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The map label for this gene is livM [H]

Identifier: 91786888

GI number: 91786888

Start: 1005447

End: 1006496

Strand: Direct

Name: livM [H]

Synonym: Bpro_0988

Alternate gene names: 91786888

Gene position: 1005447-1006496 (Clockwise)

Preceding gene: 91786887

Following gene: 91786889

Centisome position: 19.33

GC content: 64.67

Gene sequence:

>1050_bases
ATGGCGATGACTCCCCTTATTTCACGGCCCAGCGCCTGGGTTCCCCTGCTGGCGCTGCTGCTGCTGGCGACCGTTCCCTT
TGTGGCGCAGGCCACCGACCAGCAGTTTTATGTCGCGTTTTTTGCGCGCATCATCATCTACGCGATTGCGGCCTGCGCGC
TGAACATCGCGCTGGGTTACGGCGGGCTGGTGAGCTTCGGCCATTCACTGTTCCTCGGACTGGGCGGCTATGCCGTCGGC
CTGGCATCTTTTTATGGGGTCGGCAACGGCTGGGTGCACCTGGCGTTGACCCTCGGCGTGTGCGGCCTGGTGGCGCTGGT
CACCGGCGCCATCAGCCTGCGCACCACCGGCATCGCCTTCATCATGATCACGCTGGCCTTCGCGCAGATGGGTTACTTTC
TCTTCGTCAGCCTGAAGCACTACGGCGGCGATGACGGCATGCCCATCGCGCAGACCAGCCGCTTCGGCCCGCTCGACCTG
TCGTCCGCGACCAATGTGTACGTCGTCGCCTTCGTCGTGCTGGTGCTGTCGATCTGGTGGCTCGCCAGGCTGCGCGTCGC
GCCCTTCGGCATGGTGATCCGCGGCGCCAAACAGAACGCACGCCGGGTCAACGCCGCCGGCATCCCGGTGCTGCGTTACC
AGTTGCTGGCCTATGTGATGTCGGGCATGTTGTGTGGCGTGGCCGGTCTGCTGCTGGCCAACCTCAATGCCTTCGCCTCG
CCCAGCACCCTGGCCTGGGCTGTTTCCGGCGAGCTGATCGTCATCGTCGTCATCGGCGGTCTGGGCACGGTGTTCGGTCC
CTTGATGGGGGCGCTGGTCTTCCTGGGTCTCGAAGAGATCCTGAAAGGCTTCACCGATCACTGGATGGTCATCTTCGGCC
CGCTCATTGTCATCGTCGCCCTCCTGGGCAAGCGCGGCATCATCGGCCTGCTGCAGCGTTTTGACTCGCGGGGAAAGCTG
CCCGCCAAAATAACCACCACCACCACCACCACCGCAGCGGCTGTGGCGGCGACGGGTGTGGCGACTGGTGTGGCGAAGGG
AGCCCTGTGA

Upstream 100 bases:

>100_bases
CGGCCGGCCCGGCGCTGGCCTCCATGCTGGTGTACCTGCTGATGGCGGTGGTGCTGGCGTGGCGCCCGCAAGGTCTTTTT
CCGGCGAACAGGTGAAGGTG

Downstream 100 bases:

>100_bases
TGGCCAGCGTACTTCGCACCGACTCCCTCACCAAGCGCTACGGCGCGCTGCTGGTCACCGACGCGGTGTCGCTCGACATC
GGCGAGGGCGAGCTCCACGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAMTPLISRPSAWVPLLALLLLATVPFVAQATDQQFYVAFFARIIIYAIAACALNIALGYGGLVSFGHSLFLGLGGYAVG
LASFYGVGNGWVHLALTLGVCGLVALVTGAISLRTTGIAFIMITLAFAQMGYFLFVSLKHYGGDDGMPIAQTSRFGPLDL
SSATNVYVVAFVVLVLSIWWLARLRVAPFGMVIRGAKQNARRVNAAGIPVLRYQLLAYVMSGMLCGVAGLLLANLNAFAS
PSTLAWAVSGELIVIVVIGGLGTVFGPLMGALVFLGLEEILKGFTDHWMVIFGPLIVIVALLGKRGIIGLLQRFDSRGKL
PAKITTTTTTTAAAVAATGVATGVAKGAL

Sequences:

>Translated_349_residues
MAMTPLISRPSAWVPLLALLLLATVPFVAQATDQQFYVAFFARIIIYAIAACALNIALGYGGLVSFGHSLFLGLGGYAVG
LASFYGVGNGWVHLALTLGVCGLVALVTGAISLRTTGIAFIMITLAFAQMGYFLFVSLKHYGGDDGMPIAQTSRFGPLDL
SSATNVYVVAFVVLVLSIWWLARLRVAPFGMVIRGAKQNARRVNAAGIPVLRYQLLAYVMSGMLCGVAGLLLANLNAFAS
PSTLAWAVSGELIVIVVIGGLGTVFGPLMGALVFLGLEEILKGFTDHWMVIFGPLIVIVALLGKRGIIGLLQRFDSRGKL
PAKITTTTTTTAAAVAATGVATGVAKGAL
>Mature_348_residues
AMTPLISRPSAWVPLLALLLLATVPFVAQATDQQFYVAFFARIIIYAIAACALNIALGYGGLVSFGHSLFLGLGGYAVGL
ASFYGVGNGWVHLALTLGVCGLVALVTGAISLRTTGIAFIMITLAFAQMGYFLFVSLKHYGGDDGMPIAQTSRFGPLDLS
SATNVYVVAFVVLVLSIWWLARLRVAPFGMVIRGAKQNARRVNAAGIPVLRYQLLAYVMSGMLCGVAGLLLANLNAFASP
STLAWAVSGELIVIVVIGGLGTVFGPLMGALVFLGLEEILKGFTDHWMVIFGPLIVIVALLGKRGIIGLLQRFDSRGKLP
AKITTTTTTTAAAVAATGVATGVAKGAL

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=291, Percent_Identity=24.3986254295533, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 36470; Mature: 36339

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMTPLISRPSAWVPLLALLLLATVPFVAQATDQQFYVAFFARIIIYAIAACALNIALGY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLVSFGHSLFLGLGGYAVGLASFYGVGNGWVHLALTLGVCGLVALVTGAISLRTTGIAF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMITLAFAQMGYFLFVSLKHYGGDDGMPIAQTSRFGPLDLSSATNVYVVAFVVLVLSIWW
HHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LARLRVAPFGMVIRGAKQNARRVNAAGIPVLRYQLLAYVMSGMLCGVAGLLLANLNAFAS
HHHHHHCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSTLAWAVSGELIVIVVIGGLGTVFGPLMGALVFLGLEEILKGFTDHWMVIFGPLIVIVA
CCCEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGKRGIIGLLQRFDSRGKLPAKITTTTTTTAAAVAATGVATGVAKGAL
HHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AMTPLISRPSAWVPLLALLLLATVPFVAQATDQQFYVAFFARIIIYAIAACALNIALGY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GGLVSFGHSLFLGLGGYAVGLASFYGVGNGWVHLALTLGVCGLVALVTGAISLRTTGIAF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMITLAFAQMGYFLFVSLKHYGGDDGMPIAQTSRFGPLDLSSATNVYVVAFVVLVLSIWW
HHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LARLRVAPFGMVIRGAKQNARRVNAAGIPVLRYQLLAYVMSGMLCGVAGLLLANLNAFAS
HHHHHHCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PSTLAWAVSGELIVIVVIGGLGTVFGPLMGALVFLGLEEILKGFTDHWMVIFGPLIVIVA
CCCEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGKRGIIGLLQRFDSRGKLPAKITTTTTTTAAAVAATGVATGVAKGAL
HHCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]