921569, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=41.7040358744395, Blast_Score=355, Evalue=7e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=46.1363636363636, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=46.1024498886414, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=525, Percent_Identity=31.047619047619, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=32.7586206896552, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=45.1467268623025, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=451, Percent_Identity=46.5631929046563, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=44.3349753694581, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.0198807157058, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.0198807157058, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.0198807157058, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.0198807157058, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49814; Mature: 49814

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIALRIQRACRELGVKAVMVYSEADREAKYIKLADESVCIGPAPSSHSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCEEECCCCCCCCE
LNMPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFKFIGPTPESIRIMGDKVSAK
ECCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCHHHH
QTMIKAGVPCVPGSEGALPDDPVVIKRIAKQVGYPVIIKAAGGGGGRGMRVVHTEAALLH
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVQTTKAEAGAAFGNPEVYMEKFLQNPRHVEIQILADQHRNAVWLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRKLIEKIGERCVAAVKKINYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EWITGVDIVKTQIMVAAGEKLPFLQRDIQFKGHAIECRINAEDPYKFIPSPGRITTWHTP
HHHCCHHHHHHEEEEECCCCCCCHHHHHEECCEEEEEEECCCCCCEECCCCCCEEEEECC
GGPGVRVDSHIYANYFVPPNYDSMIGKIIVHGDTREQALARMRTALAETVVEGINTNIPL
CCCCEEECCEEEEEEECCCCHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCE
HRELMVDAKFMDGGTNIHYLEEWLSKRDR
EHEEEEEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKILIANRGEIALRIQRACRELGVKAVMVYSEADREAKYIKLADESVCIGPAPSSHSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCEEECCCCCCCCE
LNMPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFKFIGPTPESIRIMGDKVSAK
ECCCHHEEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCHHHH
QTMIKAGVPCVPGSEGALPDDPVVIKRIAKQVGYPVIIKAAGGGGGRGMRVVHTEAALLH
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHH
AVQTTKAEAGAAFGNPEVYMEKFLQNPRHVEIQILADQHRNAVWLGERDCSMQRRHQKVI
HHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGIPRKLIEKIGERCVAAVKKINYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EWITGVDIVKTQIMVAAGEKLPFLQRDIQFKGHAIECRINAEDPYKFIPSPGRITTWHTP
HHHCCHHHHHHEEEEECCCCCCCHHHHHEECCEEEEEEECCCCCCEECCCCCCEEEEECC
GGPGVRVDSHIYANYFVPPNYDSMIGKIIVHGDTREQALARMRTALAETVVEGINTNIPL
CCCCEEECCEEEEEEECCCCHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCE
HRELMVDAKFMDGGTNIHYLEEWLSKRDR
EHEEEEEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]