Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 91786706

GI number: 91786706

Start: 830060

End: 831403

Strand: Direct

Name: hisD [H]

Synonym: Bpro_0804

Alternate gene names: 91786706

Gene position: 830060-831403 (Clockwise)

Preceding gene: 91786705

Following gene: 91786707

Centisome position: 15.96

GC content: 65.33

Gene sequence:

>1344_bases
ATGAATTTAGTAGCCAACCCCGTACGCCTTTCGACCGCTTCCAGCACATTCGATGCTGAATTCAAGGCGCGCCTGCACTG
GTCTGCCGATACCGATGCGGCCATCGAACAGCGGGTGGCTGACATCCTCCTGGACGTGCAGCGGCGCGGCGATACGGCTG
TGCTCGAGTACACCGCGCGTTTTGACGGCCTGAGCGTCTCGGCCATGAGTGCGCTGGAGCTCAGCCAGGCCGAGCTGAAG
GCCGCGTTTGATGCGATTCCTGCCGCCCAGCGCGCTGCCTTGCAGGCTGCGGCCCGCCGGGTGCGCAGCTACCACGAGGC
CCAGAAGAAGGCCAATGGTGAAGGCTGGAGCTACCGTGATGAAGACGGCACCCTGCTCGGCCAGAAGGTCACACCGCTGG
ACCGCGTCGGCATCTATGTGCCGGGTGGCAAGGCGGCTTACCCCTCATCGGTGCTGATGAACGCCATTCCGGCCCACGTG
GCCGGTGTGGGCGAAATCATCATGGTGGTGCCCACACCCAAGGGCGAGAAGAACCCGCTGGTTCTGGCCGCTGCCTATGT
GGCCGGCGTGACGCGCGCCTTCACCATTGGCGGCGCGCAGGCCGTGGCTGCGCTGGCCTACGGTACCTCGACCATTCCCG
CGGTCGACAAGATCACCGGCCCCGGCAATGCCTACGTGGCCGCGGCCAAGCGCCGCGTCTTCGGCACGGTGGGCATCGAC
ATGATTGCCGGCCCTTCCGAAATCCTGGTGCTGGCCGACGGCAGCACCCCCGTCGACTGGGTGGCCATGGATTTGTTCAG
CCAGGCCGAGCACGATGAACTGGCGCAAAGCATTTTGCTGTGTCCGGATGCGGCCTACATCGACCAGGTGCACGAGGCCC
TCAACCGCCTGCTGCCTGCCATGCCGCGCGCCGAGATCATTGCCAAATCGCTCAACGGCCGGGGTGTGCTGATCCATACC
CGCAGCATGGAAGAGGCCTGCGCCCTCAGCAACCGCATTGCGCCCGAGCACCTGGAAGTCTCCAGCAGCCAGCCGCATGA
ATGGGAGCCGCTGCTCAAGCACGCCGGCGCCATCTTCCTCGGCGCCTACACCAGCGAGTCGCTGGGCGACTACTGCGCCG
GCCCCAACCACGTGCTGCCCACCAGCGGCACGGCACGCTTTTCCAGCCCGCTGGGCGTGTATGACTTCCAGAAACGCTCC
AGCCTGATCGAAGTGAGCGAGCAGGGTGCCCAGACACTGGGCAGGATTGCCGCTGAACTGGCCTACGGCGAAGGTCTGCA
GGCGCATGCCCGCGCCGCCGAGATGCGCCTGCACACCGTACCCGATATGAAAGTGACCAAATGA

Upstream 100 bases:

>100_bases
GGTGGTCAACCAGACCGCCCTCAAACTCAAGCAGGCGCCCATCCGCAGGCTGATTGACGCCTTGTCCTTGGCCATCACGC
AATAGTCCGCAAAGAATGCT

Downstream 100 bases:

>100_bases
CCGCGCTGGACCCGAAGTTCAAACAGCTGATTCGCCAGGACGTGCAGTCCATGCATGCCTATGCCATTCAGGACTCCGTT
GGCATGGTCAAGCTCGATGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MNLVANPVRLSTASSTFDAEFKARLHWSADTDAAIEQRVADILLDVQRRGDTAVLEYTARFDGLSVSAMSALELSQAELK
AAFDAIPAAQRAALQAAARRVRSYHEAQKKANGEGWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVGEIIMVVPTPKGEKNPLVLAAAYVAGVTRAFTIGGAQAVAALAYGTSTIPAVDKITGPGNAYVAAAKRRVFGTVGID
MIAGPSEILVLADGSTPVDWVAMDLFSQAEHDELAQSILLCPDAAYIDQVHEALNRLLPAMPRAEIIAKSLNGRGVLIHT
RSMEEACALSNRIAPEHLEVSSSQPHEWEPLLKHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQTLGRIAAELAYGEGLQAHARAAEMRLHTVPDMKVTK

Sequences:

>Translated_447_residues
MNLVANPVRLSTASSTFDAEFKARLHWSADTDAAIEQRVADILLDVQRRGDTAVLEYTARFDGLSVSAMSALELSQAELK
AAFDAIPAAQRAALQAAARRVRSYHEAQKKANGEGWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVGEIIMVVPTPKGEKNPLVLAAAYVAGVTRAFTIGGAQAVAALAYGTSTIPAVDKITGPGNAYVAAAKRRVFGTVGID
MIAGPSEILVLADGSTPVDWVAMDLFSQAEHDELAQSILLCPDAAYIDQVHEALNRLLPAMPRAEIIAKSLNGRGVLIHT
RSMEEACALSNRIAPEHLEVSSSQPHEWEPLLKHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQTLGRIAAELAYGEGLQAHARAAEMRLHTVPDMKVTK
>Mature_447_residues
MNLVANPVRLSTASSTFDAEFKARLHWSADTDAAIEQRVADILLDVQRRGDTAVLEYTARFDGLSVSAMSALELSQAELK
AAFDAIPAAQRAALQAAARRVRSYHEAQKKANGEGWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVGEIIMVVPTPKGEKNPLVLAAAYVAGVTRAFTIGGAQAVAALAYGTSTIPAVDKITGPGNAYVAAAKRRVFGTVGID
MIAGPSEILVLADGSTPVDWVAMDLFSQAEHDELAQSILLCPDAAYIDQVHEALNRLLPAMPRAEIIAKSLNGRGVLIHT
RSMEEACALSNRIAPEHLEVSSSQPHEWEPLLKHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQTLGRIAAELAYGEGLQAHARAAEMRLHTVPDMKVTK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=413, Percent_Identity=41.4043583535109, Blast_Score=290, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=439, Percent_Identity=36.4464692482916, Blast_Score=263, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47487; Mature: 47487

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVANPVRLSTASSTFDAEFKARLHWSADTDAAIEQRVADILLDVQRRGDTAVLEYTAR
CCCCCCCEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHH
FDGLSVSAMSALELSQAELKAAFDAIPAAQRAALQAAARRVRSYHEAQKKANGEGWSYRD
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
EDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVGEIIMVVPTPKGEKNPL
CCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
VLAAAYVAGVTRAFTIGGAQAVAALAYGTSTIPAVDKITGPGNAYVAAAKRRVFGTVGID
EEEHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCHHCCCCCCCCEEHHHHHHHHEECCHH
MIAGPSEILVLADGSTPVDWVAMDLFSQAEHDELAQSILLCPDAAYIDQVHEALNRLLPA
EECCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
MPRAEIIAKSLNGRGVLIHTRSMEEACALSNRIAPEHLEVSSSQPHEWEPLLKHAGAIFL
CCHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCEEEE
GAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQTLGRIAAEL
EECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYGEGLQAHARAAEMRLHTVPDMKVTK
HHCCCHHHHHHHHHHHEECCCCCCCCC
>Mature Secondary Structure
MNLVANPVRLSTASSTFDAEFKARLHWSADTDAAIEQRVADILLDVQRRGDTAVLEYTAR
CCCCCCCEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEHH
FDGLSVSAMSALELSQAELKAAFDAIPAAQRAALQAAARRVRSYHEAQKKANGEGWSYRD
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
EDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVGEIIMVVPTPKGEKNPL
CCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
VLAAAYVAGVTRAFTIGGAQAVAALAYGTSTIPAVDKITGPGNAYVAAAKRRVFGTVGID
EEEHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCHHCCCCCCCCEEHHHHHHHHEECCHH
MIAGPSEILVLADGSTPVDWVAMDLFSQAEHDELAQSILLCPDAAYIDQVHEALNRLLPA
EECCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
MPRAEIIAKSLNGRGVLIHTRSMEEACALSNRIAPEHLEVSSSQPHEWEPLLKHAGAIFL
CCHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCEEEE
GAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQTLGRIAAEL
EECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYGEGLQAHARAAEMRLHTVPDMKVTK
HHCCCHHHHHHHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]