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The map label for this gene is pgi [H]

Identifier: 91786655

GI number: 91786655

Start: 771205

End: 772782

Strand: Direct

Name: pgi [H]

Synonym: Bpro_0753

Alternate gene names: 91786655

Gene position: 771205-772782 (Clockwise)

Preceding gene: 91786654

Following gene: 91786656

Centisome position: 14.83

GC content: 63.5

Gene sequence:

>1578_bases
ATGAGTCAGTCCATGAAACGCCTTCGTTGTGATCAGACCCCGGCCTGGGCGGCGCTGCAGGCCAGCTTTGAAGCCGGCGG
AAAATCCTTCGATCTGCGTGAGGCATTTGCCGGCGACGCGGAGCGGTTTTTCCGCTTCAGCCAGGAAGCGCCCTACGTTT
TTGCCGATCTCTCCAAGAATCTTCTGGATGTGACCAGTGAGGCGCTGTTGCTGGACCTGGCCGTCCAGTGCCAGCTGGAG
CAACACCGCGACGCCATGTTTGCCGGCGACAGGATCAACAGCACCGAGCAACGCGCGGTGATGCATTTCCTGTTGCGACA
ACCGGCTCTTCCCGCTTTGGAGCAGGCGCAGTCGGCCATAAAAAACACAGCGCATGAGCTGAGCCAGGTCCACGCCACGC
TGGACGCCATGCTGGCTTACGCAGAAGAGGTGCGCGCCGATGAGGCCATTACCGATGTCGTCAACATCGGCATCGGTGGC
TCGGACCTGGGGCCGCAAATGGCGGTGCTGGCGCTGGGCGAATTTGCCACCACGGGCAAACGCTTTCACTTTGTCTCCAA
CGTTGATGGCCAGGAACTGGCCGGCGTGCTGGCGCAGTGCCAGCCGCACAGCACGCTGTTCCTCGTCGCATCCAAGACCT
TCACCACCAACGAAACCATGAGCAATGCGCATTCCGCAAAGCGCTGGTTTGAGGCGGGTGGTGGCCGCGACATCAACCGG
CATTTCGCCGCGCTGACGACCAATGTCGTGGCGGCCAATGCATTTGGCATACGCAGCACCTTCGGGTTTTGGGACTGGGT
GGGCGGCCGCTACTCGCTGTGGTCGGCCATTGGTTTGCCGGTTGCCATCGCCATTGGCGCTGTCGGCTTTCGCGAGTTGC
TGGCCGGCGCGCACGCGATGGACGAGCACTTTCGCACCGCCGCGCTGGCCCGCAACCTGCCTGTGCGCCTTGGCCTGCTG
GATGTCTGGTACCGCAATTTCCACGGCTTCGGCAGCCGCAGCATCGCCCCCTACAGCAGTGCCTTGCGGCGCCTGCCGGC
GTACTTGCAGCAGCTGGAAATGGAGAGCAATGGCAAACGCGTGGATACGGACGGCCAGCCCCTGCCGTTTGCGACCGCGC
CGGTGCTGTGGGGCGAGCCCGGCACCAATGGTCAGCACGCCTATTTCCAGATGCTGCACCAGGGCACTTCCGTGGTGCCG
ATCGAGTTCGTGGCCGTCAGGAAGGCGGCGCATGGCTTGCCCGGGCACCATGAACAATTGCTGGCCAATGTGCTGGCGCA
GGCACAGGCGCTGATGCAGGGCAAAAACGACGAGGGTGGCCACAGGCATTTTCCCGGCAACCGGCCCAGTACCTTTTTAC
TGCTGGACCAGCTCACGCCCGCCAGCCTGGGCGCGCTGATCGCCCTGCAGGAGCACCGTGTGTTTGTGAGCGGCGCCCTC
TGGGGCATCAACAGCTTCGACCAGTGGGGCGTTGAGCTCGGCAAGGTGCTGGCCAAAGACATTGAGCCGCGTTTGCGCAG
CGGGGATACATCGGGGCTTGACGGCTCCACGGCCGGGCTGTTGCAGCGCCTGCGCTAG

Upstream 100 bases:

>100_bases
ACGCGCTCAACGAAGACGCCATGGCCACCGAAAAGCTGGCCGAAGGCATACGCGCCTTTGCGGCCGATGCGATCAAGCTT
GAGCAGCTGATGGTGGCGGC

Downstream 100 bases:

>100_bases
ATGTAGTTTCCCAAGAGGTTGTTCACCCGAGGTGAAGGAAGATGGAGGTTCTGACATCTCCCAAACCCCTTCAGGACTCC
CCGGATGAACATCCACAAGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSQSMKRLRCDQTPAWAALQASFEAGGKSFDLREAFAGDAERFFRFSQEAPYVFADLSKNLLDVTSEALLLDLAVQCQLE
QHRDAMFAGDRINSTEQRAVMHFLLRQPALPALEQAQSAIKNTAHELSQVHATLDAMLAYAEEVRADEAITDVVNIGIGG
SDLGPQMAVLALGEFATTGKRFHFVSNVDGQELAGVLAQCQPHSTLFLVASKTFTTNETMSNAHSAKRWFEAGGGRDINR
HFAALTTNVVAANAFGIRSTFGFWDWVGGRYSLWSAIGLPVAIAIGAVGFRELLAGAHAMDEHFRTAALARNLPVRLGLL
DVWYRNFHGFGSRSIAPYSSALRRLPAYLQQLEMESNGKRVDTDGQPLPFATAPVLWGEPGTNGQHAYFQMLHQGTSVVP
IEFVAVRKAAHGLPGHHEQLLANVLAQAQALMQGKNDEGGHRHFPGNRPSTFLLLDQLTPASLGALIALQEHRVFVSGAL
WGINSFDQWGVELGKVLAKDIEPRLRSGDTSGLDGSTAGLLQRLR

Sequences:

>Translated_525_residues
MSQSMKRLRCDQTPAWAALQASFEAGGKSFDLREAFAGDAERFFRFSQEAPYVFADLSKNLLDVTSEALLLDLAVQCQLE
QHRDAMFAGDRINSTEQRAVMHFLLRQPALPALEQAQSAIKNTAHELSQVHATLDAMLAYAEEVRADEAITDVVNIGIGG
SDLGPQMAVLALGEFATTGKRFHFVSNVDGQELAGVLAQCQPHSTLFLVASKTFTTNETMSNAHSAKRWFEAGGGRDINR
HFAALTTNVVAANAFGIRSTFGFWDWVGGRYSLWSAIGLPVAIAIGAVGFRELLAGAHAMDEHFRTAALARNLPVRLGLL
DVWYRNFHGFGSRSIAPYSSALRRLPAYLQQLEMESNGKRVDTDGQPLPFATAPVLWGEPGTNGQHAYFQMLHQGTSVVP
IEFVAVRKAAHGLPGHHEQLLANVLAQAQALMQGKNDEGGHRHFPGNRPSTFLLLDQLTPASLGALIALQEHRVFVSGAL
WGINSFDQWGVELGKVLAKDIEPRLRSGDTSGLDGSTAGLLQRLR
>Mature_524_residues
SQSMKRLRCDQTPAWAALQASFEAGGKSFDLREAFAGDAERFFRFSQEAPYVFADLSKNLLDVTSEALLLDLAVQCQLEQ
HRDAMFAGDRINSTEQRAVMHFLLRQPALPALEQAQSAIKNTAHELSQVHATLDAMLAYAEEVRADEAITDVVNIGIGGS
DLGPQMAVLALGEFATTGKRFHFVSNVDGQELAGVLAQCQPHSTLFLVASKTFTTNETMSNAHSAKRWFEAGGGRDINRH
FAALTTNVVAANAFGIRSTFGFWDWVGGRYSLWSAIGLPVAIAIGAVGFRELLAGAHAMDEHFRTAALARNLPVRLGLLD
VWYRNFHGFGSRSIAPYSSALRRLPAYLQQLEMESNGKRVDTDGQPLPFATAPVLWGEPGTNGQHAYFQMLHQGTSVVPI
EFVAVRKAAHGLPGHHEQLLANVLAQAQALMQGKNDEGGHRHFPGNRPSTFLLLDQLTPASLGALIALQEHRVFVSGALW
GINSFDQWGVELGKVLAKDIEPRLRSGDTSGLDGSTAGLLQRLR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=550, Percent_Identity=43.6363636363636, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI296080693, Length=543, Percent_Identity=41.4364640883978, Blast_Score=414, Evalue=1e-115,
Organism=Escherichia coli, GI1790457, Length=554, Percent_Identity=46.5703971119134, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71996708, Length=552, Percent_Identity=43.4782608695652, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71996703, Length=550, Percent_Identity=43.4545454545455, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319673, Length=545, Percent_Identity=45.3211009174312, Blast_Score=448, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24651916, Length=547, Percent_Identity=44.7897623400366, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24651914, Length=547, Percent_Identity=44.7897623400366, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17737445, Length=547, Percent_Identity=44.7897623400366, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 57192; Mature: 57061

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSMKRLRCDQTPAWAALQASFEAGGKSFDLREAFAGDAERFFRFSQEAPYVFADLSKN
CCCCHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEHHHHHH
LLDVTSEALLLDLAVQCQLEQHRDAMFAGDRINSTEQRAVMHFLLRQPALPALEQAQSAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
KNTAHELSQVHATLDAMLAYAEEVRADEAITDVVNIGIGGSDLGPQMAVLALGEFATTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
RFHFVSNVDGQELAGVLAQCQPHSTLFLVASKTFTTNETMSNAHSAKRWFEAGGGRDINR
EEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHH
HFAALTTNVVAANAFGIRSTFGFWDWVGGRYSLWSAIGLPVAIAIGAVGFRELLAGAHAM
HHHHHHHHHHHHCCCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEHFRTAALARNLPVRLGLLDVWYRNFHGFGSRSIAPYSSALRRLPAYLQQLEMESNGKR
HHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
VDTDGQPLPFATAPVLWGEPGTNGQHAYFQMLHQGTSVVPIEFVAVRKAAHGLPGHHEQL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
LANVLAQAQALMQGKNDEGGHRHFPGNRPSTFLLLDQLTPASLGALIALQEHRVFVSGAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHEEHHCCEEEEEEEE
WGINSFDQWGVELGKVLAKDIEPRLRSGDTSGLDGSTAGLLQRLR
CCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SQSMKRLRCDQTPAWAALQASFEAGGKSFDLREAFAGDAERFFRFSQEAPYVFADLSKN
CCCHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEHHHHHH
LLDVTSEALLLDLAVQCQLEQHRDAMFAGDRINSTEQRAVMHFLLRQPALPALEQAQSAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
KNTAHELSQVHATLDAMLAYAEEVRADEAITDVVNIGIGGSDLGPQMAVLALGEFATTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
RFHFVSNVDGQELAGVLAQCQPHSTLFLVASKTFTTNETMSNAHSAKRWFEAGGGRDINR
EEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHH
HFAALTTNVVAANAFGIRSTFGFWDWVGGRYSLWSAIGLPVAIAIGAVGFRELLAGAHAM
HHHHHHHHHHHHCCCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEHFRTAALARNLPVRLGLLDVWYRNFHGFGSRSIAPYSSALRRLPAYLQQLEMESNGKR
HHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
VDTDGQPLPFATAPVLWGEPGTNGQHAYFQMLHQGTSVVPIEFVAVRKAAHGLPGHHEQL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
LANVLAQAQALMQGKNDEGGHRHFPGNRPSTFLLLDQLTPASLGALIALQEHRVFVSGAL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHEEHHCCEEEEEEEE
WGINSFDQWGVELGKVLAKDIEPRLRSGDTSGLDGSTAGLLQRLR
CCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA