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The map label for this gene is serS [H]

Identifier: 91786855

GI number: 91786855

Start: 975832

End: 977238

Strand: Direct

Name: serS [H]

Synonym: Bpro_0953

Alternate gene names: 91786855

Gene position: 975832-977238 (Clockwise)

Preceding gene: 91786854

Following gene: 91786869

Centisome position: 18.77

GC content: 61.76

Gene sequence:

>1407_bases
ATGCGCCCGAGAATCGGATTTATAGAAGTCCCGAAATACAATCCCCCCATGCTAGACATCAACCTGCTCCGCAAAGACCT
GCCCTCGGCTATCGCCCGCCTGGAGATGCGCAAGAGCCCGCAAGCCTTCCTCAACGTGGAAGCGTTCCAGGCCCTGGAGG
CCGAACGCAAAGCCCTGCAAATCCGCACGGAAGAGCTGCAGAGCCAGCGCAACACCCTGTCCAAACAGATCGGCCAGCTC
AAGTCCAAAGGCGAGGACGCCAGCGCCATCATGGCGCAGGTGAGCGCCTCCAAGGCCGAGCTGGAGTCCTCCGCGGCCCG
GCTCGACCAGATCCAGTCCGAACTGCAGGGCCTGCTGCTGGCGGTGCCCAATTTGCCGCACGAATCGGTGCCGCTGGGTA
CCGACGAGCAGGGCAATGTCGAAGTGCGCAAATGGAGCCCGATCGAAGGGCCGGGCGGCGAGCCGCCGGCCTTTGCATTC
GAGGTCAAGGACCATGTGGACGTAGGCCAGCCACTCGGGCTGGACTTTGAGCTGGGCACCAAGCTGACGGGTTCGCGTTT
TACCGTGATGAAAGGCCAGCTCGCGCGCTTGCACCGCGCCCTGGCCCAGTTTATGCTGGACGTGCAGACGCTGGAGCACG
GTTATACCGAGTGCTACACGCCCTACATCGTCAACGGCGACTCCTTGCGTGGTACCGGCCAGCTGCCCAAGTTCGAGGGG
GATCTGTTTCGCGTGGAAGCTGGTTTGGGTTTGGCGACTGCTCATGACGAGCAGATCGCGGAGTTGACCAAACGCTCTTT
GTATTTGATTCCCACGTCGGAAGTGCCGCTCACCAACTTCGTGCGCGACGAGATCGTGCCCGAGGCGCAGCTGCCACTGA
AATTCACCGCCCACACACCGTGCTTTCGCTCCGAAGCCGGCAGCTATGGCCGCGACACCCGCGGCATGATCCGCCAGCAC
CAGTTCGACAAGGTTGAAATGGTGCAGATCGTGCATCCGGAGAAAAGCTACGAAGCGCTGGAAGACATGACCGGCCACGC
CGAAATGATTTTGCAAAAGCTCGGCCTGCCTTATCGCGTCATGTTGCTGTGCACCGGCGACATGGGGTTTGGCGCCAGCA
AGACCTACGACCTGGAAGTATGGCTGCCGGCCCAGAGCACCTACCGCGAAATCAGTTCGATCTCCAACTGCGAAGCCTTC
CAGGCGCGCAGGCTGCAGGCCCGCTTCAAGAACGCCCAAGGCAAAAACGAGTTCGTGCACACCCTGAACGGCTCCGGTCT
CGCCGTAGGCCGCACCCTGGTGGCCGTGCTGGAAAATTACCAGCACGCCGACGGCACCGTCGAGGTGCCGTTGGTGTTGC
AGCCCTATATGGGCGGCATGACGGTGCTTGCACCGTCGGCTGGGTAA

Upstream 100 bases:

>100_bases
TAGAAATTCGATTGTCGGGATGCAGGGCAAGGCGCACGGAGCACAGGACACCGGAATGCACTTCGGTGCATGAGGATTCC
GAGCACCGCGGAACGCCGCC

Downstream 100 bases:

>100_bases
TTTCGGTGAAGGCCAAGCTTCGCGCAGTACGCGAAGCGCCAAGCAGCGTGGGGCCCTGTTTTTCCGCAGGGCCGCCCCAA
GGAAAAATGCACCCCCTCGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MRPRIGFIEVPKYNPPMLDINLLRKDLPSAIARLEMRKSPQAFLNVEAFQALEAERKALQIRTEELQSQRNTLSKQIGQL
KSKGEDASAIMAQVSASKAELESSAARLDQIQSELQGLLLAVPNLPHESVPLGTDEQGNVEVRKWSPIEGPGGEPPAFAF
EVKDHVDVGQPLGLDFELGTKLTGSRFTVMKGQLARLHRALAQFMLDVQTLEHGYTECYTPYIVNGDSLRGTGQLPKFEG
DLFRVEAGLGLATAHDEQIAELTKRSLYLIPTSEVPLTNFVRDEIVPEAQLPLKFTAHTPCFRSEAGSYGRDTRGMIRQH
QFDKVEMVQIVHPEKSYEALEDMTGHAEMILQKLGLPYRVMLLCTGDMGFGASKTYDLEVWLPAQSTYREISSISNCEAF
QARRLQARFKNAQGKNEFVHTLNGSGLAVGRTLVAVLENYQHADGTVEVPLVLQPYMGGMTVLAPSAG

Sequences:

>Translated_468_residues
MRPRIGFIEVPKYNPPMLDINLLRKDLPSAIARLEMRKSPQAFLNVEAFQALEAERKALQIRTEELQSQRNTLSKQIGQL
KSKGEDASAIMAQVSASKAELESSAARLDQIQSELQGLLLAVPNLPHESVPLGTDEQGNVEVRKWSPIEGPGGEPPAFAF
EVKDHVDVGQPLGLDFELGTKLTGSRFTVMKGQLARLHRALAQFMLDVQTLEHGYTECYTPYIVNGDSLRGTGQLPKFEG
DLFRVEAGLGLATAHDEQIAELTKRSLYLIPTSEVPLTNFVRDEIVPEAQLPLKFTAHTPCFRSEAGSYGRDTRGMIRQH
QFDKVEMVQIVHPEKSYEALEDMTGHAEMILQKLGLPYRVMLLCTGDMGFGASKTYDLEVWLPAQSTYREISSISNCEAF
QARRLQARFKNAQGKNEFVHTLNGSGLAVGRTLVAVLENYQHADGTVEVPLVLQPYMGGMTVLAPSAG
>Mature_468_residues
MRPRIGFIEVPKYNPPMLDINLLRKDLPSAIARLEMRKSPQAFLNVEAFQALEAERKALQIRTEELQSQRNTLSKQIGQL
KSKGEDASAIMAQVSASKAELESSAARLDQIQSELQGLLLAVPNLPHESVPLGTDEQGNVEVRKWSPIEGPGGEPPAFAF
EVKDHVDVGQPLGLDFELGTKLTGSRFTVMKGQLARLHRALAQFMLDVQTLEHGYTECYTPYIVNGDSLRGTGQLPKFEG
DLFRVEAGLGLATAHDEQIAELTKRSLYLIPTSEVPLTNFVRDEIVPEAQLPLKFTAHTPCFRSEAGSYGRDTRGMIRQH
QFDKVEMVQIVHPEKSYEALEDMTGHAEMILQKLGLPYRVMLLCTGDMGFGASKTYDLEVWLPAQSTYREISSISNCEAF
QARRLQARFKNAQGKNEFVHTLNGSGLAVGRTLVAVLENYQHADGTVEVPLVLQPYMGGMTVLAPSAG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=489, Percent_Identity=34.1513292433538, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI8923421, Length=465, Percent_Identity=28.6021505376344, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI225579074, Length=467, Percent_Identity=28.051391862955, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1787120, Length=447, Percent_Identity=59.9552572706935, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17539260, Length=477, Percent_Identity=31.2368972746331, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=350, Percent_Identity=28.2857142857143, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=418, Percent_Identity=33.7320574162679, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=454, Percent_Identity=27.9735682819383, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24581334, Length=477, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17737985, Length=285, Percent_Identity=34.0350877192982, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 51776; Mature: 51776

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPRIGFIEVPKYNPPMLDINLLRKDLPSAIARLEMRKSPQAFLNVEAFQALEAERKALQ
CCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IRTEELQSQRNTLSKQIGQLKSKGEDASAIMAQVSASKAELESSAARLDQIQSELQGLLL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AVPNLPHESVPLGTDEQGNVEVRKWSPIEGPGGEPPAFAFEVKDHVDVGQPLGLDFELGT
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCC
KLTGSRFTVMKGQLARLHRALAQFMLDVQTLEHGYTECYTPYIVNGDSLRGTGQLPKFEG
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCCCCCCCCCC
DLFRVEAGLGLATAHDEQIAELTKRSLYLIPTSEVPLTNFVRDEIVPEAQLPLKFTAHTP
CEEEEECCCCEEECCHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCC
CFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPEKSYEALEDMTGHAEMILQKLGLPYRV
CHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCEEE
MLLCTGDMGFGASKTYDLEVWLPAQSTYREISSISNCEAFQARRLQARFKNAQGKNEFVH
EEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEE
TLNGSGLAVGRTLVAVLENYQHADGTVEVPLVLQPYMGGMTVLAPSAG
EECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCC
>Mature Secondary Structure
MRPRIGFIEVPKYNPPMLDINLLRKDLPSAIARLEMRKSPQAFLNVEAFQALEAERKALQ
CCCCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IRTEELQSQRNTLSKQIGQLKSKGEDASAIMAQVSASKAELESSAARLDQIQSELQGLLL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
AVPNLPHESVPLGTDEQGNVEVRKWSPIEGPGGEPPAFAFEVKDHVDVGQPLGLDFELGT
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCC
KLTGSRFTVMKGQLARLHRALAQFMLDVQTLEHGYTECYTPYIVNGDSLRGTGQLPKFEG
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEECCCCCCCCCCCCCCCC
DLFRVEAGLGLATAHDEQIAELTKRSLYLIPTSEVPLTNFVRDEIVPEAQLPLKFTAHTP
CEEEEECCCCEEECCHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEECCCC
CFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVHPEKSYEALEDMTGHAEMILQKLGLPYRV
CHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCEEE
MLLCTGDMGFGASKTYDLEVWLPAQSTYREISSISNCEAFQARRLQARFKNAQGKNEFVH
EEEEECCCCCCCCCEEEEEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEE
TLNGSGLAVGRTLVAVLENYQHADGTVEVPLVLQPYMGGMTVLAPSAG
EECCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA