Click here to switch to the map view.

The map label for this gene is exuT [H]

Identifier: 91212522

GI number: 91212522

Start: 3471634

End: 3473052

Strand: Direct

Name: exuT [H]

Synonym: UTI89_C3531

Alternate gene names: 91212522

Gene position: 3471634-3473052 (Clockwise)

Preceding gene: 91212518

Following gene: 162138371

Centisome position: 68.53

GC content: 54.33

Gene sequence:

>1419_bases
ATGGCAACGTTCGGGGCGTGCCGGTTTTTTTTCGGTTACCCGGTCGTAACTAACATCTTCAGCCTCTGGCGGGATGATGG
CCGCGCTTCCTGCGGATATAACAAAACGATGAGGTTTTACATGCGTAAAATTAAAGGGTTACGTTGGTATATGATCGCAC
TGGTGACGCTCGGCACCGTGCTTGGTTACCTGACGCGTAACACTGTGGCGGCAGCTGCGCCAACTCTGATGGAAGAGTTA
AACATCTCCACCCAACAGTATTCCTATATCATCGCAGCGTATTCTGCTGCTTATACGGTCATGCAACCGGTAGCGGGTTA
TGTACTGGATGTGCTGGGTACGAAAATCGGTTATGCAATGTTTGCTGTACTGTGGGCCGTGTTCTGTGGTGCAACTGCGC
TGGCAGGTAGTTGGGGTGGCCTGGCGGTTGCTCGTGGTGCGGTCGGTGCCGCGGAAGCCGCGATGATTCCGGCGGGTCTG
AAAGCCAGCTCCGAATGGTTCCCGGCGAAAGAGCGTTCCATCGCGGTAGGTTACTTTAACGTAGGTTCTTCGATTGGTGC
GATGATTGCGCCGCCGCTGGTGGTATGGGCAATCGTGATGCACAGCTGGCAGATGGCATTTATCATCTCCGGTGCGTTGA
GCTTTATCTGGGCGATGGCATGGCTGATTTTCTATAAACATCCGCGCGACCAGAAACATCTGACCGATGAAGAACGCGAC
TACATTATTAATGGTCAGGAAGCCCAGCACCAGGTTGACACAGCGAAGAAAATGTCCGTTGGTCAGATCCTGCGCAACCG
TCAGTTCTGGGGTATCGCGCTGCCGCGCTTCCTGGCAGAACCGGCATGGGGTACTTTTAACGCGTGGATCCCGCTGTTCA
TGTTTAAAGTTTACGGCTTTAACCTGAAAGAGATCGCGATGTTTGCCTGGATGCCGATGCTGTTTGCTGACCTCGGTTGT
ATCCTCGGTGGTTACCTGCCGCCGCTGTTCCAGCGTTGGTTTGGTGTGAACCTGATCGTTTCCCGTAAGATGGTCGTAAC
GCTGGGTGCGGTGCTGATGATTGGCCCGGGTATGATCGGTCTGTTCACCAACCCGTATGTCGCGATTATGCTGCTGTGTA
TCGGTGGTTTTGCTCACCAGGCACTGTCTGGCGCACTGATTACGCTCTCGTCTGACGTGTTCGGTCGTAACGAAGTGGCG
ACGGCGAACGGTTTAACCGGGATGTCCGCATGGCTGGCAAGTACGCTGTTTGCACTGGTAGTCGGTGCACTGGCTGACAC
CATCGGCTTCAGCCCGCTGTTCGCAGTTCTGGCAGTGTTCGACCTGTTAGGTGCGCTGGTTATCTGGACCGTGTTGCAGA
ACAAACCGGCGATTGAGGTGGCGCAGGAATCACATAACGATCCCGCACCGCAACATTAA

Upstream 100 bases:

>100_bases
GTCGCAAATCATAAGTCGACGGAATGCAAATTGCCGATTCATTCATTTGTTAGATGAATCGGGTTAACCGGTACGGAAGC
CGAATTAGCACGAAACTTTC

Downstream 100 bases:

>100_bases
GGCTTCGTGTAAGTTTTAGTTTCCCTTCAAAGCCGCCTTCTCAGGCGGCTTTTTCATCACTGCGAGTAGAGCTAAACTCG
CAAAAGTGGTATAACAAATA

Product: hexuronate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MATFGACRFFFGYPVVTNIFSLWRDDGRASCGYNKTMRFYMRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEEL
NISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGL
KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQKHLTDEERD
YIINGQEAQHQVDTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGC
ILGGYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVA
TANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQESHNDPAPQH

Sequences:

>Translated_472_residues
MATFGACRFFFGYPVVTNIFSLWRDDGRASCGYNKTMRFYMRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEEL
NISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGL
KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQKHLTDEERD
YIINGQEAQHQVDTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGC
ILGGYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVA
TANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQESHNDPAPQH
>Mature_471_residues
ATFGACRFFFGYPVVTNIFSLWRDDGRASCGYNKTMRFYMRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELN
ISTQQYSYIIAAYSAAYTVMQPVAGYVLDVLGTKIGYAMFAVLWAVFCGATALAGSWGGLAVARGAVGAAEAAMIPAGLK
ASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGALSFIWAMAWLIFYKHPRDQKHLTDEERDY
IINGQEAQHQVDTAKKMSVGQILRNRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCI
LGGYLPPLFQRWFGVNLIVSRKMVVTLGAVLMIGPGMIGLFTNPYVAIMLLCIGGFAHQALSGALITLSSDVFGRNEVAT
ANGLTGMSAWLASTLFALVVGALADTIGFSPLFAVLAVFDLLGALVIWTVLQNKPAIEVAQESHNDPAPQH

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=383, Percent_Identity=22.976501305483, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI148743791, Length=256, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI154800443, Length=409, Percent_Identity=23.4718826405868, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI2367193, Length=472, Percent_Identity=99.5762711864407, Blast_Score=956, Evalue=0.0,
Organism=Escherichia coli, GI87082320, Length=410, Percent_Identity=26.8292682926829, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI2367379, Length=308, Percent_Identity=27.9220779220779, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1789515, Length=410, Percent_Identity=25.8536585365854, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789152, Length=382, Percent_Identity=23.5602094240838, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082071, Length=441, Percent_Identity=23.3560090702948, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552542, Length=318, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533554, Length=270, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115533556, Length=270, Percent_Identity=23.3333333333333, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45550460, Length=412, Percent_Identity=25.4854368932039, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24580790, Length=291, Percent_Identity=24.3986254295533, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24655255, Length=382, Percent_Identity=28.2722513089005, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639764, Length=456, Percent_Identity=22.1491228070175, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129235, Length=360, Percent_Identity=25.2777777777778, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641682, Length=371, Percent_Identity=23.1805929919137, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24658658, Length=301, Percent_Identity=24.2524916943522, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573708, Length=280, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573707, Length=280, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573299, Length=406, Percent_Identity=22.6600985221675, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51586; Mature: 51455

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATFGACRFFFGYPVVTNIFSLWRDDGRASCGYNKTMRFYMRKIKGLRWYMIALVTLGTV
CCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH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HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]