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The map label for this gene is murC

Identifier: 91786974

GI number: 91786974

Start: 1108886

End: 1110289

Strand: Direct

Name: murC

Synonym: Bpro_1076

Alternate gene names: 91786974

Gene position: 1108886-1110289 (Clockwise)

Preceding gene: 91786973

Following gene: 91786975

Centisome position: 21.32

GC content: 64.03

Gene sequence:

>1404_bases
ATGAAACACGCCATCAAAAACATTCACTTCATCGGGCTGGGCGGCTCCGGCATGTCAGGCATTGCCGAAGTGCTGCACAA
CCTGGGTTACGTCATTTCGGGATCTGACCTGTCGGACAGCGCCACATTACAGCGGCTGGCCAGGCTTGGCATCAAGACCT
TTGTCGGGCATGCCGCCAGCAACCTGGCCAAGGTCGATGCGGTGGTGACCTCCACCGCGGTGCAGGCCGACAACCCCGAG
GTGCTGGCGGCGCGCGAAAAGCGCATTCCCGTGGTGCCCCGTGCCCTGATGCTGGCCGAACTGATGCGCCTGAAGCAGGG
CATTGCGATTGCGGGTACCCATGGCAAGACCACGACGACCAGCCTGGTGGCCAGTGTGCTGGCCGAAGCCGGGCTGGATC
CGACGTTTGTCATCGGTGGCCGGCTCAACAGCGCGGGTGCCAATGCCAGGCTGGGCCTGGGCGACTACATCGTGGTGGAA
GCCGACGAGTCCGATGCATCGTTCCTGAACCTGTTGCCGGTGATGGCGGTCGTGACCAACATCGACGCCGACCACATGGA
AACCTATGGCCATGATTTCGCCAATCTGAAGAAGGCCTTCGTCGACTTTTTGCATCGCATGCCTTTTTACGGTACCGCCA
TTTTGTGCACCGATGACCCCGCGGTGCGTGAGATCGTCCCGCAGGTTTCCTGCCCGATCACCAGCTACGGTTTCGGTGAG
GACGCGCAGGTGCGGGCTGTCAACGTGCGGCCGGTGGGCGCGCAGATGCACTTCACCGCGCAGCGCCGCAATGGCGTCAC
CTTGCCGGACCTGGAGGTCGTGCTCAATCTCGCCGGCGAGCACAACGTGCTCAATGCCTTGTCAGCCATTGCGGTGGCGG
TGGAGCTCAACGTGCCCGACACGGCAGTGCAAAAAGCGTTGGCCGAATTCAAGGGCGTGGGCCGGCGCTTCCAGAGCTAC
GGCGATGTGCCTGCCAAAGGCGGTGGCCATTTCACGGTCATCGAGGACTACGGCCACCATCCGGTCGAGGTGGCTGCCAC
GCTGGCCGCTGCGCGCGGTGCCTTCCCGGGCAGGCGGCTGGTGCTGGCGTTCCAGCCGCACCGCTACACCCGGACCCGCG
ACTGCTTTGAGGACTTCGTCAAGGTCATCGGCCAGGCCGATGCCGTGCTGCTGGCGGAGGTCTATGCCGCCGGCGAGACA
CCCATCGTGGCGGCAGACGGCCGCTCGCTGGCGCGCGCGCTGCGCGTGGCGGGCAAGCTGGAGCCGGTATTTGTGAGCGA
GATCGACGCGATGCCGCAAGCCATCCTGGATAACGCACTGGGAGGCGATGTCGTGATGTGCATGGGTGCCGGATCGATTG
GGCTCGTGCCCGGCAAATTGTTGGAACTGGAAGGTGCGCAGTGA

Upstream 100 bases:

>100_bases
CAGATCGATCCGCGCTGCTTCAATGCGCGCTAAAAGCCAAAACCATGCAAAAAACCGATGCCACAACGCGCGTTGTGGCT
GCTTGCGAGGAGCTTGCAAG

Downstream 100 bases:

>100_bases
GTAGCAACGCAGACACATCCCAGGCCGTGAGCGCCGGGACAAGCGTGGGGGCCACGTTTGGCAAGGTCGCCGTCCTCATG
GGGGGCATGTCGGCCGAGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKHAIKNIHFIGLGGSGMSGIAEVLHNLGYVISGSDLSDSATLQRLARLGIKTFVGHAASNLAKVDAVVTSTAVQADNPE
VLAAREKRIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANARLGLGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFANLKKAFVDFLHRMPFYGTAILCTDDPAVREIVPQVSCPITSYGFGE
DAQVRAVNVRPVGAQMHFTAQRRNGVTLPDLEVVLNLAGEHNVLNALSAIAVAVELNVPDTAVQKALAEFKGVGRRFQSY
GDVPAKGGGHFTVIEDYGHHPVEVAATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVIGQADAVLLAEVYAAGET
PIVAADGRSLARALRVAGKLEPVFVSEIDAMPQAILDNALGGDVVMCMGAGSIGLVPGKLLELEGAQ

Sequences:

>Translated_467_residues
MKHAIKNIHFIGLGGSGMSGIAEVLHNLGYVISGSDLSDSATLQRLARLGIKTFVGHAASNLAKVDAVVTSTAVQADNPE
VLAAREKRIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANARLGLGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFANLKKAFVDFLHRMPFYGTAILCTDDPAVREIVPQVSCPITSYGFGE
DAQVRAVNVRPVGAQMHFTAQRRNGVTLPDLEVVLNLAGEHNVLNALSAIAVAVELNVPDTAVQKALAEFKGVGRRFQSY
GDVPAKGGGHFTVIEDYGHHPVEVAATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVIGQADAVLLAEVYAAGET
PIVAADGRSLARALRVAGKLEPVFVSEIDAMPQAILDNALGGDVVMCMGAGSIGLVPGKLLELEGAQ
>Mature_467_residues
MKHAIKNIHFIGLGGSGMSGIAEVLHNLGYVISGSDLSDSATLQRLARLGIKTFVGHAASNLAKVDAVVTSTAVQADNPE
VLAAREKRIPVVPRALMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEAGLDPTFVIGGRLNSAGANARLGLGDYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFANLKKAFVDFLHRMPFYGTAILCTDDPAVREIVPQVSCPITSYGFGE
DAQVRAVNVRPVGAQMHFTAQRRNGVTLPDLEVVLNLAGEHNVLNALSAIAVAVELNVPDTAVQKALAEFKGVGRRFQSY
GDVPAKGGGHFTVIEDYGHHPVEVAATLAAARGAFPGRRLVLAFQPHRYTRTRDCFEDFVKVIGQADAVLLAEVYAAGET
PIVAADGRSLARALRVAGKLEPVFVSEIDAMPQAILDNALGGDVVMCMGAGSIGLVPGKLLELEGAQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=464, Percent_Identity=51.0775862068966, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1790680, Length=478, Percent_Identity=29.4979079497908, Blast_Score=169, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_POLSJ (Q12EL4)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547926.1
- ProteinModelPortal:   Q12EL4
- SMR:   Q12EL4
- STRING:   Q12EL4
- GeneID:   4012083
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1076
- NMPDR:   fig|296591.1.peg.3329
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q12EL4
- ProtClustDB:   PRK00421
- BioCyc:   PSP296591:BPRO_1076-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49253; Mature: 49253

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAIKNIHFIGLGGSGMSGIAEVLHNLGYVISGSDLSDSATLQRLARLGIKTFVGHAAS
CCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
NLAKVDAVVTSTAVQADNPEVLAAREKRIPVVPRALMLAELMRLKQGIAIAGTHGKTTTT
HHHHHHHHHHHHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEAGLDPTFVIGGRLNSAGANARLGLGDYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFANLKKAFVDFLHRMPFYGTAILCTDDPAVREIVPQVSCPITSYGFGE
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC
DAQVRAVNVRPVGAQMHFTAQRRNGVTLPDLEVVLNLAGEHNVLNALSAIAVAVELNVPD
CCEEEEEEEEECCCEEEEEEHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHEEEEEECCCH
TAVQKALAEFKGVGRRFQSYGDVPAKGGGHFTVIEDYGHHPVEVAATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEE
VLAFQPHRYTRTRDCFEDFVKVIGQADAVLLAEVYAAGETPIVAADGRSLARALRVAGKL
EEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVSEIDAMPQAILDNALGGDVVMCMGAGSIGLVPGKLLELEGAQ
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCC
>Mature Secondary Structure
MKHAIKNIHFIGLGGSGMSGIAEVLHNLGYVISGSDLSDSATLQRLARLGIKTFVGHAAS
CCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
NLAKVDAVVTSTAVQADNPEVLAAREKRIPVVPRALMLAELMRLKQGIAIAGTHGKTTTT
HHHHHHHHHHHHEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEAGLDPTFVIGGRLNSAGANARLGLGDYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFANLKKAFVDFLHRMPFYGTAILCTDDPAVREIVPQVSCPITSYGFGE
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC
DAQVRAVNVRPVGAQMHFTAQRRNGVTLPDLEVVLNLAGEHNVLNALSAIAVAVELNVPD
CCEEEEEEEEECCCEEEEEEHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHEEEEEECCCH
TAVQKALAEFKGVGRRFQSYGDVPAKGGGHFTVIEDYGHHPVEVAATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEE
VLAFQPHRYTRTRDCFEDFVKVIGQADAVLLAEVYAAGETPIVAADGRSLARALRVAGKL
EEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVSEIDAMPQAILDNALGGDVVMCMGAGSIGLVPGKLLELEGAQ
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA