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The map label for this gene is hisG [H]

Identifier: 91786705

GI number: 91786705

Start: 829343

End: 830044

Strand: Direct

Name: hisG [H]

Synonym: Bpro_0803

Alternate gene names: 91786705

Gene position: 829343-830044 (Clockwise)

Preceding gene: 91786704

Following gene: 91786706

Centisome position: 15.95

GC content: 61.4

Gene sequence:

>702_bases
ATGCTGTCGCCCATCGGCTTTTTTGCGTCCCTTTTCTTGTCCCTTTTCTTTGAAGGCATCACCGTGATCACGCTCGCACT
TTCCAAAGGCCGCATCTTCGACGACATCCTGCCGCTGCTCAGAAGCGCCGGGATCGAAGTGCTCGACGACCCTGAAAAAT
CACGCAAGCTGATCCTGCGGACCAACCAGCCCGATCTGCGCGTGGTACTGGTGCGTGCCACCGATGTGCCGACCTATGTG
CAGTATGGCGGCGCGGACATTGGCGTGGTTGGCAAGGACACTCTGCTGGAGTCCGGCAGCCAGGGCCTGTACCAGCCGCT
GGACCTGCAAATCGCCCGGTGCCGCATCAGCGTGGCCGTGCGCGAAGGTTTTGACTATGCGGCTGCCGTGAAGCAGGGCT
CGCGGCTGAAAGTGGCGACCAAGTACGTGGCCATTGCCCGCGACTTCTTTGCCTCCAAGGGTGTGCACGTCGACCTGATC
AAGCTTTACGGCAGCATGGAGCTGGCGCCGCTCACCGGCCTGGCCGACGCCATCGTCGACCTGGTTTCCACCGGCAGCAC
GCTCAAGGCCAACCACCTGATCGAGGTCGAGCGCATCATGGACATCAGCTCGCACCTGGTGGTCAACCAGACCGCCCTCA
AACTCAAGCAGGCGCCCATCCGCAGGCTGATTGACGCCTTGTCCTTGGCCATCACGCAATAG

Upstream 100 bases:

>100_bases
CACGCTTGTCGCTTCGCGTACTACGCTGCCCCCCGAGGGGGCCGCCCGCCTGCAGTCCGGCGAAGCCGGCCCTGCGGCTT
GAACTTGGCAAGGCGGGACG

Downstream 100 bases:

>100_bases
TCCGCAAAGAATGCTATGAATTTAGTAGCCAACCCCGTACGCCTTTCGACCGCTTCCAGCACATTCGATGCTGAATTCAA
GGCGCGCCTGCACTGGTCTG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MLSPIGFFASLFLSLFFEGITVITLALSKGRIFDDILPLLRSAGIEVLDDPEKSRKLILRTNQPDLRVVLVRATDVPTYV
QYGGADIGVVGKDTLLESGSQGLYQPLDLQIARCRISVAVREGFDYAAAVKQGSRLKVATKYVAIARDFFASKGVHVDLI
KLYGSMELAPLTGLADAIVDLVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRRLIDALSLAITQ

Sequences:

>Translated_233_residues
MLSPIGFFASLFLSLFFEGITVITLALSKGRIFDDILPLLRSAGIEVLDDPEKSRKLILRTNQPDLRVVLVRATDVPTYV
QYGGADIGVVGKDTLLESGSQGLYQPLDLQIARCRISVAVREGFDYAAAVKQGSRLKVATKYVAIARDFFASKGVHVDLI
KLYGSMELAPLTGLADAIVDLVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRRLIDALSLAITQ
>Mature_233_residues
MLSPIGFFASLFLSLFFEGITVITLALSKGRIFDDILPLLRSAGIEVLDDPEKSRKLILRTNQPDLRVVLVRATDVPTYV
QYGGADIGVVGKDTLLESGSQGLYQPLDLQIARCRISVAVREGFDYAAAVKQGSRLKVATKYVAIARDFFASKGVHVDLI
KLYGSMELAPLTGLADAIVDLVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRRLIDALSLAITQ

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=218, Percent_Identity=34.4036697247706, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=194, Percent_Identity=29.3814432989691, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25351; Mature: 25351

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPIGFFASLFLSLFFEGITVITLALSKGRIFDDILPLLRSAGIEVLDDPEKSRKLILR
CCCHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEE
TNQPDLRVVLVRATDVPTYVQYGGADIGVVGKDTLLESGSQGLYQPLDLQIARCRISVAV
CCCCCEEEEEEEECCCCHHHHCCCCEEEECCCHHHHHCCCCCCCCCHHHEEEHHEEEEHH
REGFDYAAAVKQGSRLKVATKYVAIARDFFASKGVHVDLIKLYGSMELAPLTGLADAIVD
HCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHH
LVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRRLIDALSLAITQ
HHHCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLSPIGFFASLFLSLFFEGITVITLALSKGRIFDDILPLLRSAGIEVLDDPEKSRKLILR
CCCHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHHHHHHHCCCCEECCCCCCCEEEEE
TNQPDLRVVLVRATDVPTYVQYGGADIGVVGKDTLLESGSQGLYQPLDLQIARCRISVAV
CCCCCEEEEEEEECCCCHHHHCCCCEEEECCCHHHHHCCCCCCCCCHHHEEEHHEEEEHH
REGFDYAAAVKQGSRLKVATKYVAIARDFFASKGVHVDLIKLYGSMELAPLTGLADAIVD
HCCCCHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHHHH
LVSTGSTLKANHLIEVERIMDISSHLVVNQTALKLKQAPIRRLIDALSLAITQ
HHHCCCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA