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The map label for this gene is pyrC [H]

Identifier: 91786923

GI number: 91786923

Start: 1050394

End: 1051461

Strand: Direct

Name: pyrC [H]

Synonym: Bpro_1024

Alternate gene names: 91786923

Gene position: 1050394-1051461 (Clockwise)

Preceding gene: 91786922

Following gene: 91786924

Centisome position: 20.2

GC content: 64.98

Gene sequence:

>1068_bases
ATGACTTCAGCCATCAGCACCCCGGTTTCCACCCTGACCATCACCCGCCCCGACGACTGGCACCTGCATGTGCGGGACGG
CGACGCATTGAGCACGGTGGTGCCGCATACCGCCGCCCAGTTTGGCCGGGCCATCATCATGCCCAACCTGCGCCCGCCGG
TGACCACCGCGGCCCAGGCTGTTGCCTACCGCGAGCGCATCCAGGCCGCCGTGCCCGCGGGCGTGGCTTTCGAGCCGCTG
ATGACGCTGTATTTGACCGACAACCTGCCGCCCGACGAGATCAAGCGGGCCAAAGAGGCCGGCGTGGTCGCCACCAAGCT
CTACCCGGCCGGCGCCACCACCAACAGCGATGCGGGCGTGACCGACCTGCGCAAGACCTACAAGACACTCGAAGCGATGC
AGCGCGAAGGCCTGCTGCTGCTGGTGCATGGCGAGGTGACCTCGCCCGACATTGACCTGTTTGACCGCGAGGCGGTGTTC
ATCGACACGCAGCTGATTCCACTGCGCCGCGATTTCCCTGAGCTGAAGATCGTGTTTGAGCACATCACCACGAAAGAAGC
CGCGCAGTATGTGCATGACGCCGACCGCTTCACGGGCGCCACCATCACCGCGCACCATCTGCTGTACAACCGCAACGCGA
TTTTCACCGGCGGCATCCGGCCGCACTACTACTGCCTGCCCGTGCTCAAGCGCGAAACGCATCGCGTCGCGCTGGTCGAG
GCGGCCACCAGTGGCAACCACCGGTTTTTCCTCGGCACGGACAGCGCACCGCACCCGGCCCACCTCAAGGAGCATGCCAC
CGGCTGCGCCGGCTGCTACACCGCCCATGCGGCGATGGAGCTGTATGCCGAAGCCTTTGATGCGGCGGGCGCACTCGACA
AGCTCGAGGCCTTTGCCAGTTTCAACGGCGCGGACTTCTATGGCTTGCCGCGCAACCAGGGCACCATCACCCTGAAAAAG
GAAAGCTGGCGGCCCCCCGAGAGTTATGCGTTTGGCGAGGCTGAACTCAAGCCGCTGCGCTCGGGTGAAAGCCTGCCATG
GAAGCTTTACTCCACCCGGAGCGAATGA

Upstream 100 bases:

>100_bases
ACTTGGCCCGCGGTATTCCCCACGGCAAGTACATGATCAGGATTGGCGCGTATAGCCGGTTTTTCTTCTAGTGGTAGCGA
CCGGTGCGACAATTCAAGCC

Downstream 100 bases:

>100_bases
TGGACCACAAACCGCGCGTTGCCCTGCTGATTGACGCCGACAATTCACCGGCGTCCAAAATAGACCTGATCCTCAACGAG
TTGTCGACCTTTGGCGAGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTSAISTPVSTLTITRPDDWHLHVRDGDALSTVVPHTAAQFGRAIIMPNLRPPVTTAAQAVAYRERIQAAVPAGVAFEPL
MTLYLTDNLPPDEIKRAKEAGVVATKLYPAGATTNSDAGVTDLRKTYKTLEAMQREGLLLLVHGEVTSPDIDLFDREAVF
IDTQLIPLRRDFPELKIVFEHITTKEAAQYVHDADRFTGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHRVALVE
AATSGNHRFFLGTDSAPHPAHLKEHATGCAGCYTAHAAMELYAEAFDAAGALDKLEAFASFNGADFYGLPRNQGTITLKK
ESWRPPESYAFGEAELKPLRSGESLPWKLYSTRSE

Sequences:

>Translated_355_residues
MTSAISTPVSTLTITRPDDWHLHVRDGDALSTVVPHTAAQFGRAIIMPNLRPPVTTAAQAVAYRERIQAAVPAGVAFEPL
MTLYLTDNLPPDEIKRAKEAGVVATKLYPAGATTNSDAGVTDLRKTYKTLEAMQREGLLLLVHGEVTSPDIDLFDREAVF
IDTQLIPLRRDFPELKIVFEHITTKEAAQYVHDADRFTGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHRVALVE
AATSGNHRFFLGTDSAPHPAHLKEHATGCAGCYTAHAAMELYAEAFDAAGALDKLEAFASFNGADFYGLPRNQGTITLKK
ESWRPPESYAFGEAELKPLRSGESLPWKLYSTRSE
>Mature_354_residues
TSAISTPVSTLTITRPDDWHLHVRDGDALSTVVPHTAAQFGRAIIMPNLRPPVTTAAQAVAYRERIQAAVPAGVAFEPLM
TLYLTDNLPPDEIKRAKEAGVVATKLYPAGATTNSDAGVTDLRKTYKTLEAMQREGLLLLVHGEVTSPDIDLFDREAVFI
DTQLIPLRRDFPELKIVFEHITTKEAAQYVHDADRFTGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHRVALVEA
ATSGNHRFFLGTDSAPHPAHLKEHATGCAGCYTAHAAMELYAEAFDAAGALDKLEAFASFNGADFYGLPRNQGTITLKKE
SWRPPESYAFGEAELKPLRSGESLPWKLYSTRSE

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=346, Percent_Identity=54.9132947976879, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=34.8314606741573, Blast_Score=188, Evalue=9e-49,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39082; Mature: 38950

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAISTPVSTLTITRPDDWHLHVRDGDALSTVVPHTAAQFGRAIIMPNLRPPVTTAAQA
CCCCCCCCCEEEEEECCCCCEEEEECCCCHHHHCCHHHHHHCCEEECCCCCCCHHHHHHH
VAYRERIQAAVPAGVAFEPLMTLYLTDNLPPDEIKRAKEAGVVATKLYPAGATTNSDAGV
HHHHHHHHHHCCCCCCHHHEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCH
TDLRKTYKTLEAMQREGLLLLVHGEVTSPDIDLFDREAVFIDTQLIPLRRDFPELKIVFE
HHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHH
HITTKEAAQYVHDADRFTGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHRVALVE
HHHHHHHHHHHHHHHHHCCCEEEEEHEEEECCEEEECCCCCCEEEEEHHHCCCCEEEEEE
AATSGNHRFFLGTDSAPHPAHLKEHATGCAGCYTAHAAMELYAEAFDAAGALDKLEAFAS
EECCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
FNGADFYGLPRNQGTITLKKESWRPPESYAFGEAELKPLRSGESLPWKLYSTRSE
CCCCCEECCCCCCCEEEEECCCCCCCHHCCCCCHHCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TSAISTPVSTLTITRPDDWHLHVRDGDALSTVVPHTAAQFGRAIIMPNLRPPVTTAAQA
CCCCCCCCEEEEEECCCCCEEEEECCCCHHHHCCHHHHHHCCEEECCCCCCCHHHHHHH
VAYRERIQAAVPAGVAFEPLMTLYLTDNLPPDEIKRAKEAGVVATKLYPAGATTNSDAGV
HHHHHHHHHHCCCCCCHHHEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCH
TDLRKTYKTLEAMQREGLLLLVHGEVTSPDIDLFDREAVFIDTQLIPLRRDFPELKIVFE
HHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCHHHHHHH
HITTKEAAQYVHDADRFTGATITAHHLLYNRNAIFTGGIRPHYYCLPVLKRETHRVALVE
HHHHHHHHHHHHHHHHHCCCEEEEEHEEEECCEEEECCCCCCEEEEEHHHCCCCEEEEEE
AATSGNHRFFLGTDSAPHPAHLKEHATGCAGCYTAHAAMELYAEAFDAAGALDKLEAFAS
EECCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
FNGADFYGLPRNQGTITLKKESWRPPESYAFGEAELKPLRSGESLPWKLYSTRSE
CCCCCEECCCCCCCEEEEECCCCCCCHHCCCCCHHCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA